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Liang Chen et al.
Journal of hazardous materials, 286, 624-631 (2015-02-11)
Fluorides negatively affect the development of organisms and are a threat to human health and environmental safety. In this study, Bombyx mori N cell line (BmN) were used to explore effects of NaF on insect cells. We found that 8h...
Katarzyna Kaczyńska et al.
Neuropeptides, 54, 29-34 (2015-09-08)
The study investigated the share of vagal input at infra- and supra-nodosal level and the contribution of CCK1 and CCK2 receptors to the cardiorespiratory responses produced by an intravenous injection of sulfated cholecystokinin octapeptide (CCK-8) in anesthetized rats. This compound...
María C Blanco et al.
European journal of medicinal chemistry, 86, 291-309 (2014-09-01)
New series of polysubstituted (2SR,4RS)-2-heteroaryltetrahydro-1,4-epoxy-1-benzazepines and cis-2-heteroaryl-4-hydroxytetrahydro-1H-1-benzazepines were designed and synthesized in moderate to high yields using a three-step procedure from ortho-allylanilines. Their antiparasitic activity was evaluated against the extracellular and intracellular forms of Trypanosoma cruzi and Leishmania (Leishmania) infantum...
Nitira Anakkul et al.
Theriogenology, 82(8), 1137-1144 (2014-09-02)
Generally, laparoscopic artificial insemination (LAI) provides a higher success rate than of cervical insemination in goats. However, the sperm distribution after LAI in goats remains unknown, particularly when frozen-thawed semen is used. This study evaluated the distribution of frozen-thawed goat...
Isabel Meister et al.
Antimicrobial agents and chemotherapy, 58(9), 5466-5472 (2014-07-02)
A racemic mixture of R and S enantiomers of praziquantel (PZQ) is currently the treatment of choice for schistosomiasis. Though the S enantiomer and the metabolites are presumed to contribute only a little to the activity of the drug, in-depth...
Elise Ivarsen et al.
Journal of AOAC International, 97(5), 1282-1290 (2015-04-24)
Clostridium perfringens is the causative agent of necrotic enteritis leading to significant losses in the poultry industry. Dichloromethane and n-hexane extracts of aerial parts of Artemisia annua (Asteraceae) exhibited activity against C. perfringens with minimum inhibitory concentrations (MIC) of 185...
M A Caporizzo et al.
Langmuir : the ACS journal of surfaces and colloids, 31(10), 3027-3038 (2015-02-18)
This study systematically investigates how polymer composition changes nanoparticle (NP) grafting and diffusion in solvated random copolymer thin films. By thermal annealing from 135 to 200 °C, thin films with a range of hydrophobicity are generated by varying acrylic acid...
A S Garanina et al.
Biochemistry. Biokhimiia, 80(11), 1469-1477 (2015-11-30)
Entosis is a type of cell cannibalism during which one cell penetrates into another cell and usually dies inside it. Researchers mainly pay attention to initial and final stages of entosis. Besides, tumor cells in suspension are the primary object...
Rui Shi et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 24(11), 2411-2424 (2015-08-01)
The potential of stem cell niches (SCNs) in the intervertebral disc (IVD) region, which may be of great significance in the regeneration process, was recently proposed. To the best of our knowledge, no previous in vitro study has examined the...
Aleta Pupovac et al.
Immunology and cell biology, 93(1), 77-85 (2014-08-27)
Activation of the P2X7 receptor by the extracellular damage-associated molecular pattern, adenosine 5'-triphosphate (ATP), induces the shedding of cell surface molecules including the low-affinity IgE receptor, CD23, from human leukocytes. A disintegrin and metalloprotease (ADAM) 10 mediates P2X7-induced shedding of...
Fan Li et al.
International journal of biological macromolecules, 72, 664-672 (2014-09-02)
The crude polysaccharides of Dendrobium huoshanense were fractionated by anion-exchange chromatography and gel permeation chromatography, giving one homogeneous fraction DHP-4A with molecular weight of 2.32 × 10(5)Da. UV spectrum indicated that there was no existence of proteins and nucleic acids...
Rishabh Agarwal et al.
ACS chemical neuroscience, 6(3), 494-504 (2015-02-18)
Luminescent semiconductor ∼9.5 nm nanoparticles (quantum dots: QDs) have intrinsic physiochemical and optical properties which enable us to begin to understand the mechanisms of nanoparticle mediated chemical/drug delivery. Here, we demonstrate the ability of CdSe/ZnS core/shell QDs surface functionalized with...
Louise Pallant et al.
Parasites & vectors, 8, 2-2 (2015-01-07)
Giardia is now considered the most common enteric parasite in well cared for dogs and cats in developed countries. The ecology, epidemiology and clinical impact of infections with this parasite in such animals is still not fully understood due to...
Yuki Kondo et al.
Drug metabolism and pharmacokinetics, 29(3), 237-243 (2013-12-18)
The use of human induced pluripotent stem (iPS) cells would be of great value for a variety of applications involving drug development studies. Several reports have been published on the differentiation of human iPS cells into hepatocyte-like cells; however, the...
Robert M Sharkey et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(22), 5131-5138 (2015-06-25)
This study examined the delivery of SN-38 to Trop-2-expressing tumors and assessed the constitutive products in the serum, liver, and small intestine in nude mice bearing human tumor xenografts (Capan-1 or NCI-N87) given a single injection of irinotecan (40 mg/kg;...
