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D0879

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Identification of a novel splice variant isoform of TREM-1 in human neutrophil granules
Baruah S, et al.
Journal of Immunology, 195(12), 5725-5731 (2015)
Robin Roychaudhuri et al.
Journal of immunology (Baltimore, Md. : 1950), 193(5), 2469-2482 (2014-07-27)
A disintegrin and a metalloproteinase domain (ADAM) 9 is known to be expressed by monocytes and macrophages. In this study, we report that ADAM9 is also a product of human and murine polymorphonuclear neutrophils (PMNs). ADAM9 is not synthesized de
Stefania Butini et al.
Journal of medicinal chemistry, 51(11), 3154-3170 (2008-05-16)
Protein conformational fluctuations are critical for biological functions, although the relationship between protein motion and function has yet to be fully explored. By a thorough bioinformatics analysis of cholinesterases (ChEs), we identified specific hot spots, responsible for protein fluctuations and
Christopher A McGoldrick et al.
BMC cancer, 14, 675-675 (2014-09-23)
Cancer cell esterases are often overexpressed and can have chiral specificities different from that of the corresponding normal cells and can, therefore, be useful targets for activating chemotherapeutic prodrug esters. Prodrug esters are inactive compounds that can be preferentially activated
Ludwig T Weckbach et al.
The Journal of experimental medicine, 216(2), 350-368 (2019-01-17)
Heart failure due to dilated cardiomyopathy is frequently caused by myocarditis. However, the pathogenesis of myocarditis remains incompletely understood. Here, we report the presence of neutrophil extracellular traps (NETs) in cardiac tissue of patients and mice with myocarditis. Inhibition of
Kevin A Harvey et al.
Lipids in health and disease, 14, 9-9 (2015-04-19)
Thrombosis and immune dysfunction are two important complications that result from the administration of parenteral nutrition. Endothelial cells within the vasculature are crucial components necessary for maintenance of normal coagulation and immune function. We compared the effects of three commercial
Beynon, R.J. and Bond, J.S., ed.
Proteolytic Enzymes: A Practical Approach, 239-243 (1989)
Naiyu Zheng et al.
Rapid communications in mass spectrometry : RCM, 26(11), 1291-1304 (2012-05-05)
Esterase inhibitors are widely used to stabilize ester-containing drugs in biological matrices for quantitative liquid chromatography/tandem mass spectrometry (LC/MS/MS) assays. These co-existing inhibitors could cause matrix effects on bioanalysis and jeopardize the assay performance. We therefore developed an LC/MS/MS methodology
Laxmikant S Deshpande et al.
Toxicological sciences : an official journal of the Society of Toxicology, 116(2), 623-631 (2010-05-26)
Organophosphate (OP) compounds are among the most lethal chemical weapons ever developed and are irreversible inhibitors of acetylcholinesterase. Exposure to majority of OP produces status epilepticus (SE) and severe cholinergic symptoms that if left untreated are fatal. Survivors of OP
Guido Crisponi et al.
PloS one, 10(7), e0133050-e0133050 (2015-07-21)
A number of reports have appeared in literature calling attention to the depletion of essential metal ions during chelation therapy on β-thalassaemia patients. We present a speciation study to determine how the iron chelators used in therapy interfere with the
Powers, J.C. and Harper, J.W. et al.
Protease Inhibitors, 55-112 (1986)
Marko S Todorovic et al.
Epilepsy research, 101(3), 268-276 (2012-05-15)
Organophosphates (OPs) inhibit the enzyme cholinesterase and cause accumulation of acetylcholine, and are known to cause seizures and status epilepticus (SE) in humans. The animal models of SE caused by organophosphate analogs of insecticides are not well characterized. SE caused
A V Terry et al.
Neurotoxicology and teratology, 34(1), 1-8 (2011-10-26)
The acute toxicity of organophosphates (OPs) has been studied extensively; however, much less attention has been given to the subject of repeated exposures that are not associated with overt signs of toxicity (i.e., subthreshold exposures). The objective of this study
Evangelia Vlachodimitropoulou Koumoutsea et al.
British journal of haematology, 170(6), 874-883 (2015-06-03)
Iron chelators are increasingly combined clinically but the optimal conditions for cellular iron mobilization and mechanisms of interaction are unclear. Speciation plots for iron(III) binding of paired combinations of the licensed iron chelators desferrioxamine (DFO), deferiprone (DFP) and deferasirox (DFX)
Carlos A Ruiz et al.
The Journal of biological chemistry, 290(34), 20774-20781 (2015-07-04)
The vast majority of newly synthesized acetylcholinesterase (AChE) molecules do not assemble into catalytically active oligomeric forms and are rapidly degraded intracellularly by the endoplasmic reticulum-associated protein degradation pathway. We have previously shown that AChE in skeletal muscle is regulated
Lei Yin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 998-999, 8-14 (2015-07-08)
A liquid chromatography-tandem mass spectrometric (LC-MS/MS) method using positive/negative electrospray ionization (ESI) switching for the simultaneous quantitation of carboprost methylate and carboprost in dog plasma has been developed and validated. After screening, the esterase inhibitor, dichlorvos was added to the
Tatyana Belinskaya et al.
