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Kaare V Grunddal et al.
Endocrinology, 157(1), 176-194 (2015-10-16)
The 2 gut hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are well known to be coexpressed, costored, and released together to coact in the control of key metabolic target organs. However, recently, it became clear that several other gut...
Jonatan Tuncel et al.
The Journal of experimental medicine, 216(6), 1328-1344 (2019-04-17)
Perinatal T cells broadly access nonlymphoid tissues, where they are exposed to sessile tissue antigens. To probe the outcome of such encounters, we examined the defective elimination of self-reactive clones in Aire-deficient mice. Nonlymphoid tissues were sequentially seeded by distinct...
Yifan Li et al.
Oncology reports, 41(5), 2679-2688 (2019-03-14)
Dendritic cells (DCs), as professional antigen‑presenting cells are essential for the initial activation of adaptive antitumor immunity. CD1d is considered to present phospholipid and glycosphingolipid antigens to NKT cells. However, it is currently unknown whether CD1d expression on DCs is...
Evelyn Menares et al.
Nature communications, 10(1), 4401-4401 (2019-09-29)
Tissue-resident memory CD8+ T (Trm) cells mediate potent local innate and adaptive immune responses and play a central role against solid tumors. However, whether Trm cells cross-talk with dendritic cells (DCs) to support anti-tumor immunity remains unclear. Here we show...
Monica Viladomiu et al.
Cell host & microbe, 29(4), 607-619 (2021-02-05)
Adherent-invasive E. coli (AIEC) are enriched in the intestinal microbiota of patients with Crohn's disease (CD) and promote intestinal inflammation. Yet, how AIEC metabolism of nutrients impacts intestinal homeostasis is poorly defined. Here, we show that AIEC encoding the large subunit...
Angeliki M Nikolakopoulou et al.
Nature neuroscience, 22(7), 1089-1098 (2019-06-27)
Pericytes are positioned between brain capillary endothelial cells, astrocytes and neurons. They degenerate in multiple neurological disorders. However, their role in the pathogenesis of these disorders remains debatable. Here we generate an inducible pericyte-specific Cre line and cross pericyte-specific Cre...
Nicole Schmitner et al.
Disease models & mechanisms, 10(3), 307-321 (2017-02-01)
The exocrine pancreas displays a significant capacity for regeneration and renewal. In humans and mammalian model systems, the partial loss of exocrine tissue, such as after acute pancreatitis or partial pancreatectomy induces rapid recovery via expansion of surviving acinar cells....
Rahul Dhandapani et al.
Nature communications, 9(1), 1640-1640 (2018-04-25)
Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve...
C Uherek et al.
The Journal of biological chemistry, 273(15), 8835-8841 (1998-05-16)
Modular fusion proteins that combine distinct functions required for cell type-specific uptake and intracellular delivery of DNA present an attractive approach for the development of self-assembling vectors for targeted gene delivery. Here, we describe a novel DNA carrier protein termed...
Xuefei Tian et al.
JCI insight, 5(22) (2020-11-20)
Evidence for reduced expression of cyclin G associated kinase (GAK) in glomeruli of patients with chronic kidney disease was observed in the Nephroseq human database, and GAK was found to be associated with the decline in kidney function. To examine...
Ning Shen et al.
Current biology : CB, 30(10), 1916-1926 (2020-04-04)
Homeostatic plasticity stabilizes input and activity levels during neural development, but whether it can restore connectivity and preserve circuit function during neurodegeneration is unknown. Photoreceptor degeneration is the most common cause of blindness in the industrialized world. Visual deficits are...
Changchuin Mao et al.
Antibody therapeutics, 3(3), 157-162 (2021-01-01)
Most pathogens establish infection through mucosa, where secretary IgA (sIgA) plays an "immune exclusion" role in humoral defense. Extravasation of intravenously administrated therapeutic IgG mainly relies on convection and/or FcRn-mediated transcytosis from circulation into interstitial space. Active transport of interstitial...
Augusto Escalante et al.
Cell reports, 33(8), 108422-108422 (2020-11-26)
Chronic itch represents an incapacitating burden on patients suffering from a spectrum of diseases. Despite recent advances in our understanding of the cells and circuits implicated in the processing of itch information, chronic itch often presents itself without an apparent...
Angela M Tatum et al.
Journal of immunology (Baltimore, Md. : 1950), 185(5), 2763-2772 (2010-07-28)
The magnitude and complexity of Ag-specific CD8(+) T cell responses is determined by intrinsic properties of the immune system and extrinsic factors, such as vaccination. We evaluated mechanisms that regulate the CD8(+) T cell response to two distinct determinants derived...
Jason S Seidman et al.
Immunity, 52(6), 1057-1074 (2020-05-05)
Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep understanding of mechanisms controlling diversification. Here, we investigate origins and epigenetic trajectories of hepatic macrophages during diet-induced...
Genevra Kuziel et al.
