Showing 1-30 of 248 results for "C1768"
Lida Kalmanti et al.
Annals of hematology, 93(1), 71-80 (2013-10-29)
Since the advent of tyrosine kinase inhibitors, the impact of age on outcome of chronic myeloid leukemia (CML) patients has changed. We therefore analyzed patients from the randomized CML study IV to investigate disease manifestations and outcome in different age...
Elias Campo et al.
Blood, 125(1), 48-55 (2014-12-17)
Mantle cell lymphoma (MCL) is a rare and aggressive form of non-Hodgkin's lymphoma that generally affects older individuals and continues to have one of the worst outcomes of all the lymphomas. Over the last decade, there has been a widespread...
Alberto Diez-Torrubia et al.
Journal of medicinal chemistry, 53(2), 559-572 (2009-12-17)
Here we explore the applicability of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to a variety of amine-containing drugs. Efficient procedures have been developed for the synthesis of dipeptide and tetrapeptide amide prodrugs including N-acylation protocols of the exocyclic...
Haiyang Yu et al.
Science (New York, N.Y.), 371(6529) (2020-12-19)
The RNA binding protein TDP-43 forms intranuclear or cytoplasmic aggregates in age-related neurodegenerative diseases. In this study, we found that RNA binding-deficient TDP-43 (produced by neurodegeneration-causing mutations or posttranslational acetylation in its RNA recognition motifs) drove TDP-43 demixing into intranuclear...
Carlo Visco et al.
American journal of hematology, 88(4), 289-293 (2013-03-02)
Treatment of patients with B-cell chronic lymphocytic leukemia (CLL) relapsed/refractory (R/R) to conventional treatments is particularly challenging. The combination of bendamustine and cytarabine has demonstrated distinct and synergistic mechanisms of action in preclinical studies on cell lines and primary tumor...
Noortje Thielen et al.
Annals of hematology, 92(8), 1049-1056 (2013-04-11)
Despite the revolutionary change in the prognosis of chronic myeloid leukemia (CML) patients with the introduction of imatinib, patients with resistant disease still pose a considerable problem. In this multicenter, randomized phase III trial, we investigate whether the combination of...
Gautam Borthakur et al.
American journal of hematology, 89(10), 964-968 (2014-07-06)
Despite being considered "good-risk" acute myelogenous leukemia (AML), long term outcomes in core binding factor (CBF) AML suggest room for improvement. We report on a regimen consisting of fludarabine, cytarabine, granulocyte colony stimulating factor, and low dose gemtuzumab ozogamicin (FLAG-GO)...
Serge H Boyer et al.
Journal of medicinal chemistry, 49(26), 7711-7720 (2006-12-22)
Cytotoxic nucleosides have proven to be ineffective for the treatment of hepatocellular carcinoma (HCC) due, in part, to their inadequate conversion to their active nucleoside triphosphates (NTP) in the liver tumor and high conversion in other tissues. These characteristics lead...
Michael E Rytting et al.
Cancer, 120(23), 3660-3668 (2014-07-22)
Various trials have reported improved outcomes for adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) who received treatment with pediatric-based regimens. Those reports prompted the current investigation of the pediatric augmented Berlin-Frankfurt-Münster (ABFM) regimen in AYA patients. The...
Juan C Sanchez-Arias et al.
eNeuro, 7(4) (2020-08-02)
The integration of neurons into networks relies on the formation of dendritic spines. These specialized structures arise from dynamic filopodia-like dendritic protrusions. It was recently reported that cortical neurons lacking the channel protein pannexin 1 (PANX1) exhibited higher dendritic spine...
Evgeny Shlevkov et al.
Cell reports, 28(12), 3224-3237 (2019-09-19)
Dysregulated axonal trafficking of mitochondria is linked to neurodegenerative disorders. We report a high-content screen for small-molecule regulators of the axonal transport of mitochondria. Six compounds enhanced mitochondrial transport in the sub-micromolar range, acting via three cellular targets: F-actin, Tripeptidyl...
Xi Zhang et al.
Leukemia research, 37(6), 657-664 (2013-03-30)
In a well-controlled multi-center randomized trial in southwestern China, 228 patients with refractory or relapsed AML were received a low-dose CAG regimen either with etoposide (E-CAG) or without etoposide (CAG). The complete remission (CR) rate, overall survival (OS) and toxicity...
Valeria Di Stefano et al.
The Journal of biological chemistry, 286(10), 8644-8654 (2011-01-07)
Proliferation of mammalian cardiomyocytes stops rapidly after birth and injured hearts do not regenerate adequately. High cyclin-dependent kinase inhibitor (CKI) levels have been observed in cardiomyocytes, but their role in maintaining cardiomyocytes in a post-mitotic state is still unknown. In...
Mutant DNMT3A clone evading chemotherapy and infiltrating central nervous system in a patient with molecularly good-risk acute myeloid leukemia.
Yi-Yang Chen et al.
Annals of hematology, 93(8), 1441-1442 (2013-12-18)
Benjamin Morin et al.
The Journal of biological chemistry, 289(14), 9961-9969 (2014-02-15)
The RNA synthesis machinery of non-segmented negative-sense RNA viruses comprises a ribonucleoprotein complex of the genomic RNA coated by a nucleocapsid protein (N) and associated with polymerase. Work with vesicular stomatitis virus (VSV), a prototype, supports a model of RNA...
