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Annemie Deiteren et al.
Gut, 63(12), 1873-1882 (2014-02-25)
Substantial evidence implicates mast cells and their main constituent histamine in the pathogenesis of visceral hypersensitivity. We explored the specific contribution of histamine H4 (H4R) and H1 (H1R) receptors to visceral hypersensitivity in a postinflammatory rat model. Trinitrobenzenesulfonic acid (TNBS)-colitis...
Cetirizine hydrochloride suppresses the CCL17 production of epidermal keratinocytes and dermal fibroblasts.
Yuichiro Tsunemi et al.
International journal of dermatology, 51(8), 1003-1005 (2012-07-14)
Ko-Haung Lue et al.
International journal of pediatric otorhinolaryngology, 76(7), 994-1001 (2012-04-20)
Supplementary consumption of probiotics may temporarily alter the intestinal microflora of infants and children, thereby preventing and treating allergic disorders. To compare the clinical efficacy of levocetirizine with that of levocetirizine plus Lactobacillus johnsonii EM1 (Lj EM1) for treating perennial...
Acute interstitial nephritis secondary to long-term use of cetirizine for the treatment of urticaria pigmentosa.
R Raghavendran et al.
Clinical and experimental dermatology, 38(1), 100-101 (2012-10-23)
Fadia F Mahmoud et al.
Acta physiologica Hungarica, 99(2), 173-184 (2012-08-02)
Novel strategies are evaluated for management of allergic rhinitis and asthma in patients co-afflicted with both disorders. It is hypothesized that the platelet activating factor receptor antagonist ginkgolide B (GB) and the carotenoid antioxidant astaxanthin (ASX) interact with antihistamines cetirizine...
Ralph N Mead et al.
Environmental toxicology and chemistry, 33(10), 2240-2245 (2014-07-22)
The photodegradation rate of the anti-histamine cetirizine (Zyrtec®) was investigated in various water matrices. The average observed first-order photodegradation rate coefficient (kobs ), obtained by linear regression of the logarithmic-transformed cetirizine concentrations versus irradiation time in simulated sunlight, was 0.024...
Ayako Nonaka et al.
Brain research, 1493, 19-26 (2012-11-28)
Antihistamines are widely used to treat allergy symptoms. First-generation antihistamines have adverse effects on the central nervous system (CNS), such as hypnotic and amnesic effects, whereas second-generation antihistamines have poor brain penetration, and therefore, have fewer CNS-related adverse effects. Memory...
Saeed Nojavan et al.
Journal of separation science, 35(15), 1959-1966 (2012-07-04)
In this work, two-step hollow fiber-based liquid-phase microextraction procedure was evaluated for extraction of the zwitterionic cetirizine (CTZ) and basic hydroxyzine (HZ) in human plasma. In the first step of extraction, the pH of sample was adjusted at 5.0 in...
O V Zaĭtseva
Vestnik otorinolaringologii, (5)(5), 62-65 (2012-02-16)
Allergic rhinitis is a common disease of great socio-economic significance. The treatment of this condition is carried out on an individual basis depending on the clinical course of the disease; it includes prevention of contacts with the allergen, medicamental and...
Macheng Yan et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 33(1), 60-64 (2013-04-20)
To investigate the potential rules and knowledge of Traditional Chinese Medicine (TCM) and Western Medicine (WM) treatment on chronic urticaria (CU) based on data-mining methods. Sixty patients with chronic urticaria, treated with TCM and WM, were selected. Gray correlation analyses...
Rajeev B Ahuja et al.
Burns : journal of the International Society for Burn Injuries, 39(1), 24-29 (2012-10-24)
Post-burn itch is a distressing symptom in burns rehabilitation and its treatment often proves frustrating for the patient and the multidisciplinary burns team. Traditionally, the mainstay of antipruritic therapy for decades has been antihistamines and massage with emollients. With a...
Susan D Mathias et al.
Allergy and asthma proceedings, 33(2), 186-190 (2012-04-25)
The Urticaria Patient Daily Diary, including the Urticaria Activity Score, has recently been validated in adults with chronic idiopathic urticaria (CIU), but its validity in adolescents is unknown. This study was designed to (1) assess the content validity of the...
Alexa Kollmeier et al.
The Journal of pharmacology and experimental therapeutics, 350(1), 181-187 (2014-05-13)
The histamine H4 receptor (H4R) is a promising target for the treatment of pruritus. A clinical study was conducted to evaluate the safety and efficacy of the H4R antagonist, JNJ 39758979 [(R)-4-(3-amino-pyrrolidin-1-yl)-6-isopropyl-pyrimidin-2-ylamine], on histamine-induced pruritus in healthy subjects. A single...
Min-Hee Kang et al.
