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Kazuo Mukai et al.
Journal of agricultural and food chemistry, 59(5), 1705-1712 (2011-02-12)
A kinetic study of the quenching reaction of singlet oxygen ((1)O(2)) with pyrroloquinolinequinol (PQQH(2), a reduced form of pyrroloquinolinequinone (PQQ)), PQQNa(2) (disodium salt of PQQ), and seven kinds of natural antioxidants (vitamin C (Vit C), uric acid (UA), epicatechin (EC)...
Sunil Kumar et al.
Applied and environmental microbiology, 81(16), 5593-5603 (2015-06-07)
Agmatine, a significant polyamine in bacteria and plants, mostly arises from the decarboxylation of arginine. The functional importance of agmatine in fungi is poorly understood. The metabolism of agmatine and related guanidinium group-containing compounds in Aspergillus niger was explored through...
Michael R VanEngelen et al.
Environmental science & technology, 45(3), 937-942 (2010-12-21)
Uranium as an environmental contaminant has been shown to be toxic to eukaryotes and prokaryotes; however, no specific mechanisms of uranium toxicity have been proposed so far. Here a combination of in vivo, in vitro, and in silico studies are...
Kazuki Kimura et al.
Free radical biology & medicine, 53(6), 1239-1251 (2012-07-25)
Pyrroloquinoline quinone (PQQ), a redox cofactor for bacterial dehydrogenases, has been implicated to be an important nutrient in mammals functioning as a potent growth factor. However, the underlying molecular mechanisms have not been elucidated. The present study revealed that PQQ...
A Bishop et al.
Nutrition reviews, 56(10), 287-293 (1998-11-12)
Pyrroloquinoline quinone (PQQ), otherwise known as methoxatin, is a water-soluble, redox-cycling orthoquinone that was initially isolated from cultures of methylotropic bacteria. It has been found to be a cofactor of some bacterial alcohol dehydrogenases, and is present in many animal...
Robert Rucker et al.
Alternative medicine review : a journal of clinical therapeutic, 14(3), 268-277 (2009-10-07)
Pyrroloquinoline quinone (PQQ) is a novel biofactor for which a proposition can be made for physiological importance. PQQ was first recognized as an enzyme cofactor in bacteria. It has recently been tentatively identified as a component of interstellar dust. Thus...
Hiromi Hattori et al.
Applied microbiology and biotechnology, 95(6), 1531-1540 (2012-03-22)
We succeeded in obtaining a strain adapted to higher temperature from a thermotolerant strain, Gluconobacter frateurii CHM43, for sorbose fermentation. The adapted strain showed higher growth and L-sorbose production than original CHM43 strain at higher temperature around 38.5-40 °C. It...
Quanxin Long et al.
Journal of cellular biochemistry, 113(10), 3051-3055 (2012-05-26)
Tuberculosis (TB) remains a great threat to global public health. The high biosafety level III required to tackle its causative agent Mycobacterium tuberculosis seriously hinders the exploration of its biology and new countermeasures. M. smegmatis is a widely recognized good...
C Anthony
Antioxidants & redox signaling, 3(5), 757-774 (2002-01-05)
This review summarises the characteristics, identification, and measurement of pyrroloquinoline quinone, the prosthetic group of bacterial quinoprotein dehydrogenases whose structures, mechanisms, and electron transport functions are described in detail. Type I alcohol dehydrogenase includes the "classic" methanol dehydrogenase; its x-ray...
A Oubrie et al.
Protein science : a publication of the Protein Society, 9(7), 1265-1273 (2000-08-10)
On the basis of crystal structures of the pyrroloquinoline quinone (PQQ) dependent enzymes methanol dehydrogenase (MDH) and soluble glucose dehydrogenase (s-GDH), different catalytic mechanisms have been proposed. However, several lines of biochemical and kinetic evidence are strikingly similar for both...
Mounira Ben Farhat et al.
FEMS microbiology letters, 362(5) (2015-03-07)
The actinomycetes isolates (128) which were taken from agricultural soil samples and collected near a rock phosphate processing unit were screened for mineral phosphate-solubilizing (MPS) ability. A significant MPS activity was observed for 30 isolates on various phosphate sources when...
Nanocurcumin--pyrroloquinoline formulation prevents hypertrophy--induced pathological damage by relieving mitochondrial stress in cardiomyocytes under hypoxic conditions
Nehra S, et al.
Experimental & Molecular Medicine, 49(12), e404-e404 (2017)
Pyrroloquinoline quinone and molecules mimicking its functional domains. Modulators of connective tissue formation?
H M Hanauske-Abel et al.
FEBS letters, 214(2), 236-243 (1987-04-20)
David Sarauli et al.
Acta biomaterialia, 9(9), 8290-8298 (2013-06-20)
Sulfonated polyanilines have become promising building blocks in the construction of biosensors, and therefore we use here differently substituted polymer forms to investigate the role of their structural composition and properties in achieving a direct electron transfer with the redox...
