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Shun Hasegawa et al.
Zygote (Cambridge, England), 27(5), 329-336 (2019-08-16)
Mammalian Pou5f1 encodes the POU family class V (POU-V) transcription factor which is essential for the pluripotency of embryonic cells and germ cells. In vertebrates, various POU-V family genes have been identified and classified into the POU5F1 family or its
Rui Zhang et al.
PLoS pathogens, 15(2), e1007329-e1007329 (2019-03-01)
Mycobacterial pathogens are the causative agents of chronic infectious diseases like tuberculosis and leprosy. Autophagy has recently emerged as an innate mechanism for defense against these intracellular pathogens. In vitro studies have shown that mycobacteria escaping from phagosomes into the
Lingling Hu et al.
Environmental science & technology, 52(15), 8885-8893 (2018-07-24)
Although microplastic (MP) pollution in freshwater systems is gaining attention, our knowledge of its distribution in small waterbodies is scarce. Small waterbodies are freshwater habitats to many species, including amphibians, that are vulnerable to MP pollution. This study analyzed the
Zonghao Yue et al.
Marine pollution bulletin, 129(2), 806-812 (2017-11-05)
This study investigated the anti-estrogenic effects of chronic exposure to a new marine pollutant, semicarbazide (SMC; 1, 10, and 100μg/L), in female Paralichthys olivaceus, as well as the associated mechanism. After 130days of exposure, plasma 17β-estradiol and testosterone concentrations, and
Jiri Kristan et al.
Neuro endocrinology letters, 33 Suppl 3, 66-71 (2013-01-29)
The objectives of the study were to compare the effects of Propiscin, 2-phenoxyethanol, clove oil and tricaine methane sulphonate (MS 222), anaesthetics frequently used in aquaculture. The haematological and biochemical blood profiles of pikeperch (Sander lucioperca L.) anesthetized with Propiscin
H Gholipour Kanani et al.
Fish & shellfish immunology, 34(2), 692-696 (2012-12-12)
There is a little available information on the suppressive effect of anaesthesia on immune response in fish, especially electro-anaesthesia. In the present study, two anaesthetics, MS222 (50 ppm), clove oil (25 ppm), and electro-anaesthesia were tested in rainbow trout (Oncorhynchus
Jeffrey A Scales et al.
The Journal of experimental biology, 220(Pt 5), 938-951 (2016-12-14)
Elastic-recoil mechanisms can improve organismal performance and circumvent the thermal limitations of muscle contraction, yet they require the appropriate motor control to operate. We compare muscle activity during tongue projection in salamanders with elastically powered, ballistic projection with activity of
Marta Lozano-Ortega et al.
PLoS biology, 16(7), e2004404-e2004404 (2018-07-20)
Directional mechanoreception by hair cells is transmitted to the brain via afferent neurons to enable postural control and rheotaxis. Neuronal tuning to individual directions of mechanical flow occurs when each peripheral axon selectively synapses with multiple hair cells of identical
Amit Kumar Sinha et al.
PloS one, 10(8), e0135091-e0135091 (2015-08-05)
Salinity fluctuation is one of the main factors affecting the overall fitness of marine fish. In addition, water borne ammonia may occur simultaneously with salinity stress. Additionally, under such stressful circumstances, fish may encounter food deprivation. The physiological and ion-osmo
Abirami Santhanam et al.
Cells, 9(10) (2020-10-11)
More than 1.5 million people suffer from Retinitis Pigmentosa, with many experiencing partial to complete vision loss. Regenerative therapies offer some hope, but their development is challenged by the limited regenerative capacity of mammalian model systems. As a step toward
Amit Kumar Sinha et al.
Aquatic toxicology (Amsterdam, Netherlands), 170, 129-141 (2015-12-15)
The main objective of this study was to understand the mode of interaction between waterborne copper (Cu) and high environmental ammonia (HEA) exposure on freshwater fish, and how they influence the toxicity of each other when present together. For this
Jeroen Brijs et al.
The Journal of experimental biology, 221(Pt 14) (2018-05-26)
The fish gut is responsible for numerous potentially energetically costly processes, yet little is known about its metabolism. Here, we provide the first in vivo measurements of aerobic metabolism of the gut in a teleost fish by measuring gut blood
Valentina Olivera-Pasilio et al.
Frontiers in neuroscience, 11, 437-437 (2017-09-02)
Adult neurogenesis, an essential mechanism of brain plasticity, enables brain development along postnatal life, constant addition of new neurons, neuronal turnover, and/or regeneration. It is amply distributed but negatively modulated during development and along evolution. Widespread cell proliferation, high neurogenic
Amanda Stenzel et al.
Reproductive toxicology (Elmsford, N.Y.), 87, 79-86 (2019-05-19)
Developmental exposure to endocrine disruptors can cause organizational changes resulting in latent and transgenerational disease. We exposed zebrafish to environmentally relevant concentrations of triclosan during the critical period of metamorphosis and somatic sex differentiation to determine effects on metamorphosis and
Danny C LeBert et al.
Development (Cambridge, England), 142(12), 2136-2146 (2015-05-28)
Acute and chronic injuries are characterized by leukocyte infiltration into tissues. Although matrix metalloproteinase 9 (Mmp9) has been implicated in both conditions, its role in wound repair remains unclear. We previously reported a zebrafish chronic inflammation mutant caused by an
Anna Kaufmann et al.
