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d8001

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Guo-Biao Liang et al.
Molecular medicine reports, 12(2), 2577-2583 (2015-05-06)
Chronic allograft nephropathy (CAN) is a major cause of graft loss following kidney transplantation and may result from the interactions of various immune and non-immune factors. The aim of the present study was to establish an in vitro model of
Carmen Ranftler et al.
Methods in molecular biology (Clifton, N.J.), 931, 437-447 (2012-10-03)
Detailed insight into the fine structure and 3D-architecture of the complex and dynamic compartments of the endocytic system is essential for a morpho-functional analysis of retrograde traffic from the cell surface to different intracellular destinations. Here, we describe a cytochemical
Noah Frydenlund et al.
Human pathology, 46(8), 1209-1216 (2015-06-15)
Perineural invasion (PNI) has been recently added to the American Joint Committee on Cancer cutaneous squamous cell carcinoma (cSCC) staging criteria as a high-risk tumor characteristic and is purportedly more common in cSCCs of the head and neck (H&N). Expression
Sajal Samanta et al.
PloS one, 6(12), e28169-e28169 (2011-12-14)
Using a lectin, Achatinin-H, having preferential specificity for glycoproteins with terminal 9-O-acetyl sialic acid derivatives linked in α2-6 linkages to subterminal N-acetylgalactosamine, eight distinct disease-associated 9-O-acetylated sialoglycoproteins was purified from erythrocytes of visceral leishmaniaisis (VL) patients (RBC(VL)). Analyses of tryptic
Varsha Meghnani et al.
The international journal of biochemistry & cell biology, 57, 54-62 (2014-10-15)
Recent studies have suggested that the receptor for advanced glycation end products (RAGE) participates in melanoma progression by promoting tumor growth. However, the mechanisms of RAGE activation in melanoma tumors are not clearly understood. To get deeper insights into these
Junjian Dong et al.
PloS one, 8(8), e73091-e73091 (2013-09-12)
Chlorosis of leaf tissue normally observed during pathogen infection may result from the degradation of chloroplasts. There is a growing evidence to suggest that the chloroplast plays a significant role during pathogen infection. Although most degradation of the organelles and
Krzysztof Symonowicz et al.
Experimental and therapeutic medicine, 8(4), 1039-1046 (2014-09-05)
The aim of the present study was to investigate the immunohistochemical expression of nuclear ubiquitous casein and cyclin-dependent kinases substrate 1 (NUCKS1) in invasive breast carcinoma of no special type, in association with clinicopathological characteristics, including the tumor grade, frequency
Hyun Yang et al.
Reproductive biology and endocrinology : RB&E, 9, 28-28 (2011-03-03)
Human endometrium resists embryo implantation except during the 'window of receptivity'. A change in endometrial gene expression is required for the development of receptivity. Uterine calbindin-D28k (CaBP-28k) is involved in the regulation of endometrial receptivity by intracellular Ca2+. Currently, this
Luigi Strizzi et al.
Oncotarget, 6(33), 34071-34086 (2015-10-16)
Nodal is highly expressed in various human malignancies, thus supporting the rationale for exploring Nodal as a therapeutic target. Here, we describe the effects of a novel monoclonal antibody (mAb), 3D1, raised against human Nodal. In vitro treatment of C8161
Anja Kafka et al.
International journal of molecular sciences, 15(6), 10635-10651 (2014-06-17)
The susceptibility of brain to secondary formation from lung cancer primaries is a well-known phenomenon. In contrast, the molecular basis for invasion and metastasis to the brain is largely unknown. In the present study, 31 brain metastases that originated from
Andrew Tsz Hang Choy et al.
PloS one, 10(6), e0131827-e0131827 (2015-06-27)
Tissue engineering offers high hopes for the treatment of intervertebral disc (IVD) degeneration. Whereas scaffolds of the disc nucleus and annulus have been extensively studied, a truly biomimetic and mechanically functional biphasic scaffold using naturally occurring extracellular matrix is yet
Ewa Rojczyk et al.
Pharmacological reports : PR, 67(6), 1208-1214 (2015-10-21)
Among many factors influencing adult neurogenesis, pharmacological modulation has been broadly studied. It is proven that neuroleptics positively affect new neuron formation in canonical neurogenic sites - subgranular zone of the hippocampal dentate gyrus and subventricular zone of the lateral
B Song et al.
Journal of biological regulators and homeostatic agents, 29(2), 471-477 (2015-07-01)
C-erbB-2 is a cancer gene originating from cells. The high-expression and amplification of C-erbB-2 and its protein products (P185) are found in a wide variety of tumors. The abnormal expression of C-erbB-2 has great influence on the occurrence and development
Larissa Nelson et al.
Cartilage, 5(4), 203-214 (2015-06-13)
Osteoarthritis (OA) is a debilitating disease affecting more than 4 million people in the United Kingdom. Despite its prevalence, there is no successful cell-based therapy currently used to treat patients whose cartilage is deemed irrecoverable. The present study aimed to
Rongwei Sun et al.
