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Showing 1-30 of 8262 results for "d2650" within Papers
Shou-Ping Shih et al.
Marine drugs, 13(5), 3132-3153 (2015-05-27)
A marine polycyclic quinone-type metabolite, halenaquinone (HQ), was found to inhibit the proliferation of Molt 4, K562, MDA-MB-231 and DLD-1 cancer cell lines, with IC50 of 0.48, 0.18, 8.0 and 6.76 μg/mL, respectively. It exhibited the most potent activity against
Luciana Costa et al.
PloS one, 9(10), e109672-e109672 (2014-10-24)
Previous results demonstrate that the hybrid synthetic pterocarpanquinone LQB-118 presents antileishmanial activity against Leishmania amazonensis in a mouse model. The aim of the present study was to use a hamster model to investigate whether LQB-118 presents antileishmanial activity against Leishmania
Hana Moon et al.
PloS one, 10(5), e0127060-e0127060 (2015-05-16)
Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways. Previously, we identified methyl syringate as an hTRPA1 agonist with
Fengzhen Huang et al.
FEBS letters, 588(24), 4791-4798 (2014-12-03)
MicroRNAs (miRNAs) have been reported to play significant roles in the pathogenesis of various polyQ diseases. This study aims to investigate the regulation of ATXN3 gene expression by miRNA. We found that miR-25 reduced both wild-type and polyQ-expanded mutant ataxin-3
Minal J Menezes et al.
Human molecular genetics, 24(8), 2297-2307 (2015-01-04)
Functional defects of the mitochondrial translation machinery, as a result of mutations in nuclear-encoded genes, have been associated with combined oxidative phosphorylation (OXPHOS) deficiencies. We report siblings with congenital sensorineural deafness and lactic acidemia in association with combined respiratory chain
Anna Morena D'Alise et al.
Nature communications, 10(1), 2688-2688 (2019-06-21)
Neoantigens (nAgs) are promising tumor antigens for cancer vaccination with the potential of inducing robust and selective T cell responses. Genetic vaccines based on Adenoviruses derived from non-human Great Apes (GAd) elicit strong and effective T cell-mediated immunity in humans.
Nadine Rosin et al.
Human molecular genetics, 24(13), 3708-3717 (2015-04-04)
DNA double-strand breaks (DSBs) are highly toxic lesions, which, if not properly repaired, can give rise to genomic instability. Non-homologous end-joining (NHEJ), a well-orchestrated, multistep process involving numerous proteins essential for cell viability, represents one major pathway to repair DSBs
Qian Zhang et al.
Journal of experimental & clinical cancer research : CR, 38(1), 320-320 (2019-07-22)
Acquired resistance remains a limitation of the clinical use of 5-fluorouracil (5-FU). Because exosomes, are important vesicles participating in intercellular communication, their contribution to the development of acquired 5-FU resistance needs to be elucidated. In this study, we aimed to
Liwei Dong et al.
International journal of molecular sciences, 16(7), 14655-14668 (2015-07-02)
Echinacoside is a natural compound with potent reactive oxygen species (ROS)-scavenging and anti-oxidative bioactivities, which protect cells from oxidative damages. As cancer cells are often under intense oxidative stress, we therefore tested if Echinacoside treatment would promote cancer development. Surprisingly
Ting Song et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 70, 64-71 (2015-01-18)
Paclitaxel is an alternative chemotherapeutic agent for chronic myelogenous leukemia (CML) when primary or secondary resistance of tyrosine kinase inhibitors (TKI) is emerging, because paclitaxel could bypass the apoptotic deficiencies linked to p53 and fas ligand pathways in CML. However
Xiao-Lei Zhu et al.
ChemMedChem, 9(7), 1512-1521 (2014-03-29)
Succinate-ubiquinone oxidoreductase (SQR, EC, also known as mitochondrial respiratory complex II or succinate dehydrogenase (SDH), catalyzes the oxidation of succinate to fumarate as part of the tricarboxylic acid cycle. SQR has been identified as a novel target of a large family
Jing-Qiang Guo et al.
International journal of oncology, 45(3), 1065-1072 (2014-06-19)
Ginsenoside Rg3 (Rg3), a trace tetracyclic triterpenoid saponin, is extracted from ginseng and shown to have anticancer activity against several types of cancers. This study explored the effect of Rg3 on pancreatic cancer vasculogenic mimicry. Altered vasculogenic mimicry formation was
Hao Guo et al.
Cellular immunology, 295(1), 19-28 (2015-03-04)
We expanded flow-sorted Foxp3(+) cynomolgus monkey regulatory T cells (Treg) >1000-fold after three rounds of stimulation with anti-CD3 mAb-loaded artificial antigen-presenting cells, rapamycin (first round only) and IL-2. The expanded Treg maintained their expression of Treg signature markers, CD25, CD27
Audrey Beaussart et al.
Nanoscale, 7(36), 14996-15004 (2015-08-27)
Many fungal pathogens produce cell surface polysaccharides that play essential roles in host-pathogen interactions. In Aspergillus fumigatus, the newly discovered polysaccharide galactosaminogalactan (GAG) mediates adherence to a variety of substrates through molecular mechanisms that are poorly understood. Here we use
Mandana Ghisari et al.