Elżbieta A Trafny et al.
International journal of medical microbiology : IJMM, 304(5-6), 554-564 (2014-04-29)
Haemophilus influenzae is one of the major pathogenic bacteria in upper respiratory tract of children. In this study, the presence of various H. influenzae genotypes were followed-up for at least 13 weeks, starting from one week before surgery. Forty-one children...
Jiaojiao Zhang et al.
Mechanisms of development, 138 Pt 3, 328-335 (2015-08-08)
The zebrafish pronephric tubule consists of proximal and distal segments and a collecting duct. The proximal segment is subdivided into the neck, proximal convoluted tubule (PCT) and proximal straight tubule (PST) segments. The distal segment consists of the distal-early (DE)...
Rajaneesh Karimpurath Gopinath et al.
Genome biology and evolution, 6(10), 2851-2865 (2014-10-16)
Hsp90 is one of the most abundant and conserved proteins in the cell. Reduced levels or activity of Hsp90 causes defects in many cellular processes and also reveals genetic and nongenetic variation within a population. Despite information about Hsp90 protein-protein...
Z Najafi et al.
Cancer gene therapy, 22(11), 530-535 (2015-10-03)
MicroRNAs (miRNAs) are small non-coding RNAs, 18-25 nucleotides long and have an important role in post-transcriptional regulation of gene. Several aspects of cellular activities such as cell growth, proliferation and differentiation are regulated by miRNAs. In many cancers and malignancies...
M Navarra et al.
Fitoterapia, 95, 83-92 (2014-03-07)
Neuroblastoma is the most common extracranial pediatric solid tumor with poor prognosis in children with disseminated stage of disease. A number of studies show that molecules largely distributed in commonly consumed fruits and vegetables may have anti-tumor activity. In this...
Huiyuan Wang et al.
Molecular pharmaceutics, 11(10), 3352-3360 (2014-08-01)
Drug resistance becomes a formidable challenge against effective cancer therapy. Defective apoptosis in cancer cells is a key factor responsible for chemoresistance or radioresistance. Promoting apoptosis is an important method to sensitize the resistant cells, thereby achieving successful treatment for...
Daimel Castillo-González et al.
Journal of chemical information and modeling, 55(10), 2094-2110 (2015-09-12)
Telomeres and telomerase are key players in tumorogenesis. Among the various strategies proposed for telomerase inhibition or telomere uncapping, the stabilization of telomeric G-quadruplex (G4) structures is a very promising one. Additionally, G4 stabilizing ligands also act over tumors mediated...
Bert E Stromberg et al.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 79(4), 290-295 (2015-10-02)
During the United States Department of Agriculture (USDA) National Animal Health Monitoring System's (NAHMS) 2007-2008 beef study, 567 producers from 24 US States were offered the opportunity to collect fecal samples from weaned beef calves and have them evaluated for...
Antoine Larrieu et al.
Nature communications, 6, 6043-6043 (2015-01-17)
Activated forms of jasmonic acid (JA) are central signals coordinating plant responses to stresses, yet tools to analyse their spatial and temporal distribution are lacking. Here we describe a JA perception biosensor termed Jas9-VENUS that allows the quantification of dynamic...
Jiwei Ma et al.
Journal of molecular neuroscience : MN, 57(4), 546-553 (2015-08-10)
Asymmetric dimethylarginine (ADMA) is emerging as a key contributor to endothelial dysfunction. The drug probucol was reported to have an anti-lipid peroxidation effect and improve endothelial dilation function. But little is known about the protective effect of probucol on ADMA-induced...
Kaiwen Chang et al.
Small (Weinheim an der Bergstrasse, Germany), 10(21), 4270-4275 (2014-07-23)
Stable full-color fluorescence patterning are achieved by multicolor polymer-dot inks. The fluorescent patterns show extraordinary stability upon various treatments, offering a superior combination of bright fluorescence, excellent photostability, chemical resistance, and eco-friendship.
Olatz Arteaga et al.
PloS one, 10(11), e0142424-e0142424 (2015-11-07)
Despite advances in neonatal care, hypoxic-ischemic brain injury is still a serious clinical problem, which is responsible for many cases of perinatal mortality, cerebral palsy, motor impairment and cognitive deficits. Resveratrol, a natural polyphenol with important anti-oxidant and anti-inflammatory properties...
Jie Zhang et al.
PloS one, 9(9), e107478-e107478 (2014-09-13)
To interrogate why redox homeostasis and glutathione S-transferase P (GSTP) are important in regulating bone marrow cell proliferation and migration, we isolated crude bone marrow, lineage negative and bone marrow derived-dendritic cells (BMDDCs) from both wild type (WT) and knockout...
Sunghee Kim et al.
BMC complementary and alternative medicine, 14, 231-231 (2014-07-10)
Excessive pro-inflammatory cytokine production from activated microglia contributes to neurodegenerative diseases, thus, microglial inactivation may delay the progress of neurodegeneration by attenuating the neuroinflammation. Among 5 selected brown algae, we found the highest antioxidant and anti-neuroinflammatory activities from Myagropsis myagroides...
Jie Lan et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3577-3589 (2014-08-26)
Latently HIV-1-infected cells are recognized as the last barrier toward viral eradication and cure. To purge these cells, we combined a provirus stimulant with a blocker of human CD59, a key member of the regulators of complement activation, to trigger...
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