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Sarah L Svensson et al.
Molecular microbiology, 71(1), 253-272 (2008-11-20)
Campylobacter jejuni, a prevalent cause of bacterial gastroenteritis, must adapt to different environments to be a successful pathogen. We previously identified a C. jejuni two-component regulatory system (Cj1226/7c) as upregulated during cell infections. Analyses described herein led us to designate
Leilani Ireland Way et al.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 23(1), 23-28 (2013-01-16)
To determine the utility of performing urine Gram stain for detection of bacteriuria compared to routine urine sediment examination and bacterial aerobic urine culture. Prospective, observational study. University teaching hospital. Urine samples acquired via cystocentesis through convenience sampling from 103
Anissa Nofita Sari et al.
Cancers, 12(5) (2020-05-10)
We have earlier reported anticancer activity in Withaferin A (Wi-A), a withanolide derived from Ashwagandha (Withania somnifera) and caffeic acid phenethyl ester (CAPE), an active compound from New Zealand honeybee propolis. Whereas Wi-A was cytotoxic to both cancer and normal
Diego Benitez et al.
Journal of medicinal chemistry, 54(10), 3624-3636 (2011-04-22)
For a fourth approach of quinoxaline N,N'-dioxides as anti-trypanosomatid agents against T. cruzi and Leishmania, we found extremely active derivatives. The present study allows us to state the correct requirements for obtaining optimal in vitro anti-T. cruzi activity. Derivatives possessing
Ridha Limame et al.
PloS one, 7(10), e46536-e46536 (2012-10-25)
Cell viability and motility comprise ubiquitous mechanisms involved in a variety of (patho)biological processes including cancer. We report a technical comparative analysis of the novel impedance-based xCELLigence Real-Time Cell Analysis detection platform, with conventional label-based endpoint methods, hereby indicating performance
Kaiyang Cai et al.
Forensic science international, 226(1-3), 240-243 (2013-02-23)
A new method based on the use of highly fluorescent water-soluble cadmium telluride (CdTe) quantum dots (QDs) capped with mercaptosuccinic acid (MSA) was explored to develop latent fingerprints. After optimized the effectiveness of QDs method contains pH value and developing
Nam-Hui Yim et al.
Oncology reports, 34(2), 1058-1064 (2015-06-11)
Betulin, a triterpene from the bark of various species of birch tree, has various biological effects, including antiviral, antifungal and anticancer activities. The aim of the present study was to elucidate the mechanisms underlying the apoptotic effect of betulin in
Chye Ling Tan et al.
The Journal of investigative dermatology, 139(8), 1638-1647 (2019-02-19)
Nicotinamide (NAM) is the main precursor of nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for DNA repair, glycolysis, and oxidative phosphorylation. NAM has anti-aging activity on human skin, but the underlying mechanisms of action are unclear. Using 3-dimensional organotypic skin models
Gian Carlo Alghisi et al.
PloS one, 4(2), e4449-e4449 (2009-02-13)
Cilengitide is a high-affinity cyclic pentapeptdic alphaV integrin antagonist previously reported to suppress angiogenesis by inducing anoikis of endothelial cells adhering through alphaVbeta3/alphaVbeta5 integrins. Angiogenic endothelial cells express multiple integrins, in particular those of the beta1 family, and little is
Zhanqi Gao et al.
Journal of separation science, 36(6), 1112-1118 (2013-02-26)
A simple, environment friendly and efficient technique, ionic liquid-based microwave-assisted extraction was first used to determine malachite green and crystal violet (CV) from water samples coupled to HPLC. The key parameters influencing extraction efficiency were investigated, such as the type
Christopher A Elkins et al.
Antimicrobial agents and chemotherapy, 51(3), 923-929 (2007-01-11)
AcrAB-TolC is the major, constitutively expressed tripartite multidrug efflux system in Escherichia coli that recognizes various structurally unrelated molecules, including many antibiotics, dyes, and steroids. The AcrB inner membrane pump portion of the efflux system has been shown in recent
Hyung-Sup Shim et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 149(3), 399-401 (2013-07-17)
Preauricular sinus is a relatively common congenital anomaly that mainly exists on the anterior aspect of the anterior limb of the ascending helix. Although many surgical techniques have been developed, extirpation of the sinus is not easy because of the
Kowit Yu Chong et al.
Cancer biology & therapy, 16(1), 149-159 (2015-01-16)
Multiple drug resistance (MDR) is a major obstacle to attenuating the effectiveness of chemotherapy to many human malignancies. Proteasome inhibition induces apoptosis in a variety of cancer cells and is recognized as a novel anticancer therapy approach. Despite its success
Alexander J Chang et al.
Anticancer research, 39(6), 2683-2687 (2019-06-10)
The treatment of renal cell carcinoma (RCC) has evolved tremendously over the past decades. Localized disease is often curative with surgical resection of the malignancy. However, in cases where the primary tumor has metastasized, immunotherapy is becoming a more prevalent
R Hartman et al.
