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Yanqiu Geng et al.
Stem cell research & therapy, 5(3), 80-80 (2014-06-26)
The mortality of rhabdomyolysis-induced acute kidney injury (AKI) is still high, as there is no effective therapy. It has been shown that bone marrow-derived mesenchymal stem cells (MSCs) can induce M2 macrophages, which mediate MSC protection in other experimental inflammation-related
Pippa Kern et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 190, 75-82 (2015-09-27)
Temperature and ultraviolet radiation (UVR) are key environmental drivers that are linked in their effects on cellular damage. Exposure to both high temperatures and UVR can cause cellular damage that result in the up-regulation of common protective mechanisms, such as
Yukio Nisimoto et al.
Biochemistry, 53(31), 5111-5120 (2014-07-26)
Nox4 is an oddity among members of the Nox family of NADPH oxidases [seven isoenzymes that generate reactive oxygen species (ROS) from molecular oxygen] in that it is constitutively active. All other Nox enzymes except for Nox4 require upstream activators
Suan-Sin Foo et al.
PLoS pathogens, 11(2), e1004649-e1004649 (2015-02-20)
The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River virus (RRV), and the lack of antiviral treatments highlight the potential threat of a global alphavirus pandemic. The immune responses underlying alphavirus virulence remain enigmatic. We
Cristina Iobagiu et al.
Cancer genetics, 208(4), 135-142 (2015-05-17)
The estrogen receptors (ESRα and β) and the androgen receptor (AR) mediate genomic and non-genomic effects on breast tumor growth and proliferation. We analyzed 101 breast cancer patients for allelic loss in microsatellites located in regulatory regions of the ESRs
Gozde Uzunalli et al.
Acta biomaterialia, 22, 8-18 (2015-05-02)
Pancreatic islet transplantation is a promising treatment for type 1 diabetes. However, viability and functionality of the islets after transplantation are limited due to loss of integrity and destruction of blood vessel networks. Thus, it is important to provide a
Bong-Kyu Kim et al.
BMB reports, 48(6), 360-366 (2015-03-17)
Colorectal cancer (CRC), the third most common cancer worldwide, also has the highest rate of cancer-related morbidity and mortality. WNT signaling is initiated by binding of WNT to various receptors, including frizzleds (FZDs), and plays a critical role in CRC
Kyoung-Woon Kim et al.
Arthritis research & therapy, 17, 41-41 (2015-04-19)
C-reactive protein (CRP) is one of the biomarkers for the diagnosis and assessment of disease activity in rheumatoid arthritis (RA). CRP is not only the by-product of inflammatory response, but also plays proinflammatory and prothrombotic roles. The aim of this
Karthik Chary et al.
NMR in biomedicine, 34(2), e4438-e4438 (2020-11-22)
The primary lesion arising from the initial insult after traumatic brain injury (TBI) triggers a cascade of secondary tissue damage, which may also progress to connected brain areas in the chronic phase. The aim of this study was, therefore, to
Jagdeep S Walia et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(3), 414-422 (2014-12-18)
G(M2) gangliosidoses are severe neurodegenerative disorders resulting from a deficiency in β-hexosaminidase A activity and lacking effective therapies. Using a Sandhoff disease (SD) mouse model (Hexb(-/-)) of the G(M2) gangliosidoses, we tested the potential of systemically delivered adeno-associated virus 9
Xingquan Xu et al.
Arthritis research & therapy, 17, 20-20 (2015-02-03)
Microfracture does not properly repair full-thickness cartilage defects. The purpose of this study was to evaluate the effect of intraarticular injection of the small-molecule compound kartogenin (KGN) on the restoration of a full-thickness cartilage defect treated with microfracture in a
S Meyer Dos Santos et al.
Thrombosis and haemostasis, 114(2), 297-312 (2015-04-24)
Endothelial chemokine CXC motif ligand 16 (CXCL16) expression is associated with atherosclerosis, while platelets, particularly those attaching to atherosclerotic plaque, contribute to all stages of atherosclerotic disease. This investigation was designed to examine the role of CXCL16 in capturing platelets
Birgit Westernströer et al.
Cell and tissue research, 361(3), 885-898 (2015-03-27)
The chemokine receptor CXCR7 interacts with the chemokines CXCL11 and CXCL12. During development, this ligand receptor system (C-X-C) provokes cell-type-specific responses in terms of migration, adhesion or ligand sequestration. It is active in zebrafish and rodents but no data are
Stephen C Helps et al.
Applied immunohistochemistry & molecular morphology : AIMM, 20(1), 82-90 (2011-12-14)
We describe a method for the automatic, nonsubjective estimation of 3,3' diaminobenzidine (DAB) in digital images obtained from routine central nervous system immunohistochemistry using freely available, platform-independent public domain image processing software. This technique estimates the amount of antigen visualized
Han Chung Chong et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(9), 1593-1604 (2014-06-07)
Impaired wound healing is a major source of morbidity in diabetic patients. Poor outcome has, in part, been related to increased inflammation, poor angiogenesis, and deficiencies in extracellular matrix components. Despite the enormous impact of these chronic wounds, effective therapies
Hiroshi Mano et al.
