Showing 1-30 of 39 results for "C7081"
Robyn Meech et al.
Physiological reviews, 99(2), 1153-1222 (2019-02-07)
UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad range of exogenous chemicals and by-products of endogenous metabolism, and also controls the levels...
Trinidad D Montero et al.
Biochemical and biophysical research communications, 419(2), 405-411 (2012-02-22)
Human equilibrative nucleoside transporter 1 (hENT1) is an important determinant for nucleoside analog based chemotherapy success. Preliminary data suggest hENT1 regulation by PPARs. Using A2780 cells, we investigated the role of PPARs on hENT1 expression and activity. PPARα and PPARγ...
Marta Garcia-Ramírez et al.
Acta diabetologica, 53(1), 109-118 (2015-05-06)
There is clinical evidence that fenofibrate, a PPARα agonist, arrests the progression of diabetic macular edema (DME). However, the underlying mechanisms of this beneficial effect remain to be elucidated. We previously reported that fenofibric acid (FA), the active metabolite of...
Stefan Clockaerts et al.
Annals of the rheumatic diseases, 71(6), 1012-1018 (2012-02-07)
Infrapatellar fat pad (IPFP) might be involved in osteoarthritis (OA) by production of cytokines. It was hypothesised that production of cytokines is sensitive to environmental conditions. To evaluate cytokine production by IPFP in response to interleukin (IL)1β and investigate the...
Katsuhiko Funai et al.
The Journal of clinical investigation, 123(3), 1229-1240 (2013-02-05)
Exogenous dietary fat can induce obesity and promote diabetes, but endogenous fat production is not thought to affect skeletal muscle insulin resistance, an antecedent of metabolic disease. Unexpectedly, the lipogenic enzyme fatty acid synthase (FAS) was increased in the skeletal...
Vladimir S Shavva et al.
Molecular and cellular biochemistry, 448(1-2), 211-223 (2018-02-15)
Apolipoprotein A-I (ApoA-I) is the main structural and functional protein component of high-density lipoprotein. ApoA-I has been shown to regulate lipid metabolism and inflammation in macrophages. Recently, we found the moderate expression of endogenous apoA-I in human monocytes and macrophages...
Divya Venkatesh et al.
Genes & development, 34(7-8), 526-543 (2020-02-23)
MDM2 and MDMX, negative regulators of the tumor suppressor p53, can work separately and as a heteromeric complex to restrain p53's functions. MDM2 also has pro-oncogenic roles in cells, tissues, and animals that are independent of p53. There is less...
Nithi Asavapanumas et al.
Drug metabolism and pharmacokinetics, 27(5), 513-519 (2012-04-05)
Fibrate drugs, the peroxisome proliferator-activated receptor alpha (PPARα) agonists, are widely prescribed for the treatment of hyperlipidemia. The present study examined the effect of fibrate drugs on renal OCT2 activity in a heterologous cell system [Chinese hamster ovary (CHO-K1) cells...
Carmen Zhang et al.
Cells, tissues, organs, 196(5), 431-441 (2012-06-09)
Peroxisome proliferators (PPs) are a diverse chemical group including hypolipidemic drugs and some fatty acids. Their stimulation of PP-activated receptors (PPARs) and subsequent control of gene expression regulates metabolism and differentiation in many cells. PPs have multiple opportunities to target...
Seong Ho Yoo et al.
Biochemical and biophysical research communications, 436(3), 366-371 (2013-06-04)
Acute lung injury (ALI) is a major cause of mortality and morbidity worldwide. The activation of peroxisome proliferator-activated receptor-α (PPARα) by its ligands, which include Wy-14643, has been implicated as a potential anti-inflammatory therapy. To address the beneficial efficacy of...
Miriam Melis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(14), 6203-6211 (2013-04-05)
Ventral tegmental area dopamine neurons control reward-driven learning, and their dysregulation can lead to psychiatric disorders. Tonic and phasic activity of these dopaminergic neurons depends on cholinergic tone and activation of nicotinic acetylcholine receptors (nAChRs), particularly those containing the β2...
A Papi et al.
Cell death and differentiation, 19(7), 1208-1219 (2012-01-21)
Recent literature highlights the importance of pro-inflammatory cytokines in the biology of breast cancer stem cells (CSCs), unraveling differences with respect to their normal counterparts. Expansion of mammospheres (MS) is a valuable tool for the in vitro study of normal...
Qilin Gu et al.
Hepatology (Baltimore, Md.), 60(6), 1929-1941 (2014-08-19)
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder caused by abnormal lipid metabolisms, such as reduced hepatic fatty acid oxidation (FAO), but intracellular control of FAO under physio- and pathological conditions remains largely undefined. Here, we...
Maria Thomas et al.
Molecular pharmacology, 83(3), 709-718 (2013-01-09)
The nuclear receptor peroxisome proliferator-activated receptor (PPAR)α is known primarily as a regulator of fatty acid metabolism, energy balance, and inflammation, but evidence suggests a wider role in regulating the biotransformation of drugs and other lipophilic chemicals. We investigated whether...
