Showing 1-30 of 154 results for "C7629"
Mark G Jones et al.
Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)
Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is...
Saori Oshiro et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 39(1), 189-192 (2002-01-05)
A 40-year-old woman was referred for several episodes of coma lasting from 2 hours to 2 days. She had been on maintenance hemodialysis for polycystic kidney disease for 9 months. Laboratory findings showed high serum levels of ammonia and citrulline...
Matthew J Kan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(15), 5969-5982 (2015-04-17)
The pathogenesis of Alzheimer's disease (AD) is a critical unsolved question; and although recent studies have demonstrated a strong association between altered brain immune responses and disease progression, the mechanistic cause of neuronal dysfunction and death is unknown. We have...
Beatrice Bocca et al.
Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <...
D Rating et al.
Journal of neurology, 230(4), 217-225 (1983-01-01)
In 14 children with epilepsy, 51 with febrile convulsions and 22 with meningitis gamma-aminobutyric acid (GABA) concentrations in lumbar CSF were determined. While the mean for CSF GABA concentrations for all epileptic children was unchanged [144 (range: 73-285) pmol/ml; controls:...
Kevin Guo et al.
Analytical chemistry, 81(10), 3919-3932 (2009-03-25)
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be...
H Mandel et al.
Journal of inherited metabolic disease, 28(4), 467-472 (2005-05-20)
A 19-month-old girl with developmental delay was found to have moderately elevated plasma citrulline and mildly elevated plasma arginine concentrations. Dietary history revealed that she consumed large quantities of watermelon (Citrullus vulgaris), a fruit containing high free citrulline and arginine...
Tyler A Churchward-Venne et al.
American journal of physiology. Endocrinology and metabolism, 307(1), E71-E83 (2014-05-16)
Aging is associated with anabolic resistance, a reduced sensitivity of myofibrillar protein synthesis (MPS) to postprandial hyperaminoacidemia, particularly with low protein doses. Impairments in postprandial skeletal muscle blood flow and/or microvascular perfusion with hyperaminoacidemia and hyperinsulinemia may contribute to anabolic...
G R DeLong et al.
Annals of neurology, 11(1), 53-58 (1982-01-01)
Ammonia metabolism in Reye syndrome was studied by quantitative analysis of the time course of hyperammonemia and the urinary excretion of ammonia, urea, and total nitrogen. These measures were then utilized to assess the effect of citrulline administration in 8...
Eddie A James et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(7), 1712-1722 (2014-03-26)
Rheumatoid arthritis (RA) is thought to be a T cell-mediated disease, based on its strong association with HLA class II alleles, clinical responsiveness to T cell-directed therapies, and the presence of CD4+ T cells in rheumatoid joints. The presence of...
Aase Haj Hensvold et al.
Annals of the rheumatic diseases, 74(2), 375-380 (2013-11-28)
To investigate the role of genetic and environmental factors in the development of anticitrullinated protein antibodies (ACPA) and ACPA-positive rheumatoid arthritis (RA) in a twin cohort. A total of 12 590 twins were analysed for the presence of ACPAs (CCP2 ELISA)...
Jace W Jones et al.
Analytical and bioanalytical chemistry, 406(19), 4663-4675 (2014-05-21)
The potential risk of a radiological catastrophe highlights the need for identifying and validating potential biomarkers that accurately predict radiation-induced organ damage. A key target organ that is acutely sensitive to the effects of irradiation is the gastrointestinal (GI) tract...
Y Origuchi et al.
Brain & development, 6(3), 328-331 (1984-01-01)
We report the case of a 16-year-old girl with a variant form of citrullinemia who had been treated with anticonvulsants for uncontrolled epilepsy during the last 4 years. The diagnosis of citrullinemia was made because she had elevated values for...
S Engelborghs et al.
Neurochemical research, 28(8), 1145-1150 (2003-07-02)
To study changes in amino acid metabolism and biogenic amines in Parkinson's disease, we set up a prospective study and measured biogenic amines, their main metabolites, and 22 different amino acids, in cerebrospinal fluid of Parkinson's disease patients (n =...
Jeremy Sokolove et al.
Arthritis and rheumatism, 65(7), 1719-1724 (2013-04-05)
To investigate whether citrullinated proteins within the atherosclerotic plaque can be targeted by anti-citrullinated protein antibodies (ACPAs), forming stimulatory immune complexes that propagate the progression of atherosclerosis. Protein lysates prepared from atherosclerotic segments of human aorta were assessed for the...
Koen M J Janssen et al.
