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Henrique Lemos et al.
European journal of immunology, 44(10), 2847-2853 (2014-08-22)
DNA is immunogenic and many cells express cytosolic DNA sensors that activate the stimulator of interferon genes (STING) adaptor to trigger interferon type I (IFN-β) release, a potent immune activator. DNA sensing to induce IFN-β triggers host immunity to pathogens
[Transcription factor Kaiso does not interact with hydroxymethylated DNA within CTGCNA sequence context].
S V Zhenilo et al.
Molekuliarnaia biologiia, 47(3), 522-525 (2013-07-31)
Francesca Trojsi et al.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 32(1), 23-26 (2013-07-16)
We report the first Italian kindred with Familial Amyotrophic Lateral Sclerosis (FALS) due to c.149T>C mutation in the exon 5 of superoxide dismutase-1 (SOD1) gene. The proband was a 49-year-old woman who came to our observation because of an history
Ali Mirabzadeh-Ardakani et al.
Gene, 551(2), 183-188 (2014-09-01)
The DEFB103 gene is a member of the β-defensin gene family. In this study, we applied multiple sets of primers to characterize the DEFB103 transcript. RT-PCR was used to determine the cDNA boundaries and it indicated that the cDNA start
Johan S Nilsson et al.
Scientific reports, 9(1), 15432-15432 (2019-10-30)
Nasopharyngeal cancer (NPC) is associated with the Epstein-Barr virus (EBV). The clinical presentation and prognosis of NPC is well described, but not in relation to intralesional EBV-DNA load. In a retrospective design, 48 patients with NPC were examined. Patient history
Kieren J Mitchell et al.
Science (New York, N.Y.), 344(6186), 898-900 (2014-05-24)
The evolution of the ratite birds has been widely attributed to vicariant speciation, driven by the Cretaceous breakup of the supercontinent Gondwana. The early isolation of Africa and Madagascar implies that the ostrich and extinct Madagascan elephant birds (Aepyornithidae) should
Ching-Yu Cheng et al.
Investigative ophthalmology & visual science, 56(1), 478-483 (2014-12-30)
Recently the common SIX6 missense variant rs33912345 was found to be highly associated with glaucoma. The aim of this study was to investigate the association between this SIX6 variant and peripapillary retinal nerve fiber layer (RNFL) thickness measured by spectral-domain
M V Ploskonos
Klinicheskaia laboratornaia diagnostika, (4)(4), 3-8 (2013-08-30)
The article presents the classification and evaluation of techniques applied in documentation of apoptosis of spermatozoids. The main point of techniques detecting the changes in DNA of apoptosis spermatozoids (SCSA technique, TUNEL test and Comet assay) is revealed The annexin
Tritiated thymidine: xeroderma pigmentosum and DNA repair.
James E Cleaver
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(7), 2742-2745 (2014-07-06)
Sayeed Ur Rehman et al.
Archives of biochemistry and biophysics, 566, 7-14 (2014-12-22)
Non-covalent interactions of chlorambucil with calf thymus DNA was investigated using multi-spectroscopic techniques and molecular docking study. Binding constant calculated was found to be 1.54×10(4)M(-1) at 290K, significantly lower than various known intercalators. Quenching process was found to be static
James Watson: thinking outside the genome.
Geoff Watts
Lancet (London, England), 383(9919), 775-775 (2014-03-04)
DNA methylation in the human placenta and fetal growth
Koukoura O, et al.
Molecular Medicine Reports, 5(4), 883-889 (2012)
Hui Y Xiong et al.
Science (New York, N.Y.), 347(6218), 1254806-1254806 (2014-12-20)
To facilitate precision medicine and whole-genome annotation, we developed a machine-learning technique that scores how strongly genetic variants affect RNA splicing, whose alteration contributes to many diseases. Analysis of more than 650,000 intronic and exonic variants revealed widespread patterns of
Piero Stratta et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(10), 1902-1909 (2014-08-12)
Inactivating mutations of the calcium-sensing receptor (CaSR), of the G-protein subunit α11 (GNA11) and of the adaptor-related protein complex 2, sigma 1 subunit (AP2S1) genes are responsible for familial hypocalciuric hypercalcaemia (FHH). The aim of this study was to analyse
Louise R A Olde Nordkamp et al.
The American journal of cardiology, 114(8), 1223-1228 (2014-09-01)
Unaffected long-QT syndrome family members (FMs) frequently experience syncope. The aims of this study were to test the hypothesis that syncope events in FMs are benign events and to compare clinical characteristics, triggers eliciting the syncope events, and long-term outcomes
Yong S Joe et al.
