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CD45RA
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Showing 1-30 of 418 results for "CD45RA" within Papers
Sisi Li et al.
Bioengineered, 13(4), 8631-8642 (2022-03-25)
CD45RA is a specific marker for leukemia stem cell (LSC) sub-populations in acute myeloid leukemia (AML). Ranpirnase (Rap), an amphibian RNase, has been extensively investigated in preclinical and clinical studies for its antitumor activity. Rap could be administered repeatedly to
Sita S Withers et al.
Developmental and comparative immunology, 87, 64-74 (2018-06-04)
While dogs are increasingly being utilized as large-animal models of disease, important features of age-related immunosenescence in the dog have yet to be evaluated due to the lack of defined naïve vs. memory T lymphocyte phenotypes. We therefore performed multi-color
Deficiency of CD8+ effector memory T cells is an early and persistent feature of multiple sclerosis.
Michael P Pender et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 20(14), 1825-1832 (2014-05-21)
Patients with multiple sclerosis (MS) have a deficiency of circulating CD8+ T cells, which might impair control of Epstein-Barr virus (EBV) and predispose to MS by allowing EBV-infected autoreactive B cells to accumulate in the central nervous system. Based on
Fumichika Matsuki et al.
Cellular immunology, 290(1), 96-101 (2014-06-22)
Increased numbers of regulatory T (Treg) cells are found in synovial fluid from patients with rheumatoid arthritis (RASF) compared with peripheral blood. However, Treg cells in RASF have been shown to have a decreased capacity to suppress T cells. Here
B D Woodward et al.
The Journal of nutrition, 125(10), 2471-2482 (1995-10-01)
The objective of this investigation was to determine whether an imbalance between naive- and memory-phenotype cells occurs within CD4+ and/or CD8+ splenic T cell subsets in models of protein-energy malnutrition (PEM) which produce wasting disease (loss of approximately 1.6% of
Nabila Seddiki et al.
Blood, 107(7), 2830-2838 (2005-12-08)
Regulatory T cells (TREGs) constitutively expressing CD4, CD25, and the transcription factor Foxp3 can prevent a wide range of experimental and spontaneous autoimmune diseases in mice. In humans, CD4+CD25bright T cells, predominantly within the CD45RO+ activated/memory subset in adults and
Naoki Mizobe et al.
Biology of the neonate, 85(1), 61-67 (2003-11-25)
To determine the expression of CD45 isoforms on T lymphocytes in neonates with fetal distress and to evaluate its diagnostic accuracy, peripheral blood samples were examined in 53 neonates who were classified into one of three groups: group I: 'control'
F Li et al.
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 18(7), 343-346 (1997-07-01)
To investigate the expression of CD45RA and CD45RO antigens in leukemias and its implication in the diagnosis and differential diagnosis of leukemias. The expression of CD45 RA and CD45RO antigens and other markers on the surface of bone marrow or
A E Koch et al.
Journal of clinical immunology, 10(4), 192-199 (1990-07-01)
We have characterized the lymphocytes in the synovium of patients with rheumatoid arthritis (RA) by immunohistochemistry using monoclonal antibodies directed against B lymphocytes, T lymphocytes, and antibodies directed against CD45RA and CD45RO, which define T-cell subsets. Both CD45RA+ and CD45RO+
Hyun-Joo Kim et al.
Journal of periodontal & implant science, 47(5), 292-311 (2017-11-03)
Beyond the limited scope of non-specific polyclonal regulatory T cell (Treg)-based immunotherapy, which depends largely on serendipity, the present study explored a target Treg subset appropriate for the delivery of a novel epitope spreader Pep19 antigen as part of a
V A Wallace et al.
The Journal of experimental medicine, 176(6), 1657-1663 (1992-12-01)
CD45 is a protein tyrosine phosphatase involved in T and B cell signaling. While peripheral T cells switch CD45 isoforms upon activation, events leading to exon switching during T cell development in the thymus have not been determined. The expression
Qian-ru Li et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 24(11), 1066-1067 (2008-11-11)
To study the relationship between the abnormal differentiation thymocytes and the pathogenesis of myasthenia gravis (MG). The gene expression of some ILs, IFN and their receptors was examined by cDNA array. The percentage of CD45RO(+) and D45RA(+) thymocytes was measured
Fu-Jun Li et al.
Blood, 105(8), 3295-3302 (2005-01-01)
CD45, a receptor-type tyrosine phosphatase, is required for interleukin-6 (IL-6)-induced proliferation in human myeloma cells, which express the shortest isoform, CD45RO, but not the longest isoform, CD45RA. Here, we showed that IL-6 induced the translocation of CD45 to lipid rafts
Javier Carrasco et al.
Blood, 108(9), 2897-2905 (2006-07-22)
The expression of CD45RA on CCR7- human CD8+ memory T cells is widely considered to be a marker of terminal differentiation. We studied the time course of CD45RA and CCR7 expression on human antitumoral cytotoxic T lymphocyte (CTL) clones and
Seiji Kobayashi et al.
Blood, 103(3), 1002-1010 (2003-10-04)
CD26 is a T-cell activation antigen that contains dipeptidyl peptidase IV activity and binds adenosine deaminase. Recent work showed that specialized membrane microdomains, also known as lipid rafts, play a key role in T-cell signaling. In this study, we investigate
Nicola J Booth et al.