Current opinion in rheumatology, 25(2), 241-247 (2013-02-02)
This article reviews the link between periodontitis and rheumatoid arthritis (RA) with regard to similarities in genetic risk factors and immunopathogenesis. Emphasis is paid to the potential role of the periodontal pathogen Porphyromonas gingivalis in the etiopathogenesis of both periodontitis...
Anna Walter et al.
Neurobiology of aging, 25(10), 1299-1303 (2004-10-07)
Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphocholine (PCh), and choline, that is, water-soluble metabolites of phosphatidylcholine (PtdCho), in human cerebrospinal fluid (CSF)....
Arif Yurdagul et al.
Cell metabolism, 31(3), 518-533 (2020-02-01)
Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here, we show that the process is optimized by linking the metabolism of engulfed cargo from initial...
C Renner et al.
European journal of pediatrics, 154(11), 909-914 (1995-11-01)
The effects of sodium citrate supplementation to improve aspartic acid supply in a 5-year-old girl with argininosuccinate lyase deficiency were studied over a period of 5 years under constant and total parenteral nutrition. Daily increasing doses of sodium citrate (0-8...
Vaidehi Agrawal et al.
Melanoma research, 24(6), 556-567 (2014-10-12)
Metastatic melanoma is a deadly form of cancer with few therapeutic options and the cause of more than 9480 deaths annually in the USA alone. Novel treatment options for this disease are urgently needed. Here we test the efficacy of...
Vincent J Huber et al.
Bioorganic & medicinal chemistry, 17(1), 411-417 (2008-01-10)
The in vitro inhibitory effects and in silico docking energies of 18 compounds with respect to aquaporin 4 (AQP4) were investigated. More than half of the compounds tested showed inhibitory activity in the in vitro functional assay and included the...
Anne-Marie Quirke et al.
Annals of the rheumatic diseases, 73(1), 263-269 (2013-03-07)
Rheumatoid arthritis (RA) is characterised by autoimmunity to citrullinated proteins, and there is increasing epidemiologic evidence linking Porphyromonas gingivalis to RA. P gingivalis is apparently unique among periodontal pathogens in possessing a citrullinating enzyme, peptidylarginine deiminase (PPAD) with the potential...
Asami Mori et al.
Journal of pharmacological sciences, 127(4), 419-423 (2015-05-09)
L-Citrulline is an effective precursor of L-arginine produced by the L-citrulline/L-arginine cycle, and it exerts beneficial effects on the cardiovascular system by supporting enhanced nitric oxide (NO) production. NO dilates retinal blood vessels via the cyclooxygenase-mediated pathway. The purpose of...
Lars Klareskog et al.
Advances in immunology, 118, 129-158 (2013-05-21)
Rheumatoid arthritis (RA) represents a disease where we have recently acquired new knowledge on etiology and molecular pathogenesis, by combining data from studies on genetic end environmental determinants of disease with molecular and cellular immunology. This combined approach has provided...
Nu-Hydroxy-L-arginine Is an Intermediate in the Biosynthesis of Nitric Oxide from L-Arginin
Dennis J. Stuehr
The Journal of Biological Chemistry, 266, 6259-6263 (1991)
l-Citrulline and l-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits.
Hayashi T
Proceedings of the National Academy of Sciences of the USA null
Yvette C Luiking et al.
Clinical science (London, England : 1979), 128(1), 57-67 (2014-07-19)
Arginine deficiency in sepsis may impair nitric oxide (NO) production for local perfusion and add to the catabolic state. In contrast, excessive NO production has been related to global haemodynamic instability. Therefore, the aim of the present study was to...
Hanning You et al.
American journal of physiology. Renal physiology, 307(11), F1292-F1301 (2014-10-17)
Our recent publication showed that pharmacological blockade of arginases confers kidney protection in diabetic nephropathy via a nitric oxide (NO) synthase (NOS)3-dependent mechanism. Arginase competes with endothelial NOS (eNOS) for the common substrate L-arginine. Lack of L-arginine results in reduced...
Response to: 'The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Antibodies against uncitrullinated peptides seem to occur prior to the antibodies to the corresponding citrullinated peptides' by Brink et al.
Paola de Pablo et al.
Annals of the rheumatic diseases, 73(7), e47-e47 (2014-04-22)
You-Lin Tain et al.
Biology of reproduction, 92(1), 7-7 (2014-11-15)
Nitric oxide (NO) deficiency induced by the NO synthase (NOS) inhibitor N(G)-nitro-L-arginine-methyl ester (L-NAME) resulted in hypertension. L-citrulline (CIT) can be converted to L-arginine to generate NO. We examined whether maternal CIT supplementation can prevent L-NAME-induced programmed hypertension. Pregnant Sprague-Dawley...

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.