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Organism
Showing 1-10 of 10 results for "dna_replication"
GMNN
geminin, DNA replication inhibitor
Synonyms:
Gem
Species:
Human GMNN (51053), Mouse Gmnn (57441), Rat Gmnn (291137), domestic guinea pig Gmnn (100735738), naked mole-rat Gmnn (101719826), Goat GMNN (100860987), sheep GMNN (101117456), Zebrafish gmnn (368320), cow GMNN (526377), domestic cat GMNN (101097559), dog GMNN (478739), chicken GMNN (421004)
Summary:
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011
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DNA2
DNA replication helicase/nuclease 2
Synonyms:
DNA2L, PEOA6, hDNA2
Species:
Human DNA2 (1763), Mouse Dna2 (327762), Rat Dna2 (309762), Zebrafish dna2 (559535), chicken DNA2 (423688), cow DNA2 (540969), Horse DNA2 (100072606), domestic cat DNA2 (101097671), dog DNA2 (489015), sheep DNA2 (101105877), domestic guinea pig Dna2 (100718416), naked mole-rat Dna2 (101702298)
Summary:
DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin et al., 2009 [PubMed 19487465
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CDT1
chromatin licensing and DNA replication factor 1
Synonyms:
DUP, RIS2
Species:
Human CDT1 (81620), Mouse Cdt1 (67177), Rat Cdt1 (292071), Zebrafish cdt1 (566787), Thale Cress CDT1 (2745823), chicken CDT1 (426254), domestic cat CDT1 (101098673), cow CDT1 (519016), Horse CDT1 (100051139), dog CDT1 (479616), naked mole-rat Cdt1 (101714018), domestic guinea pig Cdt1 (100733165), sheep CDT1 (101108074)
Summary:
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011
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KLLN
killin, p53-regulated DNA replication inhibitor
Synonyms:
CWS4, KILLIN
Species:
Human KLLN (100144748), domestic cat KLLN (101098164), sheep KLLN (101122485), naked mole-rat Klln (101701901)
Summary:
The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012
Products:
Species:
Human LOC100133137 (100133137)
Species:
Human LOC100133127 (100133127)
Species:
Rat LOC367976 (367976)
Products:
Species:
Rat LOC317415 (317415)
Products:
DSCC1
DNA replication and sister chromatid cohesion 1
Synonyms:
DCC1
Species:
Human DSCC1 (79075), Mouse Dscc1 (72107), Rat Dscc1 (299933), sheep DSCC1 (101116411), naked mole-rat Dscc1 (101713588), domestic guinea pig Dscc1 (100730981), Zebrafish dscc1 (447872), cow DSCC1 (509563), Horse DSCC1 (100066222), domestic cat DSCC1 (101098435), dog DSCC1 (609036), chicken DSCC1 (420358)
Summary:
CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176
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MCM3
minichromosome maintenance complex component 3
Synonyms:
HCC5, P1-MCM3, P1.h, RLFB
Species:
Human MCM3 (4172), Mouse Mcm3 (17215), Rat Mcm3 (316273), Zebrafish mcm3 (192323), cow MCM3 (281302), Horse MCM3 (100069108), domestic cat MCM3 (101083515), dog MCM3 (481839), Thale Cress MCM3 (834670), Zebrafish mcm3 (100536986), fruit fly Mcm3 (31449), chicken MCM3 (422043), sheep MCM3 (101104435), naked mole-rat Mcm3 (101719015), Domestic Rabbit MCM3 (100339825), domestic guinea pig Mcm3 (100729563)
Summary:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012
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