Toxicology and applied pharmacology, 284(3), 292-303 (2015-02-17)
Evidence suggest that exposure to pesticides can interfere with the endocrine system by multiple mechanisms. The endocrine disrupting potential of currently used pesticides in Denmark was analyzed as single compounds and in an equimolar mixture of 5 selected pesticides. The
Hye-Sook Seo et al.
Molecular medicine reports, 12(1), 800-818 (2015-03-18)
Retinoids possess anti-proliferative properties, which suggests that they possess chemopreventive and therapeutic potential against cancer. In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXRα agonist, Ro25-7386) were identified using an
Yanzhuo Zhang et al.
Pharmaceutical research, 32(7), 2372-2383 (2015-01-23)
A novel mesoporous carbon/lipid bilayer nanocomposite (MCLN) with a core-shell structure was synthesized and characterized as an oral drug delivery system for poorly water-soluble drugs. The objective of this study was to investigate the potential of MCLN-based formulation to modulate
Gabriela Torrea et al.
The Journal of antimicrobial chemotherapy, 70(8), 2300-2305 (2015-05-16)
The objective of this study was to evaluate the performance of the BACTEC MGIT960 system to test the susceptibility to bedaquiline for Mycobacterium tuberculosis complex. We determined the quality control (QC) range of bedaquiline using the M. tuberculosis H37Rv reference
Wei Lu et al.
Cancer biology & therapy, 15(9), 1174-1184 (2014-06-12)
Cancer stem cells (CSCs) may contribute to tumor initiation, distant metastasis and chemo-resistance. One of RNA-binding proteins, Quaking (QKI), was reported to be a tumor suppressor. Here we showed that reduced QKI levels were observed in many human oral cancer
Junjun Xu et al.
Stem cell research & therapy, 10(1), 193-193 (2019-06-30)
Pigs have emerged as one of the most popular large animal models in biomedical research, which in many cases is considered as a superior choice over rodent models. In addition, transplantation studies using pig pluripotent stem (PS) cell derivatives may
Katherine Czysz et al.
PloS one, 10(2), e0117689-e0117689 (2015-02-07)
Definitive endoderm (DE) is one of the three germ layers which during in vivo vertebrate development gives rise to a variety of organs including liver, lungs, thyroid and pancreas; consequently efficient in vitro initiation of stem cell differentiation to DE
Shi Yue et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 5343-5353 (2014-04-29)
Although the role of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in regulating cell proliferation is well established, its function in immune responses remains to be fully appreciated. In the current study, we analyzed myeloid-specific PTEN function in
Katja K Schneider et al.
Neuroreport, 26(4), 186-191 (2015-02-13)
Acetylcholine influences the speed of information processing. We examined the effect of the rs3841324 polymorphism (L/S) and the rs16969968 (G/A) polymorphism on response speed in the Stroop task and the Negative priming task. These polymorphisms are located in the gene
Hui-Zhang Li et al.
Journal of biochemical and molecular toxicology, 29(8), 382-387 (2015-04-29)
To investigate the effect of uric acid on the osteogenic and adipogenic differentiation of human bone mesenchymal stem cells (hBMSCs). The hBMSCs were isolated from bone marrow of six healthy donors. Cell morphology was observed by microscopy and cell surface
Davy Baudelet et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 35-43 (2015-02-24)
The P2X receptors are seven-transmembrane domain G protein-coupled receptors and the 7 subtypes of P2X receptors identified in humans, and named P2X1 to P2X7, are channel receptors whose endogenous ligand is ATP. New antagonists of the P2X7 receptor were developed
See-Wun Cho et al.
Archives of toxicology, 89(11), 2027-2038 (2014-09-17)
The aryl hydrocarbon receptor (AHR) is responsible for susceptibility to its ligand-dependent responses. However, the effect of non-AHR factors is less clear. To explore the non-AHR factors, we used two mouse strains with different AHR genetic variants, namely C3H/lpr and
Hengqiang Zhao et al.
Molecular therapy oncolytics, 14, 299-312 (2019-09-12)
Poor prognosis in pancreatic cancer (PanCa) is partially due to chemoresistance to gemcitabine (GEM). Glucose metabolism has been revealed to contribute to the therapeutic resistance and pluripotent state of PanCa cells. However, few studies have focused on the effects of
Bin Chen et al.
Archives of pharmacal research, 38(8), 1468-1476 (2014-12-31)
In this work, the metabolite profiles of ginsenosides Rk3 and Rh4 from steamed notoginseng in zebrafish were qualitatively investigated, and their possible metabolic pathways were subsequently proposed. Metabolites of ginsenosides Rk3 and Rh4 after exposing to zebrafish for 24 h
Mariann Kremlitzka et al.
Cellular and molecular life sciences : CMLS, 72(11), 2223-2236 (2014-12-30)
B cells are efficiently activated by CpG oligodeoxynucleotides (ODNs) to produce pro-inflammatory cytokines and antibody (Ab). Here, we describe a so far unidentified, spleen tyrosine kinase (Syk)-dependent pathway, which is indispensable for CpG-induced human B cell activation. We show that
Lanhong Zheng et al.
PloS one, 9(11), e111270-e111270 (2014-11-06)
A Gram-positive, rod-shaped bacterium, designated as S-1, was isolated from a marine sediment sample collected from South China Sea. Phylogenetic analysis based on 16S rRNA gene sequence showed that S-1 belongs to the genus Brevibacillus. A novel cytotoxic peptide was
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