Showing 1-30 of 122 results for "


Omar Taleb et al.
PloS one, 7(11), e48553-e48553 (2012-11-10)
Xanthurenic acid (XA) is a metabolite of the tryptophan oxidation pathway through kynurenine and 3-hydroxykynurenine. XA was until now considered as a detoxification compound and dead-end product reducing accumulation of reactive radical species. Apart from a specific role for XA...
Alina Ryabova et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(32), 19209-19220 (2020-07-30)
Some organisms have evolved a survival strategy to withstand severe dehydration in an ametabolic state, called anhydrobiosis. The only known example of anhydrobiosis among insects is observed in larvae of the chironomid Polypedilum vanderplanki Recent studies have led to a...
Don Otter et al.
Journal of biomedicine & biotechnology, 2011, 974701-974701 (2010-12-29)
The interleukin-10-deficient (IL10(-/-)) mouse develops colon inflammation in response to normal intestinal microflora and has been used as a model of Crohn's disease. Short-Column LCMS metabolite profiling of urine from IL10(-/-) and wild-type (WT) mice was used, in two independent...
Tengfei Xu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1048, 94-101 (2017-02-25)
Radix Astragali has been used traditionally in China to treat rheumatoid arthritis (RA) in formulas. In this paper, we conducted a holistic evaluation of Radix Astragali acted on adjuvant-induced arthritis (AIA) rats by urinary and serum metabolomic studies. Histological results...
Celia Miguel-Blanco et al.
Antimicrobial agents and chemotherapy, 59(6), 3298-3305 (2015-03-25)
In response to a call for the global eradication of malaria, drug discovery has recently been extended to identify compounds that prevent the onward transmission of the parasite, which is mediated by Plasmodium falciparum stage V gametocytes. Lately, metabolic activity...
Halina Z Malina et al.
BMC cell biology, 5, 14-14 (2004-04-08)
Xanthurenic acid is an endogenous molecule produced by tryptophan degradation, produced in the cytoplasm and mitochondria. Its accumulation can be observed in aging-related diseases, e.g. senile cataract and infectious disease. We previously reported that xanthurenic acid provokes apoptosis, and now...
Jelena Pesek et al.
Organic & biomolecular chemistry, 13(1), 178-184 (2014-10-31)
In the regurgitate (foregut content) of Spodoptera larvae we found high concentrations (0.5-5 mM) of 8-hydroxyquinoline-2-carboxylic acid (8-HQA). In a survey of different lepidopteran species, this compound was only detected in species belonging to the family of Noctuidae. 8-HQA was...
Nhat M Pham et al.
Clinical journal of the American Society of Nephrology : CJASN, 3(1), 85-90 (2007-11-30)
Protein-bound solutes are poorly cleared by peritoneal dialysis. We examined the hypothesis that plasma concentrations of bound solutes would therefore rise as residual renal function is lost. Clearances of urea indican and p-cresol sulfate were measured in peritoneal dialysis patients...
S Bapurao et al.
The American journal of clinical nutrition, 36(4), 581-586 (1982-10-01)
Two groups of pregnant women belonging to a low socioeconomic group, one with oral lesions and the other without lesions, were studied in the 3rd trimester of pregnancy for vitamin B6 nutritional status. Both the groups showed evidence of abnormal...
Bor-Kai Hsiung et al.
The Journal of experimental biology, 220(Pt 11), 1975-1983 (2017-06-02)
Elucidating the mechanisms of colour production in organisms is important for understanding how selection acts upon a variety of behaviours. Spiders provide many spectacular examples of colours used in courtship, predation, defence and thermoregulation, but are thought to lack many...
Poly-xanthurenic acid modified electrodes: An amperometric sensor for the simultaneous determination of ascorbic and uric acids.
dos Santos Silva F D A, et al.
Sensors and Actuators B, Chemical, 168, 289-296 (2012)
Yuanyuan Liu et al.
Food & function, 10(1), 432-447 (2019-01-10)
Schisandra chinensis (Turcz.) Baill is produced mainly in northeast China, Korea and Japan. Its fruit has been used in food as a nutritional and functional ingredient for centuries. Polysaccharide is an important chemical component in Schisandra. Previous studies have shown...
Kumar S Bishnupuri et al.
Cancer research, 79(6), 1138-1150 (2019-01-27)
The tryptophan-metabolizing enzyme indoleamine 2,3 dioxygenase 1 (IDO1) is frequently overexpressed in epithelial-derived malignancies, where it plays a recognized role in promoting tumor immune tolerance. We previously demonstrated that the IDO1-kynurenine pathway (KP) also directly supports colorectal cancer growth by...
S Bapurao et al.
The American journal of clinical nutrition, 31(5), 819-824 (1978-05-01)
Disturbances in tryptophan-nicotinamide adenine dinucleotide pathway, seen in pellagrins whose staple is sorghum have been ascribed to an amino acid imbalance caused by excess intake of leucine. Studies in normal human volunteers and in experimental animals have shown that administration...
Janette Reader et al.
