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Yan-Yan Wu et al.
Journal of economic entomology, 108(4), 1486-1494 (2015-10-16)
Honey bees are at an unavoidable risk of exposure to neonicotinoid pesticides, which are used worldwide. Compared with the well-studied roles of these pesticides in nontarget site (including midgut, ovary, or salivary glands), little has been reported in the target
Sherri M Biendarra-Tiegs et al.
Stem cells and development, 29(2), 75-89 (2019-11-21)
The functional maturation status of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) has a notable impact upon their use in pharmacological studies, disease modeling, and therapeutic applications. Non-cardiomyocytes (non-CMs) produced in the differentiation process have previously been identified as having
Lipin Loo et al.
Nature communications, 10(1), 134-134 (2019-01-13)
The development of the mammalian cerebral cortex depends on careful orchestration of proliferation, maturation, and migration events, ultimately giving rise to a wide variety of neuronal and non-neuronal cell types. To better understand cellular and molecular processes that unfold during
Baptiste Guey et al.
Frontiers in oncology, 10, 1683-1683 (2020-10-13)
Inflammasomes are molecular complexes that trigger an inflammatory response upon detection of pathogens or danger signals. Recent studies suggest that they are also involved in cancer progression. However, their roles during tumorigenesis remain poorly understood and controversial. Here, we investigated
Julien Gros et al.
The EMBO journal, 33(6), 621-636 (2014-02-26)
The separation of DNA replication origin licensing and activation in the cell cycle is essential for genome stability across generations in eukaryotic cells. Pre-replicative complexes (pre-RCs) license origins by loading Mcm2-7 complexes in inactive form around DNA. During origin firing
Martin Grimm et al.
BMC cancer, 13, 569-569 (2013-12-07)
Biomarkers allowing the characterization of malignancy and therapy response of oral squamous cell carcinomas (OSCC) or other types of carcinomas are still outstanding. The biochemical suicide molecule endonuclease DNaseX (DNaseI-like 1) has been used to identify the Apo10 protein epitope
Andrew B Stergachis et al.
Science (New York, N.Y.), 342(6164), 1367-1372 (2013-12-18)
Genomes contain both a genetic code specifying amino acids and a regulatory code specifying transcription factor (TF) recognition sequences. We used genomic deoxyribonuclease I footprinting to map nucleotide resolution TF occupancy across the human exome in 81 diverse cell types.
Maria V Rogacheva et al.
The Journal of biological chemistry, 289(9), 5664-5673 (2014-01-10)
Crossing over between homologous chromosomes is initiated in meiotic prophase in most sexually reproducing organisms by the appearance of programmed double strand breaks throughout the genome. In Saccharomyces cerevisiae the double-strand breaks are resected to form three prime single-strand tails
Lei Chen et al.
Nature genetics, 51(5), 777-785 (2019-04-17)
BMP/SMAD signaling is a crucial regulator of intestinal differentiation1-4. However, the molecular underpinnings of the BMP pathway in this context are unknown. Here, we characterize the mechanism by which BMP/SMAD signaling drives enterocyte differentiation. We establish that the transcription factor
Mina M Tayari et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 27(7), 1893-1903 (2021-01-27)
In preclinical studies, the lysine-specific histone demethylase 1A (LSD1) inhibitor tranylcypromine (TCP) combined with all-trans retinoic acid (ATRA) induces differentiation and impairs survival of myeloid blasts in non-acute promyelocytic leukemia acute myeloid leukemia (AML). We conducted a phase I clinical
Yougui Xiang et al.
Journal of immunology (Baltimore, Md. : 1950), 190(4), 1819-1826 (2013-01-09)
The processes of Ig gene locus contraction and looping during V(D)J-recombination are essential for creating a diverse Ab repertoire. However, no cis-acting sequence that plays a major role in specifying locus contraction has been uncovered within the Igκ gene locus.
Ilaria Cavallari et al.
Methods in molecular biology (Clifton, N.J.), 1087, 325-337 (2013-10-26)
Like other complex retroviruses such as HIV-1, HTLV-1 encodes several regulatory and auxiliary non-structural proteins from overlapping open reading frames through the generation of alternatively spliced mRNAs. HTLV-1 expression is orchestrated by the Tax and Rex regulatory proteins; Tax drives
Juliana Valencia-Serna et al.
Journal of controlled release : official journal of the Controlled Release Society, 310, 141-154 (2019-08-21)
Despite development of effective tyrosine kinase inhibitors for treatment of chronic myeloid leukemia (CML), some patients do not effectively respond to the therapy and can display resistance in response to the drug therapy. To develop an alternative approach to CML
Snehal Sonawane et al.
Investigative ophthalmology & visual science, 53(13), 8253-8263 (2012-11-22)
We determined whether nucleases are deficient in the tear fluid of dry eye disease (DED) patients, and whether this causes extracellular DNA (eDNA) and neutrophil extracellular trap (NET) accumulation in the precorneal tear film, thus causing ocular surface inflammation. Exfoliated
A Iu Konev et al.
