Showing 1-30 of 7934 results for "D2650"
Mimi C Yung et al.
Journal of bacteriology, 197(19), 3160-3172 (2015-07-22)
The ubiquitous aquatic bacterium Caulobacter crescentus is highly resistant to uranium (U) and facilitates U biomineralization and thus holds promise as an agent of U bioremediation. To gain an understanding of how C. crescentus tolerates U, we employed transposon (Tn)...
William C Wilson et al.
The Journal of general virology, 96(Pt 6), 1400-1410 (2015-02-24)
Epizootic hemorrhagic disease virus (EHDV), a member of the genus Orbivirus not reported previously in Israel, was isolated from Israeli cattle during a 'bluetongue-like' disease outbreak in 2006. To ascertain the origin of this new virus, three isolates from the...
Mabel Lum et al.
Pathogens and disease, 72(3), 174-187 (2014-07-06)
A key feature of Shigella pathogenesis is the ability to spread from cell-to-cell post-invasion. This is dependent on the bacteria's ability to initiate de novo F-actin tail polymerisation, followed by protrusion formation, uptake of bacteria-containing protrusion and finally, lysis of...
Xiaowen Wang et al.
Scientific reports, 5, 13542-13542 (2015-09-16)
Vitiligo is an acquired depigmentation disorder largely caused by defective melanocyte- or autoimmunity-induced melanocyte destruction. The aryl hydrocarbon receptor (AHR) is essential for melanocyte homeostasis and immune process, and abnormal AHR was observed in vitiligo. We previously identified the T...
Nathan Erdmann et al.
PLoS pathogens, 11(8), e1005111-e1005111 (2015-08-25)
Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains unclear. Using a computational approach on HIV...
Yunpeng Fan et al.
Carbohydrate polymers, 135, 110-120 (2015-10-11)
The antioxidative and immunoregulatory activities of ophiopogon polysaccharide liposome (OPL) were investigated. The results demonstrated that the radical-scavenging activity increased along with the increasing of OPL concentrations, and the scavenging capability of OPL was slightly stronger than ophiopogon polysaccharide (OP)...
Yong Huang et al.
Medical oncology (Northwood, London, England), 31(3), 824-824 (2014-01-29)
Matrix metalloproteinase 7 (MMP7) was reported to be a negative regulator in Fas-mediated apoptosis. The mechanism of cell killing associated with 5-FU treatment in colon cancer was also closely related to Fas-induced apoptosis, which implied that the expression level of...
Divya Pathania et al.
British journal of pharmacology, 172(1), 50-63 (2014-07-23)
Pancreatic cancer is characterized by alterations in several key signalling proteins, including increased expression and activity of the Src tyrosine kinase and focal adhesion kinase (FAK), which have been linked to its chemoresistance. Sustained Src inhibition reactivates survival pathways regulated...
Letian Xu et al.
Microbial ecology, 70(4), 1012-1023 (2015-05-20)
Bark beetles are the most important mortality agent in coniferous forests, and pheromones play important roles in their management. Dendroctonus valens LeConte was introduced from North America to China and has killed millions of healthy pines there. Trapping with semiochemicals...
Mark H Christensen et al.
Neuropharmacology, 85, 263-283 (2014-05-28)
The younger an individual starts smoking, the greater the likelihood that addiction to nicotine will develop, suggesting that neurobiological responses vary across age to the addictive component of cigarettes. Cholinergic neurons of the laterodorsal tegmental nucleus (LDT) are importantly involved...
Jooeun Bae et al.
Oncoimmunology, 3(12), e970914-e970914 (2014-01-01)
XBP1 is a critical transcriptional activator of the unfolded protein response (UPR), which increases tumor cell survival under prolonged endoplasmic reticulum (ER) stress and hypoxic conditions.This study was designed to evaluate the immunogenicity of heteroclitic XBP1 unspliced (US)
Avijit Paul et al.
Nanoscale research letters, 10, 140-140 (2015-04-09)
With advancements in nanotechnology, silver has been engineered into a nanometre size and has attracted great research interest for use in the treatment of wounds. Silver nanoparticles (AgNPs) have emerged as a potential alternative to conventional antibiotics because of their...
Angie K Marsh et al.
PloS one, 10(3), e0121339-e0121339 (2015-03-31)
Cytomegalovirus (CMV) is a highly species-specific virus that has co-evolved with its host over millions of years and thus restricting cross-species infection. To examine the extent to which host restriction may prevent cross-species research between closely related non-human primates, we...
Alireza Saeidi et al.
Cellular immunology, 297(1), 19-32 (2015-06-15)
The role of T-cell immunosenescence and functional CD8(+) T-cell responses in HIV/TB co-infection is unclear. We examined and correlated surrogate markers of HIV disease progression with immune activation, immunosenescence and differentiation using T-cell pools of HIV/TB co-infected, HIV-infected and healthy...
Lenisa Geron et al.
Neurological research, 37(8), 703-711 (2015-05-23)
Medulloblastoma (MB) is the most common malignant childhood brain tumour. Aurora kinases are essential for cell division and are primarily active during mitosis. Recently, the combination of aurora kinases inhibitors (iAURK) and histone deacetylase inhibitors (iHDAC) has shown potential antitumour...
Ling Tong et al.
