Showing 1-26 of 26 results for "C6637"
Karl Dichtl et al.
Molecular microbiology, 76(5), 1191-1204 (2010-04-20)
Farnesol is known for inducing apoptosis in some fungi and mammalian cells. To evaluate its potential role as an antifungal agent, we studied its impact on the human pathogen Aspergillus fumigatus. We found that growth of A. fumigatus wild type...
Naimeh Taheri-Talesh et al.
Molecular biology of the cell, 19(4), 1439-1449 (2008-01-25)
Hyphal tip growth in fungi is important because of the economic and medical importance of fungi, and because it may be a useful model for polarized growth in other organisms. We have investigated the central questions of the roles of...
Tehila Hyman et al.
Molecular biology of the cell, 17(1), 427-437 (2005-10-28)
In epithelial cell lines, apical but not basolateral clathrin-mediated endocytosis has been shown to be affected by actin-disrupting drugs. Using electron and fluorescence microscopy, as well as biochemical assays, we show that the amount of actin dedicated to endocytosis is...
Matteo A Russo et al.
Journal of cellular biochemistry, 113(6), 1915-1925 (2012-01-12)
The possible role of an exocytotic, vesicular mechanism in cellular volume regulation under iso-osmotic conditions has been studied in slices of rat liver. The effects of incubation conditions and agents affecting the actin cytoskeleton were examined for changes of water...
J Ishikawa et al.
Experimental cell research, 288(2), 268-276 (2003-08-14)
Single phagocytic events of cellular slime mold Dictyostelium discoideum were studied by the method of particle tracking. A 2-microm polystyrene bead, which had been covalently coated with folate, was attached to the advancing edge of a Dictyostelium ameba with the...
Yujiro Higuchi et al.
Biochemical and biophysical research communications, 340(3), 784-791 (2005-12-29)
Endocytosis is an important process for cellular activities. However, in filamentous fungi, the existence of endocytosis has been so far elusive. In this study, we used AoUapC-EGFP, the fusion protein of a putative uric acid-xanthine permease with enhanced green fluorescent...
Tohnyui Ndinyanka Fabrice et al.
International journal of molecular sciences, 21(4) (2020-02-27)
Coronin proteins are evolutionary conserved WD repeat containing proteins that have been proposed to carry out different functions. In Dictyostelium, the short coronin isoform, coronin A, has been implicated in cytoskeletal reorganization, chemotaxis, phagocytosis and the initiation of multicellular development....
Kumiko Masai et al.
Bioscience, biotechnology, and biochemistry, 68(7), 1569-1573 (2004-07-28)
The distribution of the secreted protein ribonuclease T1 (RntA) fused with the enhanced green fluorescent protein (EGFP), RntA-EGFP, was visualized in hyphae of Aspergillus oryzae in the presence of a protein transport inhibitor, brefeldin A, cytochalasin A, or nocodazole. During...
Norio Takeshita et al.
Molecular biology of the cell, 16(4), 1961-1970 (2005-02-11)
One of the essential features of fungal morphogenesis is the polarized synthesis of cell wall components such as chitin. The actin cytoskeleton provides the structural basis for cell polarity in Aspergillus nidulans, as well as in most other eukaryotes. A...
Zhe Sun et al.
American journal of physiology. Cell physiology, 295(1), C268-C278 (2008-05-23)
Integrin-mediated mechanotransduction in vascular smooth muscle cells (VSMCs) plays an important role in the physiological control of tissue blood flow and vascular resistance. To test whether force applied to specific extracellular matrix (ECM)-integrin interactions could induce myogenic-like mechanical activity at...
Xiaohe Song et al.
Protoplasma, 249(1), 99-106 (2011-02-08)
Elucidating resistance mechanisms of plant cells against pathogens is essential to develop novel strategies of disease control. The actin cytoskeleton was found intimately involved in plant defense. In order to reveal how actin would be involved in the interaction between...
Dominique Reumaux et al.
Journal of leukocyte biology, 80(6), 1424-1433 (2006-09-26)
Anti-proteinase-3 (anti-PR3) or anti-myeloperoxidase (anti-MPO) antibodies are capable of activating human neutrophils primed by TNF-alpha in vitro. We described previously the involvement of FcgammaRIIa and beta(2) integrins in this neutrophil activation. In the literature, the requirement of TNF priming has...
Tiago dos Santos et al.
PloS one, 6(9), e24438-e24438 (2011-09-29)
Nanotechnology is expected to play a vital role in the rapidly developing field of nanomedicine, creating innovative solutions and therapies for currently untreatable diseases, and providing new tools for various biomedical applications, such as drug delivery and gene therapy. In...