The Canadian veterinary journal = La revue veterinaire canadienne, 53(7), 783-786 (2013-01-02)
A 15-year-old Yorkshire terrier dog was presented after ingesting 1 capsule of an over-the-counter cold medication containing pseudoephedrine (120 mg/capsule) and cetirizine (5 mg/capsule). Treatment was initiated with acepromazine and carvedilol. The dog responded well to treatment. This is the...
Crystal structure of equine serum albumin in complex with cetirizine reveals a novel drug binding site
Handing K, et al.
Molecular Immunology, 71, 143-151 (2016)
A designer cell-based histamine-specific human allergy profiler
Auslander D, et al.
Nature Communications, 5, 4408-4408 (2014)
Natalie J Carter
Drugs, 72(9), 1257-1269 (2012-06-13)
Bilastine is an orally administered, second-generation antihistamine used in the symptomatic treatment of seasonal or perennial allergic rhinoconjunctivitis and urticaria. In two well designed phase III trials, 14 days' treatment with bilastine was associated with a significantly lower area under...
Young Hwan Park et al.
Biomolecules & therapeutics, 27(3), 311-317 (2018-10-20)
Mast cells are the most prominent effector cells of Type 1 hypersensitivity immune responses. CYC116 [4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl] pyrimidin-2-amine] is under development to be used as an anti-cancer drug, but the inhibitory effects of CYC116 on the activation of mast cells and...
Compared pharmacological characteristics in humans of racemic cetirizine and levocetirizine, two histamine H1-receptor antagonists
Tillement JP, et al.
Biochemical Pharmacology, 66(7), 1123-1126 (2003)
Françoise Bree et al.
Fundamental & clinical pharmacology, 16(6), 471-478 (2003-04-11)
The aim of the present study was to determine (1) the extent of levocetirizine binding to human blood cells, plasma and individual plasma proteins; (2) the parameters for levocetirizine binding to individual plasma proteins both at their physiological concentrations and...
Krystyna Czerwińska et al.
Acta poloniae pharmaceutica, 70(1), 19-26 (2013-04-25)
The conditions for identification were determined for four histamine antagonists: clemastine fumarate, loratadine, cetirizine dihydrochloride and desloratadine by TLC (thin-layer chromatography) method. The selected chromatographic conditions were used to develop a densitometric method for the content determination of the histamine...
Anne Marie V Schou-Pedersen et al.
Journal of pharmaceutical sciences, 103(8), 2424-2433 (2014-06-26)
Polyethylene glycols (PEGs) are attractive as excipients in the manufacture of drug products because they are water soluble and poorly immunogenic. They are used in various pharmaceutical preparations. However, because of their terminal hydroxyl groups, PEGs can participate in esterification...
Lymphangioma circumscriptum of the vulva: a rare case report.
Tasneem Nishah Shah et al.
European journal of obstetrics, gynecology, and reproductive biology, 165(1), 131-132 (2012-08-21)
Céline Caillet et al.
British journal of clinical pharmacology, 74(5), 886-889 (2012-03-13)
The physicochemical properties of racemates and stereoisomers of medicines can differ significantly, and this may affect the side-effect profile in addition to the pharmacokinetics and intended pharmacology. This is a study to investigate the profile of adverse drug reactions of...
Andy Rorie et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 112(4), 376-382 (2014-02-11)
Observational reports have linked vitamin D with chronic urticaria, yet no randomized controlled trial has been conducted. To determine whether high-dose vitamin D supplementation would decrease Urticaria Symptom Severity (USS) scores and medication burden in patients with chronic urticaria. In...
Andrée E Gravel et al.
Biochimica et biophysica acta, 1828(6), 1494-1502 (2013-03-12)
The human ether-a-go-go-related gene (hERG) voltage-gated K(+) channels are located in heart cell membranes and hold a unique selectivity filter (SF) amino acid sequence (SVGFG) as compared to other K(+) channels (TVGYG). The hERG provokes the acquired long QT syndrome...
Idiopathic bullous eosinophilic cellulitis (Wells syndrome) responsive to topical tacrolimus and antihistamine combination.
Prashant Verma et al.
Indian journal of dermatology, venereology and leprology, 78(3), 378-380 (2012-05-09)
Agnieszka Biedroł et al.
Pediatrics, 133(4), e1068-e1071 (2014-03-26)
The occurrence of stabbing headaches in children requires a thorough diagnostic approach that excludes secondary headaches. The organic background should be taken into consideration when alarming symptoms occur, such as a purely 1-sided location, a change in the character of...
Benno Brinkhaus et al.
Annals of internal medicine, 158(4), 225-234 (2013-02-20)
Chinese translation Acupuncture is frequently used to treat seasonal allergic rhinitis (SAR) despite limited scientific evidence. To evaluate the effects of acupuncture in patients with SAR. Randomized, controlled multicenter trial. ( NCT00610584) 46 specialized physicians in 6 hospital clinics and...
Summaries for patients. The effects of acupuncture on seasonal allergic rhinitis.
Annals of internal medicine, 158(4), I-40 (2013-02-20)
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