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Showing 1-30 of 142 results for "C9742" within Papers
Frédéric Peyrusson et al.
Antimicrobial agents and chemotherapy, 59(9), 5747-5760 (2015-07-15)
GSK1322322 is a peptide deformylase inhibitor active against Staphylococcus aureus strains resistant to currently marketed antibiotics. Our aim was to assess the activity of GSK1322322 against intracellular S. aureus using an in vitro pharmacodynamic model and, in parallel, to examine
S-Y Kim et al.
Clinical and experimental immunology, 176(1), 93-101 (2013-12-21)
Little information is available regarding changes in immune status for patients with Mycobacterium avium complex (MAC) lung disease during antibiotic therapy. Serum immunomolecules from 42 patients with MAC lung disease were assayed comparatively using an array-based system according to (i)
Yuping Yuan et al.
International journal of molecular medicine, 36(2), 363-368 (2015-06-18)
Helicobacter pylori (H. pylori) is a life-threatening pathogen which causes chronic gastritis, gastric ulcers and even stomach cancer. Treatment normally involves bacterial eradication; however, this type of treatment only has a rate of effectiveness of <80%. Thus, it is a
Pramodini B Kale-Pradhan et al.
Expert review of gastroenterology & hepatology, 7(3), 281-288 (2013-03-01)
This review summarizes literature regarding the role of antimicrobials for induction and maintenance of Crohn's disease (CD) remission. PubMed was searched (1966 to October 2012) for controlled trials involving adults and written in English. Five of the 13 identified studies
Guan Liu et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 25, 82-87 (2014-05-27)
A Mycobacterium parascrofulaceum strain was isolated from a pneumonia patient-the first such reported case from China. The bacteriological characteristics of the strain were determined. Species identification was performed by homologue gene sequence comparison, then a series of biochemical tests was
Hyo-Ji Kim et al.
Journal of pharmaceutical and biomedical analysis, 102, 9-16 (2014-09-15)
A simple and accurate liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method for the quantitation of 20 anti-tuberculosis (anti-TB) drugs in human plasma, was developed as a tool for therapeutic drug monitoring. Two protein precipitation methods were adopted; one using methanol
Barbara Gierlikowska et al.
Frontiers in pharmacology, 11, 1339-1339 (2020-10-06)
Phagocytosis is a crucial element of innate immune defense involved in bacterial killing. The aim of our study was to evaluate the influence of alantolactone on phagocytosis and cytokines release by THP1-derived macrophages. We assessed whether antimicrobial compound alantolactone (a
Sonja Gandhi et al.
JAMA, 310(23), 2544-2553 (2013-12-19)
Calcium-channel blockers are metabolized by the cytochrome P450 3A4 (CYP3A4; EC 1.14.13.97) enzyme. Blood concentrations of these drugs may rise to harmful levels when CYP3A4 activity is inhibited. Clarithromycin is an inhibitor of CYP3A4 and azithromycin is not, which makes
Mònica Escolà Casas et al.
Water research, 83, 293-302 (2015-07-15)
Hospital wastewater represents a significant input of pharmaceuticals into municipal wastewater. As Moving Bed Biofilm Reactors (MBBRs) appear to remove organic micro-pollutants, hospital wastewater was treated with a pilot plant consisting of three MBBRs in series. The removal of pharmaceuticals
Guido A Gualdoni et al.
Scientific reports, 5, 12016-12016 (2015-07-15)
Deregulation of inflammasome activation was recently identified to be involved in the pathogenesis of various inflammatory diseases. Although macrolide antibiotics display well described immunomodulatory properties, presumably involved in their clinical effects, their impact on inflammasome activation has not been investigated.
Granulomatous gastritis and Helicobacter pylori infection.
Jorge-Shmuel Delgado et al.
The Israel Medical Association journal : IMAJ, 15(6), 317-318 (2013-07-26)
Barbara A Brown-Elliott et al.
Journal of clinical microbiology, 53(3), 875-878 (2015-01-09)
Macrolide resistance has been linked to the presence of a functional erythromycin ribosomal methylase (erm) gene in most species of pathogenic rapidly growing mycobacteria (RGM). For these Mycobacterium isolates, extended incubation in clarithromycin is necessary to determine macrolide susceptibility. In
Michael Selgrad et al.
World journal of gastroenterology, 20(43), 16245-16251 (2014-12-05)
To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori (H. pylori) therapy-naive or pre-treated. H. pylori strains were isolated from antrum and corpus biopsies from 66 patients that
Sana Rajper et al.
JPMA. The Journal of the Pakistan Medical Association, 62(11), 1140-1144 (2013-07-23)
To assess fluoroquinolone and clarithromycin susceptibility pattern along with the types of genomic mutations involved in the resistance of Helicobacter pylori isolates. The cross-sectional study was conducted at the Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, from
Shamira J Shallom et al.
Journal of clinical microbiology, 51(9), 2943-2949 (2013-06-28)
Mycobacterium abscessus (M. abscessus sensu lato, or the M. abscessus group) comprises three closely related taxa whose taxonomic statuses are under revision, i.e., M. abscessus sensu stricto, Mycobacterium bolletii, and Mycobacterium massiliense. We describe here a simple, robust, and cost-effective
Yanhong Li et al.
