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Edgar Angelats et al.
Frontiers in cell and developmental biology, 6, 67-67 (2018-08-04)
Endocannabinoids are important players in neural development and function. They act via receptors, whose activation inhibits cAMP production. The aim of the paper was to look for calcium- and cAMP-signaling cross-talk mediated by cannabinoid CB1 receptors (CB1R) and to assess...
Ioannis M Roussis et al.
PloS one, 11(1), e0147967-e0147967 (2016-01-30)
Techniques for studying RNA-protein interactions have lagged behind those for DNA-protein complexes as a consequence of the complexities associated with working with RNA. Here we present a method for the modification of the existing In Situ Hybridisation-Proximity Ligation Assay (ISH-PLA)...
Jane Antony et al.
EMBO reports, 19(8) (2018-06-17)
In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI-anchored tumour suppressor OPCML Further, we demonstrate that AXL...
Jung Jin Lim et al.
Endocrinology, 158(4), 993-1004 (2017-03-23)
The destiny of the ovarian follicle (growth or atresia) is tightly regulated by the actions and interactions of endocrine, paracrine, and autocrine factors. Although androgens are known to be important in the regulation of folliculogenesis, whether they facilitate or suppress...
Jun-Ho Cho et al.
Experimental cell research, 368(1), 50-58 (2018-04-18)
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is implicated in cell death in addition to a role as a glycolytic enzyme. In particular, when cells are exposed to cellular stressors involving nitric oxide (NO) production, GAPDH can undergo NO-induced S-nitrosylation and S-nitrosylated GAPDH has...
Christina Servas et al.
Cellular signalling, 36, 163-175 (2017-05-11)
Apoptosis and the response to cell stress are evolutionary highly conserved mechanisms. Both processes require strict regulation, which is often performed by protein kinases. The mammalian Sterile 20-like kinase 1 (MST1) is a pro-apoptotic protein kinase, which is activated and...
Eric Dietel et al.
Oncogenesis, 7(8), 64-64 (2018-08-25)
Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20-30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled to a more aggressive and invasive...
Ding-Yu Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(8), 2072-2077 (2017-02-09)
Histone deacetylases (HDACs) and microRNAs (miRs) have emerged as two important epigenetic factors in the regulation of vascular physiology. This study aimed to elucidate the relationship between HDACs and miRs in the hemodynamic modulation of endothelial cell (EC) dysfunction. We...
Susanne Frykman et al.
Biochemical and biophysical research communications, 483(1), 352-358 (2016-12-27)
The toxic amyloid β-peptide (Aβ) is a key player in Alzheimer Disease (AD) pathogenesis and selective inhibition of the production of this peptide is sought for. Aβ is produced by the sequential cleavage of the Aβ precursor protein (APP) by...
Beidong Liu et al.
Cell, 140(2), 257-267 (2010-02-10)
The paradigm sirtuin, Sir2p, of budding yeast is required for establishing cellular age asymmetry, which includes the retention of damaged and aggregated proteins in mother cells. By establishing the global genetic interaction network of SIR2 we identified the polarisome, the...
Rosario Avolio et al.
Nucleic acids research, 46(22), 12067-12086 (2018-09-28)
Syndesmos (SDOS) is a functionally poorly characterized protein that directly interacts with p53 binding protein 1 (53BP1) and regulates its recruitment to chromatin. We show here that SDOS interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively...
Julie Colin et al.
Neurobiology of aging, 54, 84-93 (2017-03-30)
Although a major risk factor for Alzheimer's disease (AD), the "aging" parameter is not systematically considered in preclinical validation of anti-AD drugs. To explore how aging affects neuronal reactivity to anti-AD agents, the ciliary neurotrophic factor (CNTF)-associated pathway was chosen...
Lara Planas-Paz et al.
The EMBO journal, 31(4), 788-804 (2011-12-14)
In the mammalian embryo, few mechanical signals have been identified to influence organ development and function. Here, we report that an increase in the volume of interstitial or extracellular fluid mechanically induces growth of an organ system, that is, the...
Alessandra Zappulo et al.
Nature communications, 8(1), 583-583 (2017-09-21)
Protein subcellular localization is fundamental to the establishment of the body axis, cell migration, synaptic plasticity, and a vast range of other biological processes. Protein localization occurs through three mechanisms: protein transport, mRNA localization, and local translation. However, the relative...
Correction: Regulation of the DNA Repair Complex during Somatic Hypermutation and Class-Switch Recombination.
Anjani Kumar et al.
Journal of immunology (Baltimore, Md. : 1950), 201(11), 3472-3473 (2018-10-31)
Eric Hervouet et al.
Cell division, 7, 5-5 (2012-02-22)
The clonal transmission of lineage-specific DNA methylation patterns in a mammalian genome during the cellular division is a crucial biological process controlled by the DNA methyltransferase Dnmt1, mainly. To investigate possible dynamic mechanisms of DNA methylation inheritance during the cell...