Journal of immunology (Baltimore, Md. : 1950), 184(8), 4317-4326 (2010-03-17)
Although human naturally occurring regulatory T cells (Tregs) may express either CD45RA or CD45RO, we find in agreement with previous reports that the ( approximately 80%) majority of natural Tregs in adults are CD45RO(+). The proportion of CD45RA(+) Tregs decreases
H Kobayashi et al.
Clinical and experimental immunology, 137(1), 101-108 (2004-06-16)
Human CD4+ T cells can be divided into reciprocal memory and naive T cell subsets based on their expression of CD45 isoforms and CD29/integrin beta1 subunit. To identify unique cell surface molecules on human T cells, we developed a new
Nobuyasu Baba et al.
International immunology, 22(4), 237-244 (2010-02-26)
The balance between effector CD4(+) T cells secreting IL-17 (T(h)17) and regulatory T cells (Treg) plays an important role in autoimmune disorders that include rheumatoid arthritis (RA) and Crohn's disease. Tumor necrosis factor (TNF)-alpha is a key pro-inflammatory cytokine that
Seiji Kobayashi et al.
Blood, 103(3), 1002-1010 (2003-10-04)
CD26 is a T-cell activation antigen that contains dipeptidyl peptidase IV activity and binds adenosine deaminase. Recent work showed that specialized membrane microdomains, also known as lipid rafts, play a key role in T-cell signaling. In this study, we investigate
Claudia J Dembek et al.
AIDS research and therapy, 7, 20-20 (2010-07-06)
Long-term survival of HIV-1 infected individuals is usually achieved by continuous administration of combination antiretroviral therapy (ART). An exception to this scenario is represented by HIV-1 infected nonprogressors (NP) which maintain relatively high circulating CD4+ T cells without clinical symptoms
Masakatsu Suzuki et al.
Journal of immunology (Baltimore, Md. : 1950), 189(5), 2118-2130 (2012-07-24)
CD8 T cells stimulated with a suboptimal dose of anti-CD3 Abs (100 pg/ml) in the presence of IL-15 retain a naive phenotype with expression of CD45RA, CD28, CD27, and CCR7 but acquire new functions and differentiate into immunosuppressive T cells.
Xiujun Pan et al.
PloS one, 7(4), e34662-e34662 (2012-04-17)
The role of naturally occurring regulatory T cells (Treg) in the control of the development of systemic lupus erythematosus (SLE) has not been well defined. Therefore, we dissect the phenotypically heterogeneous CD4(+)FoxP3(+) T cells into subpopulations during the dynamic SLE
Urban Sester et al.
European journal of immunology, 37(10), 2881-2891 (2007-09-28)
T cell activation requires costimulation of TCR/CD3 plus accessory receptors (e.g. CD28). A hallmark of costimulation is the dynamic reorganization of the actin cytoskeleton, important for receptor polarization in the immunological synapse. The classical model of T cell costimulation was
C Pokoyski et al.
Genes and immunity, 16(8), 519-527 (2015-09-12)
Disorders in regulatory T-cell (T(reg)) function can result in the breakdown of immunological self-tolerance. Thus, the identification of mechanisms controlling the activity of T(reg) is of great relevance. We used T(reg) from individuals carrying the C77G polymorphism as models to
Yan-hui Ma et al.
Journal of immunology research, 2015, 547697-547697 (2015-05-20)
The effect of vitamin D pertinent to cardiovascular health on the heart itself is considered to shift toward an anti-inflammatory response in chronic heart failure (CHF); however, its underlying mechanism is not completely understood. In this study, we demonstrated that
Cristiana Gioia et al.
Journal of immunology (Baltimore, Md. : 1950), 168(3), 1484-1489 (2002-01-22)
In humans, the circulating pool of mycobacteria-reactive Vgamma9Vdelta2+ T cells is expanded with age and may contribute to Mycobacterium tuberculosis immunosurveillance. We observed that two subsets of Vgamma9Vdelta2+ T cells could be identified on the basis of CD27 expression in
Edward C P Waller et al.
Blood, 110(13), 4360-4366 (2007-09-20)
In healthy carriers of human cytomegalovirus (HCMV), the virus-specific memory CD8(+) T-cell population is often dominated by CD28(-) CD45RA(hi) cells that exhibit direct ex vivo cytotoxicity but whose capacity for proliferation and generation of further memory cells has been questioned.
H M Wolf et al.
British journal of haematology, 107(1), 55-68 (1999-10-16)
Congenital or acquired absence of the spleen and functional hyposplenism are associated with abnormalities of host defence such as an increased susceptibility to infection with encapsulated bacteria. The effects of the lack of the spleen on cell-mediated immunity are largely
Meital Nagar et al.
Journal of immunology (Baltimore, Md. : 1950), 184(7), 3570-3581 (2010-02-26)
Emerging data suggest that regulatory T cell (Treg) dysfunction and consequent breakdown of immunological self-tolerance in autoimmunity can be mediated by factors that are not Treg-intrinsic (e.g., cytokines). Indeed, recent studies show that in rheumatoid arthritis the proinflammatory cytokine TNF
Yi Wei Bryan Teo et al.
Immunobiology, 224(4), 526-531 (2019-05-11)
Simulated Infective Protocol (SIP) is an ex-vivo culture system modeled after the temporal changes of essential cytokines in an acute infection, and previously proven successful in converting T lymphocytes harvested and activated from peripheral blood of normal donors, to revertant
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