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Priya T Bhola et al.
European journal of human genetics : EJHG, 27(7), 1026-1032 (2019-02-20)
With the rising demand for clinical genetics services, it is a challenge for clinical geneticists to meet the needs of patients and referring primary care providers in a timely way, using current models of genetics health care delivery. One method...
Kristen S Lee et al.
PloS one, 15(2), e0228767-e0228767 (2020-02-12)
Hepatitis C (HCV) infection is a significant health threat, with increasing incidence rates in the setting of the opioid crisis. Many patients miss appointments and cannot initiate treatment. We implemented financial incentives to improve appointment attendance in a primary care-based...
Medjda Bellamri et al.
Toxicological sciences : an official journal of the Society of Toxicology, 163(2), 543-556 (2018-03-30)
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), an heterocyclic aromatic amine (HAA) formed in cooked meat, is a rodent and possible human prostate carcinogen. Recently, we identified DNA adducts of PhIP in the genome of prostate cancer patients, but adducts of 2-amino-3, 8-dimethylmidazo[4,5-f]quinoxaline (MeIQx) and...
Fanny McKellips et al.
The British journal of general practice : the journal of the Royal College of General Practitioners, 67(664), e757-e763 (2017-10-11)
Allied health services are an important part of providing effective team-based care. The Champlain BASE™ (Building Access to Specialists through eConsultation) eConsult service facilitates quick and secure communication between primary care providers (PCPs) and allied health professionals (AHPs). To assess...
Masaki Horitani et al.
Scientific reports, 10(1), 4368-4368 (2020-03-11)
Inorganic pyrophosphatase (PPase) catalyses the hydrolysis reaction of inorganic pyrophosphate to phosphates. Our previous studies showed that manganese (Mn) activated PPase from the psychrophilic bacterium Shewanella sp. AS-11 (Mn-Sh-PPase) has a characteristic temperature dependence of the activity with an optimum...
Dopamine and serotonin are both required for mate-copying in Drosophila melanogaster
Monier M, et al.
Frontiers in Behavioral Neuroscience, 12(5), 334-334 (2018)
Simone Thum et al.
European journal of medicinal chemistry, 177, 47-62 (2019-05-28)
The class of tetrahydro-1H-3-benzazepines was systematically modified in 1-, 3- and 7-position. In particular, a F-atom was introduced in β- or γ-position of the 4-phenylbutyl side chain in 3-position. Ligands with the F-atom in γ-position possess higher GluN2B affinity than...
Mara A Schonberg et al.
JAMA internal medicine, 180(6), 831-842 (2020-04-21)
Guidelines recommend that women 75 years and older be informed of the benefits and harms of mammography before screening. To test the effects of receipt of a paper-based mammography screening decision aid (DA) for women 75 years and older on...
Barbara Noli et al.
Frontiers in cellular neuroscience, 11, 158-158 (2017-06-20)
From the VGF precursor protein originate several low molecular weight peptides, whose distribution in the brain and blood circulation is not entirely known. Among the VGF peptides, those containing the N-terminus portion were altered in the cerebro-spinal fluid (CSF) and...
Masato Honda et al.
Environmental pollution (Barking, Essex : 1987), 232, 487-493 (2017-10-03)
Chlorophenols (CPs) are used in the production of pesticides and preservatives. Although human exposure to CPs has been known for years, current exposure levels to these chemicals in Asian countries are not known. In this study, we analyzed concentrations of...
Chien-Hua Chiang et al.
Journal of food and drug analysis, 27(2), 439-450 (2019-04-17)
In this study the recently developed technique of thermal desorption electrospray ionization/mass spectrometry (TD-ESI/MS) was applied to the rapid analysis of multiple controlled substances. With the reallocation of mass spectral resources [from a standard ESI source coupled with liquid chromatography...
István Gacsályi et al.
Neuropharmacology, 125, 30-38 (2017-07-12)
Previous work has shown that S44819 is a novel GABAA receptor (GABA
Jaakko Paasonen et al.
Neuropharmacology, 119, 15-25 (2017-03-28)
Current drug treatments for schizophrenia (SCZ) can alleviate positive symptoms, but have little effect on the negative symptoms and cognitive deficits that are difficult to translate into preclinical models for drug development. Therefore, we aimed to determine the dose-response effects...
Oladipupo A Aregbesola et al.
Biodegradation, 31(4-6), 369-383 (2020-10-05)
Pentachlorophenol (PCP) is a recalcitrant biocide that bioaccumulates in the environment due to its persistent nature and has been listed as a priority pollutant due to its toxicological and health effects. In this study, a novel PCP-degrading Bacillus cereus strain...
Ji Soo Choi et al.
PloS one, 13(10), e0206231-e0206231 (2018-10-26)
Pneumocystis jirovecii pneumonia (PCP) is often fatal in human immunodeficiency (HIV)-negative patients and typically presents with respiratory insufficiency. Predicting treatment failure is challenging. This study aimed to identify prognostic factors and examine PCP polymerase chain reaction (PCR)-negative conversion in non-HIV...