Journal of ethnopharmacology, 155(3), 1553-1560 (2014-08-08)
Radix Toddaliae Asiaticae has long been used as a traditional ethnic Chinese medicine for the treatment of inflammation and rheumatism. In our earlier communication we have reported the anti-arthritic activity of the ethyl alcohol extract and ethyl acetate fraction from...
Kiyoshi Watanabe et al.
PloS one, 10(6), e0129357-e0129357 (2015-06-06)
In Saccharomyces cerevisiae, the core promoters of class II genes contain either TATA or TATA-like elements to direct accurate transcriptional initiation. Genome-wide analyses show that the consensus sequence of the TATA element is TATAWAWR (8 bp), whereas TATA-like elements carry...
Wei Zhao et al.
Thoracic cancer, 6(4), 508-516 (2015-08-15)
To explore the molecular mechanisms of the anti-cancer effect of curcumin in human lung squamous cell carcinoma (LSQCC) SK-MES-1 cells. Cell viability was determined using MTT assay. Ribonucleic acid sequencing was performed to measure expression levels of transcripts in LSQCC...
Jesu Arockiaraj et al.
Gene, 546(2), 437-442 (2014-06-01)
Glutathione S-transferases play an important role in cellular detoxification and may have evolved to protect cells against reactive oxygen metabolites. In this study, we report the molecular characterization of glutathione s-transferase-theta (GST-θ) from freshwater prawn Macrobrachium rosenbergii. A full length...
Rinukshi Wimalasekera et al.
Plant physiology and biochemistry : PPB, 96, 231-240 (2015-08-28)
Polyamines (PA) are catabolised by two groups of amine oxidases, the copper-binding amine oxidases (CuAOs) and the FAD-binding polyamine oxidases (PAOs). Previously, we have shown that CuAO1 is involved in ABA associated growth responses and ABA- and PA-mediated rapid nitric...
Rajiv Sainath et al.
Developmental neurobiology, 75(7), 757-777 (2014-11-19)
The axonal transport of organelles is critical for the development, maintenance, and survival of neurons, and its dysfunction has been implicated in several neurodegenerative diseases. Retrograde axon transport is mediated by the motor protein dynein. In this study, using embryonic...
Dong Gu Lee et al.
Chemical & pharmaceutical bulletin, 63(11), 927-934 (2015-11-03)
Four phytochemical constituents were isolated from Panax ginseng root by repeated column chromatography (CC), medium pressure liquid chromatography (MPLC), high-speed counter current chromatography (HSCCC), and semi-preparative HPLC. Their structures were elucidated as the dammarane-type triterpene saponins ginsenoside-Rg18 (1), 6-acetyl ginsenoside-Rg3...
Danica E DeGroot et al.
Chemical research in toxicology, 28(6), 1176-1185 (2015-05-23)
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates the toxic and biological effects of structurally diverse chemicals, including the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). As part of a larger effort to identify the full spectrum of chemicals...
Myrna Déciga-Campos et al.
Drug development research, 76(5), 228-234 (2015-07-29)
Preclinical Research The objective of this study was to evaluate the pharmacological antihyperalgesic interaction between N-palmitoylethanolamide (PEA) and acetaminophen in diabetic rats using the formalin paw test. Streptozotocin (STZ)-induced diabetic rats received subcutaneous injections in the paw of PEA alone...
Yee-Lin Voon et al.
Oncology reports, 34(4), 1692-1700 (2015-08-08)
The small-molecule inhibitor of p53-Mdm2 interaction, Nutlin-3, is known to be effective against cancers expressing wild-type (wt) p53. p53 mutations are rare in nasopharyngeal carcinoma (NPC), hence targeting disruption of p53-Mdm2 interaction to reactivate p53 may offer a promising therapeutic...
Miho Suzuki et al.
Analytical biochemistry, 491, 10-17 (2015-09-04)
Cytometry is a versatile and powerful method applicable to different fields, particularly pharmacology and biomedical studies. Based on the data obtained, cytometric studies are classified into high-throughput (HTP) or high-content screening (HCS) groups. However, assays combining the advantages of both...
Masayuki Morita et al.
Parasitology international, 64(1), 113-117 (2014-12-03)
We have reported that two endoperoxides, N-89 and N-251, synthesized in 2001, possess potent antimalarial activities. Aiming at their eventual use for curing malaria in humans, we have been investigating various aspects of their antimalarial actions. Here we show that...
Frédéric Lamoth et al.
Journal of clinical microbiology, 53(10), 3176-3181 (2015-07-24)
Invasive mold infections are life-threatening diseases for which appropriate antifungal therapy is crucial. Their epidemiology is evolving, with the emergence of triazole-resistant Aspergillus spp. and multidrug-resistant non-Aspergillus molds. Despite the lack of interpretive criteria, antifungal susceptibility testing of molds may...
Eun-Mi Noh et al.
Oncology reports, 34(2), 803-810 (2015-06-06)
The Aurora kinase family of serine/threonine kinases are known to be crucial for cell cycle control. Aurora kinases are considered a target of anticancer drugs. However, few studies have assessed the effect of Aurora kinases in breast cancer. In the...
Jie Shen et al.
Journal of controlled release : official journal of the Controlled Release Society, 218, 2-12 (2015-10-02)
The objective of the present study was to determine whether an in vitro-in vivo correlation (IVIVC) can be established for polymeric microspheres that are equivalent in formulation composition but prepared with different manufacturing processes. Risperidone was chosen as a model...

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