Showing 1-30 of 71 results for "C3412"
Marta Díaz et al.
The Journal of clinical endocrinology and metabolism, 97(10), 3630-3638 (2012-07-14)
The aim was to compare the effects of a traditional therapy (an oral estroprogestagen) to those of a novel treatment (a low-dose combination of generics) in adolescent girls with androgen excess. In an open-label trial over 1 yr, 34 adolescents...
Cahide Gökkuşu et al.
Archives of gynecology and obstetrics, 285(3), 733-739 (2011-08-31)
Studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT). In this study, the effects of HRT were investigated on plasma total homocysteine (tHcy) and the oxidant-antioxidant status in postmenopausal women. 35 of...
S Mondal et al.
General and comparative endocrinology, 116(2), 291-298 (1999-11-24)
The splenic macrophages of wall lizards exhibited marked sex-related difference in their phagocytic activity. The percentage phagocytosis and phagocytic index in females was considerably higher than that of males. Gonadectomy resulted in significant increase in percentage phagocytosis and phagocytic index...
N Halilova
Georgian medical news, (212)(212), 19-23 (2012-12-12)
To study central genesis of disfunctional menstrual disorders was based particulary on electroencephalography and find out efficacy of pathogenetic management in infertile women with central forms of oligomenorrhoea and amenorrhoea compared to generally accepted hormone therapy. Depending on received management...
Abdullah Boztosun et al.
Ginekologia polska, 84(4), 258-262 (2013-05-25)
Idiopathic hirsutism (IH) or polycystic ovary syndrome (PCOS) are the most common causes of hirsutism which affects 5-10% of all women. The aim of this study was to evaluate the efficacy of flutamide plus diane 35 in the treatment of...
Greg N Brooke et al.
Oncotarget, 5(4), 959-969 (2014-03-25)
Prostate cancer growth is dependent upon the Androgen Receptor (AR) pathway, hence therapies for this disease often target this signalling axis. Such therapies are successful in the majority of patients but invariably fail after a median of 2 years and...
Lucía Cea-Soriano et al.
Cancer epidemiology, 36(2), 198-205 (2011-09-29)
The aetiology of meningiomas is largely unknown although hormones have been suggested to play a role. A cohort study was performed to evaluate hormone-related factors associated with meningioma. Patients (12-89 years) with a first diagnosis of meningioma (January 1996-June 2008)...
Maarten C Bosland
Endocrinology, 155(12), 4629-4633 (2014-09-24)
Testosterone is increasingly prescribed to middle aged and older men, but the safety of this treatment has been called into question, and the possible risk of prostate cancer is unknown. We treated Wistar Cpb: WU rats chronically via slow-release Silastic...
Rosalind M Tandy
The journal of family planning and reproductive health care, 38(1), 41-43 (2011-10-06)
To describe current co-cyprindiol prescribing in a large, rural general practice in England. To specifically investigate whether co-cyprindiol is prescribed within its license and Medicines and Healthcare products Regulatory Agency (MHRA) guidelines. To investigate the effect of a simple, low-cost...
E Van Caenegem et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 26(1), 35-47 (2014-11-08)
Although trans women before the start of hormonal therapy have a less bone and muscle mass compared with control men, their bone mass and geometry are preserved during the first 2 years of hormonal therapy, despite of substantial muscle loss, illustrating...
Valter Torri et al.
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 77(3), 157-163 (2005-12-24)
Prostatic carcinoma is one of the most commonly neoplasm in men, with the strongest incidence around the age of 70 years. In consideration of the high hormonodependence of prostatic neoplasm the reduction of testosterone levels represents the choice of treatment...
Michael Römer et al.
PloS one, 9(5), e97640-e97640 (2014-05-17)
In the area of omics profiling in toxicology, i.e. toxicogenomics, characteristic molecular profiles have previously been incorporated into prediction models for early assessment of a carcinogenic potential and mechanism-based classification of compounds. Traditionally, the biomarker signatures used for model construction...
Gretchen M Dickson
The Journal of family practice, 61(3), 138-145 (2012-03-07)
Let patients know that hot flashes, vaginal dryness, and other common menopausal symptoms can be treated successfully with hormonal and nonhormonal agents.
Lourdes Ibáñez et al.
The Journal of clinical endocrinology and metabolism, 96(11), 3361-3366 (2011-08-26)
The aim was to perform a first comparison between the effects of a classic therapy and those of a novel treatment for androgen excess in adolescent girls. We conducted a randomized, open-labeled trial at a university hospital. Thirty-four adolescents with...
Lucía Zubizarreta et al.
Physiology & behavior, 220, 112883-112883 (2020-03-23)
Aggressive behaviors are widespread among animals and are critical in the competition for resources. The physiological mechanisms underlying aggression have mostly been examined in breeding males, in which gonadal androgens, acting in part through their aromatization to estrogens, have a...