Journal of nanoscience and nanotechnology, 13(6), 3889-3896 (2013-07-19)
We utilize a two-dimensional four-channel DNA model, with a tight-binding (TB) Hamiltonian, and investigate the temperature and the magnetic field dependence of the transport behavior of a short DNA molecule. Random variation of the hopping integrals due to the thermal
Limb K Hapairai et al.
Journal of medical entomology, 50(4), 731-739 (2013-08-10)
The efficacy of the BG-Sentinel (BGS) and the BG-Mosquitito (BGM) mosquito traps for sampling populations of the important filariasis and dengue vector Aedes (Stegomyia) polynesiensis (Marks) was evaluated in French Polynesia against human bait collections (HBC) using a modified Centers
B Shapiro et al.
Science (New York, N.Y.), 343(6169), 1236573-1236573 (2014-01-25)
The publication of partial and complete paleogenomes within the last few years has reinvigorated research in ancient DNA. No longer limited to short fragments of mitochondrial DNA, inference of evolutionary processes through time can now be investigated from genome-wide data
A new era in noninvasive prenatal testing.
Stephanie Morain et al.
The New England journal of medicine, 369(6), 499-501 (2013-07-19)
Cell-free DNA screening for trisomy is rolled out in Israel.
Anna Petherick
Lancet (London, England), 382(9895), 846-846 (2013-09-11)
Zhao Shifang et al.
Journal of biomedical nanotechnology, 10(7), 1313-1319 (2014-05-09)
The aim of this study was to deposit simvastatin-hydroxyapatite (sim-HA) coatings on titanium surfaces by an electrochemical process and evaluate osteoprogenitor cell responses to sim-HA-coated surfaces. Simvastatin was prepared onto titanium surfaces with varying concentration (10(-7), 10(-6), 10(-5) and 10(-4)
Nanoparticle self-assembly: Bonding them all.
Ulrich Simon
Nature materials, 12(8), 694-696 (2013-07-24)
István Kiss et al.
Medicine, 93(28), e315-e315 (2014-12-20)
The association between ACE (angiotensin-converting enzyme) gene insertion/deletion (I/D) polymorphism and mortality has been inconsistently observed in earlier studies in patients on maintenance hemodialysis. We hypothesized that the effect of ACE gene I/D polymorphism on mortality may be influenced by
Sriram Kosuri et al.
Nature methods, 11(5), 499-507 (2014-05-02)
For over 60 years, the synthetic production of new DNA sequences has helped researchers understand and engineer biology. Here we summarize methods and caveats for the de novo synthesis of DNA, with particular emphasis on recent technologies that allow for
Scott O Sundberg et al.
Clinical chemistry, 60(10), 1306-1313 (2014-08-15)
Clinical molecular testing typically batches samples to minimize costs or uses multiplex lab-on-a-chip disposables to analyze a few targets. In genetics, multiple variants need to be analyzed, and different work flows that rapidly analyze multiple loci in a few targets
Sanjay Premi et al.
Science (New York, N.Y.), 347(6224), 842-847 (2015-02-24)
Mutations in sunlight-induced melanoma arise from cyclobutane pyrimidine dimers (CPDs), DNA photoproducts that are typically created picoseconds after an ultraviolet (UV) photon is absorbed at thymine or cytosine. We found that in melanocytes, CPDs are generated for >3 hours after
Ashish Gupta et al.
Biochemistry, 53(27), 4368-4380 (2014-06-24)
Members of the multiple antibiotic resistance regulator (MarR) family often regulate gene activity by responding to a specific ligand. In the absence of ligand, most MarR proteins function as repressors, while ligand binding causes attenuated DNA binding and therefore increased
Alexandre Rodrigues-Correia et al.
Organic letters, 16(19), 5128-5131 (2014-09-19)
The synthesis and use of the new nucleobase-caged nucleotides dT(pHP) and dT(NDEACM) is reported. Through a combination of time and wavelength selectivity four levels of selective uncaging with only two cages, and only two wavelengths, were obtained. The new residue
Yuzhong Cheng et al.
Developmental biology, 395(1), 131-143 (2014-08-31)
invected (inv) and engrailed (en) form a gene complex that extends about 115 kb. These two genes encode highly related homeodomain proteins that are co-regulated in a complex manner throughout development. Our dissection of inv/en regulatory DNA shows that most
Liying Liu et al.
Biochemical and biophysical research communications, 450(1), 851-856 (2014-06-28)
High mobility group box 1 (HMGB1) is a prototype damage-associated molecular pattern (DAMP) that can induce inflammatory and immune responses alone as well as in combination with other molecules such as DNA. However, the intricate molecular mechanisms underlying HMGB1-DNA complex-mediated
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