Showing 1-30 of 185 results for "C7774"
Meng Hu et al.
The Journal of pharmacology and experimental therapeutics, 351(1), 87-95 (2014-07-23)
Myofibroblasts are effector cells in fibrotic disorders that synthesize and remodel the extracellular matrix (ECM). This study investigated the role of the Src kinase pathway in myofibroblast activation in vitro and fibrogenesis in vivo. The profibrotic cytokine, transforming growth factor...
Ana K Bedran-Russo et al.
American journal of dentistry, 26(5), 244-248 (2014-02-01)
To assess in non-cavitated carious teeth the mechanical properties of dentin matrix by measuring its reduced modulus of elasticity and the effect of dentin biomodification strategies on three dentin matrix zones: caries-affected, apparently normal dentin below caries-affected zone and sound...
Niraj Kumar Srivastava et al.
Indian journal of experimental biology, 52(7), 673-682 (2014-07-26)
Collagen-induced arthritis (CIA) was induced in female Wistar rats by intradermal injection of porcine immunization grade native collagen type II (Chondrex). Development and progression of CIA was monitored by studying histopathological, radiographical and biochemical features of arthritic manifestations in the...
Marta Biedzka-Sarek et al.
Infection and immunity, 76(11), 5016-5027 (2008-09-04)
Yersinia enterocolitica is an enteric pathogen that exploits diverse means to survive in the human host. Upon Y. enterocolitica entry into the human host, bacteria sense and respond to variety of signals, one of which is the temperature. Temperature in...
Invited commentary.
Xiaofeng Ye
The Annals of thoracic surgery, 98(1), 71-71 (2014-07-06)
Michael G Sarr et al.
Surgery, 156(4), 902-908 (2014-09-23)
This prospective, multicenter, randomized clinical trial was performed to compare the effectiveness of the bioprosthesis Surgisis Gold (Cook Biotech, Inc, West Lafayette, IN) to suture closure alone in reinforcing the abdominal wall after open Roux-en-Y gastric bypass (RYGB). A total...
A Chaudhuri et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 48(2), 220-225 (2014-06-01)
Small published series suggest a higher failure rate for Angio-Seal vascular closure device (VCD) deployment after antegrade femoral puncture, despite the need for shorter haemostasis times, early discharge, and possibly higher turnover. We seek to compare the deployment efficacy and...
Giovanpaolo Pini-Prato et al.
European journal of oral implantology, 7(1), 9-43 (2014-06-04)
The purpose of this clinical guidelines project was to determine the most appropriate surgical techniques, in terms of efficacy, complications, and patient opinions, for the treatment of buccal single gingival recessions without loss of interproximal soft and hard tissues. Literature...
Immediate effect of ultraviolet-a collagen cross-linking therapy on the biomechanics and histology of the human cornea.
María A Del Buey et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 31(1), 70-71 (2015-01-20)
Xiaomin He et al.
Journal of nanoscience and nanotechnology, 13(6), 3818-3825 (2013-07-19)
Electrospinning has recently received much attention, showing great potential as a novel scaffold fabrication method for cartilage tissue engineering. In this study, we developed a biodegradable hybrid nanofibrous membrane of collagen and poly(L-lactic acid-co-epsilon-caprolactone) (PLCL, 75:25) by electrospinning for cartilage...
Tim Lämmermann et al.
Nature, 498(7454), 371-375 (2013-05-28)
Neutrophil recruitment from blood to extravascular sites of sterile or infectious tissue damage is a hallmark of early innate immune responses, and the molecular events leading to cell exit from the bloodstream have been well defined. Once outside the vessel...
Chunlin Yang et al.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 18(2), 103-119 (2004-03-30)
Collagen is the main structural protein in vertebrates. It plays an essential role in providing a scaffold for cellular support and thereby affecting cell attachment, migration, proliferation, differentiation, and survival. As such, it also plays an important role in numerous...
Wei Chen et al.
Human pathology, 45(1), 160-165 (2013-12-11)
During progression from normal liver to cirrhosis, total collagen increases nearly 10-fold with an abnormal increase in fibril-forming collagen and other extracellular matrix molecules. However, little is known regarding the changes each collagen type undergoes during fibrogenesis. We assessed the...
Discussion.
Surgery, 156(4), 908-909 (2014-09-23)
Arianna Carolina Rosa et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 308-316 (2014-09-04)
Pulmonary fibrosis, a progressive and lethal lung disease characterized by inflammation and accumulation of extracellular matrix components, is a major therapeutic challenge for which new therapeutic strategies are warranted. Cyclooxygenase (COX) inhibitors have been previously utilized to reduce inflammation. Histamine...
Xinghuo Wu et al.
