Showing 1-30 of 502 results for "C1386"
Dawn Chin et al.
Current medicinal chemistry, 20(32), 3955-3985 (2013-08-13)
As demographics in developed nations shift towards an aging population, neurodegenerative pathologies, especially dementias such as Alzheimer's disease, pose one of the largest challenges to the modern health care system. Since there is yet no cure for dementia, there is...
Hui Guo et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(11), 8511-8517 (2015-06-03)
Prostate cancer (PC) is a prevalent cancer in aged men. Curcumin is an active ingredient that has been extracted from the rhizome of the plant Curcuma longa. Recently, a potential of Curcumin against PC has been reported in PC, whereas...
W Zhang et al.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 16(8), 708-713 (2013-12-03)
Curcumin, a natural phytochemical, exhibits potent anticancer activities. Here, we sought to determine the molecular mechanisms underlying the cytotoxic effects of curcumin against human non-small cell lung cancer (NSCLC) cells. MTT assay and annexin-V/PI staining were used to analyze the...
Carlos Alberto Arcaro et al.
PloS one, 9(12), e113993-e113993 (2014-12-04)
Knowing that curcumin has low bioavailability when administered orally, and that piperine has bioenhancer activity by inhibition of hepatic and intestinal biotransformation processes, the aim of this study was to investigate the antidiabetic and antioxidant activities of curcumin (90 mg/kg)...
Fatma M Abdelhamid et al.
Environmental science and pollution research international, 27(10), 10950-10965 (2020-01-19)
Lead, toxic heavy metal of global concern, induces toxicity in various organs via oxidative stress. Thereby, in this study, the protective role of curcumin against lead acetate-induced toxicity was evaluated. Thirty-two male albino rats were allocated equally into four groups...
Venus Singh Mithu et al.
The Journal of biological chemistry, 289(16), 11122-11131 (2014-03-07)
Amyloid β (Aβ) fibrillar deposits in the brain are a hallmark of Alzheimer disease (AD). Curcumin, a common ingredient of Asian spices, is known to disrupt Aβ fibril formation and to reduce AD pathology in mouse models. Understanding the structural...
Mehmet Oz et al.
Neurobiology of learning and memory, 123, 43-49 (2015-05-20)
The present study has been designed to investigate the role of curcumin on cisplatin-inducedcognitive impairment and to reveal mechanisms of cisplatin's detrimental actions on cognition in rats. Animals were treated with cisplatin (5mg/kg/week) and/or curcumin (300mg/kg/day) for 5weeks. Morris water...
Qinghua Yao et al.
International journal of molecular medicine, 36(4), 1118-1126 (2015-08-28)
Curcumin has been found to exhibit anticancer activity and certain studies have shown that curcumin triggers the apoptosis of human A549 lung adenocarcinoma cells. However, the mechanism underlying curcumin‑mediated apoptosis is not completely understood. The present study was designed to investigate...
Zun-Jing Liu et al.
Journal of neuroscience research, 92(11), 1549-1559 (2014-07-01)
The turmeric derivative curcumin protects against cerebral ischemic injury. We previously demonstrated that curcumin activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor involved in both neuroprotective and anti-inflammatory signaling pathways. This study tested whether the neuroprotective effects of curcumin...
Wen-Ying Lee et al.
Toxicology and applied pharmacology, 274(1), 55-62 (2013-11-12)
Heme oxygenase (HO)-1 is an oxidative stress-response enzyme which catalyzes the degradation of heme into bilirubin, ferric ion, and carbon monoxide (CO). Induction of HO-1 was reported to have antitumor activity; the inhibitory mechanism, however, is still unclear. In the...
Reham M Milhem et al.
The international journal of biochemistry & cell biology, 60, 119-129 (2015-01-07)
Muscle, skeletal, receptor tyrosine kinase (MuSK) is a key organizer at the postsynaptic membrane and critical for proper development and maintenance of the neuromuscular junction. Mutations in MUSK result in congenital myasthenic syndrome (CMS). We hypothesized that the CMS-causing missense...
Bingshan Wu et al.
DNA and cell biology, 32(6), 292-297 (2013-04-30)
DNA methylation plays an essential role in carcinogenesis. Promoter hypermethylation can result in transcriptional silencing of specific genes, such as tumor suppressors. Thus far, few reports have investigated the effect of curcumin, an active component of the perennial herb Curcuma...
Shilpa Sood et al.
Biochemical and biophysical research communications, 438(4), 600-606 (2013-08-15)
More than 85% of breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens and co-carcinogens. To identify co-carcinogens with abilities to induce cellular pre-malignancy, we studied the activity of triclocarban (TCC), an antimicrobial agent commonly used in...
Xi Lu et al.
PloS one, 9(7), e103067-e103067 (2014-07-23)
Epigenetic modifications, particularly histone acetylation, have been implicated in Alzheimer's disease (AD). While previous studies have suggested that histone hypoacetylation may regulate the expression of genes associated with memory and learning in AD, little is known about histone regulation of...
Yangwei Wang et al.
Biochimica et biophysica acta, 1852(1), 34-46 (2014-12-03)
Glomerulosclerosis and interstitial fibrosis represent the key events in development of diabetic nephropathy (DN), with connective tissue growth factor (CTGF), plasminogen activator inhibitor-1 (PAI-1) and fibronectin 1 (FN-1) playing important roles in these pathogenic processes. To investigate whether the plant...