Matthew J Ehrhardt et al.
Journal of pediatric hematology/oncology, 37(1), e37-e40 (2013-12-11)
Langerhans cell histiocytosis (LCH) is a disorder of dendritic cell proliferation with subsequent tissue damage often requiring chemotherapy. Neurodegenerative LCH presents with neuromuscular, cognitive, and behavioral alterations typically occurring years after diagnosis of active LCH. We present a male child...
Hong Jun Rhee et al.
Cell reports, 27(7), 2212-2228 (2019-05-16)
iPSC-derived human neurons are expected to revolutionize studies on brain diseases, but their functional heterogeneity still poses a problem. Key sources of heterogeneity are the different cell culture systems used. We show that an optimized autaptic culture system, with single...
Final report of phase II study of sorafenib, cytarabine and idarubicin for initial therapy in younger patients with acute myeloid leukemia.
F Ravandi et al.
Leukemia, 28(7), 1543-1545 (2014-02-04)
Xin Ge et al.
Leukemia research, 37(12), 1697-1703 (2013-10-31)
Acidic serine protease (ASPNJ) purified from Neanthes japonica, is a fibrinolytic enzyme. Earthworm fibrinolytic enzyme has been recently reported with anti-tumor activity on human hepatoma cells. To investigate if ASPNJ play therapeutic effects on emergent blood cancer, acute promyelocytic leukemia...
Jan-Henrik Mikesch et al.
Annals of hematology, 92(8), 1041-1048 (2013-03-28)
High-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) is considered standard in the treatment of patients with relapsed or refractory aggressive peripheral T cell lymphoma (PTCL). However, the optimal salvage regimen before ASCT has not yet been established....
Richard M Stone
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(10), 1262-1266 (2013-02-27)
A 42-year-old woman presented with bruising and fatigue. Her WBC count was 10,370/μL, with a differential showing 5% polys, 5% monos, 10% lymphocytes, and 80% myeloid-appearing blasts, some of which contained Auer rods (Fig 1). Bone marrow examination revealed 90%...
Dagmara Baraniak et al.
Bioorganic & medicinal chemistry letters, 21(2), 723-726 (2011-01-05)
Novel nucleoside-Cinchona alkaloid conjugates were synthesized using 'click' chemistry approach based on the copper(I) catalyzed Huisgen azide-alkyne cycloaddition. Two series of conjugates were prepared employing 3'-azido-3'-deoxythymidine (AZT) as the azide component and the four 10,11-didehydro Cinchona alkaloids as well as...
Caterina Rizzi et al.
Glia, 66(7), 1395-1416 (2018-02-24)
Microglia are the sentinels of the brain but a clear understanding of the factors that modulate their activation in physiological and pathological conditions is still lacking. Here we demonstrate that Nerve Growth Factor (NGF) acts on microglia by steering them...
Giuliano Berellini et al.
Journal of medicinal chemistry, 52(14), 4488-4495 (2009-07-17)
The prediction of human pharmacokinetics early in the drug discovery cycle has become of paramount importance, aiding candidate selection and benefit-risk assessment. We present herein computational models to predict human volume of distribution at steady state (VD(ss)) entirely from in...
Ni-sha Wang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(4), 3933-3940 (2014-01-01)
It is known that chemoresistance is a major cause of treatment failure in acute myeloid leukemia (AML). Substantial data indicate that the CD44 adhesion molecule is strongly expressed on AML blasts and that it can also inhibit apoptosis. Our study...
Hiroya Asou et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(11), 1489-1495 (2013-11-16)
This report summarizes the use of gemcitabine for the treatment of malignant lymphoma. Gemcitabine is a deoxycytidine antagonist that has characteristics different from those of the deoxycytidine antagonist cytarabine(Ara-C). International guidelines based on the results of recent clinical studies recommend...
David Wegrzyn et al.
The European journal of neuroscience, 53(12), 3920-3941 (2020-08-07)
Activation of the maternal immune system (MIA) during gestation is linked to neuropsychiatric diseases like schizophrenia. While many studies address behavioural aspects, less is known about underlying cellular mechanisms. In the following study, BALB/c mice received intraperitoneal injections of polyinosinic-polycytidylic...
Ajay Vora et al.
The Lancet. Oncology, 15(8), 809-818 (2014-06-14)
No randomised study has shown whether stratification of treatment by minimal residual disease (MRD) response improves outcome in children and young people with acute lymphoblastic leukaemia (ALL). We assessed whether children and young people with clinical standard and intermediate-risk ALL...
Joan Francesc Mir et al.
Molecular neurobiology, 55(9), 7216-7228 (2018-02-06)
Lipid metabolism, specifically fatty acid oxidation (FAO) mediated by carnitine palmitoyltransferase (CPT) 1A, has been described to be an important actor of ghrelin action in hypothalamus. However, it is not known whether CPT1A and FAO mediate the effect of ghrelin...
Stephen H Petersdorf et al.
Blood, 121(24), 4854-4860 (2013-04-18)
This randomized phase 3 clinical trial evaluated the potential benefit of the addition of gemtuzumab ozogamicin (GO) to standard induction and postconsolidation therapy in patients with acute myeloid leukemia. Patients were randomly assigned to receive daunorubicin (45 mg/m(2) per day...

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