Showing 1-29 of 29 results for "deprotonations"
Selective Metalation, Deprotonation, and Additions
Transformative reagents for selective metalation, deprotonation and nucleophilic additions have allowed for unprecedented selective converstions to reactive intermediates within a molecule which contains sensative functionalities under mild reactions.
New Reagents for Selective Metalation, Deprotonation, and 1,2-Additions
We present an article concerning Reagents for Selective Metalation, Deprotonation, and 1,2-Additions.
Universal (Switchable) RAFT Agents for Well-Defined Block Copolymers
Universal (Switchable) RAFT agents allow for the polymerization of both less activated and more activated monomers and are ideal for the synthesis of well-defined block copolymers.
BASIL™—BASF’s Processes Based on Ionic Liquids
The most important application of Ionic Liquids described is their use as reaction media for chemical processes. A major breakthrough was reached with BASF’s introduction of the first application on a commercial scale: the BASIL™-process.
HPLC Analysis of Proteins by Cation Exchange on Proteomix® WCX-NP5: Affect of pH
Separation of Ribonuclease A from bovine pancreas, Type I-A, powder, ≥60% RNase A basis (SDS-PAGE), ≥50 Kunitz units/mg protein; α-Chymotrypsinogen A from bovine pancreas, essentially salt-free, lyophilized powder; Cytochrome c from bovine heart, ≥95% based on Mol. Wt. 12,327 basis;...
RAFT Polymerization Lecture
This webinar features an overview of Reversible Addition Fragmentation Chain Transfer (RAFT) Polymerization and highlights advances, such as switchable RAFT agents.
Coltart Group – Professor Product Portal
Synthetic organic chemistry is the unifying feature of all research in the Coltart group. We have a particular interest in the development of new synthetic methods and the use of those methods to enable the total synthesis of structurally complex...
Selective 1,2-Additions with LaCl3·2LiCl
While the 1,2-addition of Grignard reagents to ketones is undoubtedly a powerful transformation, oftentimes selectivity issues arising from competitive alpha-deprotonation detract from the use of these reagents.
Chiral Amines
Chiral amines have found widespread application in asymmetric synthesis serving, for instance, as chiral bases in enantioselective deprotonation reactions or being valuable substances for resolving racemic mixtures of acids.
Preparing Terminal Alkynes: Vinyl N,N-Diisopropylcarbamate for Stereospecific Alkynylation of Chiral Boronic Esters
Prof. Aggarwal et al developed a stereospecific alkynylation of chiral secondary & tertiary pinacol boronic esters, allowing the facile preparation of terminal alkynes.
Knoevenagel Condensation Reaction
Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.
Peptide Stability and Potential Degradation Pathways
To prevent or minimize peptide degradation we recommend storing the peptide in lyophilized form at –20 °C or –80 °C. Once in solution, the peptide/protein should be stored frozen in individual aliquots to avoid freeze-thaw cycles. Also, prolonged exposure to...
How to Maximize Sensitivity in LC-MS
Various measures and options for maximized LC-MS sensitivity and low limit of detection (LOD) are shown on this page. Each and every tip avoids contaminations causing signal suppression, adduct formation, elevated background noise and increased spectrum complexity.
Solid Phase Synthesis
Peptides are manufactured using solid phase FMOC or BOC chemistry methodologies on a PEG-Polystyrene support resin. Upon synthesis completion, side chain protecting groups are removed and the peptides are simultaneously cleaved from the resin. The cleaved and deprotected ...
Electrochemical Allylic C–H Oxidation with N-Hydroxytetrachlorophthalimide (TCNHPI)
Professor Phil Baran and coworkers have developed a new reagent, <i>N<i>-Hydroxytetrachlorophthalimide (ALD00564), which provides a cheap, scalable, and safe synthetic alternative to highly used transformations like allylic oxidations, as well as Negishi and Suzuki–Miyaura type cross-coupling reactions.
Cinchona Alkaloids
Asymmetric phase-transfer catalysis (PTC) has been recognized as a “green” alternative to many homogeneous synthetic organic transformations, and has found widespread application. Synthetically modified cinchona alkaloids are typical chiral organocatalysts used in asymmetric PTC.
Super Silyl Protecting Groups
The super silyl group is a powerful tool for the synthetic chemist, showing great efficacy in various carbon–carbon bond forming reactions.
Fluorescent Labeling of Peptides
Fluorescent Labeling of Peptides
Controlling SPE Selectivity Through pH and Organic Modifier Manipulation
Controlling SPE Selectivity Through pH and Organic Modifier Manipulation
Gold Catalysts
Recent advancements, spearheaded by F. Dean Toste (University of California, Berkeley) and others, have propelled gold into the forefront of transition metal catalysts
Gold Catalyst
We are proud to offer a treasure-trove of gold precatalysts and silver salts, as well as an extensive portfolio of unsaturated building blocks to accelerate your research success in this exciting field.
G3 and G4 Buchwald Precatalysts
G3 and G4 Buchwald palladium precatalysts are the newest air, moisture, and thermally stable crossing-coupling complexes used in bond formation for their versatility and high reactivity.
Protein Mass Spectrometry
An overview of techniques for protein mass spectrometry used in the identification and quantification of proteins, post-translational modifications, glycan profiling, and protein-protein interactions in drug discovery and proteomics research.
TrueGel3D™ Hydrogel for 3D Cell Culture
TrueGel3D™ is a synthetic hydrogels platform for 3D cell culture that aim to mimic the natural extracellular environment for more physiological culture conditions
Micro and Nanometer Scale Photopatterning of Self-Assembled Monolayers
Self-assembled monolayers (SAMs) have attracted enormous interest for a wide variety of applications in micro- and nano-technology. In this article, we compare the benefits of three different classes of SAM systems (alkylthiolates on gold).
Metal-Organic Frameworks in Sustainable Energy Technologies
Metal-organic frameworks, a subset of coordination polymers, represent a powerful new tool for a plethora of alternative energy applications. MOFs are readily available using simple synthetic strategies that supply tailored, high surface area materials.
Understanding and Successfully Applying Materials for Dye-Sensitized Solar Cells
While dye sensitization as the basis for color photography has been accepted for a very long time,1 attempts to use this principle for the conversion of solar light to electricity generally had resulted only in very low photocurrents, below 100...
Organic Bioelectronic Materials and Devices for Bridging Biology and Traditional Electronics
Professor Rivnay (Northwestern University, USA) discusses using organic mixed conductors as an alternative to efficiently bridge the ionic world of biology with contemporary microelectronics.
Stimuli-Responsive Materials as Intelligent Drug Delivery Systems
By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

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