Oncotarget, 5(23), 12398-12409 (2014-11-05)
Lysosomal associated membrane protein 3 (LAMP3) is a newly identified tumor-specific protein. It is a downstream target gene of tumor suppressor TP53 and its expression has been associated with hypoxia-induced metastasis and poor overall survival in cervical and breast cancers.
Eleonora Björkman et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 16(3), 570-577 (2014-01-24)
The human esophageal mucosa expresses various components of the renin-angiotensin system (RAS), e.g. the main effector peptide angiotensin II (AngII). The aim of this study was to investigate the esophageal presence of angiotensin III (AngIII) and angiotensin IV (AngIV) forming
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Young-Sam Cho et al.
Molecular medicine reports, 12(2), 2563-2569 (2015-05-09)
Neurogenic lower urinary tract dysfunction (NLUTD) is a major problem in patients with various neurological disorders, and may result in debilitating symptoms and serious complications, including chronic renal failure and recurrent urinary tract infections. Clinically, stroke is associated with voiding
Amparo Novejarque et al.
Frontiers in neuroanatomy, 5, 54-54 (2011-10-19)
Rodents constitute good models for studying the neural basis of sociosexual behavior. Recent findings in mice have revealed the molecular identity of the some pheromonal molecules triggering intersexual attraction. However, the neural pathways mediating this basic sociosexual behavior remain elusive.
Gaetano Magro et al.
Acta histochemica, 117(4-5), 415-424 (2015-03-15)
The protein cyclin D1 (CD1), which belongs to a family of proteins functioning as regulators of CDKs (cyclin-dependent kinases) throughout the cell cycle, has been immunohistochemically detected in a wide variety of human malignant tumors. The aim of the present
Jie Ding et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 35(4), 460-467 (2015-10-03)
To evaluate the estrogenic efficacy of Renshen (Radix Ginseng) (GS) on reproductive target tissues in immature mice. One hundred and ten female immature Kunming (KM) mice, 21-day-old, were randomly assigned to eleven groups, 10 for each; one served as control
Lars Zimmermann et al.
Neuroscience letters, 489(2), 89-93 (2010-12-09)
Palisade endings are found in the extraocular muscles (EOMs) of almost every mammalian species, including primates. These nerve specializations surrounding the muscle fiber insertion have been postulated to be the proprioceptors of the EOMs. However, it was recently demonstrated that
Karen Cortés-Sarabia et al.
Applied microbiology and biotechnology, 104(14), 6173-6183 (2020-05-29)
Bacterial vaginosis is one of the most frequent vaginal infections. Its main etiological agent is Gardnerella vaginalis, which produces several virulence factors involved in vaginal infection and colonization, in particular, sialidase (SLD), a potential clinical biomarker that participates in immune
Michiaki Okuda et al.
PloS one, 10(2), e0117511-e0117511 (2015-02-07)
In tauopathies, a neural microtubule-associated protein tau (MAPT) is abnormally aggregated and forms neurofibrillary tangle. Therefore, inhibition of the tau aggregation is one of the key approaches for the treatment of these diseases. Here, we have identified a novel tau
Yuheng Tian et al.
Cell cycle (Georgetown, Tex.), 17(10), 1188-1198 (2018-06-09)
Long non-coding RNAs (lncRNAs) can actively participate in tumorigenesis in various cancers. However, the involvement of lncRNA long stress induced non-coding transcripts 5 (LSINCT5) in non-small cell lung cancer (NSCLC) remains largely unknown. Here we showed a novel lncRNA signature
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Bruno Lopes dos Santos-Lobato et al.
Arquivos de neuro-psiquiatria, 73(9), 779-783 (2015-09-10)
Nitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson's disease, are more prevalent on aged individuals. We investigated the effects of aging on neuronal density and diameter/area of
Z Majercikova et al.
Endocrine regulations, 46(4), 217-223 (2012-11-07)
The aim of the present study was to introduce a new approach of the light microscopic immunohistochemical triple-staining enabling to study the differences in the activity of at least two different phenotypes of neurons on the same histological section. For
Deepak Panwar et al.
PloS one, 10(6), e0127993-e0127993 (2015-06-18)
Molecular interactions between mesenchymal-derived Keratinocyte growth factor (KGF) and Kit ligand (KITLG) are essential for follicular development. These factors are expressed by theca and granulosa cells. We determined full length coding sequence of buffalo KGF and KITLG proteins having 194
Song-Fong Huang et al.
World journal of surgical oncology, 13, 202-202 (2015-06-17)
Gastrinomas are one of the neuroendocrine tumors with potential distant metastasis. Most gastrinomas are originated from pancreas and duodenum, but those of gastric origin have been much less reported. The aim of the study is to compare gastrinomas of gastric
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