Showing 1-13 of 13 results for "D2429"
Ernesto Cortes et al.
EMBO reports, 20(1) (2018-12-13)
The mechanical properties of the tumor microenvironment are emerging as attractive targets for the development of therapies. Tamoxifen, an agonist of the G protein-coupled estrogen receptor (GPER), is widely used to treat estrogen-positive breast cancer. Here, we show that tamoxifen...
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Caren E Petrie Aronin et al.
Immunity, 47(5), 862-874 (2017-11-23)
Chemoattractant-mediated recruitment of hematopoietic cells to sites of pathogen growth or tissue damage is critical to host defense and organ homeostasis. Chemotaxis is typically considered to rely on spatial sensing, with cells following concentration gradients as long as these are...
Midori Awazu et al.
PloS one, 15(4), e0230289-e0230289 (2020-04-07)
We previously reported that maternal nutrient restriction (NR) inhibited ureteric branching, metanephric growth, and nephrogenesis in the rat. Here we examined whether folic acid, a methyl-group donor, rescues the inhibition of kidney development induced by NR and whether DNA methylation...
Qinjie Weng et al.
Scientific reports, 7(1), 1705-1705 (2017-05-13)
Folate, an essential micronutrient, is a critical cofactor in one-carbon metabolism for many cellular pathways including DNA synthesis, metabolism and maintenance. Folate deficiency has been associated with an increased risk of neurological disease, cancer and cognitive dysfunction. Dihydrofolate reductase (DHFR)...
Debonil Maity et al.
Soft matter, 15(12), 2617-2626 (2019-02-28)
Extracellular matrices in animal tissue are hydrogels mostly made of collagen. In these matrices, collagen fibers are hierarchically assembled and cross-linked to form a porous and elastic material, through which migrating cells can move by either pushing through open matrix...
Muge Sarper et al.
Breast cancer research : BCR, 19(1), 33-33 (2017-03-24)
Normal myoepithelial cells (MECs) play an important tumour-suppressor role in the breast but display an altered phenotype in ductal carcinoma in situ (DCIS), gaining tumour-promoter functions. Matrix metalloproteinase-8 (MMP-8) is expressed by normal MECs but is lost in DCIS. This...
Yi Li et al.
Physiological genomics, 50(3), 158-168 (2018-01-18)
Folic acid supplements taken during pregnancy can prevent neural tube defects and other developmental abnormalities. Here, we explored the effects of folate supplementation on gene expression and DNA methylation during C2C12 differentiation. Based on the folic acid concentration, this study...
Tejas Shah et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 526-534 (2016-10-04)
Folic acid (FA) and iron are essential supplements during pregnancy. Similarly effects of vitamin B12 (B12) inadequacy and high folate and low B12 status, on pregnancy outcome are available. However there are no mandatory recommendations for B12. There are many...
Antonietta Aversano et al.
International journal of molecular medicine, 46(4), 1359-1366 (2020-09-19)
Balneotherapy and spa therapy have been used in the treatment of ailments since time immemorial. Moreover, there is evidence to suggest that the beneficial effects of thermal water continue for months following the completion of treatment. The mechanisms through which...
Fredrick J Rosario et al.
The Journal of physiology, 595(13), 4189-4206 (2017-04-05)
Folate deficiency during pregnancy is associated with restricted fetal growth, although the underlying mechanisms are poorly understood. Here we show that mechanistic target of rapamycin (mTOR) functions as a folate sensor in primary human trophoblast (PHT) cells. Folate sensing by...
Maria Guix et al.
Scientific reports, 6, 21701-21701 (2016-02-26)
Novel approaches to develop naturally-induced drug delivery in tumor environments in a deterministic and controlled manner have become of growing interest in recent years. Different polymeric-based microstructures and other biocompatible substances have been studied taking advantage of lactic acidosis phenomena...
Ernesto Cortes et al.
EMBO reports, 20(1) (2018-12-13)
The tumor microenvironment is fundamental to cancer progression, and the influence of its mechanical properties is increasingly being appreciated. Tamoxifen has been used for many years to treat estrogen-positive breast cancer. Here we report that tamoxifen regulates the level and...

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