Jianping Chen et al.
Journal of agricultural and food chemistry, 63(28), 6440-6449 (2015-06-09)
Curcumin (Cur), an active ingredient from the rhizome of the plant Curcuma longa, has wide anticancer activities. However, due to its poor solubility and hence poor absorption, Cur has limited clinical applications. It is therefore important to develop an effective...
Lujing Wang et al.
Journal of pharmacokinetics and pharmacodynamics, 47(2), 131-144 (2020-02-06)
Curcumin (CUR) is a major component of turmeric Curcuma longa, which is often used in food or as a dietary supplement. The purpose of this preclinical study is to investigate the acute pharmacokinetic and pharmacodynamic (PK/PD) profiles of two commercially...
Ganji Purnachandra Nagaraju et al.
Cancer letters, 341(2), 195-203 (2013-08-13)
DNA methylation is a rational therapeutic target in pancreatic cancer. The activity of novel curcumin analogues EF31 and UBS109 as demethylating agents were investigated. MiaPaCa-2 and PANC-1 cells were treated with vehicle, curcumin, EF31 or UBS109. EF31 and UBS109 resulted...
Benjawan Meesarapee et al.
Phytotherapy research : PTR, 28(4), 611-616 (2013-07-17)
6-Hydroxydopamine (6-OHDA) selectively enters dopaminergic neurons and undergoes auto-oxidation resulting in the generation of reactive oxygen species and dopamine quinones, subsequently leading to apoptosis. This mechanism mimics the pathogenesis of Parkinson's disease and has been used to induce experimental Parkinsonism...
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Linsheng Yu et al.
The American journal of the medical sciences, 349(6), 521-525 (2015-04-14)
Curcumin, extracted from South Asian spice turmeric, has been determined to have the promising ability in antioxidation and anti-inflammation. However, the effect of curcumin on treating brain damage has been not reported. In this article, the aim was to evaluate...
Anggakusuma et al.
Gut, 63(7), 1137-1149 (2013-08-02)
Hepatitis C virus (HCV) infection causes severe liver disease and affects more than 160 million individuals worldwide. People undergoing liver organ transplantation face universal re-infection of the graft. Therefore, affordable antiviral strategies targeting the early stages of infection are urgently...
Misaki Ono et al.
Anticancer research, 33(5), 1861-1866 (2013-05-07)
Curcumin has potent antitumor activity against many types of human cancers. However, the inhibitory effects and possible mechanisms of curcumin on gallbladder cancer remains to be determined. Using HAG-1 human gallbladder adenocarcinoma cells, we investigated the effects of curcumin on...
Nirparaj Pradhan et al.
Journal of molecular medicine (Berlin, Germany), 93(10), 1095-1106 (2015-04-17)
Corneal neovascularization is a leading cause for compromised vision. Therapeutic prevention of corneal neovascularization is a major clinical challenge, and there is a compelling need to seek effective and safe therapy for this pathology. This study is aimed to evaluate...
Angus Lau et al.
Nature neuroscience, 23(1), 21-31 (2019-12-04)
The clinical and pathological differences between synucleinopathies such as Parkinson's disease and multiple system atrophy have been postulated to stem from unique strains of α-synuclein aggregates, akin to what occurs in prion diseases. Here we demonstrate that inoculation of transgenic...
Špela Zupančič et al.
Molecular pharmaceutics, 11(7), 2334-2345 (2014-05-24)
Curcumin has potent antioxidant and anti-inflammatory properties but poor absorption following oral administration owing to its low aqueous solubility. Development of novel formulations to improve its in vivo efficacy is therefore challenging. In this study, formulation of curcumin-loaded DQAsomes (vesicles...
Dewan M S Hossain et al.
Immunology, 144(4), 561-573 (2014-10-07)
Tumour progression is associated with immune-suppressive conditions that facilitate the escape of tumour cells from the regimen of immune cells, subsequently paralysing the host defence mechanisms. Induction of CD4(+)  CD25(+)  FoxP3(+) T regulatory (Treg) cells has been implicated in the...
Dairong Feng et al.
Biochimica et biophysica acta, 1849(8), 1104-1115 (2015-05-03)
Nonsense-mediated mRNA decay (NMD), an mRNA surveillance mechanism, eliminates premature termination codon-containing (PTC⁺) transcripts. For instance, it maintains the homeostasis of splicing factors and degrades aberrant transcripts of human genetic disease genes. Here we examine the inhibitory effect on the...
Juliana Bender Hoppe et al.
Toxicology in vitro : an international journal published in association with BIBRA, 27(8), 2325-2330 (2013-10-19)
Increasing evidence demonstrates that beta-amyloid (Aβ) is toxic to synapses, resulting in the progressive dismantling of neuronal circuits. Counteract the synaptotoxic effects of Aβ could be particularly relevant for providing effective treatments for Alzheimer's disease (AD). Curcumin was recently reported...
Jianping Chen et al.
PloS one, 9(6), e101277-e101277 (2014-06-28)
This study was to investigate the synergistic effect of NB/Cur on growth and apoptosis in A375 human melanoma cell line by MTT assay, flow cytometry and Western blotting. Our results demonstrated that NB effectively synergized with Cur to enhance its...

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