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Showing 1-30 of 76 results for "D9154" within Papers
Necrostatin-1 inhibits Hmgb1-IL-23/IL-17 pathway and attenuates cardiac ischemia reperfusion injury.
Anbin Zhang et al.
Transplant international : official journal of the European Society for Organ Transplantation, 27(10), 1077-1085 (2014-05-09)
Ischemia reperfusion (IR) injury is a major issue in cardiac transplantation and inflammatory processes play a major role in myocardial IR injury. Necrostatin-1 (Nec-1) is a small molecule capable of inhibiting RIP1 kinase activity and attenuates inflammation-mediated tissue injury. In
Ozcan Erel
Clinical biochemistry, 38(12), 1103-1111 (2005-10-11)
To develop a new, colorimetric and automated method for measuring total oxidation status (TOS). The assay is based on the oxidation of ferrous ion to ferric ion in the presence of various oxidant species in acidic medium and the measurement
Huangqin-Tang Ameliorates TNBS-Induced Colitis by Regulating Effector and Regulatory CD4(+) T Cells.
Ying Zou et al.
BioMed research international, 2015, 102021-102021 (2015-09-09)
Huangqin-Tang decoction (HQT) is a classic traditional Chinese herbal formulation that is widely used to ameliorate the symptoms of gastrointestinal disorders, including inflammatory bowel disease (IBD). This study was designed to investigate the therapeutic potential and immunological regulatory activity of
H Tayefi-Nasrabadi et al.
Pakistan journal of biological sciences : PJBS, 11(22), 2589-2593 (2009-03-06)
In this study, for clarifying some possible mechanism of zinc toxicity, the effect of increasing amounts of Zn2+ ion on peroxidase activity was investigated in vitro in serum of cow. The H2O2-mediated oxidation of o-dianisidine was used to assess the
Wei Shen et al.
Biosensors & bioelectronics, 44, 171-176 (2013-02-22)
Herein we report a label-free microRNA (miRNA) biosensor in which the formation of a thin insulating film is used to amplify the analytical signal. Briefly, the biosensor is made of an oligonucleotide-coated gold electrode. After hybridizing with a target miRNA
Francesca Pintus et al.
Biochemistry, 49(40), 8739-8747 (2010-09-09)
The oxidation of the pseudohalide thiocyanate (SCN(-)) by Euphorbia peroxidase, in the presence or absence of added calcium, is investigated. After incubation of the native enzyme with hydrogen peroxide, the formation of Compound I occurs and serves to catalyze the
Imène Chaïr-Yousfi et al.
International immunopharmacology, 25(1), 19-29 (2015-01-21)
Lung injury and respiratory distress syndrome are frequent symptoms observed in the most severe cases of scorpion envenomation. The uncontrolled transmigration of leukocyte cells into the lung interstitium and alveolar space and pulmonary edema may be the cause of death.
Elena García-Martín et al.
Clinical biochemistry, 40(16-17), 1339-1341 (2007-09-11)
Serum diamine oxidase (DAO; EC 1.4.3.6) activity is often employed as a clinical indicator of the integrity of intestinal mucosa. However, interindividual variation in enzyme activity and reference values for healthy women and men have not been studied. DAO activity
Urvish Chhaya et al.
Journal of basic microbiology, 50(1), 43-51 (2010-01-19)
Laccase production by solid state fermentation (SSF) using an indigenously isolated litter dwelling fungus Fusarium incarnatum LD-3 was optimized. Fourteen medium components were screened by the initial screening method of Plackett-Burman. Each of the components was screened on the basis
Sharon McClellan et al.
Journal of immunology (Baltimore, Md. : 1950), 194(4), 1776-1787 (2015-01-16)
High-mobility group box 1 (HMGB1), a prototypic alarmin, mediates the systemic inflammatory response syndrome. Treatment with vasoactive intestinal peptide, an anti-inflammatory neuropeptide, downregulates proinflammatory cytokines and promotes healing in a susceptible (cornea perforates) model of Pseudomonas aeruginosa keratitis, and also
Berkay Ozcelik et al.
Advanced healthcare materials, 3(9), 1496-1507 (2014-03-22)
Corneal endothelial cells (CECs) are responsible for maintaining the transparency of the human cornea. Loss of CECs results in blindness, requiring corneal transplantation. In this study, fabrication of biocompatible and biodegradable poly(ethylene glycol) (PEG)-based hydrogel films (PHFs) for the regeneration
Rong Gao et al.
American journal of physiology. Lung cellular and molecular physiology, 308(8), L847-L853 (2015-02-11)
Excessive inflammation is a major cause of organ damage during sepsis. The elderly are highly susceptible to sepsis-induced organ injury. Sirt1 expression is reduced during aging. In the present study, we investigated the role of Sirt1, a histone deacetylase, in
Erica S Schwartz et al.
Pain, 156(8), 1537-1544 (2015-04-29)
Chronic nonbacterial prostatitis, characterized by genitourinary pain in the pelvic region in the absence of an identifiable cause, is common in adult males. Surprisingly, the sensory innervation of the prostate and mediators that sensitize its innervation have received little attention.
Annemie Deiteren et al.
Gut, 63(12), 1873-1882 (2014-02-25)
Substantial evidence implicates mast cells and their main constituent histamine in the pathogenesis of visceral hypersensitivity. We explored the specific contribution of histamine H4 (H4R) and H1 (H1R) receptors to visceral hypersensitivity in a postinflammatory rat model. Trinitrobenzenesulfonic acid (TNBS)-colitis
3,3'-Dimethoxybenzidine and dyes metabolized to 3,3'-dimethoxybenzidine: 3,3'-dimethoxybenzidine.
