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R Docampo et al.
Biomedical and environmental sciences : BES, 1(4), 406-413 (1988-12-01)
Blood transfusion is the second most important mechanism of transmission of Chagas' disease. Gentian violet, a cationic dye, is currently used in blood banks in endemic areas in attempts to eliminate such transmission. A photodynamic action of gentian violet has
Ian Bayles et al.
The Journal of clinical investigation, 129(10), 4377-4392 (2019-09-10)
Despite progress in intensification of therapy, outcomes for patients with metastatic osteosarcoma (OS) have not improved in thirty years. We developed a system that enabled preclinical screening of compounds against metastatic OS cells in the context of the native lung
R Docampo et al.
Drug metabolism reviews, 22(2-3), 161-178 (1990-01-01)
Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. To date, no
José Mauricio dos Santos Filho et al.
Bioorganic & medicinal chemistry, 17(18), 6682-6691 (2009-08-18)
Research in recent years has demonstrated that the Trypanosoma cruzi cysteine protease cruzain (TCC) is a valid chemotherapeutic target, since inhibitors of this protease affect the pathology appropriately. By exploring the N-acylhydrazones (NAH) as privileged structures usually present in antiparasitic
Alexander J Chang et al.
Anticancer research, 39(6), 2683-2687 (2019-06-10)
The treatment of renal cell carcinoma (RCC) has evolved tremendously over the past decades. Localized disease is often curative with surgical resection of the malignancy. However, in cases where the primary tumor has metastasized, immunotherapy is becoming a more prevalent
Jayant S Raut et al.
Biofouling, 29(1), 87-96 (2012-12-12)
Biofilm-related infections caused by Candida albicans and associated drug resistant micro-organisms are serious problems for immunocompromised populations. Molecules which can prevent or remove biofilms are needed. Twenty-eight terpenoids of plant origin were analysed for their activity against growth, virulence attributes
Ruchi P Patel et al.
Translational oncology, 14(1), 100917-100917 (2020-11-01)
Although the first line of therapy for epithelial ovarian cancer typically consists of taxane-platinum combination therapy, many patients develop a platinum-resistant tumor within a year. Several previous studies have looked at this cross-resistance between cisplatin and anti-microtubule drugs, but their
Anissa Nofita Sari et al.
Cancers, 12(5) (2020-05-10)
We have earlier reported anticancer activity in Withaferin A (Wi-A), a withanolide derived from Ashwagandha (Withania somnifera) and caffeic acid phenethyl ester (CAPE), an active compound from New Zealand honeybee propolis. Whereas Wi-A was cytotoxic to both cancer and normal
Tomoyuki Fujita et al.
Journal of the National Cancer Institute, 100(13), 940-949 (2008-06-26)
Neuroblastomas are characterized by hemizygous 1p deletions, suggesting that a tumor suppressor gene resides in this region. We previously mapped the smallest region of consistent deletion to a 2-Mb region of 1p36.31 that encodes 23 genes. Based on mutation analysis
Tingting Zhang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 27(6), 1183-1194 (2019-04-29)
Radioresistant cervical cancer is likely to give rise to local recurrence, distant metastatic relapse, and decreased survival rates. Recent studies revealed microRNA mediated regulation of tumor aggressiveness and metastasis; however, whether specific microRNAs regulate tumor radioresistance and can be exploited
Jae-Hoon Ji et al.
Nucleic acids research, 47(12), 6299-6314 (2019-05-03)
Histone H2AX undergoes a phosphorylation switch from pTyr142 (H2AX-pY142) to pSer139 (γH2AX) in the DNA damage response (DDR); however, the functional role of H2AX-pY142 remains elusive. Here, we report a new layer of regulation involving transcription-coupled H2AX-pY142 in the DDR.
Chunmei Sai et al.
Frontiers in pharmacology, 12, 668348-668348 (2021-08-24)
Macleayins A (MA), a novel compound, was isolated from Macleaya cordata (Willd.) R. Br. and Macleaya microcarpa (Maxim.) Fedde. The plant species are the member of Papaveraceae family and have been used traditionally for diverse therapeutic purposes. According to the
Eufrânio N da Silva Júnior et al.
Bioorganic & medicinal chemistry, 16(9), 5030-5038 (2008-04-02)
New naphthoquinone derivatives were synthesized and assayed against bloodstream trypomastigote forms of Trypanosoma cruzi, the etiological agent of Chagas' disease. The compounds were rationalized based on hybrid drugs and appear as important compounds against this parasite. From nor-lapachol were prepared
Erika Terzuoli et al.
Cancers, 11(12) (2019-12-11)
Melanoma and non-small-cell lung carcinoma (NSCLC) cell lines are characterized by an intrinsic population of cancer stem-like cells (CSC), and high expression of detoxifying isozymes, the aldehyde dehydrogenases (ALDHs), regulating the redox state. In this study, using melanoma and NSCLC
Yuchen Zhang et al.
Molecular cancer therapeutics, 20(1), 150-160 (2020-10-11)
Pancreatic ductal adenocarcinoma (PDAC) has a prominent fibrotic stroma, which is a result of interactions between tumor, immune and pancreatic stellate cells (PSC), or cancer-associated fibroblasts (CAF). Targeting inflammatory pathways present within the stroma may improve access of effector immune
Zhanqi Gao et al.
