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Meenakshi Rani et al.
Shock (Augusta, Ga.), 43(6), 589-597 (2015-02-19)
Trauma-hemorrhage (TH) promotes acute lung injury (ALI) and other pulmonary-related complications in part through an exaggerated inflammatory response. Studies have implicated γδ T cells in the development of inflammatory complications after major injury; however, it is unknown whether γδ T
Robert W Cho et al.
Stem cells (Dayton, Ohio), 26(2), 364-371 (2007-11-03)
In human breast cancers, a phenotypically distinct minority population of tumorigenic (TG) cancer cells (sometimes referred to as cancer stem cells) drives tumor growth when transplanted into immunodeficient mice. Our objective was to identify a mouse model of breast cancer
Goetz Parsiegla et al.
Biochemistry, 51(51), 10250-10258 (2012-12-12)
Recombinant human DNase I (Pulmozyme, dornase alfa) is used for the treatment of cystic fibrosis where it improves lung function and reduces the number of exacerbations. The physiological mechanism of action is thought to involve the reduction of the viscoelasticity
Clément Lafon-Placette et al.
The New phytologist, 197(2), 416-430 (2012-12-21)
DNA methylation is involved in the control of plant development and adaptation to the environment through modifications of chromatin compaction and gene expression. In poplar (Populus trichocarpa), a perennial plant, variations in DNA methylation have been reported between genotypes and
Marcelo B de Jesus et al.
Journal of biomedical nanotechnology, 10(2), 355-365 (2014-04-18)
Solid lipid nanoparticles (SLNs) are a promising system for the delivery of lipophilic and hydrophilic drugs. They consist of a solid lipid core that is stabilized by a layer of surfactants. By the incorporation of cationic lipids in the formulation
A Benard et al.
British journal of cancer, 109(12), 3073-3083 (2013-11-14)
We evaluated the clinical prognostic value of methylation of two non-coding repeat sequences, long interspersed element 1 (LINE-1) and Alu, in rectal tumour tissues. In addition to DNA methylation, expression of histone modifications H3K27me3 and H3K9Ac was studied in this
Johanna Finn et al.
Cell reports, 26(11), 2942-2954 (2019-03-14)
Lung alveolar type I cells (AT1) and alveolar type II cells (AT2) regulate the structural integrity and function of alveoli. AT1, covering ∼95% of the surface area, are responsible for gas exchange, whereas AT2 serve multiple functions, including alveolar repair
Beatrice Dyring-Andersen et al.
Nature communications, 11(1), 5587-5587 (2020-11-07)
Human skin provides both physical integrity and immunological protection from the external environment using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically
Asaf Sol et al.
PloS one, 7(11), e50078-e50078 (2012-11-29)
Actin exists as a monomer (G-actin) which can be polymerized to filaments) F-actin) that under the influence of actin-binding proteins and polycations bundle and contribute to the formation of the cytoskeleton. Bundled actin from lysed cells increases the viscosity of
T Liao
The Journal of biological chemistry, 250(10), 3831-3836 (1975-05-25)
In the course of experiments on the role of the COOH-terminal residues in pancreatic deoxyribonuclease, we undertook to ascertain whether the presence of sodium dodecyl sulfate would render the normally unavailable terminus susceptible to hydrolysis by carboxypeptidase A. When DNase
Bisphenol A and benzophenone-3 exposure alters milk protein expression and its transcriptional regulation during functional differentiation of the mammary gland in vitro.
Altamirano, et al.
Environmental Research, 191, 110185-110185 (2021)
Lepakshi Ranjha et al.
The Journal of biological chemistry, 289(9), 5674-5686 (2014-01-21)
MutLγ, a heterodimer of the MutL homologues Mlh1 and Mlh3, plays a critical role during meiotic homologous recombination. The meiotic function of Mlh3 is fully dependent on the integrity of a putative nuclease motif DQHAX2EX4E, inferring that the anticipated nuclease
Liudmila M Tsybalova et al.
PloS one, 13(8), e0201429-e0201429 (2018-08-24)
Influenza infection could be more effectively controlled if a multi-purpose vaccine with the ability to induce responses against most, or all, influenza A subtypes could be generated. Conserved viral proteins are a promising basis for the creation of a broadly
Daniela De Stefano et al.
Autophagy, 10(11), 2053-2074 (2014-10-29)
Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures rescue the functional expression of the most frequent
Sambrook, J., and Russell, D.W
Molecular Cloning: A Laboratory Manual, 2(2), 5-5 null
Amritha Varshini Hanasoge Somasundara et al.
Cell reports, 37(10), 110099-110099 (2021-12-09)
Pregnancy reprograms mammary epithelial cells (MECs) to control their responses to pregnancy hormone re-exposure and carcinoma progression. However, the influence of pregnancy on the mammary microenvironment is less clear. Here, we used single-cell RNA sequencing to profile the composition of
Anna Ligasová et al.