Report on carcinogens : carcinogen profiles, 12, 164-165 (2011-08-20)
Enzyme-immunoassay for the measurement of antigens using peroxidase conjugates.
S Avrameas et al.
Biochimie, 54(7), 837-842 (1972-01-01)
Uta Merle et al.
Journal of hepatology, 51(5), 925-930 (2009-09-02)
A low serum ceruloplasmin concentration is considered diagnostic for Wilson's disease. We aimed to evaluate an enzymatic test for ceruloplasmin oxidase activity and to compare it with the routinely used immunological ceruloplasmin measurement. Serum ceruloplasmin was measured enzymatically with o-dianisidine
Xiao Xiao et al.
Food chemistry, 167, 438-446 (2014-08-26)
With the prevalence of inflammatory bowel disease (IBD) and its associated risk for development of colorectal cancer, it is of great importance to prevent and treat IBD. However, due to the complexity of etiology and potentially serious adverse effects, treatment
Hulya Toker et al.
Journal of periodontal research, 47(5), 572-577 (2012-03-01)
The aim of this study was to evaluate the impact of smoking on the relationship between interleukin-1 (IL-1β) and oxidation in patients with periodontitis and response to nonsurgical periodontal therapy. Data were obtained from 30 patients with generalized chronic periodontitis
Frédéric Frottin et al.
Molecular & cellular proteomics : MCP, 5(12), 2336-2349 (2006-09-12)
Methionine aminopeptidase (MAP) is a ubiquitous, essential enzyme involved in protein N-terminal methionine excision. According to the generally accepted cleavage rules for MAP, this enzyme cleaves all proteins with small side chains on the residue in the second position (P1')
Koji Takeuchi et al.
Life sciences, 110(2), 77-85 (2014-07-02)
The present study compared the effects of frequently used anti-platelet drugs, such as clopidogrel, ticlopidine, and cilostazol, on the gastric bleeding and ulcerogenic responses induced by intraluminal perfusion with 25 mM aspirin acidified with 25 mM HCl (acidified ASA) in
Tsong-Long Hwang et al.
Bioorganic & medicinal chemistry, 23(5), 1123-1134 (2015-02-05)
Proteinase 3 (Pr3), and human neutrophil elastase (HNE) are two major neutrophilic serine proteases (NsPs) expressed in neutrophil azurophil granules. Emerging data suggest that excessive release of proteases mediates tissue damage, and therefore prolonged neutrophil accumulation has an important role
Ana L M Ivan et al.
Journal of photochemistry and photobiology. B, Biology, 138, 124-133 (2014-06-14)
Ultraviolet B (UVB) irradiation may cause oxidative stress- and inflammation-dependent skin cancer and premature aging. Pyrrolidine dithiocarbamate (PDTC) is an antioxidant and inhibits nuclear factor-κB (NF-κB) activation. In the present study, the mechanisms of PDTC were investigated in cell free
Priscilla F C Justino et al.
Cancer chemotherapy and pharmacology, 75(3), 559-567 (2015-01-13)
Lactobacillus acidophilus is widely used for gastrointestinal disorders, but its role in inflammatory conditions like in chemotherapy-induced mucositis is unclear. Here, we report the effect of L. acidophilus on 5-fluorouracil-induced (5-FU) intestinal mucositis in mice. Mice weighing 25-30 g (n = 8) were
Tamia K Lapointe et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(2), G87-G99 (2015-05-30)
Quiescent phases of inflammatory bowel disease (IBD) are often accompanied by chronic abdominal pain. Although the transient receptor potential vanilloid 1 (TRPV1) ion channel has been postulated as an important mediator of visceral hypersensitivity, its functional role in postinflammatory pain
Patrudu Makena et al.
Environmental and molecular mutagenesis, 48(5), 404-413 (2007-03-21)
4-Aminobyphenyl (4-Ab), benzidine (Bz), and Bz congeners were evaluated for their ability to induce genotoxicity through an oxidative mechanism. The mutagenicity of these compounds was tested in the presence and absence of Aroclor 1254-induced rat S9 mix using Salmonella typhimurium
Iain S MacPherson et al.
Protein engineering, design & selection : PEDS, 23(3), 137-145 (2010-01-20)
Directed evolution methods were developed for Cu-containing nitrite reductase (NiR) from Alcaligenes faecalis S-6. The PCR cloning strategy allows for the efficient production of libraries of 100 000 clones by a modification of a megaprimer-based whole-plasmid synthesis reaction. The high-throughput
Irina Pozdnyakova et al.
Biochimica et biophysica acta, 1804(4), 740-744 (2009-11-26)
Enzymes catalyze biochemical reactions in highly crowded environments where the amount of macromolecules may occupy up to 40% of the volume. Here we report how cell-like conditions tune catalytic parameters for the monomeric multi-copper oxidase, Saccharomyces cerevisiae Fet3p, in vitro.
Mariángeles Noto Llana et al.
PloS one, 9(11), e111282-e111282 (2014-11-05)
Foodborne diseases caused by Salmonella enterica serovar Enteritidis (S. Enteritidis) are a significant health problem. Pregnancy, state of immunological tolerance, is a predisposing condition for the development of infections with intracellular pathogens. Salmonella species can cause pregnancy complications such as
José Fernando Bastos Moura et al.
International journal of radiation biology, 91(6), 500-509 (2015-03-12)
To design a novel model to study Cobalt-60 (Co-60)-induced radiation mucositis and to describe the pathways involved in its development. Hamsters' cheeks were treated with Co-60 radiation (10, 20, 30 or 35 Gy). Three days later, oral mucosa scarification was
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