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C3036

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Florence Haudin et al.
Physical chemistry chemical physics : PCCP, 17(19), 12804-12811 (2015-04-25)
The growth of chemical gardens is studied experimentally in a horizontal confined geometry when a solution of metallic salt is injected into an alkaline solution at a fixed flow rate. Various precipitate patterns are observed-spirals, flowers, worms or filaments-depending on...
Bhagwan S Batule et al.
International journal of nanomedicine, 10 Spec Iss, 137-142 (2015-09-09)
We developed a simple but efficient method to synthesize protein-inorganic hybrid nanostructures with a flower-like shape (nanoflowers), which relies on sonication to facilitate the synthesis of the nanoflowers. With this technique, we synthesized nanoflowers containing laccase as a model protein...
Zhiguo Li et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(11), 2247-2251 (2014-05-08)
The Cu(I) -catalyzed 1,3-dipolar azide-alkyne cycloaddition (CuAAC) has arisen as one of the most useful chemical transformations for introducing complexity onto surfaces and materials owing to its functional-group tolerance and high yield. However, methods for monitoring such reactions in situ...
Yang Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 52-58 (2014-05-03)
A novel TiO2/diatomite composite (TD) was prepared and then characterized by scanning electron microscope (SEM) and Fourier Transform Infrared (FTIR). The results of SEM showed that after modification, the porous surface of diatomite was covered with TiO2. Both diatomite and...
Sun Young Kim et al.
Toxicological sciences : an official journal of the Society of Toxicology, 148(1), 167-182 (2015-08-12)
Cadmium (Cd(2+)) is a major environmental pollutant that induces cytotoxicity by heavy-metal accumulation. Prolonged Cd(2+) exposure leads to cell damage by oxidative stress mainly in the kidneys, a critical organ for detoxification. To identify reliable on invasive protein biomarkers for...
Mizuha Sakashita et al.
Bioorganic & medicinal chemistry, 22(19), 5212-5219 (2014-08-27)
Highly efficient drug carriers targeting hepatocyte is needed for treatment for liver diseases such as liver cirrhosis and virus infections. Galactose or N-acetylgalactosamine is known to be recognized and incorporated into the cells through asialoglycoprotein receptor (ASGPR) that is exclusively...
Anna Golunova et al.
Biomacromolecules, 16(4), 1146-1156 (2015-03-03)
The ability to tailor mechanical properties and architecture is crucial in creating macroporous hydrogel scaffolds for tissue engineering. In the present work, a technique for the modification of the pore size and stiffness of acrylamide-based cryogels is demonstrated via the...
Fange Liu et al.
The Journal of biological chemistry, 290(25), 15621-15634 (2015-04-29)
The rubredoxin motif is present in over 74,000 protein sequences and 2,000 structures, but few have known functions. A secondary, non-catalytic, rubredoxin-like iron site is conserved in 3-hydroxyanthranilate 3,4-dioxygenase (HAO), from single cellular sources but not multicellular sources. Through the...
Rossana Canavesi et al.
Journal of pharmaceutical and biomedical analysis, 97, 141-150 (2014-05-28)
Pantethine (d-bis-(N-pantothenyl-β-aminoethyl)-disulfide, PAN), the stable disulfide form of pantetheine, has beneficial effects in vascular diseases being able to decrease the hyperlipidaemia, moderate the platelet function and prevent the lipid peroxidation. Furthermore, recent studies suggested that PAN may be an effective...
Kürşad Oğuz Oskay et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 72(1), 52-62 (2015-06-27)
This study aimed to recover and remove copper from industrial model wastewater solution by non-dispersive solvent extraction (NDSX). Two mathematical models were developed to simulate the performance of an integrated extraction-stripping process, based on the use of hollow fiber contactors...
Sofia Amadori et al.
Journal of materials science. Materials in medicine, 26(2), 69-69 (2015-01-30)
Sterilization through γ-irradiation has been reported to affect collagen mechanical properties, but its possible effects on gelatin based materials have not been investigated up to now. Herein we report the results of a mechanical, chemical and thermal study performed on...
Gabriela M B Haverroth et al.
Ecotoxicology and environmental safety, 122, 440-447 (2015-09-20)
Copper is a heavy metal found at relatively high concentrations in surface waters around the world. Copper is a micronutrient at low concentrations and is essential to several organisms. At higher concentrations copper can become toxic, which reveal the importance...
Tyson Smyth et al.
Bioconjugate chemistry, 25(10), 1777-1784 (2014-09-16)
A method for conjugation of ligands to the surface of exosomes was developed using click chemistry. Copper-catalyzed azide alkyne cycloaddition (click chemistry) is ideal for biocojugation of small molecules and macromolecules to the surface of exosomes, due to fast reaction...
Elaine L Ferguson et al.
Molecular pharmaceutics, 11(12), 4437-4447 (2014-11-02)
Polymer therapeutics offer potential benefits in the treatment of multidrug resistant (MDR) infections; affording targeted delivery of biologically active agents to the site of inflammation, potential decreases in systemic toxicity, and the retention of antimicrobial activity at the target site....
Meritxell Navarro-Reig et al.