PloS one, 7(12), e52584-e52584 (2013-01-10)
A new method of the light microscopy detection of BrdU-labeled DNA in situ is described. It is based on the oxidative attack at the deoxyribose moiety by copper(I) in the presence of oxygen, which leads to the abstraction of hydrogen
Adrienne Wright et al.
Stem cells and development, 29(11), 695-713 (2020-03-10)
Mesenchymal stromal cells (MSCs) hold great promise in the field of regenerative medicine due to their ability to create a variable localized anti-inflammatory effect in injuries such as Crohn's disease and osteoarthritis or by incorporation in tissue engineered constructs. Currently
Rika Kitazume-Taneike et al.
Biochemical and biophysical research communications, 515(3), 442-447 (2019-06-05)
In myocardial ischemia/reperfusion injury, the innate immune and subsequent inflammatory responses play a crucial role in the extension of myocardial damage. Toll-like receptor 9 (TLR9) is a critical receptor for recognizing unmethylated CpG motifs that mitochondria contain in their DNA
Laurence Colin et al.
Methods in molecular biology (Clifton, N.J.), 1087, 85-101 (2013-10-26)
Upon integration into the host cell genome, the nucleosomal organization and epigenetic control of the HIV-1 provirus play an active role in its transcriptional regulation. Therefore, characterization of the chromatin changes that occur in the viral promoter region in response
J Mauro Calabrese et al.
Cell, 151(5), 951-963 (2012-11-28)
The inactive X chromosome's (Xi) physical territory is microscopically devoid of transcriptional hallmarks and enriched in silencing-associated modifications. How these microscopic signatures relate to specific Xi sequences is unknown. Therefore, we profiled Xi gene expression and chromatin states at high
Clemens Grimm et al.
Acta crystallographica. Section D, Biological crystallography, 66(Pt 6), 685-697 (2010-06-03)
Most commercially available crystallization screens are sparse-matrix screens with a predominance of inorganic salts and polyethylene glycols (PEGs) as precipitants. It was noted that commercially available screens are largely unsatisfactory for the purpose of the crystallization of multimeric protein and
Nicolás Toro et al.
PloS one, 8(1), e55102-e55102 (2013-01-29)
Group II introns are self-splicing RNAs that act as mobile retroelements in the organelles of plants, fungi and protists. They are also widely distributed in bacteria, and are generally assumed to be the ancestors of nuclear spliceosomal introns. Most bacterial
Housheng Hansen He et al.
Nature methods, 11(1), 73-78 (2013-12-10)
Sequencing of DNase I hypersensitive sites (DNase-seq) is a powerful technique for identifying cis-regulatory elements across the genome. We studied the key experimental parameters to optimize performance of DNase-seq. Sequencing short fragments of 50-100 base pairs (bp) that accumulate in
Christopher J Folts et al.
PLoS biology, 14(12), e1002583-e1002583 (2016-12-16)
Neurodegenerative lysosomal storage disorders (LSDs) are severe and untreatable, and mechanisms underlying cellular dysfunction are poorly understood. We found that toxic lipids relevant to three different LSDs disrupt multiple lysosomal and other cellular functions. Unbiased drug discovery revealed several structurally
Liping Huang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(6), e21555-e21555 (2021-05-29)
Preeclampsia (PE) is a life-threatening disease of pregnant women associated with severe hypertension, proteinuria, or multi-organ injuries. Mitochondrial-mediated placental oxidative stress plays a key role in the pathogenesis of PE. However, the underlying mechanism remains to be revealed. Here, we
Mayra Paolillo et al.
International journal of oncology, 53(6), 2683-2694 (2018-10-04)
The malignancy of glioblastoma (GB) is primarily due to the ability of glioma cancer stem cells (GSC) to disseminate into surrounding brain tissues, despite surgery and chemotherapy, and to form new tumoral masses. Members of the RGD-binding integrin family, which recognize the
Berta Terré et al.
Development (Cambridge, England), 146(8) (2019-04-03)
GEMC1 and MCIDAS are geminin family proteins that transcriptionally activate E2F4/5-target genes during multiciliogenesis, including Foxj 1 and Ccno Male mice that lacked Gemc1, Mcidas or Ccno were found to be infertile, but the origin of this defect has remained
Mengying Wei et al.
EBioMedicine, 61, 103068-103068 (2020-10-26)
Paracellular barriers play an important role in the pathogenesis of Inflammatory bowel disease (IBD) and maintain gut homeostasis. N-myc downstream-regulated gene 2 (NDRG2) has been reported to be a tumour suppressor gene and to inhibit colorectal cancer metastasis. However, whether
Manish Shukla et al.
PloS one, 7(12), e51913-e51913 (2013-01-04)
UVI31+ is an evolutionarily conserved BolA family protein. In this study we examine the presence, localization and possible functions of this protein in the context of a unicellular alga, Chlamydomonas reinhardtii. UVI31+ in C. reinhardtii exhibits DNA endonuclease activity and
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