Showing 1-30 of 639 results for "DUO92101"
Can Huang et al.
The Journal of biological chemistry, 292(35), 14362-14370 (2017-07-01)
Nitric oxide (NO) modulates many physiological events through production of cGMP from its receptor, the NO-sensitive guanylyl cyclase (GC1). NO also appears to function in a cGMP-independent manner, via S-nitrosation (SNO), a redox-based modification of cysteine thiols. Previously, we have...
Melanie Märklin et al.
Nature communications, 8(1), 755-755 (2017-10-04)
Chronic lymphocytic leukaemia (CLL) is a clonal disorder of mature B cells. Most patients are characterised by an indolent disease course and an anergic phenotype of their leukaemia cells, which refers to a state of unresponsiveness to B cell receptor...
Tamás Sticz et al.
Pathology oncology research : POR (2018-06-09)
Several monoclonal antibodies and inhibitors targeting signalling pathways are being used in personalised medicine. Anti-EGFR antibodies seem to be effective, however, therapy resistance often occurs in colon carcinoma cases. mTOR inhibitors (mTORIs) could have a potential role in the breakthrough...
Marthe H R Ludtmann et al.
Nature communications, 9(1), 2293-2293 (2018-06-14)
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that aggregation of monomers generates beta sheet-rich oligomers that localise to...
Ming-Xin An et al.
The Journal of cell biology, 216(12), 4091-4105 (2017-11-09)
Aerobic glycolysis, a phenomenon known historically as the Warburg effect, is one of the hallmarks of cancer cells. In this study, we characterized the role of BAG3 in aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) and its molecular mechanisms. Our...
Benjamin A Hilton et al.
Molecular cell, 60(1), 35-46 (2015-09-22)
ATR, a PI3K-like protein kinase, plays a key role in regulating DNA damage responses. Its nuclear checkpoint kinase function is well documented, but little is known about its function outside the nucleus. Here we report that ATR has an antiapoptotic...
Elizabeth Bloch et al.
The Journal of biological chemistry, 294(49), 18796-18806 (2019-11-05)
Receptor protein tyrosine phosphatases (RPTPs) play critical regulatory roles in mammalian signal transduction. However, the structural basis for the regulation of their catalytic activity is not fully understood, and RPTPs are generally not therapeutically targetable. This knowledge gap is partially...
Yuxuan Miao et al.
Cell host & microbe, 22(3), 330-342 (2017-09-15)
Rab small GTPases control membrane trafficking through effectors that recruit downstream mediators such as motor proteins. Subcellular trafficking typically involves multiple Rabs, with each specific step mediated by a distinct Rab protein. We describe a collaboration between two distinct Rab-protein-orchestrated...
Elisabetta Mattioli et al.
Cells, 7(10) (2018-10-18)
LMNA linked-Emery-Dreifuss muscular dystrophy (EDMD2) is a rare disease characterized by muscle weakness, muscle wasting, and cardiomyopathy with conduction defects. The mutated protein lamin A/C binds several nuclear envelope components including the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex and...
Joanna Korfanty et al.
Reproduction (Cambridge, England), 156(3), 195-206 (2018-06-09)
SPEN (spen family transcription repressor) is a nucleic acid-binding protein putatively involved in repression of gene expression. We hypothesized that SPEN could be involved in general downregulation of the transcription during the heat shock response in mouse spermatogenic cells through...
Ienglam Lei et al.
Frontiers in cell and developmental biology, 7, 358-358 (2020-02-11)
Dissecting epigenetic mechanisms controlling early cardiac differentiation will provide insights into heart regeneration and heart disease treatment. SWI/SNF complexes remodel nucleosomes to regulate gene expression and play a key role in organogenesis. Here, we reported a unique function of BAF250a...
Daniela Toro-Ascuy et al.
Nucleic acids research (2018-09-22)
Gag synthesis from the full-length unspliced mRNA is critical for the production of the viral progeny during human immunodeficiency virus type-1 (HIV-1) replication. While most spliced mRNAs follow the canonical gene expression pathway in which the recruitment of the nuclear...
Manuela D'Eletto et al.
Cell reports, 25(13), 3573-3581 (2018-12-28)
Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in mitochondria homeostasis under stressful cellular conditions. TG2 interactome analysis reveals an enzyme interaction with GRP75 (glucose-regulated protein 75). GRP75 localizes in mitochondria-associated membranes (MAMs) and acts...
Stephanie A Luff et al.
PloS one, 13(9), e0203991-e0203991 (2018-09-20)
Megakaryocytes (Mks) derive from hematopoietic stem and progenitor cells (HSPCs) in the bone marrow and develop into large, polyploid cells that eventually give rise to platelets. As Mks mature, they migrate from the bone marrow niche into the vasculature, where...
Réginald Philippe et al.
Cell calcium, 62, 47-59 (2017-02-13)
Cystic Fibrosis (CF) is the most frequent fatal genetic disease in Caucasian populations. Mutations in the chloride channel CF Transmembrane Conductance Regulator (CFTR) gene are responsible for functional defects of the protein and multiple associated dysregulations. The most common mutation...