Katja Savolainen et al.
Psychopharmacology, 236(4), 1245-1253 (2018-12-12)
Social withdrawal is a core feature of the negative symptoms of schizophrenia. Currently available pharmacotherapies have only limited efficacy towards the negative symptoms, i.e., there is a significant unmet medical need in the treatment of these symptoms. We wanted to...
Ilhem Belarbi et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 79(4), 741-752 (2019-04-13)
The development of new catalysts from abundant raw materials, generating attractive photocatalytic activity, constitutes a real challenge in the context of sustainable development concerns. In this setting, a dolomite was treated at 800 °C (D800) and then chemically modified by...
Kei Eto et al.
Brain research, 1414, 50-57 (2011-08-30)
Thyrotropin-releasing hormone (TRH) and its analogs have been reported to modulate descending monoaminergic inhibitory neurons, resulting in antinociception. However, it remains unknown whether TRH exerts an antiallodynic effect during persistent pain. Here, we investigated the action of taltirelin, a stable...
Yuqing Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(12), 5342-5355 (2017-08-11)
Impaired pancreatic β-cell function is the primary defect in type 2 diabetes. Glucose is an important regulator of β-cell growth and function; however, the mechanisms that are involved in the chronic adaptation of β cells to hyperglycemia remain largely unknown....
Chaochao Zhou et al.
Journal of biomechanical engineering (2019-10-02)
Total disc arthroplasty (TDA) using an artificial disc (AD) is an attractive surgical technique for the treatment of spinal disorders, since it can maintain or restore spinal motion (unlike interbody fusion). However, adverse surgical outcomes of contemporary lumbar TDAs have...
Henrik Kylin et al.
Environmental pollution (Barking, Essex : 1987), 229, 688-695 (2017-07-18)
The production and use of pentachlorophenol (PCP) was recently prohibited/restricted by the Stockholm Convention on persistent organic pollutants (POPs), but environmental data are few and of varying quality. We here present the first extensive dataset of the continent-wide (Eurasia and...
Meng Wang et al.
Chinese medicine, 12, 32-32 (2017-11-03)
C57BL/6 mice were orally administered an aqueous extract of PCP (5.15 and 10.3 g/kg BW) or silymarin (100 mg/kg) once daily for 1 week prior to CCl A single dose of CCl Results indicated that the pretreatment of PCP (10.3 g/kg BW) effectively protected...
Yiyang Du et al.
Journal of separation science, 43(11), 2019-2030 (2020-02-20)
Insomnia is a common clinical disease that can seriously damage the normal lives of sufferers. Suan-Zao-Ren decoction has been used to treat insomnia for a long time. However, the underlying molecular mechanism of Suan-Zao-Ren decoction is still not clear. In...
Andrea Šlampová et al.
Analytica chimica acta, 887, 92-100 (2015-09-01)
Electrolysis is omnipresent in all electrochemical processes including electromembrane extraction (EME). The effects of electrolysis on quantitative aspects of EME were comprehensively evaluated for a set of acidic (substituted phenols) and basic (basic drugs) analytes. EMEs were carried out across...
Matthew Quinn et al.
Forensic science international, 307, 110135-110135 (2020-01-11)
Identifying drug analogs can be a vexing problem for forensic scientists particularly in today's evolving drug market. This study proposes a method that utilizes microcrystalline tests, Raman microspectroscopy, and chemometrics to help solve this problem. In the present case, the...
Sergio Hidalgo et al.
ACS chemical neuroscience, 8(10), 2168-2179 (2017-07-01)
A better comprehension on how different molecular components of the serotonergic system contribute to the adequate regulation of behaviors in animals is essential in the interpretation on how they are involved in neuropsychiatric and pathological disorders. It is possible to...
Mark J Airhart et al.
Neurotoxicology and teratology, 34(1), 152-160 (2011-09-07)
In this study, p-chlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase (the rate limiting enzyme of serotonin synthesis), was used to reduce serotonin (5HT) levels during early development in zebrafish embryos. One day old dechorionated embryos were treated with 25 μM...
Cruz-Pérez Alejandra Lucía et al.
Journal of ethnobiology and ethnomedicine, 17(1), 7-7 (2021-02-12)
Oaxaca is one of the most diverse states in Mexico from biological and cultural points of view. Different ethnic groups living there maintain deep and ancestral traditional knowledge of medicinal plants as well as traditional practices and beliefs about diseases/illnesses...
Adrienne G Waks et al.
Breast cancer research and treatment, 154(2), 359-367 (2015-10-01)
Opportunistic infection with Pneumocystis jiroveci pneumonia (PCP) has not been recognized as a significant complication of early-stage breast cancer treatment. However, we have observed an increase in PCP incidence among patients receiving chemotherapy for early-stage breast cancer. Herein we identify...
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