Journal of separation science, 36(6), 1112-1118 (2013-02-26)
A simple, environment friendly and efficient technique, ionic liquid-based microwave-assisted extraction was first used to determine malachite green and crystal violet (CV) from water samples coupled to HPLC. The key parameters influencing extraction efficiency were investigated, such as the type
Sarah L Svensson et al.
Molecular microbiology, 71(1), 253-272 (2008-11-20)
Campylobacter jejuni, a prevalent cause of bacterial gastroenteritis, must adapt to different environments to be a successful pathogen. We previously identified a C. jejuni two-component regulatory system (Cj1226/7c) as upregulated during cell infections. Analyses described herein led us to designate
Leilani Ireland Way et al.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 23(1), 23-28 (2013-01-16)
To determine the utility of performing urine Gram stain for detection of bacteriuria compared to routine urine sediment examination and bacterial aerobic urine culture. Prospective, observational study. University teaching hospital. Urine samples acquired via cystocentesis through convenience sampling from 103
Lene K Vestby et al.
BMC veterinary research, 5, 43-43 (2009-11-26)
Biofilm has been shown to be one way for Salmonella to persist in the feed factory environment. Matrix components, such as fimbriae and cellulose, have been suggested to play an important role in the survival of Salmonella in the environment.
Eleonora Grisard et al.
EBioMedicine, 46, 79-93 (2019-07-16)
Metastatic colorectal cancer (CRC) remains a deadly disease. Identifying locally advanced CRC patients with high risk of developing metastasis and improving outcome of metastatic CRC patients require discovering master regulators of metastasis. In this context, the non-coding part of the
Kamini Kunasegaran et al.
PloS one, 9(10), e110191-e110191 (2014-10-25)
The transcriptional repressor Tbx3 is involved in lineage specification in several tissues during embryonic development. Germ-line mutations in the Tbx3 gene give rise to Ulnar-Mammary Syndrome (comprising reduced breast development) and Tbx3 is required for mammary epithelial cell identity in
Diego Benitez et al.
Journal of medicinal chemistry, 54(10), 3624-3636 (2011-04-22)
For a fourth approach of quinoxaline N,N'-dioxides as anti-trypanosomatid agents against T. cruzi and Leishmania, we found extremely active derivatives. The present study allows us to state the correct requirements for obtaining optimal in vitro anti-T. cruzi activity. Derivatives possessing
Ridha Limame et al.
PloS one, 7(10), e46536-e46536 (2012-10-25)
Cell viability and motility comprise ubiquitous mechanisms involved in a variety of (patho)biological processes including cancer. We report a technical comparative analysis of the novel impedance-based xCELLigence Real-Time Cell Analysis detection platform, with conventional label-based endpoint methods, hereby indicating performance
Kaiyang Cai et al.
Forensic science international, 226(1-3), 240-243 (2013-02-23)
A new method based on the use of highly fluorescent water-soluble cadmium telluride (CdTe) quantum dots (QDs) capped with mercaptosuccinic acid (MSA) was explored to develop latent fingerprints. After optimized the effectiveness of QDs method contains pH value and developing
Abhijnya Vijayavittal Kanugovi et al.
Journal of cellular biochemistry, 121(4), 2770-2781 (2019-11-07)
The Hsp90 chaperone has become the attractive pharmacological target to inhibit tumor cell proliferation. However, tumor cells can evolve with mechanisms to overcome Hsp90 inhibition. Using human neuroblastoma, we have investigated one such limitation. Here, we demonstrate that neuroblastoma cells
Afra Khiralla et al.
Microorganisms, 8(9) (2020-09-10)
An endophytic fungus isolated from Vernonia amygdalina, a medicinal plant from Sudan, was taxonomically characterized as Curvularia papendorfii. Ethyl acetate crude extract of C. papendorfii revealed an important antiviral effect against two viral pathogens, the human coronavirus HCoV 229E and
Henry M Wu et al.
BMC infectious diseases, 13, 26-26 (2013-01-24)
Although cerebrospinal fluid (CSF) culture is the diagnostic reference standard for bacterial meningitis, its sensitivity is limited, particularly when antibiotics were previously administered. CSF Gram staining and real-time PCR are theoretically less affected by antibiotics; however, it is difficult to
Antimicrobial stewardship lessons: know when to say no to vancomycin.
Rodrigo Pires dos Santos et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56(4), 616-617 (2012-10-24)
Lise Crémet et al.
Diagnostic microbiology and infectious disease, 75(3), 252-255 (2013-01-15)
Biofilm formation seems to be a key factor in many bacterial infections, particularly those involving prosthetic implants or urinary catheters, where Escherichia coli is frequently involved. We have determined the ability to form biofilm in vitro of 34 E. coli
Nam-Hui Yim et al.
Oncology reports, 34(2), 1058-1064 (2015-06-11)
Betulin, a triterpene from the bark of various species of birch tree, has various biological effects, including antiviral, antifungal and anticancer activities. The aim of the present study was to elucidate the mechanisms underlying the apoptotic effect of betulin in
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