European cells & materials, 36, 171-183 (2018-10-20)
Robust cellular bioenergetics is vital in the energy-demanding process of maintaining matrix homeostasis in the intervertebral disc. Age-related decline in disc cellular bioenergetics is hypothesised to contribute to the matrix homeostatic perturbation observed in intervertebral disc degeneration. The present study
Manal Mehibel et al.
The Journal of clinical investigation, 131(11) (2021-06-02)
Hypoxia, a hallmark feature of the tumor microenvironment, causes resistance to conventional chemotherapy, but was recently reported to synergize with poly(ADP-ribose) polymerase inhibitors (PARPis) in homologous recombination-proficient (HR-proficient) cells through suppression of HR. While this synergistic killing occurs under severe
R Docampo et al.
Biomedical and environmental sciences : BES, 1(4), 406-413 (1988-12-01)
Blood transfusion is the second most important mechanism of transmission of Chagas' disease. Gentian violet, a cationic dye, is currently used in blood banks in endemic areas in attempts to eliminate such transmission. A photodynamic action of gentian violet has
Songyuan Bao et al.
Molecular biology reports, 40(2), 1927-1936 (2012-10-19)
Two new laccase genes, named lac1 and lac2, were cloned from the edible basidiomycete Coprinus comatus. Comparison of the deduced amino acid sequences revealed two laccases showed 66.12 % identity and clustered with lac2 and lac3 from Coprinopsis cinerea in same
Douglas V Faget et al.
PloS one, 7(10), e47868-e47868 (2012-10-31)
The proteins belonging to the nuclear factor of activated T cells (NFAT) family of transcription factors are expressed in several cell types and regulate genes involved in differentiation, cell cycle and apoptosis. NFAT proteins share two conserved domains, the NFAT-homology
F Jahan et al.
The Malaysian journal of pathology, 36(3), 175-180 (2014-12-17)
Urethritis is one of the most important causes of morbidity and mortality in developing countries. The aim of this study was to detect common bacterial causes of urethritis in men by Gram stain, culture and multiplex PCR.185 male patients who
J X Zhang et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(4), 737-744 (2013-01-12)
The adsorption of crystal violet dye from aqueous solutions onto an activated carbon prepared from peanut shells was analyzed in this study. The effects of particle size, initial concentration, time and temperature on crystal violet removal were studied in batch
Ting Xu et al.
Oncology reports, 33(5), 2631-2638 (2015-03-31)
Slug is involved in the radioresistance and chemoresistance of several types of cancers. In the present study, we first studied the effect of Slug on the radioresistance of nasopharyngeal carcinoma (NPC). We established radioresistant CNE-2 cells (CNE-2-RES) by exposing CNE-2
Yuchen Zhang et al.
Molecular cancer therapeutics, 20(1), 150-160 (2020-10-11)
Pancreatic ductal adenocarcinoma (PDAC) has a prominent fibrotic stroma, which is a result of interactions between tumor, immune and pancreatic stellate cells (PSC), or cancer-associated fibroblasts (CAF). Targeting inflammatory pathways present within the stroma may improve access of effector immune
Gram stain for Vibrio species.
Chia-Chang Kuo et al.
The American journal of emergency medicine, 31(5), 877-878 (2013-03-19)
José Mauricio dos Santos Filho et al.
Bioorganic & medicinal chemistry, 17(18), 6682-6691 (2009-08-18)
Research in recent years has demonstrated that the Trypanosoma cruzi cysteine protease cruzain (TCC) is a valid chemotherapeutic target, since inhibitors of this protease affect the pathology appropriately. By exploring the N-acylhydrazones (NAH) as privileged structures usually present in antiparasitic
Jayant S Raut et al.
Biofouling, 29(1), 87-96 (2012-12-12)
Biofilm-related infections caused by Candida albicans and associated drug resistant micro-organisms are serious problems for immunocompromised populations. Molecules which can prevent or remove biofilms are needed. Twenty-eight terpenoids of plant origin were analysed for their activity against growth, virulence attributes
R Docampo et al.
Drug metabolism reviews, 22(2-3), 161-178 (1990-01-01)
Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. To date, no
Ruchi P Patel et al.
Translational oncology, 14(1), 100917-100917 (2020-11-01)
Although the first line of therapy for epithelial ovarian cancer typically consists of taxane-platinum combination therapy, many patients develop a platinum-resistant tumor within a year. Several previous studies have looked at this cross-resistance between cisplatin and anti-microtubule drugs, but their
Laura Lecce et al.
The Journal of clinical investigation, 131(15) (2021-08-03)
Endothelial-mesenchymal transition (EndMT) is associated with various cardiovascular diseases and in particular with atherosclerosis and plaque instability. However, the molecular pathways that govern EndMT are poorly defined. Specifically, the role of epigenetic factors and histone deacetylases (HDACs) in controlling EndMT
Bin He et al.
Molecular biology reports, 40(9), 5397-5405 (2013-05-15)
Cancer targeting gene-viro-therapy (CTGVT) may prove to be an effective treatment for pancreatic cancer (PC). This study was intended to explore the anti-tumor effect of ZD55-IL-24 (oncolytic adenovirus ZD55 harboring IL-24) on PC in immune-competent mice. The expression of gene
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