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G Wu et al.
Pharmacological research, 35(6), 553-556 (1997-06-01)
Micellar electrokinetic capillary chromatography was used to separate levodopa (L-3,4-dihydroxyphenyl-L-alanine), dextrodopa (D-3,4-dihydroxyphenyl-L-alanine) and DL-3-O-methyl-dopa, a metabolite of dopa, which were derivatised with the Marfey's reagent, in sodium borate, sodium dodecyl sulfate and acetonitile buffer system. Whereas DL-dopa derivatives could be
J M Floberg et al.
Physics in medicine and biology, 58(4), 1151-1168 (2013-02-02)
We introduce a method for denoising dynamic PET data, spatio-temporal expectation-maximization (STEM) filtering, that combines four-dimensional Gaussian filtering withEMdeconvolution. The initial Gaussian filter suppresses noise at a broad range of spatial and temporal frequencies and EM deconvolution quickly restores the
Ewa Chodurek et al.
Acta poloniae pharmaceutica, 69(6), 1334-1341 (2013-01-05)
Drug binding by melanin biopolymers influence the effectiveness of the chemotherapy, radiotherapy and photodynamic therapy. Free radicals of melanins take part in formation of their complex with drugs. The aim of this work was to determine the effect of the
Ming Chang Hu et al.
American journal of physiology. Renal physiology, 304(9), F1169-F1180 (2013-02-22)
The intrarenal autocrine/paracrine dopamine (DA) system contributes to natriuresis in response to both acute and chronic Na(+) loads. While the acute DA effect is well described, how DA induces natriuresis chronically is not known. We used an animal and a
Karlo J Lizarraga et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 30-36 (2013-10-30)
Brain metastases are frequently treated with radiation. It is critical to distinguish recurrent or progressive brain metastases (RPBM) from late or delayed radiation injury (LDRI). The purpose of this study was to examine the diagnostic accuracy as well as the
Dongyeop X Oh et al.
Biotechnology progress, 29(2), 505-512 (2013-01-16)
Chitosan is one of the most widely used structural polymers for biomedical applications because it has many favorable properties. However, one of the most critical drawbacks regarding the use of chitosan as a biomedical material is its poor mechanical properties
Lionel C Libert et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(7), 1154-1161 (2013-05-10)
6-(18)F-fluoro-L-dopa ((18)F-FDOPA) has proven to be a useful radiopharmaceutical for the evaluation of presynaptic dopaminergic function using PET. In comparison to electrophilic synthesis, the no-carrier-added (NCA) nucleophilic method has several advantages. These include much higher available activity and specific activity.
Suneeta Yadav et al.
Indian journal of experimental biology, 52(5), 489-495 (2014-05-24)
Specific temporal phase relation of neural oscillations appears to be the regulator of gonadal development in many seasonally breeding species. To find out the specific phase angle of two neural oscillations that triggers gonado-inhibitory or gonado-stimulatory response, and to test
Wei Wei et al.
Journal of the American Chemical Society, 135(1), 377-383 (2012-12-12)
Dopa (3,4-dihydroxyphenylalanine) is recognized as a key chemical signature of mussel adhesion and has been adopted into diverse synthetic polymer systems. Dopa's notorious susceptibility to oxidation, however, poses significant challenges to the practical translation of mussel adhesion. Using a surface
David S Goldstein et al.
Journal of neurochemistry, 126(5), 591-603 (2013-06-22)
Intra-neuronal metabolism of dopamine (DA) begins with production of 3,4-dihydroxyphenylacetaldehyde (DOPAL),which is toxic. According to the 'catecholaldehyde hypothesis', DOPAL destroys nigrostriatal DA terminals and contributes to the profound putamen DA deficiency that characterizes Parkinson’s disease (PD). We tested the feasibility
Constantin Lapa et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(10), 1611-1616 (2014-08-16)
High-grade gliomas (HGGs) are the most common malignant primary tumors of the central nervous system. PET probes of amino acid transport such as O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET), 3,4-dihydroxy-6-(18)F-fluoro-l-phenylalanine ((18)F-DOPA), and (11)C-methionine ((11)C-MET) detect primary and recurrent tumors with a high accuracy. (18)F-FET
Oliver D Howes et al.
Brain : a journal of neurology, 136(Pt 11), 3242-3251 (2013-10-08)
Elevated in vivo markers of presynaptic striatal dopamine activity have been a consistent finding in schizophrenia, and include a large effect size elevation in dopamine synthesis capacity. However, it is not known if the dopaminergic dysfunction is limited to the
Jigang Yang et al.
Journal of pediatric endocrinology & metabolism : JPEM, 25(7-8), 619-622 (2012-11-20)
Congenital hyperinsulinism (CHI) during infancy is characterized by inappropriate insulin secretion resulting in persistent hypoglycemia. This can lead to irreversible severe neurological damage in the infant. There are two main histologic subtypes: diffuse and focal, both of which may require
Kyuri Lee et al.
International journal of pharmaceutics, 445(1-2), 196-202 (2013-01-19)
Calcium phosphate (CAP) has a wide range of applications in biomedical systems. Although there is great potential for the use of CAP in the development of gene delivery systems, the uncontrollable growth of CAP crystal makes it difficult to use
Thorben Schlüter et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(43), 16889-16896 (2013-10-25)
Cerebral dopamine (DA) transmission is thought to be an important modulator for the development and occurrence of aggressive behavior. However, the link between aggression and DA transmission in humans has not been investigated using molecular imaging and standardized behavioral tasks.
Dina Rībena et al.