Analytical and bioanalytical chemistry, 407(29), 8835-8847 (2015-09-26)
The comprehensive analysis of untargeted metabolomics data acquired using LC-MS is still a major challenge. Different data analysis tools have been developed in recent years such as XCMS (various forms (X) of chromatography mass spectrometry) and multivariate curve resolution alternating...
Zilan Zhou et al.
International journal of pharmaceutics, 487(1-2), 81-90 (2015-04-14)
A dual functional nano-scaled drug carrier, comprising of a targeting ligand and pH sensitivity, has been made in order to increase the specificity and efficacy of the drug delivery system. The nanoparticles are made of a tri-block copolymer, poly(d,l lactide-co-glycolide)...
Yan Wang et al.
Pharmaceutical research, 31(11), 3106-3119 (2014-05-23)
Although Cu complexes have been investigated as anticancer agents, there has been no description of Cu itself as a cancer killing agent. A stealth liposomal Cu formulation (LpCu) was studied in vitro and in vivo. LpCu was evaluated in prostate...
Surendra Vutti et al.
Chembiochem : a European journal of chemical biology, 16(5), 782-791 (2015-03-05)
Stable primary functionalization of metal surfaces plays a significant role in reliable secondary attachment of complex functional molecules used for the interfacing of metal objects and nanomaterials with biological systems. In principle, this can be achieved through chemical reactions either...
Tuhua Zhong et al.
BioMed research international, 2015, 456834-456834 (2015-07-03)
Our long-term goal is to develop a hybrid cellulose-copper nanoparticle material as a functional nanofiller to be incorporated in thermoplastic resins for efficiently improving their antimicrobial properties. In this study, copper nanoparticles were first synthesized through chemical reduction of cupric...
Shuai Jin et al.
Molecular cell, 79(5), 728-740 (2020-07-30)
Cytosine base editors (CBEs) generate C-to-T nucleotide substitutions in genomic target sites without inducing double-strand breaks. However, CBEs such as BE3 can cause genome-wide off-target changes via sgRNA-independent DNA deamination. By leveraging the orthogonal R-loops generated by SaCas9 nickase to...
Che-Fan Huang et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(2), 114-119 (2015-01-06)
Protein oxidation by reactive oxygen species has been associated with aging and neurodegenerative disorders, and histidine is one of the major oxidation targets due to its metal-chelating property and susceptibility to metal-catalyzed oxidation. 2-Oxohistidine, the major product of histidine oxidation...
Yuan Chen et al.
Biochemical and biophysical research communications, 459(3), 529-533 (2015-03-10)
Apolipoprotein E (ApoE) genotypes are related to clinical presentations in patients with Wilson's disease, indicating that ApoE may play an important role in the disease. However, our understanding of the role of ApoE in Wilson's disease is limited. High copper...
Hugo Pereira et al.
Marine drugs, 13(6), 3531-3549 (2015-06-06)
Four lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules. Methanol extracts were thus prepared from freeze-dried biomass and screened for...
R Freiry et al.
Bulletin of environmental contamination and toxicology, 93(4), 442-445 (2014-08-30)
The sensitivity of Danio rerio to three chemicals was compared at two growth stages [larval (10 ± 2 after hatching) and post-larval (60 ± 4 days after hatching)] based on acute toxicity tests. Thirty-nine 48 h acute toxicity tests were...
Shigehiro Kagaya et al.
Talanta, 147, 342-350 (2015-11-26)
The effect of the molecular weight of polyethyleneimine (PEI), defined as a compound having two or more ethyleneamine units, and of its carboxymethylation rate (CM/N), represented by the ratio of ion-exchange capacity to the amount of N on the resin...
Gaulthier Rydzek et al.
ACS nano, 8(5), 5240-5248 (2014-04-18)
Simple preparation methods of chemically versatile and highly functionalizable surfaces remain rare and present a challenging research objective. Here, we demonstrate a simultaneous electropolymerization and electro-click functionalization process (SEEC) for one-pot self-construction of aniline- and naphthalene-based functional polymer films where...
Karla Lucía F Alvarez et al.
BMC veterinary research, 16(1), 230-230 (2020-07-08)
In the poultry industry, quantitative analysis of chicken T cell proliferation is important in many biological applications such as drug screening, vaccine production, and cytotoxicity assessment. Several assays have been established to evaluate this immunological response in chicken cells. However...
Özge Erdemli et al.
Journal of biomaterials applications, 29(4), 524-542 (2014-05-24)
Anti-tumor necrosis factor α (TNFα) drugs such as etanercept (ETN) have been mostly used in systemic treatment of rheumatoid arthritis. To eliminate the side effects in long-term treatments and to achieve a local sustained anti-inflammatory effect, a controlled drug delivery...
Burcu Somturk et al.
Dalton transactions (Cambridge, England : 2003), 44(31), 13845-13852 (2015-05-06)
In this study, we report the preparation, catalytic activity and stability of a hybrid nanoflower (hNF) formed from horseradish peroxidase (HRP) enzyme and copper ions (Cu(2+)). We studied the morphology of hNFs as a function of the concentrations of copper...
Fengwei Tian et al.
PloS one, 10(11), e0143318-e0143318 (2015-11-26)
Lactobacillus plantarum CCFM8246, which has a relatively strong copper binding capacity and tolerance to copper ions, was obtained by screening from 16 lactic acid bacteria in vitro. The selected strain was then applied to a mouse model to evaluate its...
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