Biochimica et biophysica acta, 1824(5), 701-710 (2012-03-10)
Senescence marker protein-30 (SMP-30) is a candidate enzyme that can function as a catalytic bioscavenger of organophosphorus (OP) nerve agents. We purified SMP-30 from mouse (Mo) liver and compared its hydrolytic activity towards various esters, lactones, and G-type nerve agents
T Oda et al.
Bioscience, biotechnology, and biochemistry, 62(2), 325-333 (1998-04-09)
Diisopropylfluorophosphate (DFP), a general serine protease inhibitor, inhibited the DNA fragmentation and cell death in MDCK cells treated with ricin, modeccin, Pseudomonas toxin, or diphtheria toxin. A trypsin-like serine protease inhibitor, N-tosyl-L-lysine chloromethyl ketone (TLCK) also prevented ricin-induced DNA fragmentation
Gabriel Birkus et al.
Antimicrobial agents and chemotherapy, 51(2), 543-550 (2006-12-06)
GS-7340 and GS-9131 {9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]-propyl]adenine and 9-(R)-4'-(R)-[[[(S)-1-[(ethoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]-2'-fluoro-1'-furanyladenine, respectively} are novel alkylalaninyl phenyl ester prodrugs of tenofovir {9-R-[(2-phosphonomethoxy)propyl]adenine} (TFV) and a cyclic nucleotide analog, GS-9148 (phosphonomethoxy-2'-fluoro-2', 3'-dideoxydidehydroadenosine), respectively. Both prodrugs exhibit potent antiretroviral activity against both wild-type and drug-resistant human immunodeficiency virus
Kori L Brewer et al.
The American journal of emergency medicine, 31(4), 676-679 (2013-02-06)
Acute poisoning with organophosphate compounds can cause chronic neuropsychological disabilities not prevented by standard antidotes of atropine and pralidoxime. We determine the efficacy of naltrexone in preventing delayed encephalopathy after poisoning with the sarin analogue diisofluorophosphate (DFP) in rats. A
P A Ferchmin et al.
Neurochemical research, 40(10), 2143-2151 (2015-10-07)
Diisopropylfluorophosphate (DFP) is an irreversible inhibitor of acetylcholine esterase and a surrogate of the organophosphorus (OP) nerve agent sarin. The neurotoxicity of DFP was assessed as a reduction of population spike (PS) area elicited by synaptic stimulation in acute hippocampal
Alexandar Tzankov et al.
Journal of hematology & oncology, 8, 70-70 (2015-06-14)
The prognostic role of tumor-related parameters in diffuse large B cell lymphoma (DLBCL) is a matter of controversy. We investigated the prognostic value of phenotypic and genotypic profiles in DLBCL in clinical trial (NCT00544219) patients homogenously treated with six cycles
Laxmikant S Deshpande et al.
Neurotoxicology, 44, 17-26 (2014-05-03)
Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations. Exposure to POX produces high mortality. OP poisoning is often associated with chronic neurological disorders. In this study, we optimize
Iris Mangas et al.
Toxicology and applied pharmacology, 256(3), 360-368 (2011-05-24)
Some published studies suggest that low level exposure to organophosphorus esters (OPs) may cause neurological and neurobehavioral effects at long term exposure. These effects cannot be explained by action on known targets. In this work, the interactions (inhibition, spontaneous reactivation
Michael Costante et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(1), 182-188 (2011-11-29)
Human prolidase (PROL), which has structural homology to bacterial organophosphate acid anhydrolase that hydrolyze organophosphates and nerve agents has been proposed recently as a potential catalytic bioscavenger. To develop PROL as a catalytic bioscavenger, we evaluated the in vitro hydrolysis
I Mangas et al.
Toxicology letters, 225(1), 167-176 (2013-12-21)
Low level exposure to organophosphorus esters (OPs) may cause long-term neurological effects and affect specific cognition domains in experimental animals and humans. Action on known targets cannot explain most of these effects by. Soluble carboxylesterases (EC 3.1.1.1) of chicken brain
Sarit Oriel et al.
Behavioural pharmacology, 25(7), 661-672 (2014-08-30)
The long-term effects of postnatal exposure to an organophosphate substance diisopropylfluorophosphate (DFP) were examined on fear conditioning in adult mice. Immediate and long-term changes in the expression of synaptic acetylcholinesterase (AChE-S) and readthrough acetylcholinesterase (AChE-R) transcripts were explored, in view
Amina Khadjavi et al.
Toxicology and applied pharmacology, 286(3), 198-206 (2015-05-06)
In chronic wounds, efficient epithelial tissue repair is hampered by hypoxia, and balances between the molecules involved in matrix turn-over such as matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are seriously impaired. Intriguingly, new oxygenating nanocarriers such as
Asheebo Rojas et al.
Neurobiology of disease, 140, 104863-104863 (2020-04-14)
Seizures can be evident within minutes of exposure to an organophosphorus (OP) agent and often progress to status epilepticus (SE) resulting in a high mortality if left untreated. Effective medical countermeasures are necessary to sustain patients suffering from OP poisoning
Yi Xue et al.
The Journal of biological chemistry, 287(5), 3099-3107 (2011-12-02)
Rhomboid proteases have many important biological functions. Unlike soluble serine proteases such as chymotrypsin, the active site of rhomboid protease, which contains a Ser-His catalytic dyad, is submerged in the membrane and surrounded by membrane-spanning helices. Previous crystallographic analyses of
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