Rita Pinto et al.
Journal of cellular and molecular medicine, 16(7), 1474-1484 (2011-09-03)
Mucin glycoproteins are major secreted or membrane-bound molecules that, in cancer, show modifications in both the mucin proteins expression and in the O-glycosylation profile, generating some of the most relevant tumour markers in clinical use for decades. Thus far, the...
Fangfang Duan et al.
Journal of hepatology, 68(6), 1191-1202 (2018-02-18)
Aberrant oncogenic mRNA translation and protein O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) are general features during tumorigenesis. Nevertheless, whether and how these two pathways are interlinked remain unknown. Our previous study indicated that ribosomal receptor for activated C-kinase 1 (RACK1) promoted chemoresistance and...
Gemma Navarro et al.
Biochemical pharmacology, 157, 148-158 (2018-09-09)
Currently, biased agonism is at the center stage of drug development approaches. We analyzed effects of a battery of cannabinoids plus/minus cannabidiol (CBD) in four functional parameters (cAMP levels, phosphorylation of extracellular signal-regulated kinases (ERK1/2), β-arrestin recruitment and label-free/DMR) in...
A molecular mechanism of nickel (II): reduction of nucleotide excision repair activity by structural and functional disruption of p53.
Yeo Jin Kim et al.
Carcinogenesis, 39(10), 1310-1310 (2018-09-22)
Katharina Stoiber et al.
British journal of cancer, 118(1), 43-51 (2017-11-08)
Although altered membrane physiology has been discussed within the context of cancer, targeting membrane characteristics by drugs being an attractive therapeutic strategy has received little attention so far. Various acetyl-CoA carboxylase 1 (ACC1), and fatty acid synthase (FASN) inhibitors (like...
Sandra Derouiche et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(4), 1841-1854 (2017-12-01)
Several ion channels and transporters regulate fluid secretion in salivary and lacrimal glands. In salivary glands, the major anion channel involved in fluid secretion is the calcium-activated chloride channel anoctamin 1 (ANO1). Several members of the transient receptor potential (TRP)...
M Guy Roukens et al.
Nature cell biology, 12(10), 933-942 (2010-09-14)
We show that the transcriptional repressor Tel plays an evolutionarily conserved role in angiogenesis: it is indispensable for the sprouting of human endothelial cells and for normal development of the Danio rerio blood circulatory system. Tel orchestrates endothelial sprouting by...
Fatemeh Dibaji et al.
Iranian endodontic journal, 12(4), 443-448 (2017-12-12)
Dentinal canal walls are in direct contact with endodontic sealers prior to post space preparation and luting cements after post space preparation. This direct contact may affect the bond strength of intraradicular posts to root dentin. This study aimed to...
Ryouhei Tsutsumi et al.
Nature communications, 8(1), 466-466 (2017-09-08)
Reactive oxygen species are produced transiently in response to cell stimuli, and function as second messengers that oxidize target proteins. Protein-tyrosine phosphatases are important reactive oxygen species targets, whose oxidation results in rapid, reversible, catalytic inactivation. Despite increasing evidence for...
Nadia Canu et al.
Frontiers in molecular neuroscience, 10, 15-15 (2017-02-16)
The amyloid precursor protein (APP) interacts with the tropomyosin receptor kinase A (TrkA) in normal rat, mouse, and human brain tissue but not in Alzheimer's disease (AD) brain tissue. However, it has not been reported whether the two proteins interact...
Eva De Mol et al.
Structure (London, England : 1993), 26(1), 145-152 (2017-12-12)
The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription regulators are therefore of potential therapeutic interest. The mechanistic basis of these interactions is poorly understood...
Rosario Prados-Carvajal et al.
DNA repair, 66-67, 11-23 (2018-05-01)
The appropriate repair of DNA double strand breaks is critical for genome maintenance. Thus, several cellular pathways collaborate to orchestrate a coordinated response. These include the repair of the breaks, which could be achieved by different mechanisms. A key protein...
Edwin J Wiest et al.
Biochemical and biophysical research communications, 501(4), 858-862 (2018-05-13)
We discovered that SU11274, a class I c-Met inhibitor, fluoresces when excited by 488 nm laser light and showed rapid specific accumulation in distinct subcellular compartments. Given that SU11274 reduces cancer cell viability, we exploited these newly identified spectral properties to...
Srinivasan Ramakrishnan et al.
Pathogens (Basel, Switzerland), 7(2) (2018-03-23)
Membrane contact sites are regions of close apposition between two organelles, typically less than 30 nanometers apart, that facilitate transfer of biomolecules. The presence of contact sites has been demonstrated in yeast, plants, and mammalian cells. Here, we investigated the...
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