Langmuir : the ACS journal of surfaces and colloids, 28(49), 16900-16908 (2012-11-20)
The adhesive proteins secreted by marine mussels contain an unusual amino acid, 3,4-dihydroxyphenylalanine (DOPA), that is responsible for the cohesive and adhesive strength of this natural glue and gives mussels the ability to attach themselves to rocks, metals, and plastics.
Eun Kyung Jeon et al.
Chemical communications (Cambridge, England), 49(33), 3392-3394 (2013-02-26)
We report a facile green approach to the synthesis of silver nanoparticles (Ag NPs) on the surface of graphene oxide nanosheets functionalized with mussel-inspired dopamine (GO-Dopa) without additional reductants or stabilizers at room temperature. The resulting hybrid Ag/GO-Dopa exhibits good
Giovanni Morana et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(5), 718-723 (2014-03-22)
Infiltrative astrocytomas (IAs) represent a group of astrocytic gliomas ranging from low-grade to highly malignant, characterized by diffuse invasion of the brain parenchyma. When compared with their adult counterpart, pediatric IAs may be considered biologically distinct entities; nevertheless, similarly to
Dong Soo Hwang et al.
Acta biomaterialia, 9(9), 8110-8117 (2013-06-25)
Many marine invertebrates utilize biomacromolecules as building blocks to form their load-bearing tissues. These polymeric tissues are appealing for their unusual physical and mechanical properties, including high hardness and stiffness, toughness and low density. Here, a marine hydroid perisarc of
Yufei Ai et al.
Journal of photochemistry and photobiology. B, Biology, 120, 183-190 (2012-12-26)
The catecholic amino acid 3,4-Dihydroxyphenyl-l-alanine (DOPA) is believed to be responsible for the water-resistant adhesive characteristics of mussel adhesive proteins (MAPs). In this paper, the synthesis of three-armed poly(ethylene glycol)s with dopamine endgroups (PEG-DOPAs) using acylation reaction and Michael addition
Multimodal magnetic resonance imaging and 18F-L-dihydroxyphenylalanine positron emission tomography in early characterization of pseudoresponse and nonenhancing tumor progression in a pediatric patient with malignant transformation of ganglioglioma treated with bevacizumab.
Giovanni Morana et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(1), e1-e5 (2012-11-22)
Jie Xue et al.
Journal of photochemistry and photobiology. B, Biology, 119, 31-36 (2013-01-15)
Synthetic adhesives inspired by marine mussel have attracted great attention due to its excellent water-resistance and good biocompatibility. In this study, a photocrosslinkable bioadhesive containing 3,4-Dihydroxy-l-phenylalanine (DOPA) functional group, which is central to curing mussel adhesive proteins, was prepared by
A Piccardo et al.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 57(1), 29-39 (2013-03-12)
123Iodine-metaiodobenzylguanidine (123I-MIBG) scintigraphy is currently the tracer of choice for neuroblastoma (NB). It has high diagnostic accuracy and prognostic value for the assessment of patients after chemotherapy. A positive 123I-MIBG scan is also used for the basis of targeted radionuclide
Ki Sung Kang et al.
Brain research, 1497, 1-14 (2012-12-05)
Levodopa (L-DOPA) is widely used for symptomatic management in Parkinson's disease. We recently showed that (-)-epigallocatechin-3-gallate, a tea polyphenol, not only inhibits L-DOPA methylation, but also protects against oxidative hippocampal neurodegeneration. In the present study, we sought to determine several
Steven L Saville et al.
Nanoscale, 5(5), 2152-2163 (2013-02-08)
It has been recently reported that for some suspensions of magnetic nanoparticles the transverse proton relaxation rate, R(2), is dependent on the time that the sample is exposed to an applied magnetic field. This time dependence has been linked to
A V Lebedev et al.
Biofizika, 58(1), 47-53 (2013-05-09)
Treatment of catechol, pyrogallol, DOPA, dopamine, norepinephrine, and natural polyhydroxy-1,4-naphthoquinone echinochrome by aqueous solution of potassium superoxide (KO2) in the presence of CaCl2 leads to the formation of water-insoluble dark pigments with stable paramagnetic properties ("calcium melanins"). In control experiments
Andrew C Meyer et al.
Journal of neurochemistry, 127(2), 187-198 (2013-07-24)
Vesicular monoamine transporter-2 (VMAT2) inhibitors reduce methamphetamine (METH) reward in rats. The current study determined the effects of VMAT2 inhibitors lobeline (LOB; 1 or 3 mg/kg) and N-(1,2R-dihydroxylpropyl)-2,6-cis-di(4-methoxyphenethyl)piperidine hydrochloride (GZ-793A; 15 or 30 mg/kg) on METH-induced (0.5 mg/kg, SC) changes
Marie Krogsgaard et al.
Biomacromolecules, 14(2), 297-301 (2013-01-26)
Self-healing hydrogels can be made using either reversible covalent cross-links or coordination chemistry bonds. Here we present a multi-pH-responsive system inspired by the chemistry of blue mussel adhesive proteins. By attaching DOPA to an amine-functionalized polymer, a multiresponsive system is
Z Y Wu et al.
Drug discoveries & therapeutics, 6(5), 238-241 (2012-12-12)
Catecholamines, such as dopamine and L-dihydroxyphenylalanine (L-DOPA), are associated with different physiological functions and diseases. In our recent studies, a novel water-soluble boronic acid compound 3c was identified as a selective fluorescent sensor for L-DOPA. This compound not only has
Jigang Yang et al.
Nuclear medicine communications, 34(4), 347-353 (2013-02-05)
Studies have reported the applications of F-dihydroxyphenylalanine (F-DOPA) PET in patients with congenital hyperinsulinism (CHI). The aim of this study was to systematically review and perform a meta-analysis of published data on the diagnostic role of F-DOPA PET in patients
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