Kathryn Bauerly et al.
PloS one, 6(7), e21779-e21779 (2011-08-05)
We have reported that pyrroloquinoline quinone (PQQ) improves reproduction, neonatal development, and mitochondrial function in animals by mechanisms that involve mitochondrial related cell signaling pathways. To extend these observations, the influence of PQQ on energy and lipid relationships and apparent...
Xingqin Zhou et al.
Se pu = Chinese journal of chromatography, 30(2), 196-200 (2012-06-12)
As a new neurotransmitter present in the glial cells, D-serine (DSer) plays an important role in central nervous system diseases. Pyrroloquinoline quinine (PQQ) can promote the production of the nerve growth factor and has a protective effect on nerve injuries....
The cofactor pyrroloquinoline quinone.
J A Duine et al.
Annual review of nutrition, 10, 297-318 (1990-01-01)
E A Decker
Nutrition reviews, 53(3), 49-58 (1995-03-01)
Oxidative reactions have been implicated in the development of numerous diseases including atherosclerosis and cancer. Oxidation of lipids, proteins, and nucleic acids can result in loss of membrane integrity and function, inactivation of enzymes, modification of lipoproteins, and chemical alteration...
Hao-huan Li et al.
Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery, 27(4), 298-303 (2011-11-22)
To investigate the effects of pyrroloquinoline quinine (PQQ) on proliferation and expression of c-fos, c-jun, CREB and PCNA in cultured Schwann cells. Schwann cells were cultured and purified in vitro. The purity of Schwann cells was identified by immunofluorescence of...
Qi Zhang et al.
Toxicology and applied pharmacology, 252(1), 62-72 (2011-02-16)
Pyrroloquinoline quinone (PQQ), a cofactor in several enzyme-catalyzed redox reactions, possesses a potential capability of scavenging reactive oxygen species (ROS) and inhibiting cell apoptosis. In this study, we investigated the effects of PQQ on glutamate-induced cell death in primary cultured...
Dezheng Gong et al.
European journal of pharmacology, 697(1-3), 53-58 (2012-10-16)
Pyrroloquinoline quinone PQQ is a naturally occurring redox cofactor that acts as an essential nutrient, antioxidant, and redox modulator. PQQ has been demonstrated to oxidize the redox modulatory site of N-methyl-d-aspartic acid (NMDA) receptors. Such agents are known to be...
Jianqiang Xu et al.
Biochemical pharmacology, 83(6), 815-820 (2012-01-10)
Pyrroloquinoline quinone (PQQ) is a redox active cofactor for bacterial quinoproteins. Dietary PQQ also has prominent physiological effects in mammals although no mammalian quinoprotein has yet been conclusively identified. Here we found that PQQ has substantial effects on the redox...
C R Smidt et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 197(1), 19-26 (1991-05-01)
Pyrroloquinoline quinone (PQQ, methoxatin) is a dissociable cofactor for a number of bacterial dehydrogenases. The compound is unusual because of its ability to catalyze redox cycling reactions at a high rate of efficiency and it has the potential of catalyzing...
[Pyrroloquinoline quinone and its physiological effects].
J P Liu et al.
Sheng li ke xue jin zhan [Progress in physiology], 27(2), 170-172 (1996-04-01)
Yao-Qing Shen et al.
Biochemistry, 51(11), 2265-2275 (2012-02-14)
Pyrroloquinoline quinone (PQQ) is a small, redox active molecule that serves as a cofactor for several bacterial dehydrogenases, introducing pathways for carbon utilization that confer a growth advantage. Early studies had implicated a ribosomally translated peptide as the substrate for...
Dongwei Jia et al.
PloS one, 10(3), e0121939-e0121939 (2015-03-31)
Liver fibrosis represents the consequences of a sustained wound healing response to chronic liver injuries, and its progression toward cirrhosis is the major cause of liver-related morbidity and mortality worldwide. However, anti-fibrotic treatment remains an unconquered area for drug development....
[Discovery and recent development of a novel coenzyme pyrroloquinoline quinone (PQQ)].
K Matsushita et al.
Seikagaku. The Journal of Japanese Biochemical Society, 63(3), 218-221 (1991-03-01)
Andrea Heinz et al.
Matrix biology : journal of the International Society for Matrix Biology, 38, 12-21 (2014-07-30)
This study aimed to characterize the structures of two elastin-like constructs, one composed of a cross-linked elastin-like polypeptide and the other one of cross-linked tropoelastin, and native aortic elastin. The structures of the insoluble materials and human aortic elastin were...
Pyrroloquinoline quinone (PQQ) from methanol dehydrogenase and tryptophan tryptophylquinone (TTQ) from methylamine dehydrogenase.
V L Davidson
Advances in protein chemistry, 58, 95-140 (2001-10-23)
The pyrroloquinoline quinone (PQQ)-containing quinoprotein dehydrogenases.
C Anthony
Biochemical Society transactions, 26(3), 413-417 (1998-10-10)
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