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Zhong Wang et al.
Mediators of inflammation, 2011, 848309-848309 (2011-03-16)
Our previous study concerning brain trauma has shown that progesterone could regulate toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) signaling pathway in the brain, which also has been proved to play important roles in early brain injury (EBI)...
Katrine Pilely et al.
Atherosclerosis, 283, 35-42 (2019-02-18)
Cholesterol crystal (CC)-induced inflammation is a critical step in the development of atherosclerosis. CCs activate the complement system and induce an inflammatory response resulting in phagocytosis of the CCs, production of reactive oxygen species (ROS) and release of cytokines. The...
Zhentian Wang et al.
Cancer cell, 37(6), 834-849 (2020-05-23)
Molecular mechanisms underlying adaptive targeted therapy resistance in pancreatic ductal adenocarcinoma (PDAC) are poorly understood. Here, we identify SETD5 as a major driver of PDAC resistance to MEK1/2 inhibition (MEKi). SETD5 is induced by MEKi resistance and its deletion restores...
Cristina Cardona et al.
Molecular reproduction and development, 84(5), 423-435 (2017-04-19)
Semen analysis lacks a functional component and best identifies extreme cases of infertility. The ganglioside G
Wei-Chia Tseng et al.
Disease models & mechanisms, 11(9) (2018-08-24)
Niemann-Pick disease type C1 (NPC1) is a rare autosomal recessive lysosomal storage disease primarily caused by mutations in NPC1 NPC1 is characterized by abnormal accumulation of unesterified cholesterol and glycolipids in late endosomes and lysosomes. Common signs include neonatal jaundice...
Sebastian Heck et al.
Neuroimmunomodulation, 24(6), 331-340 (2018-04-24)
The chemokine CXCL12 interacting with the CXC receptor 4 (CXCR4) has been reported to play a role in the development and progression of bronchial asthma, but its mechanism of action is still unknown. The objective of this study was to...
Rui Su et al.
Cancer cell, 38(1), 79-96 (2020-06-13)
Fat mass and obesity-associated protein (FTO), an RNA N6-methyladenosine (m6A) demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the development of effective targeted therapeutics. Here, we report two potent small-molecule FTO inhibitors that exhibit strong anti-tumor effects...
Allison Bradbury et al.
The Journal of pharmacology and experimental therapeutics, 358(2), 254-261 (2016-06-17)
Niemann-Pick type C (NPC) 1 disease is a rare, inherited, neurodegenerative disease. Clear evidence of the therapeutic efficacy of 2-hydroxypropyl-β-cyclodextrin (HPβCD) in animal models resulted in the initiation of a phase I/IIa clinical trial in 2013 and a phase IIb/III...
Jing Wang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(50), 9751-9771 (2020-11-08)
Expression of the 17β-estradiol (E2) synthesis enzyme aromatase is highly upregulated in astrocytes following brain injury. However, the precise role of astrocyte-derived E2 in the injured brain remains unclear. In the current study, we generated a glial fibrillary acidic protein...
Rachel J Smith et al.
The European journal of neuroscience, 30(3), 493-503 (2009-08-07)
The orexin/hypocretin system has recently been implicated in reward-processing and addiction. We examined the involvement of the orexin system in cue-induced reinstatement of extinguished cocaine-seeking by administering the orexin 1 receptor antagonist SB-334867 (SB) or the orexin 2 receptor antagonist...
Melissa A Moody et al.
Molecular reproduction and development, 84(5), 408-422 (2017-04-19)
Sperm must undergo capacitation to become fertilization competent. Here we validated that monosialotetrahexosylganglioside (G
Li Zhang et al.
Neurochemistry international, 118, 304-313 (2018-05-25)
Fisetin, a natural flavonoid, has neuroprotection properties in many brain injury models. However, its role in traumatic brain injury (TBI) has not been fully explained. In the present study, we aimed to explore the neuroprotective effects of fisetin in a...
Meilan He et al.
The Journal of pathology, 242(3), 309-321 (2017-04-11)
Primary effusion lymphoma (PEL) is a rare and aggressive B-cell lymphoma with a dismal prognosis caused by infection of Kaposi's sarcoma-associated herpesvirus. Despite the findings that numerous viral genes and cellular pathways are essential for the proliferation and survival of...
Valentino J Stella et al.
Toxicologic pathology, 36(1), 30-42 (2008-03-14)
beta-cyclodextrin (beta-CD) and other cyclodextrins (CDs) have utility for solubilizing and stabilizing drugs; however, some are nephrotoxic when administered parenterally. A number of workers have attempted to identify, prepare, and evaluate various CD derivatives with superior inclusion complexation and maximal...
François Daubeuf et al.
Respiratory research, 16, 77-77 (2015-06-27)
Potential involvement of the CCR10/CCL28 axis was recently reported in murine models of allergic asthma. If confirmed, blockade of the CCR10 receptor would represent an alternative to current asthma therapies. We evaluated the effect of a novel Protein Epitope Mimetic...
Xuan Wang et al.
