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Anna Pratima G Nikalje et al.
European journal of medicinal chemistry, 46(11), 5448-5455 (2011-09-21)
A series of 2-(1,3-dioxoisoindolin-2-yl)-N-(4-oxo-2-substitutedthiazolidin-3-yl) acetamide derivatives were designed and synthesized using appropriate synthetic route, keeping in view the structural requirement of pharmacophore and evaluated for anticonvulsant activity and CNS depressant activities in mice. The synthesized derivatives were examined in the...
Marcelo Emir Requia Abreu et al.
The Journal of oral implantology, 41(4), e102-e109 (2014-06-20)
To evaluate the action of recombinant human growth hormone (rhGH) on osseointegration of titanium implants in rabbits. Fourteen adult New Zealand rabbits, aged 30 weeks, were used in the study, and randomly divided into 2 groups. In each animal, 2...
Philemon Karli et al.
The spine journal : official journal of the North American Spine Society, 14(12), 2976-2984 (2014-06-10)
In canine intervertebral disc (IVD) disease, a useful animal model, only little is known about the inflammatory response in the epidural space. To determine messenger RNA (mRNA) expressions of selected cytokines, chemokines, and matrix metalloproteinases (MMPs) qualitatively and semiquantitatively over...
S Barkarmo et al.
Journal of biomaterials applications, 29(5), 737-747 (2014-07-13)
To investigate the bone response to threaded polyetheretherketone (PEEK) implants coated with nanohydroxyapatite. A total of 39 PEEK implants were coated with nanocrystalline hydroxyapatite and 39 uncoated implants were used as controls. The implant surface was characterized by optical interferometry...
B V Ashalatha et al.
European journal of medicinal chemistry, 42(5), 719-728 (2006-12-27)
Nine new 2-(substituted phenyl)/alkyl[1,3,4]thiadiazolo[2,3-b]-6,7,8,9-tetrahydrobenzo(b)thieno[3,2-e]pyrimidin-5(4H)-ones, six new 3-amino-2-[(2-oxo-2-(aryl)ethyl)thio]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-ones, one 2-mercapto[1,3,4]thiadiazolo[2,3-b]-6,7,8,9-tetrahydrobenzo(b)thieno[3,2-e]pyrimidin-5(4H)-one and one 2-chloromethyl[1,3,4]thiadiazolo[2,3-b]-6,7,8,9-tetrahydrobenzo(b)thieno[3,2-e]pyrimidin-5(4H)-one were synthesized from 3-amino-2-mercapto-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one. The newly synthesized compounds were characterized by analytical and spectral data. Compounds were screened for anti-inflammatory, CNS depressant and antimicrobial activities. Some of the...
Rocío L Pérez et al.
Analytica chimica acta, 835, 19-28 (2014-06-24)
Following the green analytical chemistry principles, an efficient strategy involving second-order data provided by liquid chromatography (LC) with diode array detection (DAD) was applied for the simultaneous determination of estriol, 17β-estradiol, 17α-ethinylestradiol and estrone in natural water samples. After a...
Adrian Wong et al.
Drug and alcohol dependence, 154, 296-299 (2015-07-25)
Severe cases of alcohol withdrawal syndrome (AWS) may not resolve despite escalating doses of benzodiazepines (BZDs). Benzodiazepine-resistant alcohol withdrawal (RAW) is a subset of severe alcohol withdrawal defined by the requirement of ≥40mg of diazepam administered within one hour. Use...
Paweł Zajdel et al.
Bioorganic & medicinal chemistry, 15(8), 2907-2919 (2007-02-27)
Novel arylpiperazines with N-acylated amino acids, selected on the basis of a preliminary screening of two libraries previously synthesized on SynPhase Lanterns, were prepared in solution and their affinity for 5-HT(1A), 5-HT(2A), and D(2) receptors was evaluated. The compounds bearing...
Cristiane Metzker de Oliveira et al.
Journal of natural products, 74(10), 2062-2068 (2011-09-24)
Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production. The present study was undertaken to evaluate whether 1 has antinociceptive properties in models of inflammatory pain and to investigate its possible...
Xiaoyan Yang et al.
Cellular and molecular neurobiology, 35(6), 871-880 (2015-03-19)
Epilepsy is a common neurological disorder. Because its underlying mechanisms remain incompletely understood, current treatments are not adequate for all epilepsy patients, and some patients progress to refractory epilepsy. Under physiological conditions, excitatory and inhibitory neurons function in a dynamic...
Paige Coutu et al.
Veterinary anaesthesia and analgesia, 42(5), 518-526 (2015-02-17)
Hypoxemia is common during equine field anesthesia. Our hypothesis was that oxygen therapy from a portable oxygen concentrator would increase PaO2 during field anesthesia compared with the breathing of ambient air. Prospective clinical study. Fifteen yearling (250 - 400 kg) horses...
Mohammad M Iqbal et al.
Delaware medical journal, 74(3), 127-135 (2002-04-20)
Antianxiety medications such as benzodiazepines (BZDs) are frequently and appropriately used to ameliorate the anxiety symptoms of depression, dysthymic disorder, panic disorder, agoraphobia, obsessive-compulsive disorder, generalized anxiety disorder, eating disorder, and many personality disorders. Pregnancy may be accompanied by anxiety...
Giampaolo Primofiore et al.
Journal of medicinal chemistry, 50(7), 1627-1634 (2007-03-06)
Novel N-substituted indol-3-ylglyoxylamides (10-37) were synthesized and evaluated as ligands of the benzodiazepine receptor (BzR). In an effort to achieve affinity-based selectivity among BzR subtypes, these compounds were designed to probe the LDi and L2 lipophilic regions. Taking the alpha1-selective...