Tsitologiia, 55(3), 198-203 (2013-06-26)
This article presents an analysis of the causes of chromatin decompaction of interbands in Drosophila polytene chromosomes. On the example of interband 3C6/C7 of X chromosome, we investigate the ability of different DNA segments from the region to form an
Daniel J Gaffney et al.
PLoS genetics, 8(11), e1003036-e1003036 (2012-11-21)
Nucleosomes are important for gene regulation because their arrangement on the genome can control which proteins bind to DNA. Currently, few human nucleosomes are thought to be consistently positioned across cells; however, this has been difficult to assess due to
Xuhua Ge et al.
Journal of the American Society of Nephrology : JASN, 31(10), 2372-2391 (2020-08-02)
Maintenance of the intricate interdigitating morphology of podocytes is crucial for glomerular filtration. One of the key aspects of specialized podocyte morphology is the segregation and organization of distinct cytoskeletal filaments into different subcellular components, for which the exact mechanisms
Stability of DNase I in footprinting experiments.
B Ward et al.
Nucleic acids research, 16(17), 8724-8724 (1988-09-12)
[NETs in pathogenesis of vasculitis].
Daigo Nakazawa et al.
Nihon Jinzo Gakkai shi, 56(2), 117-123 (2014-04-16)
Daniel Engelbertsen et al.
Scientific reports, 9(1), 10608-10608 (2019-07-25)
CD47, also known as integrin-associated protein (IAP), is a transmembrane protein with multiple biological functions including regulation of efferocytosis and leukocyte trafficking. In this study we investigated the effect of CD47-deficiency on atherosclerosis using a model of adeno-associated virus (AAV)-induced
Troels T Marstrand et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(6), E645-E654 (2014-01-29)
A problem of substantial interest is to systematically map variation in chromatin structure to gene-expression regulation across conditions, environments, or differentiated cell types. We developed and applied a quantitative framework for determining the existence, strength, and type of relationship between
Allan Lazarovici et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6376-6381 (2013-04-12)
DNA binding proteins find their cognate sequences within genomic DNA through recognition of specific chemical and structural features. Here we demonstrate that high-resolution DNase I cleavage profiles can provide detailed information about the shape and chemical modification status of genomic
Sicong Li et al.
The Journal of biological chemistry, 289(11), 7825-7834 (2014-02-07)
ARTEMIS is a member of the metallo-β-lactamase protein family. ARTEMIS has endonuclease activity at DNA hairpins and at 5'- and 3'-DNA overhangs of duplex DNA, and this endonucleolytic activity is dependent upon DNA-PKcs. There has been uncertainty about whether ARTEMIS
Piotr Siupka et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(7), 2598-2613 (2017-03-25)
Brain capillary endothelium mediates the exchange of nutrients between blood and brain parenchyma. This barrier function of the brain capillaries also limits passage of pharmaceuticals from blood to brain, which hinders treatment of several neurological disorders. Receptor-mediated transport has been
Sapna Tibrewal et al.
Investigative ophthalmology & visual science, 54(13), 8051-8061 (2013-11-21)
To determine the abundance of extracellular DNA (eDNA) in tear fluid of patients with dry eye disease (DED) and to report clinical outcomes after DNase I eyedrops use to reduce excessive tear fluid eDNA. Tear fluid was collected from healthy
Caitlin C Murdoch et al.
PLoS pathogens, 15(3), e1007381-e1007381 (2019-03-08)
The intestinal microbiota influences the development and function of myeloid lineages such as neutrophils, but the underlying molecular mechanisms are unresolved. Using gnotobiotic zebrafish, we identified the immune effector Serum amyloid A (Saa) as one of the most highly induced
Femke Stephan et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(3), 686-693 (2014-02-28)
Removal of dead cells is essential in the maintenance of tissue homeostasis, and efficient removal prevents exposure of intracellular content to the immune system, which could lead to autoimmunity. The plasma protease factor VII-activating protease (FSAP) can release nucleosomes from
Teerawat Wiwatpanit et al.
The Journal of clinical endocrinology and metabolism, 105(3) (2019-10-16)
Polycystic ovary syndrome (PCOS) is a prevalent disorder in reproductive aged women associated with a number of endocrine and metabolic complications, including increased risk of endometrial cancer. To study the effect of the characteristic increased androgen levels in PCOS on
Isoelectric focusing of multiple forms of DNase in thin layers of polyacrylamide gel and detection of enzymatic activity with a zymogram method following separation.
H S Kim et al.
Analytical biochemistry, 119(1), 96-101 (1982-01-01)
Adam M Chaker et al.
International archives of allergy and immunology, 176(1), 15-25 (2018-04-16)
Allergic upper airway disease involves pro-inflammatory type-2 cytokines such as IL-5 and regulatory tissue repair mediators, in particular transforming growth factor (TGF)-β1. The TGF-β-superfamily member activin-A displays multiple biological functions and shares certain signalling pathways with TGF-β1. We aimed to
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