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Showing 1-30 of 89 results for "E6402" within Papers
Sumit Paliwal et al.
Plastic and reconstructive surgery, 134(6), 1224-1233 (2014-11-22)
Hyaluronic acid-based dermal fillers have gained rapid acceptance for treating facial wrinkles and deep tissue folds. Although their space-filling properties are well understood, this study evaluates the cellular and molecular changes in skin, as a secondary effect, following injection of
Three-in-one chromatography-free purification, tag removal, and site-specific modification of recombinant fusion proteins using sortase A and elastin-like polypeptides.
Joseph J Bellucci et al.
Angewandte Chemie (International ed. in English), 52(13), 3703-3708 (2013-02-21)
Cassandra A Latimer et al.
The Journal of surgical research, 186(1), 73-80 (2013-09-17)
Bipolar devices are routinely used to seal blood vessels instead of sutures and clips. Recent work examining the impact of vascular proteins on bipolar seal performance found that collagen and elastin (CE) content within porcine arteries was a significant predictor
Dimitrios P Sokolis
Computer methods in biomechanics and biomedical engineering, 17(15), 1653-1670 (2013-02-27)
There are few previous studies on the elastic properties of ureter and most have been limited to essentially one-dimensional deformation measurements. The object of this study was, therefore, to identify regional variations in the multiaxial behaviour of rabbit ureter, subjected
Alex S Huang et al.
Investigative ophthalmology & visual science, 54(7), 4813-4820 (2013-06-08)
In situ 2-photon excitation fluorescence (TPEF) of the human trabecular meshwork (TM) reveals beams of heterogeneous autofluorescence (AF) comprising high intensity fluorescent fibers (AF-high) on a background of lower intensity fluorescence (AF-low). To determine the sources of this AF heterogeneity
Alkiviadis Tsamis et al.
Journal of the Royal Society, Interface, 10(83), 20121004-20121004 (2013-03-29)
Aortic disease is a significant cause of death in developed countries. The most common forms of aortic disease are aneurysm, dissection, atherosclerotic occlusion and ageing-induced stiffening. The microstructure of the aortic tissue has been studied with great interest, because alteration
Zhongyuan Sun et al.
Journal of the American Chemical Society, 135(9), 3675-3679 (2013-02-07)
The chimeric proteins, silk-elastin-like protein polymers (SELPs), consist of repeating units of silk and elastin to retain the mechanical strength of silk, while incorporating the dynamic environmental sensitivity of elastin. A retinal-modified SELP was prepared, modified, and studied for photodynamic
O V Matseliukh et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 84(6), 25-36 (2013-02-08)
The scheme of isolation and purification of Bacillus thuringiensis IMV B-7324 peptidase has been developed. This scheme includes ammonium sulfate precipitation and chromatography on neutral and charged TSK-gels. It was found that the enzyme hydrolyzes elastin and fibrin. The molecular
Xin Du et al.
The Journal of biological chemistry, 288(48), 34871-34881 (2013-10-15)
Cathepsin V is a highly effective elastase and has been implicated in physiological and pathological extracellular matrix degradation. However, its mechanism of action remains elusive. Whereas human cathepsin V exhibits a potent elastolytic activity, the structurally homologous cathepsin L, which
S Michael Sinclair et al.
Journal of controlled release : official journal of the Controlled Release Society, 171(1), 38-47 (2013-07-09)
Radiculopathy, a painful neuroinflammation that can accompany intervertebral disc herniation, is associated with locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα). Systemic administration of TNF antagonists for radiculopathy in the clinic has shown mixed results, and
Frank M Davis et al.
Arteriosclerosis, thrombosis, and vascular biology, 35(1), 155-162 (2014-11-15)
Low-density lipoprotein receptor-related protein 1 (LRP1), a multifunctional protein involved in endocytosis and cell signaling pathways, leads to several vascular pathologies when deleted in vascular smooth muscle cells (SMCs). The purpose of this study was to determine whether LRP1 deletion
Purification and comparison of elastins from different animal species.
B C Starcher et al.
Analytical biochemistry, 74(2), 441-447 (1976-08-01)
Lihua Jian et al.
Biochemical and biophysical research communications, 446(4), 1022-1028 (2014-04-01)
The extracellular matrix (ECM) is an essential element of mammalian organisms, and its cross-linking formation plays a vital role in ECM development and postnatal homeostasis. Defects in cross-link formation caused by aging, genetic, or environmental factors are known to cause
Venugopal Gunda et al.
Investigative ophthalmology & visual science, 54(13), 7828-7835 (2013-11-07)
The inhibitory effects and mechanism(s) of type IV collagen α-6 chain-derived noncollagenous domain (α6[IV]NC1 or hexastatin) on elastin-derived peptide (EDP)-activated choroidal endothelial cell migration, kinase signaling, and membrane type 1 metalloproteinase (MT1-MMP) activation are explored. Mouse choroidal endothelial cells (MCECs)
Reply to Elastin-based molecular MRI of liver fibrosis.
Antonella Pellicoro et al.
Hepatology (Baltimore, Md.), 58(4), 1518-1519 (2013-02-21)
Yulian Wang et al.