Yue-Min Nan et al.
Lipids in health and disease, 12, 11-11 (2013-02-08)
Peroxisome proliferator activated receptor alpha (PPARα) ameliorates ethanol induced hepatic steatohepatitis. However, its role in alcoholic liver fibrosis has not been fully clarified. The aim of this study was to elucidate the effect and the molecular basis of PPARα in...
Yutaka Masuda et al.
Thrombosis and haemostasis, 108(1), 74-85 (2012-04-27)
Thrombin-activatable fibrinolysis inhibitor (TAFI) (carboxypeptidase B2) is a plasma zymogen that is biosynthesised in the liver and released into the circulation. Activated TAFI is a prothrombotic factor which inhibits fibrin clot lysis. Cultured human hepatoma HepG2 cells were treated with...
Zdenek Tauber et al.
Medical molecular morphology, 53(3), 141-148 (2019-12-12)
Fibrates belong to a group of ligands of peroxisome proliferator-activated receptor alpha (PPARα), which play a role in the regulation of CYP epoxygenases and soluble epoxide hydrolase (sEH), key enzymes in the metabolism of biologically highly active epoxyeicosatrienoic acids (EETs)....
Bora Kim et al.
International journal of dermatology, 51(6), 733-741 (2012-05-23)
Retinoids have been used for the treatment of skin disorders such as acne, psoriasis, and photoaging. However, despite their beneficial effects, topical retinoids often cause severe local irritation called retinoid dermatitis. We previously developed a novel vitamin A derivative, retinyl...
Chen Qu et al.
European journal of pharmacology, 696(1-3), 101-110 (2012-10-02)
Experiments were designed to determine if Wy14643 ([[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid), a preferential agonist at peroxisome proliferator-activated receptors (PPAR) α, improves vascular function in hypertension, and if so, the mechanism(s) involved. Isometric tension was measured in isolated thoracic aorta of spontaneously hypertensive...
WY-14643, a selective agonist of peroxisome proliferator-activated receptor-alpha, ameliorates lipopolysaccharide-induced depressive-like behaviors by preventing neuroinflammation and oxido-nitrosative stress in mice
Yang R, et al.
Pharmacology, Biochemistry, and Behavior, 153, 97-104 (2017)
Táňa Ravingerová et al.
Canadian journal of physiology and pharmacology, 90(8), 1135-1144 (2012-07-20)
Peroxisome proliferator-activated receptors (PPAR) regulate the expression of genes involved in lipid metabolism, energy production, and inflammation. Their role in ischaemia-reperfusion (I/R) is less clear, although research indicates involvement of PPARs in some forms of preconditioning. This study aimed to...
Verena Paulitschke et al.
PloS one, 7(9), e46103-e46103 (2012-10-11)
Peroxisome proliferator-activated receptors (PPARs) have been originally thought to be restricted to lipid metabolism or glucose homeostasis. Recently, evidence is growing that PPARγ ligands have inhibitory effects on tumor growth. To shed light on the potential therapeutic effects on melanoma...
Gabi Reichenbach et al.
Angiogenesis, 16(1), 223-233 (2012-10-26)
Cathepsin B has been shown to be important in angiogenesis; therefore, understanding its regulation in endothelial cells should provide fundamental information that will aid in the development of new treatment options. Peroxisome proliferator-activated receptors (PPARs) have been shown to have...
Andrew D Patterson et al.
Hepatology (Baltimore, Md.), 56(1), 281-290 (2012-02-10)
Acetaminophen (APAP) overdose causes acute liver failure in humans and rodents due in part to the destruction of mitochondria as a result of increased oxidative stress followed by hepatocellular necrosis. Activation of the peroxisome proliferator-activated receptor alpha (PPARα), a member...
PPAR-alpha activation mediates innate host defense through induction of TFEB and lipid catabolism
Kim YS, et al.
Journal of Immunology, 198(8), 3283-3295 (2017)
T Chiba et al.
Allergy, 67(7), 936-942 (2012-05-16)
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which regulate not only adipogenesis and proliferation/differentiation but also the immune response of cells. Because topical application of the activators of some PPAR isoforms improved clinical symptoms in patients with atopic dermatitis (AD)...
Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) alphagamma
Moldes-Anaya A, et al.
Marine drugs, 15(6), 148-148 (2017)
Jun-Li Ding et al.
Pancreas, 42(1), 114-122 (2012-06-23)
The peroxisome proliferator-activated receptor-α (PPAR-α) has attracted considerable attention for its anti-inflammatory properties; however, Toll-like receptor (TLR) pathways have an essential proinflammatory role in acute pancreatitis (AP). This study aimed to evaluate the attenuation of inflammation by PPAR-α and to...
Oshri Avraham et al.
Nature communications, 11(1), 4891-4891 (2020-10-01)
Peripheral sensory neurons regenerate their axon after nerve injury to enable functional recovery. Intrinsic mechanisms operating in sensory neurons are known to regulate nerve repair, but whether satellite glial cells (SGC), which completely envelop the neuronal soma, contribute to nerve...
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