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Current treatment for multiple myeloma.
David Avigan et al.
The New England journal of medicine, 371(10), 961-962 (2014-09-04)
Shirzad Nasiri et al.
The American surgeon, 79(12), 1258-1262 (2013-12-20)
Voice alteration is one of the most common complications after thyroidectomy. It has a serious effect on social communication and economic and psychosocial status of patients. It has been hypothesized that inflammation and edema in the surgery site has a
Jin Seok Park et al.
Stem cells (Dayton, Ohio), 37(3), 368-381 (2018-11-18)
Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into mature cells of various cell types. Although the differentiation process of MSCs requires lineage-specific transcription factors, the exact molecular mechanism that determines MSCs differentiation is not clearly addressed. Here
Chengyun Wang et al.
Experimental eye research, 129, 74-82 (2014-12-03)
Dexamethasone is a glucocorticoid that is widely used in the ophthalmic arena. The recent FDA approved dexamethasone implant can provide a three month efficacy but with high rate of drug related cataract and high intraocular pressure (IOP). It seems that
Katja Rezonja et al.
Anesthesia and analgesia, 118(4), 755-763 (2014-03-22)
Corticosteroids are frequently used during anesthesia to provide substitution therapy in patients with adrenal insufficiency, as a first-line treatment of several life-threatening conditions, to prevent postoperative nausea and vomiting, and as a component of multimodal analgesia. For these last 2
Yasunobu Sekiguchi et al.
Journal of clinical and experimental hematopathology : JCEH, 53(1), 21-28 (2013-06-27)
A 56-year-old man developed epistaxis, hoarseness, and swelling of a finger in March 2010. On the basis of biopsies of the masses in the pharynx and finger, he was diagnosed with extramedullary plasmablastic plasmacytoma, with somewhat immature CD45(+), MPC-1(-), and
Karen Dendoncker et al.
PloS one, 12(7), e0181101-e0181101 (2017-07-08)
Glucocorticoid resistance (GCR), i.e. unresponsiveness to the beneficial anti-inflammatory activities of the glucocorticoid receptor (GR), poses a serious problem in the treatment of inflammatory diseases. One possible solution to try and overcome GCR, is to identify molecules that prevent or
Chunliang Xu et al.
Immunity, 53(2), 417-428 (2020-08-01)
Psychological stress has adverse effects on various human diseases, including those of the cardiovascular system. However, the mechanisms by which stress influences disease activity remain unclear. Here, using vaso-occlusive episodes (VOEs) of sickle cell disease as a vascular disease model
Samantha J England et al.
Blood, 117(9), 2708-2717 (2010-12-04)
In the hematopoietic hierarchy, only stem cells are thought to be capable of long-term self-renewal. Erythroid progenitors derived from fetal or adult mammalian hematopoietic tissues are capable of short-term, or restricted (10(2)- to 10(5)-fold), ex vivo expansion in the presence
Hikaru Yagi et al.
[Rinsho ketsueki] The Japanese journal of clinical hematology, 54(12), 2171-2176 (2014-01-24)
A 56-year-old male presented with pathological rib fracture and lumbago in 2006. He was diagnosed with multiple myeloma (IgG-lambda type, D&S stage IIIA, ISS 2). He was treated with VAD therapy and tandem auto-PBSCT, and achieved CR in 2007. He
Xiu-Fang Xin et al.
Molecular plant-microbe interactions : MPMI, 26(8), 861-867 (2013-07-03)
The pleiotropic drug resistance (PDR) proteins belong to the super-family of ATP-binding cassette (ABC) transporters. AtPDR8, also called PEN3, is required for penetration resistance of Arabidopsis to nonadapted powdery mildew fungi. During fungal infection, plasma-membrane-localized PEN3 is concentrated at fungal
Hyperkalemia: a clue to the diagnosis of adrenal insufficiency.
Daniel El Fassi et al.
Circulation, 128(24), 2620-2621 (2013-12-18)
Regina M Myers et al.
Cancer, 120(9), 1417-1425 (2014-01-30)
The authors prospectively assessed anxiety, depression, and behavior in children with standard-risk acute lymphoblastic leukemia (SR-ALL) during the first year of therapy and identified associated risk factors. A cohort study was performed of 159 children (aged 2 years-9.99 years) with
Florian A Britto et al.
American journal of physiology. Endocrinology and metabolism, 307(11), E983-E993 (2014-10-16)
REDD1 (regulated in development and DNA damage response 1) has been proposed to inhibit the mechanistic target of rapamycin complex 1 (mTORC1) during in vitro hypoxia. REDD1 expression is low under basal conditions but is highly increased in response to
Aline Fernanda de Souza et al.
Cells, 10(11) (2021-11-28)
Turner syndrome (TS) is a genetic disorder in females with X Chromosome monosomy associated with highly variable clinical features, including premature primary gonadal failure leading to ovarian dysfunction and infertility. The mechanism of development of primordial germ cells (PGCs) and
Laura C Gunder et al.
Biomedicines, 8(10) (2020-10-21)
Glucocorticoids promote muscle atrophy by inducing a class of proteins called atrogenes, resulting in reductions in muscle size and strength. In this work, we evaluated whether a mouse model with pre-existing diet-induced obesity had altered glucocorticoid responsiveness. We observed that
Yajun Chen et al.