Tatiana K Rostovtseva et al.
The Journal of biological chemistry, 293(28), 10949-10962 (2018-05-20)
The microtubule protein tubulin is a heterodimer comprising α/β subunits, in which each subunit features multiple isotypes in vertebrates. For example, seven α-tubulin and eight β-tubulin isotypes in the human tubulin gene family vary mostly in the length and primary...
SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks.
Sunetra Roy et al.
The Journal of cell biology, 217(4), 1553-1553 (2018-03-25)
Alexander Brobeil et al.
Leukemia research, 35(10), 1367-1375 (2011-04-26)
Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is known to be expressed in blood cells with restriction to the myeloid lineage. All myeloid progenitor cells are PTPIP51 positive except for the myeloblasts. To define the expression of PTPIP51 in acute...
Joshua W Russo et al.
Cancer letters, 438, 97-104 (2018-09-16)
Phosphorylation of serine 81 (pS81) in the N-terminal transactivation domain of the androgen receptor (AR) has been linked to its transcriptional activation in prostate cancer (PCa) cell lines, but in vivo studies have been limited. Moreover, the role of pS81...
Alexander Brobeil et al.
The international journal of biochemistry & cell biology, 46, 19-31 (2014-02-07)
Protein tyrosine phosphatse interacting protein (PTPIP51) is involved in the modulation of the mitogen activated protein kinase (MAPK) signaling pathway. Up to now, less is known about the regulation of this modulation. A recent study hinted to the phosphorylation status...
Georgia Dalagiorgou et al.
Cellular and molecular life sciences : CMLS, 74(5), 921-936 (2016-10-05)
Polycystin-1 (PC1) has been proposed as a chief mechanosensing molecule implicated in skeletogenesis and bone remodeling. Mechanotransduction via PC1 involves proteolytic cleavage of its cytoplasmic tail (CT) and interaction with intracellular pathways and transcription factors to regulate cell function. Here...
Seham A Abd El-Aleem et al.
Journal of molecular histology, 49(5), 531-543 (2018-08-26)
The AnxA2/S100A10 complex has been implicated in various placental functions but although the localisation of these proteins individually has been studied, there is no information about the localisation of their complex in situ at the cellular level. Using the proximity...
Poornima Ramkumar et al.
The Journal of biological chemistry, 290(49), 29617-29628 (2015-10-16)
JLP (JNK-associated leucine zipper protein) is a scaffolding protein that interacts with various signaling proteins associated with coordinated regulation of cellular process such as endocytosis, motility, neurite outgrowth, cell proliferation, and apoptosis. Here we identified PLK1 (Polo-like kinase 1) as...
Camille Samson et al.
Nucleic acids research, 46(19), 10460-10473 (2018-08-24)
Lamins are the main components of the nucleoskeleton. Whereas their 3D organization was recently described using cryoelectron tomography, no structural data highlights how they interact with their partners at the interface between the inner nuclear envelope and chromatin. A large...
Paola Arcidiacono et al.
Nature communications, 9(1), 1021-1021 (2018-03-11)
Hyperproliferative keratinocytes induced by trauma, hyperkeratosis and/or inflammation display molecular signatures similar to those of palmoplantar epidermis. Inherited gain-of-function mutations in RHBDF2 (encoding iRHOM2) are associated with a hyperproliferative palmoplantar keratoderma and squamous oesophageal cancer syndrome (termed TOC). In contrast...
Raviteja Inturi et al.
Journal of virology, 92(3) (2017-11-17)
Human adenoviruses (HAdVs) are common human pathogens encoding a highly abundant histone-like core protein, VII, which is involved in nuclear delivery and protection of viral DNA as well as in sequestering immune danger signals in infected cells. The molecular details...
Xiaodong Xu et al.
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 49(11), 677-681 (2015-01-28)
To evaluate and compare the physical and chemical properties of four different dental cements under long-term water storage. A glass-ionomer cement (A:Fuji I), a resin reinforced glass-ionomer (B: Fuji Plus), a self-adhesive resin cement (C:G-Cem), and an etch & rinse...
Mine Dündar et al.
Clinical oral investigations, 14(5), 579-586 (2009-08-20)
Effect of desensitizers on the bond strength of resin cements to dentin was evaluated. Intact premolars (N = 90) were embedded in polymethyl methacrylate; dentin surfaces were exposed, and they were randomly divided into two main groups of cements (Duolink...
Kinga Szafran-Pilch et al.
Brain research bulletin, 135, 92-97 (2017-10-11)
The interaction between the dopaminergic and somatostatinergic systems is considered to play a potential role in mood regulation. Chronic administration of antidepressants influences release of both neurotransmitters. The molecular basis of the functional cooperation may stem from the physical interaction...
Deborah Mattinzoli et al.
International journal of biological sciences, 14(6), 586-598 (2018-06-16)
Recently it has been demonstrated that Fetuin-A, an anti-inflammatory protein synthesized by the liver, is produced also in bone by an FGF23-regulated pathway. FGF23 has been also demonstrated to induce inflammatory cytokine production in the liver. This study aimed to...

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