Gabriella Guerrini et al.
Bioorganic & medicinal chemistry, 15(7), 2573-2586 (2007-02-20)
The synthesis and the binding study of new 3-iodiopyrazolo[5,1-c][1,2,4] benzotriazine 5-oxides 8-alkyloxy substituted are reported. The replacement at position 3 with an iodine atom, with respect to substituents capable to form a three centered hydrogen bond and/or to form pi-pi...
James D'Amour et al.
Experimental neurology, 269, 102-119 (2015-04-14)
In catamenial epilepsy, seizures exhibit a cyclic pattern that parallels the menstrual cycle. Many studies suggest that catamenial seizures are caused by fluctuations in gonadal hormones during the menstrual cycle, but this has been difficult to study in rodent models...
Azusa Sugiyama et al.
Neuropharmacology, 97, 322-328 (2015-06-28)
Strategies to enhance recognition memory and facilitate extinction of fear memory have attracted increasing attention for enhancing the effectiveness of exposure therapy for anxiety disorders. Previously, we demonstrated that systemic administration of riluzole has clear anxiolytic-like effects, without impairing memory...
G Asuntha et al.
Indian journal of experimental biology, 53(1), 31-35 (2015-02-14)
Argemone mexicana (L.) has a role in the treatment of epileptic disorders in Indian traditional system of medicine. We studied its effect on induced status epilepticus (SE) and oxidative stress in rats. SE was induced in male albino rats by...
Elisabet Lázaro et al.
Journal of medicinal chemistry, 51(7), 2009-2017 (2008-03-20)
We report here a new, label-free approach to measure serum protein binding constants. The assay is able to measure HSA K d values in the milli-molar to micromolar range. The protein is not immobilized on any surface and the assay...
Treatments for pediatric status epilepticus--reply.
James M Chamberlain et al.
JAMA, 312(9), 963-963 (2014-09-04)
Robert W Carling et al.
Journal of medicinal chemistry, 48(23), 7089-7092 (2005-11-11)
There is increasing evidence that compounds with selectivity for gamma-aminobutyric acid(A) (GABA(A)) alpha2- and/or alpha3-subtypes may retain the desirable anxiolytic activity of nonselective benzodiazepines but possess an improved side effect profile. Herein we describe a novel series of GABA(A) alpha2/alpha3...
Lorella Marinucci et al.
Expert opinion on drug safety, 10(1), 23-33 (2010-07-22)
This review analyses international studies investigating the combined genetic and environmental causes of cleft lip with or without cleft palate (CL/P) and describes successes and limitations in identifying underlying genetic and environmental factors. CL/P, the most common congenital facial malformation...
Frantisek Vyskocil
Ceskoslovenska fysiologie, 55(3), 111-114 (2007-08-10)
The effect of atropine and diazepam on the mammalian neuromuscular junction. Nicotinolytic effect of atropine on the neuromuscular junction is discussed as a main mechanism of the beneficial effect of this drug during war and agriculture poisoning by anticholinesterases. Atropine...
Dinesh Kumar et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(7), 1010-1014 (2014-01-28)
Stachys tibetica Vatke (Himalayan or mountain tea) grows abundantly in the tropical and subtropical locations of the world including India, Tibet and China. The traditional healers of Kargil and adjoining areas in Ladakh, Jammu and Kashmir in India use the...
Chen Liang et al.
Journal of separation science, 38(10), 1680-1690 (2015-03-18)
A liquid chromatography with tandem mass spectrometry method was developed for the simultaneous screening of 34 drugs and poisons in forensic cases. Blood (0.5 mL, diluted 1:1 with water) or 1.0 mL of urine was purified by solid-phase extraction. Gastric...
Yasuo Uchida et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 578-588 (2014-06-21)
The aim of this study was to investigate whether in vivo drug distribution in brain in monkeys can be reconstructed by integrating four factors: protein expression levels of P-glycoprotein (P-gp)/multidrug resistance protein 1 at the blood-brain barrier (BBB), in vitro...
Laurel K Dodgen et al.
Environmental pollution (Barking, Essex : 1987), 198, 144-153 (2015-01-17)
The reuse of treated wastewater for agricultural irrigation in arid and hot climates where plant transpiration is high may affect plant accumulation of pharmaceutical and personal care products (PPCPs) and endocrine disrupting chemicals (EDCs). In this study, carrot, lettuce, and...
An unusual cause of torticollis.
Elisa Benelli et al.
The Journal of pediatrics, 163(5), 1523-1523 (2013-08-07)
Lelia Duley et al.
The Cochrane database of systematic reviews, (12)(12), CD000127-CD000127 (2010-12-15)
Eclampsia, the occurrence of a seizure in association with pre-eclampsia, remains a rare but serious complication of pregnancy. A number of different anticonvulsants are used to control eclamptic fits and to prevent further fits. The objective of this review was...
Hannah F Clarke et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(13), 4176-4181 (2015-03-17)
Dysregulation of the orbitofrontal and ventrolateral prefrontal cortices is implicated in anxiety and mood disorders, but the specific contributions of each region are unknown, including how they gate the impact of threat on decision making. To address this, the effects...
Jia Liu et al.
The Cochrane database of systematic reviews, 2(2), CD008502-CD008502 (2013-03-02)
The treatment baclofen can rapidly reduce symptoms of severe alcohol withdrawal syndrome (AWS) in alcoholic patients, with a significant reduction in the cost. Baclofen is easy to manage, and rare euphoria, craving and other pleasant effects are reported by patients...
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