Cancers, 12(8) (2020-08-01)
Obesity is correlated with breast tumor desmoplasia, leading to diminished chemotherapy response and disease-free survival. Obesity causes chronic, macrophage-driven inflammation within breast tissue, initiated by chemokine ligand 2 (CCL2) signaling from adipose stromal cells. To understand how CCL2-induced inflammation alters...
Changyong Tang et al.
Neuron, 101(1), 32-44 (2018-12-01)
In the neurogenic niches, adult neural stem and/or progenitor cells (NSCs) generate functional neurons throughout life, which has been implicated in learning and memory and affective behaviors. During adult neurogenesis, newborn neurons release feedback signals into the niches to regulate...
Yanina V Martos et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(11), 2849-2858 (2017-02-15)
The mechanisms underlying social dysfunction in neuropsychiatric conditions such as obsessive-compulsive disorder and Tourette syndrome remain uncertain. However, it is known that dysfunctions in basal ganglia, including a reduced number of striatal cholinergic interneurons (SCIN), are involved in their pathophysiology....
Mor Gross-Vered et al.
eLife, 9 (2020-01-10)
Monocytes are circulating short-lived macrophage precursors that are recruited on demand from the blood to sites of inflammation and challenge. In steady state, classical monocytes give rise to vasculature-resident cells that patrol the luminal side of the endothelium. In addition...
Daniel Hillier et al.
Nature neuroscience, 20(7), 960-968 (2017-05-23)
How neuronal computations in the sensory periphery contribute to computations in the cortex is not well understood. We examined this question in the context of visual-motion processing in the retina and primary visual cortex (V1) of mice. We disrupted retinal...
Sheng-Yan Wu et al.
Cells, 9(1) (2019-12-28)
Myeloid-derived cells have been implicated as playing essential roles in cancer therapy, particularly in cancer immunotherapy. Most studies have focused on either CD11b+Ly6G+Ly6C+ granulocytic or polymorphonuclear myeloid-derived suppressor cells (G-MDSCs or PMN-MDSCs) or CD11b+Ly6G-Ly6C+ monocytic MDSCs (M-MDSCs), for which clear...
Brett A Shook et al.
Cell stem cell, 26(6), 880-895 (2020-04-18)
Mature adipocytes store fatty acids and are a common component of tissue stroma. Adipocyte function in regulating bone marrow, skin, muscle, and mammary gland biology is emerging, but the role of adipocyte-derived lipids in tissue homeostasis and repair is poorly...
Mary F Fontana et al.
PLoS pathogens, 12(12), e1006046-e1006046 (2016-12-07)
Dynamic regulation of leukocyte population size and activation state is crucial for an effective immune response. In malaria, Plasmodium parasites elicit robust host expansion of macrophages and monocytes, but the underlying mechanisms remain unclear. Here we show that myeloid expansion...
Yingjun Liu et al.
Glia, 68(2), 345-355 (2019-09-14)
Microglia play vital roles in the health and diseases of the central nervous system. Loss of microglia homeostatic state is a key feature of brain aging and neurodegeneration. However, the mechanisms underlying the maintenance of distinct microglia cellular states are...
Li-Feng Jiang-Xie et al.
Neuron, 102(5), 1053-1065 (2019-04-23)
How general anesthesia (GA) induces loss of consciousness remains unclear, and whether diverse anesthetic drugs and sleep share a common neural pathway is unknown. Previous studies have revealed that many GA drugs inhibit neural activity through targeting GABA receptors. Here...
Ludwig Ruder et al.
Nature, 590(7846), 445-450 (2021-01-08)
The brainstem is a key centre in the control of body movements. Although the precise nature of brainstem cell types and circuits that are central to full-body locomotion are becoming known1-5, efforts to understand the neuronal underpinnings of skilled forelimb...
Clemens Duerrschmid et al.
Nature medicine, 23(12), 1444-1453 (2017-11-07)
Asprosin is a recently discovered fasting-induced hormone that promotes hepatic glucose production. Here we demonstrate that asprosin in the circulation crosses the blood-brain barrier and directly activates orexigenic AgRP
Shuoshuo Li et al.
Journal of neuroinflammation, 18(1), 7-7 (2021-01-07)
Alteration of immune status in the central nervous system (CNS) has been implicated in the development of post-traumatic stress disorder (PTSD). However, the nature of overall changes in brain immunocyte landscape in PTSD condition remains unclear. We constructed a mouse...
Man Zhang et al.
Nature communications, 11(1), 6119-6119 (2020-12-02)
The efficacy of checkpoint immunotherapy to non-small cell lung cancer (NSCLC) largely depends on the tumor microenvironment (TME). Here, we demonstrate that CCL7 facilitates anti-PD-1 therapy for the KrasLSL-G12D/+Tp53fl/fl (KP) and the KrasLSL-G12D/+Lkb1fl/fl (KL) NSCLC mouse models by recruiting conventional...
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