Lourdes Ibáñez et al.
The Journal of clinical endocrinology and metabolism, 98(5), E902-E907 (2013-04-03)
An oral estro-progestagen is the standard medication given to adolescent girls with androgen excess, even when those girls are not at risk of pregnancy. The aim of this study was to compare on-treatment and post-treatment effects of intervention with an...
C Beylot et al.
Dermatology (Basel, Switzerland), 196(1), 148-152 (1998-04-29)
The sebaceous gland is a target of androgens, and hormonal influences play an important role in the multifactorial pathogenesis of acne. In both men and women, acne may be related to an excessive hypersensitivity of the sebaceous end organ to...
[The antiandrogen cyproterone acetate. Its history from discovery to marketing].
F Neumann et al.
Pharmazie in unserer Zeit, 17(2), 33-50 (1988-03-01)
Miguel Gil et al.
British journal of clinical pharmacology, 72(6), 965-968 (2011-06-02)
Information from the spontaneous reporting system raised the hypothesis of an increased risk of meningioma in patients treated with high doses of cyproterone acetate (CPA). The objective of this study was to test the hypothesis of an increased risk of...
H J de Voogt
The Prostate. Supplement, 4, 91-95 (1992-01-01)
Cyproterone acetate is a steroidal anti-androgen that blocks the androgen-receptor interaction and reduces serum testosterone through its weak anti-gonadotropic action. It can be regarded as the only anti-hormone that causes complete androgen blockade as monotherapy. Many animal experiments and several...
Ludovico Abenavoli et al.
Annals of hepatology, 12(1), 152-155 (2013-01-08)
Cyproterone acetate (CPA) is an oral anti-androgen commonly used to treat advanced prostate cancer. A variety of hepatotoxic reactions has been reported with CPA. Here we describe a case of a male patient who developed severe drug-induced hepatotoxicity during the...
Hélène Rime et al.
Aquatic toxicology (Amsterdam, Netherlands), 164, 34-42 (2015-04-26)
In the present study, we aimed at characterizing the effect of cyproterone acetate (CPA), an anti-androgenic compound, on oocyte meiotic maturation in a freshwater teleost fish species, the rainbow trout (Oncorhynchus mykiss). Fully-grown post-vitellogenic ovarian follicles were incubated in vitro...
Scrutiny of Diane-35 due to potential dangers of off-label prescribing.
Roger Collier
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 185(5), E217-E218 (2013-02-27)
P Kasper
Pharmacology & toxicology, 88(5), 223-231 (2001-06-08)
Cyproterone acetate, a widely used synthetic progestagen with antiandrogenic activity, is known for years to produce liver tumours in rats, with a higher incidence in females. This effect was attributed to a rodent-specific tumour promoting mode of action based on...
O Esteban-Jiménez et al.
Semergen, 39(3), 175-178 (2013-04-02)
The Primary Care physician must know the risk factors and to suspect the presence of a pulmonary thromboembolism (PTE) when there is a compatible clinical picture. We present two cases of a massive PTE in young healthy women in whom...
Symptomatic epidural lipomatosis following cyproterone acetate therapy.
M Grayling et al.
The Australian and New Zealand journal of surgery, 70(3), 233-235 (2000-04-15)
Anita Kumar et al.
Molecular and cellular endocrinology, 404, 91-101 (2015-02-01)
Spermiation, the sperm release process, is imperative to male fertility and reproduction. Morphologically, it is characterized by removal of atypical adherens junctions called ectoplasmic specializations, and formation of transient endocytic devices called tubulobulbar complexes requiring cytoskeleton remodeling and recruitment of...
J Santiago-Moreno et al.
The Journal of endocrinology, 214(2), 155-163 (2012-05-31)
This work examines the effect of testosterone secretion and photoperiod on seasonal changes in horn growth and sperm variables in the Iberian ibex (Capra pyrenaica), here used as a model for polygynous wild bovids. The hypothesis that high levels of...
Carina M Woodruff et al.
Mayo Clinic proceedings, 90(12), 1679-1693 (2015-12-15)
Hidradenitis suppurativa is a chronic inflammatory disease of apocrine gland-bearing skin. Although immunologic derangements, genetic predisposition, obesity, and smoking are likely important factors, the pathogenesis of the disease and the effect of available treatments on disease course have not been...
Ioanna Savidou et al.
World journal of gastroenterology, 12(46), 7551-7555 (2006-12-15)
Cyproterone acetate (CPA) is a steroidal synthetic progestagen and anti-androgenic compound widely administered in prostate cancer which has been evidentially correlated with a severe hepatotoxic potency. Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged...

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