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Daniel Roth et al.
Journal of cell science, 132(4) (2018-09-29)
EB proteins track the ends of growing microtubules and regulate microtubule dynamics both directly and by acting as the hub of the tip-tracking network. Mammalian cells express cell type-specific combinations of three EB proteins with different cellular roles. Here, we...
Richard J Smith et al.
Scientific reports, 11(1), 3301-3301 (2021-02-10)
Brillouin light scattering (BLS) is an emerging method for cell imaging and characterisation. It allows elasticity-related contrast, optical resolution and label-free operation. Phonon microscopy detects BLS from laser generated coherent phonon fields to offer an attractive route for imaging since...
ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration.
Aharonov, et al.
Nature Cell Biology, 22, 1346-1356 (2021)
Eleanor Wendy Trotter et al.
Open biology, 10(10), 200200-200200 (2020-10-15)
Each approach used to synchronize cell cycle progression of human cell lines presents a unique set of challenges. Induction synchrony with agents that transiently block progression through key cell cycle stages are popular, but change stoichiometries of cell cycle regulators...
Samir A Saidi et al.
Molecular cancer, 5, 13-13 (2006-03-30)
Fenofibrate, an agonist of PPAR-alpha, in doses above 25 microM, inhibits proliferation and induces apoptosis in Ishikawa endometrial cancer cells. We show that these effects are potentiated by retinoic acid, an agonist of the retinoid-X-receptor. DNA content analysis shows that...
Laura Ferreras et al.
Biochimica et biophysica acta. General subjects, 1863(5), 839-848 (2019-02-23)
One of the main feature of chronic kidney disease is the development of renal fibrosis. Heparan Sulfate (HS) is involved in disease development by modifying the function of growth factors and cytokines and creating chemokine gradients. In this context, we...
Kouichi Hasegawa et al.
Stem cells translational medicine, 1(1), 18-28 (2012-12-01)
An optimal culture system for human pluripotent stem cells should be fully defined and free of animal components. To date, most xeno-free culture systems require human feeder cells and/or highly complicated culture media that contain activators of the fibroblast growth...
Kelli L VanDussen et al.
Gut, 64(6), 911-920 (2014-07-11)
The technology for the growth of human intestinal epithelial cells is rapidly progressing. An exciting possibility is that this system could serve as a platform for individualised medicine and research. However, to achieve this goal, human epithelial culture must be...
Purvi C Trivedi et al.
Biochimica et biophysica acta, 1861(12 Pt A), 1893-1910 (2016-10-22)
Impaired cardiac metabolism in the obese and diabetic heart leads to glucolipotoxicity and ensuing cardiomyopathy. Glucolipotoxicity causes cardiomyocyte injury by increasing energy insufficiency, impairing proteasomal-mediated protein degradation and inducing apoptosis. Proteasome-evading proteins are degraded by autophagy in the lysosome, whose...
Sylwia Bobis-Wozowicz et al.
Journal of molecular medicine (Berlin, Germany), 95(2), 205-220 (2016-09-18)
Growing evidence indicates that intracellular signaling mediated by extracellular vesicles (EVs) released by stem cells plays a considerable role in triggering the regenerative program upon transplantation. EVs from umbilical cord mesenchymal stem cells (UC-MSC-EVs) have been shown to enhance tissue...
Irene Cervelló et al.
PloS one, 6(6), e21221-e21221 (2011-06-30)
Endometrial regeneration is mediated, at least in part, by the existence of a specialized somatic stem cell (SSC) population recently identified by several groups using the side population (SP) technique. We previously demonstrated that endometrial SP displays genotypic, phenotypic and...
Peter Dong et al.
Scientific reports, 7(1), 13869-13869 (2017-10-27)
The detection of pruritic (itchy) stimuli is mediated by a variety of receptors and channels expressed by primary sensory neurons. The G protein-coupled receptor (GPCR) MRGPRD is selectively expressed by a subset of mouse non-peptidergic nociceptors and functions as the...
Kimberly R Long et al.
Molecular biology of the cell, 28(19), 2508-2517 (2017-07-20)
Cells lining the proximal tubule (PT) have unique membrane specializations that are required to maintain the high-capacity ion transport and endocytic functions of this nephron segment. PT cells in vivo acutely regulate ion transport in response to changes in glomerular...
M Angeles Rabadán et al.
Development (Cambridge, England), 143(12), 2194-2205 (2016-04-29)
Delamination of neural crest (NC) cells is a bona fide physiological model of epithelial-to-mesenchymal transition (EMT), a process that is influenced by Wnt/β-catenin signalling. Using two in vivo models, we show that Wnt/β-catenin signalling is transiently inhibited at the time...
Annie Kathuria et al.
Genome medicine, 12(1), 34-34 (2020-04-21)
Reprogramming human induced pluripotent stem cells (iPSCs) from somatic cells and generating three-dimensional brain organoids from these iPSCs provide access to live human neuronal tissue with disease-specific genetic backgrounds. Cerebral organoids were generated from iPSCs of eight bipolar disorder (BPI)...