Journal of visualized experiments : JoVE, (60) (2012-03-01)
Mechanical forces generated in utero by repetitive breathing-like movements and by fluid distension are critical for normal lung development. A key component of lung development is the differentiation of alveolar type II epithelial cells, the major source of pulmonary surfactant.
Ryotaro Hashizume et al.
Biomaterials, 34(30), 7353-7363 (2013-07-06)
Biodegradable polyurethane patches have been applied as temporary mechanical supports to positively alter the remodeling and functional loss following myocardial infarction. How long such materials need to remain in place is unclear. Our objective was to compare the efficacy of
Samiya Al-Robaiy et al.
American journal of physiology. Lung cellular and molecular physiology, 305(7), L491-L500 (2013-09-03)
The receptor for advanced glycation end-products (RAGE) and its soluble forms are predominantly expressed in lung but its physiological importance in this organ is not yet fully understood. Since RAGE acts as a cell adhesion molecule, we postulated its physiological
Shu Liu et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(7), 1568-1579 (2013-05-11)
Elevated plasma aldosterone concentrations in patients have been linked to a spectrum of cardiovascular diseases. Mineralocorticoid receptor antagonists provide additional benefits in patients with heart failure. However, whether aldosterone and the mineralocorticoid receptor are involved in aortic aneurysm is unknown.
Ursula Mirastschijski et al.
Plastic and reconstructive surgery, 132(4), 861-869 (2013-10-01)
Xenogenous dermal matrices are used for hernia repair and breast reconstruction. Full-thickness skin replacement is needed after burn or degloving injuries with exposure of tendons or bones. The authors used a human skin organ culture model to study whether porcine
Maria Delio et al.
American journal of medical genetics. Part A, 161A(3), 527-533 (2013-02-13)
Haploinsufficiency of the elastin gene (ELN) on 7q11.23 is responsible for supravalvular aortic stenosis (SVAS) and other arteriopathies in patients with Williams-Beuren syndrome (WBS). These defects occur with variable penetrance and expressivity, but the basis of this is unknown. To
Branka Dabovic et al.
Journal of cellular physiology, 230(1), 226-236 (2014-06-26)
Mice deficient in Latent TGFβ Binding Protein 4 (Ltbp4) display a defect in lung septation and elastogenesis. The lung septation defect is normalized by genetically decreasing TGFβ2 levels. However, the elastic fiber assembly is not improved in Tgfb2(-/-) ;Ltbp4S(-/-) compared
Nancy L Sehgel et al.
Hypertension (Dallas, Tex. : 1979), 65(2), 370-377 (2014-12-03)
Hypertension and aging are both recognized to increase aortic stiffness, but their interactions are not completely understood. Most previous studies have attributed increased aortic stiffness to changes in extracellular matrix proteins that alter the mechanical properties of the vascular wall.
Chris A Bashur et al.
Stem cells translational medicine, 2(6), 401-408 (2013-05-17)
Abdominal aortic aneurysms (AAAs) are potentially fatal conditions that are characterized by decreased flexibility of the aortic wall due to proteolytic loss of the structural matrix. This leads to their gradual weakening and ultimate rupture. Drug-based inhibition of proteolytic enzymes
Naoko Morisaki et al.
PloS one, 8(2), e55947-e55947 (2013-02-19)
In most mammals, each hair follicle undergoes a cyclic process of growing, regressing and resting phases (anagen, catagen, telogen, respectively) called the hair cycle. Various biological factors have been reported to regulate or to synchronize with the hair cycle. Some
Valérie Deckert et al.
The American journal of pathology, 183(3), 975-986 (2013-07-09)
Plasma phospholipid transfer protein (PLTP) increases the circulating levels of proatherogenic lipoproteins, accelerates blood coagulation, and modulates inflammation. The role of PLTP in the development of abdominal aortic aneurysm (AAA) was investigated by using either a combination of mechanical and
Miriam Votteler et al.
Development (Cambridge, England), 140(11), 2345-2353 (2013-05-03)
Semilunar valve leaflets have a well-described trilaminar histoarchitecture, with a sophisticated elastic fiber network. It was previously proposed that elastin-containing fibers play a subordinate role in early human cardiac valve development; however, this assumption was based on data obtained from
Vincent Lemieux et al.
Methods in molecular biology (Clifton, N.J.), 991, 353-362 (2013-04-03)
Stimuli-responsive materials are playing an increasingly important role in a wide range of applications such as drug delivery, diagnostics, sensors, and tissue engineering. Among them, gold nanoparticles responding to changes in their surrounding environment are of particular interest due to
Stefanie Michael et al.
PloS one, 8(3), e57741-e57741 (2013-03-08)
Tissue engineering plays an important role in the production of skin equivalents for the therapy of chronic and especially burn wounds. Actually, there exists no (cellularized) skin equivalent which might be able to satisfactorily mimic native skin. Here, we utilized
A Panagopoulou et al.
Biochimica et biophysica acta, 1834(6), 977-988 (2013-03-27)
Dynamics of uncrystallized water and protein was studied in hydrated pellets of the fibrous protein elastin in a wide hydration range (0 to 23wt.%), by differential scanning calorimetry (DSC), thermally stimulated depolarization current technique (TSDC) and dielectric relaxation spectroscopy (DRS).
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