Malaria journal, 14, 213-213 (2015-05-23)
The discovery of malaria transmission-blocking compounds is seen as key to malaria elimination strategies and gametocyte-screening platforms are critical filters to identify active molecules. However, unlike asexual parasite assays measuring parasite proliferation, greater variability in end-point readout exists between different...
Comment on 'The photosensitiser xanthurenic acid is not present in normal human lenses' by P.G. Hains et al. [Exp. Eye Res. 77 (2003) 547-553].
Halina Z Malina
Experimental eye research, 79(3), 443-445 (2004-09-01)
Adoracion Pegalajar-Jurado et al.
Scientific reports, 8(1), 12204-12204 (2018-08-17)
Metabolites detectible in human biofluids are attractive biomarkers for the diagnosis of early Lyme disease (ELD), a vector-borne infectious disease. Urine represents an easily obtained clinical sample that can be applied for diagnostic purposes. However, few studies have explored urine...
Xu Wang et al.
The EMBO journal, 39(13), e104168-e104168 (2020-05-13)
Morphogenesis of many protozoans depends on a polarized establishment of cytoskeletal structures. In malaria-causing parasites, this can be observed when a round zygote develops into an elongated motile ookinete within the mosquito stomach. This morphogenesis is mediated by the pellicle...
Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae.
Carballar-Lejarazu, et al.
Proceedings of the National Academy of Sciences of the USA, 117, 22805-22814 (2021)
P Calandra
Acta vitaminologica et enzymologica, 29(1-6), 158-160 (1975-01-01)
The pattern of tryptophan metabolites "via kynurenine" was determined in the epidermis of man and mouse using semiquantitative method of one- and two-dimensional thin-layer-chromatography. In the epidermis of healthy man the following metabolites were present: tryptophan, kynurenine, anthranilic acid, 3-hydroxyanthranilic...
Chiaki Hiratsuka et al.
Journal of nutritional science and vitaminology, 60(4), 255-260 (2014-10-10)
We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy women. We performed a randomized, double-blind, placebo-controlled, crossover...
M Christensen et al.
Journal of inherited metabolic disease, 30(2), 248-255 (2007-03-06)
Massive urinary excretion of xanthurenic acid, 3-hydroxykynurenine and kynurenine, known as xanthurenic aciduria or hydroxykynureninuria, in a young Somali boy suggested kynureninase deficiency. Mutation analysis of KYNU encoding kynureninase of the index case revealed homozygosity for a c.593 A >...
Wenjun Zhou et al.
Brain, behavior, and immunity, 46, 147-153 (2015-02-01)
Chronic pain frequently co-occurs with major depressive disorder but the mechanisms are poorly understood. We investigated the contribution of indoleamine 2,3-dioxygenase-1 (IDO1), a rate-limiting enzyme in the conversion of tryptophan to neurotoxic metabolites, to this comorbidity using the spared nerve...
Minerva Camacho-Nuez et al.
Parasites & vectors, 10(1), 568-568 (2017-11-15)
Bovine babesiosis is a tick-borne disease caused by the protozoan parasites of the genus Babesia. In their host vector, Babesia spp. undergo sexual reproduction. Therefore, the development of sexual stages and the subsequent formation of the zygote are essential for...
Ling Li et al.
Molecular cell, 80(3), 525-540 (2020-10-18)
Well-balanced and timed metabolism is essential for making a high-quality egg. However, the metabolic framework that supports oocyte development remains poorly understood. Here, we obtained the temporal metabolome profiles of mouse oocytes during in vivo maturation by isolating large number of...
Emme C K Lin et al.
Bioorganic & medicinal chemistry letters, 22(2), 868-871 (2012-01-06)
AX10185, the phenyl amide of xanthurenic acid, was found to be a sub-100nM inhibitor of Lp-PLA(2). However, in the presence of EDTA the inhibitory activity of AX10185 was extinguished while the enzymatic activity of Lp-PLA(2) did not change. Subsequent metal...
Buranee Kanchanatawan et al.
Molecular neurobiology, 55(6), 5184-5201 (2017-09-07)
Evidence indicates that schizophrenia and in particular negative symptoms and deficit schizophrenia are accompanied by neurocognitive impairments and changes in the patterning of the tryptophan catabolite (TRYCAT) pathway. This cross-sectional study was carried out to examine the associations between cognitive...
Kynurenine pathway metabolites: relevant to vitamin B-6 deficiency and beyond.
Matthew A Ciorba
The American journal of clinical nutrition, 98(4), 863-864 (2013-08-30)
Yuanyuan Liu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1105, 93-103 (2018-12-24)
Gancao Fuzi decoction (GFD) is a classic Chinese medicine formula for the treatment of rheumatic and rheumatoid arthritis. The main active components of GFD are alkaloids, flavonoids and saponins. This study aimed to clarify the pharmacodynamic effects of the active...
Katsumi Shibata et al.
Journal of nutritional science and vitaminology, 60(4), 261-268 (2014-10-10)
The adverse effects of D-tryptophan and the possibility of it being a surrogate index for predicting adverse effects in rats were investigated. Male rats were fed one of several test diets (20% casein diets with 0% (control), 0.1%, 0.2%, 0.3%...