Dong Li et al.
Cell cycle (Georgetown, Tex.), 16(11), 1070-1084 (2017-04-21)
Previous research has shown that a subpopulation of cells within cultured human dermal fibroblasts, termed multilineage-differentiating stress enduring (Muse) cells, are preferentially reprogrammed into induced pluripotent stem cells. However, controversy exists over whether these cells are the only cells capable...
Hikari Tanaka et al.
Nature communications, 11(1), 507-507 (2020-01-26)
The timing and characteristics of neuronal death in Alzheimer's disease (AD) remain largely unknown. Here we examine AD mouse models with an original marker, myristoylated alanine-rich C-kinase substrate phosphorylated at serine 46 (pSer46-MARCKS), and reveal an increase of neuronal necrosis...
Carine Bonnard et al.
The Journal of experimental medicine, 217(12) (2020-08-28)
Failure of neural tube closure during embryonic development can result in anencephaly, one of the most common birth defects in humans. A family with recurrent anencephalic fetuses was investigated to understand its etiology and pathogenesis. Exome sequencing revealed a recessive...
Jungwook Paek et al.
ACS nano, 13(7), 7627-7643 (2019-06-14)
The vasculature is an essential component of the circulatory system that plays a vital role in the development, homeostasis, and disease of various organs in the human body. The ability to emulate the architecture and transport function of blood vessels...
Chiara de Lucia et al.
Communications biology, 3(1), 157-157 (2020-04-04)
Aging induces cellular and molecular changes including modification of stem cell pools. In particular, alterations in aging neural stem cells (NSCs) are linked to age-related cognitive decline which can be modulated by lifestyle. Nutrient-sensing pathways provide a molecular basis for...
Xing-Hua Pan et al.
Aging, 11(2), 590-614 (2019-01-24)
The relationship between bone marrow mesenchymal stem cells (BMSCs) and aging, as well as the antiaging effects of BMSCs, was observed. An aging macaque BMSC model was established. We isolated BMSCs from young and aged macaques and used RT-PCR and...
Alessandra Castaldi et al.
American journal of physiology. Lung cellular and molecular physiology, 319(1), L173-L184 (2020-05-21)
The alveolar epithelium is comprised of two cell types, alveolar epithelial type 1 (AT1) and type 2 (AT2) cells, the latter being capable of self-renewal and transdifferentiation into AT1 cells for normal maintenance and restoration of epithelial integrity following injury....
Štěpán Popelka et al.
Biomedical materials (Bristol, England), 10(4), 045022-045022 (2015-08-13)
We report on the design and fabrication of a frame-supported nanofibrous membrane for the transplantation of retinal pigment epithelial (RPE) cells, which is a promising therapeutic option for the treatment of degenerative retinal disorders. The membranous cell carrier prepared from...
Kevin A Bockerstett et al.
International journal of molecular sciences, 19(4) (2018-04-13)
The ability to analyze individual epithelial cells in the gastric mucosa would provide important insight into gastric disease, including chronic gastritis and progression to gastric cancer. However, the successful isolation of viable gastric epithelial cells (parietal cells, neck cells, chief...
Colin Charles Tièche et al.
BMC cancer, 16, 125-125 (2016-02-21)
Lung cancer is the leading cause of cancer-related mortality, and new therapeutic options are urgently needed. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers, with the current standard regimen of care for NSCLC including chemotherapy...
Raphael Lis et al.
Nature, 545(7655), 439-445 (2017-05-18)
Developmental pathways that orchestrate the fleeting transition of endothelial cells into haematopoietic stem cells remain undefined. Here we demonstrate a tractable approach for fully reprogramming adult mouse endothelial cells to haematopoietic stem cells (rEC-HSCs) through transient expression of the transcription-factor-encoding...
Antonio P A Ferreira et al.
Nature communications, 12(1), 2424-2424 (2021-04-25)
Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Fast Endophilin-mediated endocytosis, FEME, is not constitutively active but triggered upon receptor activation. High levels of growth factors induce spontaneous FEME, which can be suppressed upon serum starvation. This...
Almutez M Gharaibeh et al.
Ophthalmic research, 60(2), 100-108 (2018-05-29)
Studying genipin variable concentrations, treatment durations, and delivery methods as a substance to increase corneal stiffness by inducing corneal collagen cross-linking (CXL). 100 bovine corneas treated with different genipin concentrations (0.1, 0.5, and 1%) and treatment durations (15 min, 40...
Tiago Ferronha et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(7), 2773-2783 (2013-02-15)
Neuroblastoma is an embryonic tumor derived from cells of the neural crest. Taking advantage of a newly developed neural crest lineage tracer and based on the hypothesis that the molecular mechanisms that mediate neural crest delamination are also likely to...
Jihang Yu et al.
Oncotarget, 8(24), 38426-38443 (2017-04-19)
Recent studies suggest that lung cancer stem cells (CSCs) may play major roles in lung cancer. Therefore, identification of lung CSC drivers may provide promising targets for lung cancer. TAZ is a transcriptional co-activator and key downstream effector of the...
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