Drug delivery, 22(5), 627-637 (2014-01-30)
Pathogen evolution currently outpaces novel drug development, and because development of new antibiotics is pending, combination therapy with existing drugs may provide effective alternative treatments. The present study was aimed at evaluating the concurrent use of two antibiotics, daptomycin and
Nilanjan Ghosh et al.
American journal of hematology, 89(8), E116-E120 (2014-04-12)
The combination of clarithromycin, lenalidomide and dexamethasone (BiRd) has led to highly durable responses in newly diagnosed myeloma. However, the ability of clarithromycin to overcome resistance to lenalidomide and dexamethasone (Rd) is not known. To study this, we performed a
Yehia El-Garem et al.
Urology, 84(6), 1347-1350 (2014-11-30)
To assess the effect of treatment of seminal Helicobacter pylori in infertile asthenozoospermic men. In all, 223 infertile asthenozoospermic men were consecutively selected. They were subjected to history taking, clinical examination, semen analysis, and estimation of H pylori IgA antibodies
Jerry M Zuckerman
Infectious disease clinics of North America, 18(3), 621-649 (2004-08-17)
The advanced macrolides, azithromycin and clarithromycin, and the ketolide telithromycin are structural analogues of erythromycin. They have several distinct advantages when compared with erythromycin including enhanced spectrum of activity, more favorable pharmacokinetics and pharmacodynamics, once daily administration, and improved tolerability.
Abolfazl Zendedel et al.
JPMA. The Journal of the Pakistan Medical Association, 63(3), 336-339 (2013-08-07)
To evaluate Helicobacter pylori resistance to amoxicillin, clarithromycin, metronidazole and tetracycline in Mashhad, Iran. The cross-sectional study was done from January to May 2008 in Mashhad, involving 185 patients who had been indicated for endoscopy and lesions had been found.
Javed Yakoob et al.
BMC gastroenterology, 13, 33-33 (2013-02-26)
The aim was to investigate the reinfection rate of H. pylori during a follow-up period of 12 months in adults who had undergone eradication therapy. One hundred-twenty patients; 116 with gastritis, 3 with duodenal ulcer and 1 gastric ulcer, were
O V Skochko et al.
Likars'ka sprava, (5)(5), 72-86 (2013-03-29)
The meta-analysis of 12 clinical research of application of antibiotics (azithromycin, roxithromycin clarithromycin, gatifloxacin) in 24 949 patients with coronary heart disease were carried out. The obtained results were shown that application of short courses of antibiotic therapy in patients
[Recent topics on important drugs for H. pylori eradication: Clarithromycin (CAM)].
Tetsuya Mine et al.
Nihon rinsho. Japanese journal of clinical medicine, 63 Suppl 11, 372-375 (2005-12-21)
Alicia C Marin et al.
Expert opinion on pharmacotherapy, 14(7), 843-861 (2013-03-30)
Helicobacter pylori infection is generally treated with therapies that include a proton pump inhibitor (PPI) and, at least, two antibiotics being clarithromycin one of the most used. Antibiotic resistance, mainly to clarithromycin, seems to be increasing in many geographical areas
Nabil M Mansour et al.
European journal of gastroenterology & hepatology, 23(10), 865-870 (2011-08-04)
To evaluate the efficacy and safety of a standard-dose versus half-dose 10-day triple regimen for the eradication of Helicobacter pylori infection. A total of 115 consecutive patients with documented infection were enrolled in this open-label trial. Group A (standard dose)
[Clarithromycin: specific features of antimicrobial spectrum and clinical use].
S V Budanov et al.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 49(2), 19-25 (2004-08-03)
Sungmo Jung et al.
Journal of gastroenterology and hepatology, 30(1), 75-81 (2014-08-05)
Metachronous recurrence often occurs after endoscopic submucosal dissection for early gastric cancer, and a method for preventing recurrence is unknown. We aimed to identify risk factors for metachronous lesions, and the effects of aspirin use and Helicobacter pylori eradication on
Edyta Szałek et al.
Pharmacological reports : PR, 64(6), 1554-1559 (2013-02-15)
Macrolides are the most widely prescribed antibiotics. Clarithromycin is a well-known inhibitor of cytochrome P450 CYP3A4 and causes numerous drug interactions that are not found for azithromycin. CYP3A4 is involved in the metabolism of the new oral multikinase inhibitor sunitinib
Ilknur Basyigit et al.
The Annals of pharmacotherapy, 38(9), 1400-1405 (2004-07-15)
Clarithromycin is an antimicrobial agent that can be used for treatment of chronic obstructive pulmonary disease (COPD) exacerbations with bronchodilator therapy. However, it has also been shown that clarithromycin has antiinflammatory effects by the inhibition of cytokine production. To evaluate
Affan Denk et al.
Infectious diseases (London, England), 47(6), 364-369 (2015-02-26)
Brucellosis is a systemic infectious disease caused by Brucella bacteria. A successful treatment requires antibiotics that can penetrate into the cell at high concentrations. The aim of this study was to assess the biotype and in vitro activity of 80
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