Experimental cell research, 383(2), 111507-111507 (2019-07-30)
Fibrosis is a common pathology in renal disease. Hypertensive nephropathy (HN) is one of the most common secondary nephropathies that often progresses to severe renal fibrosis with limited treatment options beyond hypertension control. Bromodomain-containing protein 4 (Brd4) was recently recognized...
Stephanie L Guerra et al.
Cancer cell, 37(5), 705-719 (2020-04-04)
While KRAS mutations are common in non-small cell lung cancer (NSCLC), effective treatments are lacking. Here, we report that half of KRAS-mutant NSCLCs aberrantly express the homeobox protein HOXC10, largely due to unappreciated defects in PRC2, which confers sensitivity to...
Clare F Malone et al.
Cancer discovery, 7(12), 1450-1463 (2017-10-01)
Although agents that inhibit specific oncogenic kinases have been successful in a subset of cancers, there are currently few treatment options for malignancies that lack a targetable oncogenic driver. Nevertheless, during tumor evolution cancers engage a variety of protective pathways...
Fady Sharara et al.
Reproductive biomedicine online, 41(1), 69-79 (2020-06-09)
Can a previously defined relationship between sperm capacitation and the probability of a man generating pregnancy within three cycles, prospectively predict male fertility in diverse clinical settings? A second study asked, what is the prevalence of impaired sperm fertilizing ability...
Casey G Langdon et al.
Oncotarget, 6(35), 37410-37425 (2015-10-21)
Targeting anti-apoptotic proteins can sensitize tumor cells to conventional chemotherapies or other targeted agents. Antagonizing the Inhibitor of Apoptosis Proteins (IAPs) with mimetics of the pro-apoptotic protein SMAC is one such approach. We used sensitization compound screening to uncover possible...
Dmitri R Davydov et al.
Biochemistry, 47(43), 11348-11359 (2008-10-04)
To establish a direct method for monitoring substrate binding in cytochrome P450eryF applicable at elevated hydrostatic pressures, we introduce a laser dye Fluorol-7GA (F7GA) as a novel fluorescent ligand. The high intensity of fluorescence and the reasonable resolution of the...
E Sanchez-Lopez et al.
Oncogene, 35(20), 2634-2644 (2015-09-15)
The tumor microenvironment (TME) exerts critical pro-tumorigenic effects through cytokines and growth factors that support cancer cell proliferation, survival, motility and invasion. Insulin-like growth factor-1 (IGF-1) and signal transducer and activator of transcription 3 (STAT3) stimulate colorectal cancer development and...
Amy K Sutton et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(46), 15306-15318 (2014-11-14)
The paraventricular nucleus of the hypothalamus (PVH) contains a heterogeneous cluster of Sim1-expressing cell types that comprise a major autonomic output nucleus and play critical roles in the control of food intake and energy homeostasis. The roles of specific PVH...
Yangfei Xiang et al.
Molecular cell, 79(1), 84-98 (2020-06-12)
Rett syndrome (RTT), mainly caused by mutations in methyl-CpG binding protein 2 (MeCP2), is one of the most prevalent intellectual disorders without effective therapies. Here, we used 2D and 3D human brain cultures to investigate MeCP2 function. We found that...
T L Yaksh et al.
Life sciences, 48(7), 623-633 (1991-01-01)
The substituted glucopyranose ring structure 2-hydroxypropyl-beta-cyclodextrin (CDEX) increases the solubility of molecules by inclusion of the agent in the lipophilic interior of the ring. This property is of particular use for the administration of molecules by the intracerebral (ICV) or...
D E Rusyniak et al.
Neuroscience, 154(4), 1619-1626 (2008-06-07)
When given in a warm environment MDMA (3,4-methylenedioxymethamphetamine, ecstasy) causes hyperthermia by increasing interscapular brown adipose tissue (iBAT) heat production and decreasing heat loss via cutaneous vasoconstriction. When given in a cold environment, however, MDMA causes hypothermia by an unknown...
Cyclodextrin Drug Carrier Systems.
Kaneto Uekama et al.
Chemical reviews, 98(5), 2045-2076 (2002-02-19)
Jagdishbhai L Italia et al.
PloS one, 6(10), e25744-e25744 (2011-10-15)
Despite advances in the treatment, the morbidity and mortality rate associated with invasive aspergillosis remains unacceptably high (70-90%) in immunocompromised patients. Amphotericin B (AMB), a polyene antibiotic with broad spectrum antifungal activity appears to be a choice of treatment but...
Shuhua Chen et al.
PloS one, 6(8), e24293-e24293 (2011-09-16)
Previously, we demonstrated that allopregnanolone (APα) promoted proliferation of rodent and human neural progenitor cells in vitro. Further, we demonstrated that APα promoted neurogenesis in the hippocampal subgranular zone (SGZ) and reversed learning and memory deficits in the male triple...
Charles H Vite et al.
Science translational medicine, 7(276), 276ra26-276ra26 (2015-02-27)
Niemann-Pick type C1 (NPC) disease is a lysosomal storage disease caused by mutations in the NPC1 gene, leading to an increase in unesterified cholesterol and several sphingolipids, and resulting in hepatic disease and progressive neurological disease. We show that subcutaneous...