American journal of physiology. Lung cellular and molecular physiology, 306(8), L797-L807 (2014-02-04)
Chronic airway diseases are characterized by inflammation and mucus overproduction. The MUC5AC mucin gene is upregulated by the proinflammatory cytokine interleukin-1 β (IL-1β) via activation of cAMP response element-binding protein (CREB) in the NCI-H292 cancer cell line and nuclear factor-κB
Chenming Yang et al.
Journal of biomedical nanotechnology, 9(9), 1617-1623 (2013-08-29)
The purpose of this research was to investigate the possibility of dexamethasone (DEX)-loaded PLGA-TPGS nanoparticles (NPs) in rabbits after intravitreal administration for the treatment of posterior segment diseases. The DEX-loaded PLGA-TPGS NPs were fabricated and characterized in terms of surface
A Oestmann et al.
Deutsche medizinische Wochenschrift (1946), 139(30), 1518-1520 (2014-07-30)
A 54-year old man had suffered from advanced multiple myeloma for two years. After initially good response the myeloma was refractrory to treatment with dexamethasone, cyclophosphamide, bortezomibe, zoledronate and additionally doxorubicine. The patient then complained of dyspnea without clinical signs
Behshad Pournasr et al.
European journal of cell biology, 94(12), 603-610 (2015-11-13)
Direct conversion by overexpression of defined transcription factors (TFs) is a promising new method that can generate desired cell types from abundant, accessible cells. While previous studies have reported hepatic generation from fibroblasts, tremendous interest exists in the understanding of
Sahar Biglari et al.
Advanced healthcare materials, 8(1), e1801307-e1801307 (2018-12-05)
Considerable progress has been made in the field of microfluidics to develop complex systems for modeling human skin and dermal wound healing processes. While microfluidic models have attempted to integrate multiple cell types and/or 3D culture systems, to date they
Pauline Pfänder et al.
Frontiers in immunology, 10, 1554-1554 (2019-07-30)
The suppression of activated pro-inflammatory macrophages during immune response has a major impact on the outcome of many inflammatory diseases including sepsis and rheumatoid arthritis. The pro- and anti-inflammatory functions of macrophages have been widely studied, whereas their regulation under
Q Heydt et al.
Nature communications, 12(1), 5507-5507 (2021-09-19)
The specific niche adaptations that facilitate primary disease and Acute Lymphoblastic Leukaemia (ALL) survival after induction chemotherapy remain unclear. Here, we show that Bone Marrow (BM) adipocytes dynamically evolve during ALL pathogenesis and therapy, transitioning from cellular depletion in the
Andrea Cerquone Perpetuini et al.
Journal of cachexia, sarcopenia and muscle, 9(4), 727-746 (2018-05-22)
Skeletal muscle is characterized by an efficient regeneration potential that is often impaired during myopathies. Understanding the molecular players involved in muscle homeostasis and regeneration could help to find new therapies against muscle degenerative disorders. Previous studies revealed that the
M Sanson et al.
Scientific reports, 10(1), 9139-9139 (2020-06-06)
Duchenne Muscular Dystrophy (DMD) is a lethal muscle disorder, caused by mutations in the DMD gene and affects approximately 1:5000-6000 male births. In this report, we identified dysregulation of members of the Dlk1-Dio3 miRNA cluster in muscle biopsies of the
Andrew D Gaudet et al.
Scientific reports, 6, 22862-22862 (2016-03-10)
Obesity is a growing epidemic in developed countries. Obese individuals are susceptible to comorbidities, including cardiovascular disease and metabolic disorder. Increasing the ability of adipose tissue to expend excess energy could improve protection from obesity. One promising target is microRNA
Acute migraine treatment in emergency settings.
Aaron Saguil et al.
American family physician, 89(9), 742-744 (2014-05-03)
Tia J Kowal et al.
Translational vision science & technology, 10(6), 10-10 (2021-06-11)
Steroid-induced glaucoma is a common form of secondary open angle glaucoma characterized by ocular hypertension (elevated intraocular pressure [IOP]) in response to prolonged glucocorticoid exposure. Elevated IOP occurs with increased outflow resistance and altered trabecular meshwork (TM) function. Recently, we
Tracey A Quinn et al.
The Journal of endocrinology, 221(2), 347-362 (2014-03-07)
Antenatal stress disturbs the development of the fetal hypothalamic-pituitary-adrenal axis and adrenal steroidogenesis. We investigated the effect of brief maternal exposure to high glucocorticoids (dexamethasone (DEX)) at mid- and late-pregnancy on adrenal structure and production of steroids in spiny mouse.
Lancelot Wehmeyer et al.
The Journal of biological chemistry, 289(14), 10235-10251 (2014-02-22)
Cross-talk between the glucocorticoid receptor (GR) and other receptors is emerging as a mechanism for fine-tuning cellular responses. We have previously shown that gonadotropin-releasing hormone (GnRH) ligand-independently activates the GR and synergistically modulates glucocorticoid-induced transcription of an endogenous gene in
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