Bioscience, biotechnology, and biochemistry, 79(6), 960-968 (2015-02-11)
An IF5 cDNA was isolated by expression cloning from a mouse oocyte cDNA library. It encoded a protein of 250 amino acids, and the region of it encoding amino acids 1-137 showed 86.8% alignment with the anti-proliferative domain of BTG/TOB
Cristian G Torres et al.
Oncology reports, 33(5), 2235-2244 (2015-03-18)
Mammary cancer is the most frequent type of tumor in the female canine. Treatments are mainly limited to surgery and chemotherapy; however, these tumors may develop clinical recurrence, metastasis and chemoresistance. The existence of a subpopulation of cancer cells with
Qinghua Xu et al.
Biosensors & bioelectronics, 33(1), 274-278 (2012-01-20)
This manuscript describes a new technique for detecting single-nucleotide polymorphisms (SNPs) by integrating a leaky surface acoustic wave (LSAW) biosensor, enzymatic DNA ligation and enzymatic signal amplification. In this technique, the DNA target is hybridized with a capture probe immobilized
Tetsushi Hirano et al.
The Journal of veterinary medical science, 77(10), 1207-1215 (2015-05-12)
Neonicotinoids, some of the most widely used pesticides in the world, act as agonists to the nicotinic acetylcholine receptors (nAChRs) of insects, resulting in death from abnormal excitability. Neonicotinoids unexpectedly became a major topic as a compelling cause of honeybee
Bryna S Man Chow et al.
Kidney international, 86(1), 75-85 (2014-01-17)
Fibrosis is a hallmark of chronic kidney disease, for which there is currently no effective cure. The hormone relaxin is emerging as an effective antifibrotic therapy; however, its mechanism of action is poorly understood. Recent studies have shown that relaxin
Scott H Medina et al.
Biomaterials, 53, 545-553 (2015-04-22)
DNA that encodes tumor-specific antigens represents potential immunostimulatory agents. However, rapid enzymatic degradation and fragmentation of DNA during administration can result in limited vector expression and, consequently, poor efficacy. These challenges have necessitated the use of novel strategies for DNA
Craig T Werner et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(42), 26460-26469 (2020-10-07)
Relapse vulnerability in substance use disorder is attributed to persistent cue-induced drug seeking that intensifies (or "incubates") during drug abstinence. Incubated cocaine seeking has been observed in both humans with cocaine use disorder and in preclinical relapse models. This persistent
You-Kang Chang et al.
Journal of biomedical science, 18, 54-54 (2011-08-10)
Spinocerebellar ataxia (SCA) refers to a disease entity in which polyglutamine aggregates are over-produced in Purkinje cells (PCs) of the cerebellum as well as other neurons in the central nervous system, and the formation of intracellular polyglutamine aggregates result in
María Laura Doumecq et al.
Experimental parasitology, 147, 48-53 (2014-10-14)
Tritrichomonas foetus (T. foetus) is the causal agent of bovine tritrichomonosis (BT), a venereal disease that causes significant economic losses in the bovine livestock industry. The structural organization of T. foetus presents a cell membrane, an undulating membrane which extends
Stefanie Jeruschke et al.
PloS one, 10(9), e0137043-e0137043 (2015-09-04)
Glomerular podocytes are highly differentiated cells that are key components of the kidney filtration units. The podocyte cytoskeleton builds the basis for the dynamic podocyte cytoarchitecture and plays a central role for proper podocyte function. Recent studies implicate that immunosuppressive
Lauren Henry et al.
Molecular biology of the cell, 19(5), 2059-2068 (2008-02-22)
Rab8 is a monomeric GTPase that regulates the delivery of newly synthesized proteins to the basolateral surface in polarized epithelial cells. Recent publications have demonstrated that basolateral proteins interacting with the mu1-B clathrin adapter subunit pass through the recycling endosome
Cynthia S Ritter et al.
Kidney international, 87(6), 1141-1152 (2015-02-19)
Klotho plays an important role in the pathogenesis of cardiovascular disease in chronic kidney disease (CKD). Klotho is highly expressed in the kidney and parathyroid glands, but its presence in the vasculature is debated. Renal Klotho is decreased in CKD
Jorge Ivan Alvarez et al.
Neurobiology of disease, 74, 14-24 (2014-12-03)
Early changes in the normal appearing white matter of multiple sclerosis (MS) patients precede the appearance of gadolinium-enhancing lesions. Although these findings suggest blood-brain barrier (BBB) breakdown as an important feature in MS pathogenesis, limited information is available on the
Guang-Qian Xiao et al.
Human pathology, 46(11), 1607-1615 (2015-08-25)
There are currently no effective prognostic biomarkers for lung cancer. Promyelocytic leukemia zinc finger (PLZF), a transcriptional repressor, has a role in cell cycle progression and tumorigenicity in various cancers. The expression and value of PLZF in lung carcinoma, particularly
Diana Zabini et al.
The European respiratory journal, 44(4), 951-962 (2014-07-19)
Chronic thromboembolic pulmonary hypertension (CTEPH) is associated with chronic inflammation but the pathological mechanisms are largely unknown. Our study aimed to simultaneously profile a broad range of cytokines in the supernatant of pulmonary endarterectomy (PEA) surgical material, as well as
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