Inflammation, 42(5), 1575-1584 (2019-05-22)
Integrins can function synergistically with syndecan-4 (SYND4) and bind to the fibronectin (FN) matrix, resulting in the regulation of tissue regeneration. This study aimed to explore the effects of TNF-α on the formation of FN/ITGβ1/SYND4 complex and the relative mechanism...
Katarina Wolf et al.
The Journal of cell biology, 201(7), 1069-1084 (2013-06-27)
Cell migration through 3D tissue depends on a physicochemical balance between cell deformability and physical tissue constraints. Migration rates are further governed by the capacity to degrade ECM by proteolytic enzymes, particularly matrix metalloproteinases (MMPs), and integrin- and actomyosin-mediated mechanocoupling....
Emily Hams et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(1), 367-372 (2013-12-18)
Disease conditions associated with pulmonary fibrosis are progressive and have a poor long-term prognosis with irreversible changes in airway architecture leading to marked morbidity and mortalities. Using murine models we demonstrate a role for interleukin (IL)-25 in the generation of...
Dane K Lund et al.
American journal of physiology. Cell physiology, 307(2), C140-C149 (2014-06-06)
The twenty-five known matrix metalloproteases (MMPs) and their endogenous inhibitors, tissue inhibitors of metalloproteases (TIMPs), mediate cell invasion through the extracellular matrix (ECM). In a comparative three-dimensional assay, we analyzed human and mouse satellite cells' competence to invade an artificial...
Tomohiro Tanaka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(4), 1370-1379 (2014-01-24)
Formation of proper neuromuscular connections is a process coordinated by both motoneuron-intrinsic and target-dependent programs. Under these programs, motoneurons innervate target muscles, escape programmed cell death during fetal development, and form neuromuscular junctions (NMJ). Although a number of studies have...
Georgios Kotsakis et al.
The Journal of oral implantology, 40(6), 690-698 (2014-12-17)
It has been documented that after every extraction of one or more teeth, the alveolar bone of the respective region undergoes resorption and atrophy. Therefore, ridge preservation techniques are often employed after tooth extraction to limit this phenomenon. The benefits...
High fluence iontophoretic corneal collagen cross-linking: in vivo OCT imaging of riboflavin penetration.
Paolo Vinciguerra et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(6), 376-377 (2013-06-07)
M K Murphy et al.
Journal of dental research, 92(8), 753-758 (2013-06-21)
The frequency and impact of temporomandibular joint (TMJ) disorders necessitate research in characterizing the joint's function. The 6 discal attachments have not yet been systematically characterized under tension. Understanding their role in joint function may guide our study of TMJ...
E Tong et al.
Journal of wound care, 23(7), 355-357 (2014-07-22)
Reconstruction of large abdominal wall defects is a challenging procedure, often contraindicated in critically ill patients, with high incidences of complications. We present a case of a patient with a large abdominal wall defect who had reconstruction with MatriDerm® (an...
Involvement of endoplasmic reticulum stress in myofibroblastic differentiation of lung fibroblasts.
Baek HA., et al.
American Journal of Respiratory Cell and Molecular Biology (2011)
Arthur Hammer et al.
Investigative ophthalmology & visual science, 55(5), 2881-2884 (2014-03-29)
New corneal cross-linking (CXL) devices are capable of using higher UV-A light irradiances than used in original CXL protocols. The Bunsen-Roscoe law states that a photochemical reaction should stay constant if the delivered total energy is kept constant; however, little...
David Lu et al.
The Journal of biological chemistry, 288(26), 19040-19049 (2013-05-17)
The establishment of set points for cellular activities is essential in regulating homeostasis. Here, we demonstrate key determinants of the fibrogenic set point of cardiac fibroblasts (CFs) by focusing on the pro-fibrotic activity of ATP, which is released by CFs....
Harini Raghu et al.
Blood, 125(3), 427-437 (2014-10-23)
Rheumatoid arthritis is a chronic inflammatory disease characterized by synovial hyperplasia, inflammatory cell infiltration, irreversible cartilage and bone destruction, and exuberant coagulation system activity within joint tissue. Here, we demonstrate that the coagulation transglutaminase, factor XIII (fXIII), drives arthritis pathogenesis...
Kairui Zhang et al.
Biochemical and biophysical research communications, 450(1), 762-766 (2014-06-24)
NSAIDs are often ingested to reduce the pain and improve regeneration of tendon after tendon injury. Although the effects of NSAIDs in tendon healing have been reported, the data and conclusions are not consistent. Recently, tendon-derived stem cells (TDSCs) have...
He Li et al.
Investigative ophthalmology & visual science, 54(7), 4675-4682 (2013-06-15)
Trachoma is a conjunctival scarring disease, which is the leading infectious cause of blindness worldwide. Elimination of blinding trachoma is being held back by the high rate of trichiasis recurrence following surgery. There is currently no treatment available to suppress...

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