Showing 1-30 of 40 results for "D5941"
Fantao Meng et al.
Analytical biochemistry, 521, 11-19 (2017-01-11)
The role of hemoglobin (Hb) redox forms in tissue and organ toxicities remain ambiguous despite the well-documented contribution of Hb redox reactivity to cellular and subcellular oxidative changes. Moreover, several recent studies, in which Hb toxicity were investigated, have shown...
Zahra Kadri et al.
Genes & development, 29(24), 2603-2616 (2015-12-19)
Tight coordination of cell proliferation and differentiation is central to red blood cell formation. Erythropoietin controls the proliferation and survival of red blood cell precursors, while variations in GATA-1/FOG-1 complex composition and concentrations drive their maturation. However, clear evidence of...
Johanna O Zeitz et al.
Poultry science, 99(12), 6837-6847 (2020-11-30)
Exposure to high ambient temperature has been shown to impair growth performance and to cause oxidative stress in broilers. This study investigated the hypothesis that supplementation with methionine (Met) as DL-Met (DLM) more than the National Research Council recommendations improves...
Mira Abou-Diab et al.
Membranes, 10(10) (2020-10-01)
Neokyotorphin (α137-141) is recognized as an antimicrobial peptide and a natural meat preservative. It is produced by conventional enzymatic hydrolysis of bovine hemoglobin, a major component of cruor, a by-product of slaughterhouses. However, during conventional hydrolysis, chemical agents are necessary...
Adriana Albini et al.
Journal of translational medicine, 7, 5-5 (2009-01-16)
Angiostatin, an endogenous angiogenesis inhibitor, is a fragment of plasminogen. Its anti-angiogenic activity was discovered with functional assays in vivo, however, its direct action on endothelial cells is moderate and identification of definitive mechanisms of action has been elusive to...
Kirstin H Webster et al.
Ecotoxicology (London, England), 24(5), 1087-1101 (2015-04-02)
Based on detection of hepatic residues, scavenging and predatory non-target raptors are widely exposed to second generation anticoagulant rodenticides (SGARs). A small proportion, generally <10%, of tested birds are diagnosed as acutely poisoned. Little is known, however, of sub-lethal effects...
Jacelyn J Shu et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 188(3), 409-419 (2017-12-09)
Recent findings indicate that some teleost fishes may be able to greatly enhance hemoglobin-oxygen (Hb-O2) unloading at the tissues under conditions that result in catecholamine release. The putative mechanism relies on the high pH sensitivity of teleost hemoglobin (Hb), intracellular...
Francesca Margheri et al.
Neoplasia (New York, N.Y.), 11(10), 1106-1115 (2009-10-02)
We have previously shown that endothelial cell matrix metalloprotease 12 (MMP12) and pentraxin 3 (PTX3) overproduction is the main alteration accounting for reduced proneness to angiogenesis in systemic sclerosis (SSc). On this basis, we stably transfected MMP12 and PTX3 in...
Dong Xu et al.
Cancer biology & therapy, 21(4), 354-363 (2020-01-08)
Background: Transmembrane-4-L-six-family-1 (TM4SF1) functions to regulate cell growth and mobility and TM4SF1 expression was upregulated in pancreatic cancer. This study further investigated the role of TM4SF1 in regulating pancreatic cancer epithelial-mesenchymal transition (EMT) and angiogenesis and the underlying molecular events.Methods:...
Comparative study of hemoglobin estimated by Drabkin's and Sahli's methods.
Balasubramaniam P and Malathi A
Journal of Postgraduate Medicine, 38(1), 8-8 (1992)
B Gabriela Arango et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 191(1), 185-194 (2020-10-17)
Sea turtles dive with a full lung of air and these O2 stores are supplemented by O2 stored in blood and muscle. Olive ridley sea turtles exhibit polymorphic nesting behavior, mass nesting behavior called arribada, where thousands of turtles will...
Tai Lu et al.
Journal of neurochemistry, 148(1), 114-126 (2018-11-01)
Blood brain barrier (BBB) disruption is an important contributor to brain edema and neurological deficits following intracerebral hemorrhage (ICH). Macrophage stimulating protein (MSP) is a hepatocyte growth factor-like protein that mediates its functions via activating receptor tyrosine kinase recepteur d'origine...
Rodrigo Diéguez-Hurtado et al.
Nature communications, 10(1), 2817-2817 (2019-06-30)
Sufficient vascular supply is indispensable for brain development and function, whereas dysfunctional blood vessels are associated with human diseases such as vascular malformations, stroke or neurodegeneration. Pericytes are capillary-associated mesenchymal cells that limit vascular permeability and protect the brain by...
Xuanhui Liu et al.