I I Pelevina et al.
Radiatsionnaia biologiia, radioecologiia, 49(4), 419-424 (2009-10-06)
On the blood lymphocytes of prostate cancer (PCa) patients before and during radiotherapy: DNA damage by DNA commet assay (DNA double strand breaks - DSB); the frequency of cells with micronuclei (MN) with cytokinetic cytochalasin block; the adaptive response induction...
J Adrian Lunn et al.
The Journal of biological chemistry, 282(14), 10370-10379 (2007-02-10)
The results presented here demonstrate that focal adhesion kinase (FAK) Tyr-861 is the predominant tyrosine phosphorylation site stimulated by hyperosmotic stress in a variety of cell types, including epithelial cell lines (ileum-derived IEC-18, colon-derived Caco2, and stomach-derived NCI-N87), FAK null...
Elba Pereyra et al.
Protoplasma, 222(1-2), 23-30 (2003-09-27)
The tripeptide Arg-Gly-Asp (RGD) (1 mM) as well as the polymer ProNectin F (20 nM) added to culture medium of the fungus Mucor rouxii (defined medium) produced a delay in the switch from isodiametric growth to tip growth; at the...
Nicole Endlich et al.
Cell motility and the cytoskeleton, 64(12), 966-976 (2007-09-18)
Force generated in contractile actin filament bundles (stress fibers-SFs) is transmitted to the extracellular matrix (ECM) via linker proteins and transmembrane integrins at focal adhesions (FAs). Though it has long been known that actin is rapidly exchanged in FAs, the...
M Riquelme et al.
Protoplasma, 222(3-4), 211-215 (2004-01-10)
It is well established that cytoplasmic microtubules are depolymerized during nuclear division and reassembled as mitotic microtubules. Mounting evidence showing that cytoplasmic microtubules were also involved in apical growth of fungal hyphae posed the question of whether apical growth became...
Hameeda Sultana et al.
Traffic (Copenhagen, Denmark), 6(10), 930-946 (2005-09-06)
Data from mutant analysis in yeast and Dictyostelium indicate a role for the cyclase-associated protein (CAP) in endocytosis and vesicle transport. We have used genetic and biochemical approaches to identify novel interacting partners of Dictyostelium CAP to help explain its...
Gladys Corrêa et al.
Parasitology research, 98(3), 250-256 (2005-12-14)
Giardia lamblia, a flagellated protist, is the parasite most commonly found in the intestinal tract of humans and other mammals causing a disease known as giardiasis. This parasite presents several cytoskeletal structures whose major components are microtubules, namely: the ventral...
Aleksandra Virag et al.
Fungal genetics and biology : FG & B, 41(2), 213-225 (2004-01-21)
Actin has a pivotal function in hyphal morphogenesis in filamentous fungi, but it is not certain whether its function is equivalent to that of a morphogen, or if it is simply part of a mechanism that executes orders given by...
Laura A Jones et al.
Eukaryotic cell, 9(10), 1455-1465 (2010-08-10)
During the extreme polarized growth of fungal hyphae, secretory vesicles are thought to accumulate in a subapical region called the Spitzenkörper. The human fungal pathogen Candida albicans can grow in a budding yeast or hyphal form. When it grows as...
Massimiliano G Bianchi et al.
Neurochemistry international, 48(5), 341-349 (2006-01-19)
The activity and the membrane expression of EAAT3 glutamate transporter are stimulated upon PKC activation by phorbol esters in C6 rat glioma cells. To investigate the role of cytoskeleton in these effects, we have employed actin-perturbing toxins and found that...
Michael J Wolyniak et al.
Eukaryotic cell, 6(10), 1824-1840 (2007-08-24)
Changes in gene expression during reversible bud-hypha transitions of the opportunistic fungal pathogen Candida albicans permit adaptation to environmental conditions that are critical for proliferation in host tissues. Our previous work has shown that the hypha-specific adhesin gene HWP1 is...
Carolyn G Rasmussen et al.
Eukaryotic cell, 6(7), 1097-1107 (2007-05-15)
Rho-4 mutants of the filamentous fungus Neurospora crassa lack septa and asexual spores (conidia) and grow slowly. In this report, localization of green fluorescent protein-tagged RHO-4 is used to elucidate the differences in factors controlling RHO-4 localization during vegetative growth...
Jinghui Huang et al.
Glia, 58(5), 622-631 (2009-12-10)
Production of nerve growth factor (NGF) from Schwann cells (SCs) progressively declines in the distal stump, if axonal regeneration is staggered across the suture site after peripheral nerve injuries. This may be an important factor limiting the outcome of nerve...

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