Development (Cambridge, England), 139(17), 3242-3247 (2012-08-09)
Light sheet microscopy techniques, such as selective plane illumination microscopy (SPIM), are ideally suited for time-lapse imaging of developmental processes lasting several hours to a few days. The success of this promising technology has mainly been limited by the lack
Jôsimar D Moreira et al.
Frontiers in immunology, 11, 36-36 (2020-03-03)
The rapid and persistent increase of drug-resistant Mycobacterium tuberculosis (Mtb) infections poses increasing global problems in combatting tuberculosis (TB), prompting for the development of alternative strategies including host-directed therapy (HDT). Since Mtb is an intracellular pathogen with a remarkable ability
João Pedro Amorim et al.
Cell reports, 32(1), 107862-107862 (2020-07-09)
The notochord is an evolutionary novelty in vertebrates that functions as an important signaling center during development. Notochord ablation in chicken has demonstrated that it is crucial for pancreas development; however, the molecular mechanism has not been fully described. Here
Sónia Cruz et al.
The Biological bulletin, 223(3), 328-336 (2012-12-25)
Photosynthetic sea slugs have the ability to "steal" chloroplasts (kleptoplasts) from marine macroalgae and keep them structurally intact and physiologically functional. The photosynthetic activity of these symbioses has been assessed using pulse amplitude modulated (PAM) fluorometry. However, the movement of
Soo Ji Woo et al.
Fish & shellfish immunology, 63, 353-366 (2016-11-30)
Phospholipase C gamma 1 and gamma 2 (PLCG1 and PLCG2) are influential in modulating Ca
Sok-Keng Tong et al.
International journal of molecular sciences, 21(11) (2020-06-04)
Arginine vasopressin (Avp) is a conserved pleiotropic hormone that is known to regulate both water reabsorption and ion balance; however, many of the mechanisms underlying its effects remain unclear. Here, we used zebrafish embryos to investigate how Avp modulates ion
Jianbin Zhao et al.
Chemosphere, 257, 127205-127205 (2020-06-06)
Multi-walled carbon nanotubes (MWCNTs), a common nanomaterial widely used and discharged in environment, might exert toxic effects on aquatic animals. In this paper, filter-feeding tadpole of Xenopus tropicalis was selected as bioindicator to study the exposure effects of MWCNTs suspensions
Inger Hilde Zahl et al.
Fish physiology and biochemistry, 36(3), 719-730 (2009-08-15)
Stress in response to anesthesia with benzocaine, MS-222, metomidate and isoeugenol was studied in Atlantic salmon (Salmo salar), Atlantic halibut (Hippoglossus hippoglossus), and Atlantic cod (Gadus morhua) with no concomitant stress from handling or confinement in association with anesthesia or
Jonathan Stockman et al.
Veterinary anaesthesia and analgesia, 40(1), 35-47 (2012-06-26)
To evaluate the physiological effect and response to noxious stimulation at five concentrations of MS-222 in koi (Cyprinus carpio). Prospective experimental study. Twenty-one healthy adult unknown sex koi fish weighing mean 450±SD 120 g. Each fish was exposed to five
Jae Wook Jung et al.
International journal of molecular sciences, 21(11) (2020-06-18)
The presence of CD4 T lymphocytes has been described for several teleost species, while many of the main T cell subsets have not been characterized at a cellular level, because of a lack of suitable tools for their identification, e.g.
César Mattei et al.
Pharmacological research, 145, 104250-104250 (2019-05-07)
Etifoxine (EFX) is a non-benzodiazepine psychoactive drug which exhibits anxiolytic effects through a dual mechanism, by directly binding to GABAA receptors (GABAARs) and to the mitochondrial 18-kDa translocator protein, resulting in the potentiation of the GABAergic function. The β subunit
Ke Li et al.
Marine drugs, 16(9) (2018-09-12)
Three novel bile acid derivatives, petromylidenes A⁻C (1⁻3), featuring uncommon alkylidene adductive scaffolds, were isolated from water conditioned with sexually mature male sea lampreys (Petromyzon marinus). Their structures were elucidated by mass spectrometry and NMR spectroscopy, and by comparison to
Stefania Santangeli et al.
The Science of the total environment, 685, 1294-1305 (2019-07-06)
Bisphenol A (BPA) is an abundant environmental contaminant and studies have shown the presence of BPA in the urine of over 90% of population tested in Canada and USA. In addition to its reported harmful effects, there is concern for
Emily E Rosowski et al.
PLoS pathogens, 14(8), e1007229-e1007229 (2018-08-03)
In immunocompromised individuals, Aspergillus fumigatus causes invasive fungal disease that is often difficult to treat. Exactly how immune mechanisms control A. fumigatus in immunocompetent individuals remains unclear. Here, we use transparent zebrafish larvae to visualize and quantify neutrophil and macrophage
Xisheng Ding et al.
Environmental pollution (Barking, Essex : 1987), 267, 115305-115305 (2020-08-26)
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been demonstrated to be transferred from parental animals to their offspring. However, whether parental exposure to environmental concentrations of TDCIPP show neurodevelopmental toxicity in the F1 generation and the possible underlying mechanism remain unclear. Therefore, in
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