Acta neuropathologica communications, 8(1), 16-16 (2020-02-16)
Subdural haematomas (SDHs) are characterized by rapidly or gradually accumulated haematomas between the arachnoid and dura mater. The mechanism of haematoma clearance has not been clearly elucidated until now. The meningeal lymphatic vessel (mLV) drainage pathway is a novel system...
Isabelle Jubinville et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 247, 110742-110742 (2020-06-15)
When successive stages of an organism's life-history overlap, conflicts and trade-offs can emerge due to competition among physiological pathways. For example, long periods of sustained locomotion in migrating birds are supported by the androgenic up-regulation of aerobic factors, such as...
Jacob L Johansen et al.
eLife, 10 (2021-01-27)
As climate-driven heat waves become more frequent and intense, there is increasing urgency to understand how thermally sensitive species are responding. Acute heating events lasting days to months may elicit acclimation responses to improve performance and survival. However, the coordination...
Isabelle Ernens et al.
Journal of molecular and cellular cardiology, 121, 223-232 (2018-07-17)
New therapeutic approaches are needed to fight against the growing epidemic of heart failure. Unlike mammals, zebrafish possess the incredible ability to regenerate cardiac tissue after acute trauma such as apical resection. Yet, the ability of zebrafish to recover after...
Dilmurodjon Eshmuminov et al.
Nature biotechnology, 38(2), 189-198 (2020-01-15)
The ability to preserve metabolically active livers ex vivo for 1 week or more could allow repair of poor-quality livers that would otherwise be declined for transplantation. Current approaches for normothermic perfusion can preserve human livers for only 24 h. Here...
Toxic effects of silver nanoparticles and nanowires on erythrocyte rheology
Kim MJ and Shin S
Food And Chemical Toxicology, 67(6), 80-86 (2014)
Drabkin, D.L., Austin, J.H.
The Journal of Biological Chemistry, 112, 51-51 (1935)
Kang Nian Yap et al.
The Journal of experimental biology, 220(Pt 22), 4282-4291 (2017-09-28)
Foraging to obtain food, either for self-maintenance or at presumably elevated rates to provide for offspring, is thought to be an energetically demanding activity but one that is essential for fitness (higher reproductive success and survival). Nevertheless, the physiological mechanisms...
Comparative measuring between fresh and stored Drabkin's reagent preparations on hemoglobin estimation
Madani N, et al.
Sudan Medical Monitor, 10(1), 7-7 (2015)
Bo Chen et al.
Translational stroke research, 10(1), 91-103 (2018-03-24)
The transient receptor potential melastatin 4 (TRPM4) channel has been suggested to play a key role in the treatment of ischemic stroke. However, in vivo evaluation of TRPM4 channel, in particular by direct channel suppression, is lacking. In this study...
Morten Lund et al.
PloS one, 12(7), e0181109-e0181109 (2017-07-13)
Heart and skeletal muscle inflammation (HSMI) is associated with Piscine orthoreovirus (PRV) infection and is an important disease in Atlantic salmon (Salmo salar) aquaculture. Since PRV infects erythrocytes and farmed salmon frequently experience environmental hypoxia, the current study examined mutual...
Juan M Inclan-Rico et al.
PLoS pathogens, 16(5), e1008579-e1008579 (2020-05-19)
Anti-helminth responses require robust type 2 cytokine production that simultaneously promotes worm expulsion and initiates the resolution of helminth-induced wounds and hemorrhaging. However, how infection-induced changes in hematopoiesis contribute to these seemingly distinct processes remains unknown. Recent studies have suggested...
Joo Eun Jung et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(10), 2154-2165 (2020-01-26)
Astrocytes are an integral component of the neurovascular unit where they act as homeostatic regulators, especially after brain injuries, such as stroke. One process by which astrocytes modulate homeostasis is the release of functional mitochondria (Mt) that are taken up...
Laura Kouyoumdjian et al.
The Journal of experimental biology, 222(Pt 14) (2019-06-27)
Increased global temperatures have opened previously inhospitable habitats, such as at higher elevations. However, the reduction of oxygen partial pressure with increase in elevation represents an important physiological constraint that may limit colonization of such habitats, even if the thermal...
Non-invasive multimodality imaging directly shows TRPM4 inhibition ameliorates stroke reperfusion injury
Chen B, et al.
Translational Stroke Research, 1-13 (2018)
Anna Badner et al.
Journal of neurotrauma, 36(15), 2298-2307 (2019-03-08)
Although the majority of traumatic spinal cord injuries (SCIs) take place at the cervical level, pre-clinical studies have been disproportionally focused on thoracic insults. With differences in anatomy, physiology, and immune response between spinal cord levels, there is evidence that...
L Zoe Almeida et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 209, 47-55 (2017-04-25)
While severe hypoxia can be lethal and is usually avoided by mobile aquatic organisms, moderate hypoxic conditions are likely more prevalent and may affect organisms, such as fishes, in a variety of systems. However, fishes have the potential to adjust...

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