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E6527

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O Gutierrez-Navarro et al.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2012, 1081-1084 (2013-02-01)
Multi-Spectral Fluorescent Lifetime Imaging Microscopy (m-FLIM) is a technique that aims to perform noninvasive in situ clinical diagnosis of several diseases. It measures the endogenous fluorescence of molecules, recording their lifetime decay in different wavelength bands. This signal is a...
Elodie Parzy et al.
PloS one, 8(2), e57946-e57946 (2013-03-08)
Magnetic resonance imaging can reveal exquisite anatomical details. However several diseases would benefit from an imaging technique able to specifically detect biochemical alterations. In this context protease activity imaging is one of the most promising areas of research. We designed...
R Blair Dodson et al.
American journal of physiology. Lung cellular and molecular physiology, 307(11), L822-L828 (2014-10-19)
Persistent pulmonary hypertension of the newborn (PPHN) is a clinical syndrome that is characterized by high pulmonary vascular resistance due to changes in lung vascular growth, structure, and tone. PPHN has been primarily considered as a disease of the small...
Yang Lei et al.
Experimental cell research, 323(1), 198-208 (2014-01-23)
Vascular calcification can be categorized into two different types. Intimal calcification related to atherosclerosis and elastin-specific medial arterial calcification (MAC). Osteoblast-like differentiation of vascular smooth muscle cells (VSMCs) has been shown in both types; however, how this relates to initiation...
Nathan Airhart et al.
Journal of vascular surgery, 60(4), 1033-1041 (2013-10-02)
The purpose of this study was to further elucidate the role of the vascular smooth muscle cells (SMCs) in abdominal aortic aneurysm (AAA) disease. We hypothesized that that AAA SMCs are unique and actively participate in the process of degrading...
Ming Miao et al.
Biochemistry, 52(44), 7731-7741 (2013-10-11)
Elastin is a protein that provides the unusual properties of extensibility and elastic recoil to tissues. Assembly of polymeric elastin into its final architecture in the extracellular matrix involves both self-aggregation properties of its monomeric precursor, tropoelastin, and interactions with...
Andrea Heinz et al.
Biochimica et biophysica acta, 1830(4), 2994-3004 (2013-02-05)
Elastin is a vital protein and the major component of elastic fibers which provides resilience to many vertebrate tissues. Elastin's structure and function are influenced by extensive cross-linking, however, the cross-linking pattern is still unknown. Small peptides containing reactive allysine...
Mervyn J Merrilees et al.
Respiratory research, 9, 41-41 (2008-05-20)
COPD is characterised by loss of alveolar elastic fibers and by lack of effective repair. Elastic fibers are assembled at cell surfaces by elastin binding protein (EBP), a molecular chaperone whose function can be reversibility inhibited by chondroitin sulphate of...
Yuanming Liu et al.
Physical review letters, 110(16), 168101-168101 (2013-05-18)
Elastin is an intriguing extracellular matrix protein present in all connective tissues of vertebrates, rendering essential elasticity to connective tissues subjected to repeated physiological stresses. Using piezoresponse force microscopy, we show that the polarity of aortic elastin is switchable by...
Megan P Stogsdill et al.
American journal of respiratory cell and molecular biology, 49(1), 128-134 (2013-03-26)
Receptors for advanced glycation end-products (RAGE) are multiligand surface receptors detected abundantly in pulmonary tissue. Our previous work revealed increased RAGE expression in cells and lungs exposed to tobacco smoke and RAGE-mediated cytokine expression via proinflammatory mechanisms involving NF-κB. RAGE...
Diego Pesce et al.
Biomaterials, 34(17), 4360-4367 (2013-03-13)
One of the barriers to the development of protein therapeutics is effective delivery to mammalian cells. The proteins must maintain a careful balance of polar moieties to enable administration and distribution and hydrophobic character to minimize cell toxicity. Numerous strategies...
Vivek A Kumar et al.
Acta biomaterialia, 9(9), 8067-8074 (2013-06-08)
Tissue-engineered vascular grafts require long fabrication times, in part due to the requirement of cells from a variety of cell sources to produce a robust, load-bearing extracellular matrix. Herein, we propose a design strategy for the fabrication of tubular conduits...
Béla Suki
Journal of cellular physiology, 229(9), 1134-1140 (2014-03-08)
Recently, an exciting new approach has emerged in regenerative medicine pushing the forefront of tissue engineering to create bioartificial organs. The basic idea is to create biological scaffolds made of extracellular matrix (ECM) that preserves the three-dimensional architecture of an...
E Tong et al.
Journal of wound care, 23(7), 355-357 (2014-07-22)
Reconstruction of large abdominal wall defects is a challenging procedure, often contraindicated in critically ill patients, with high incidences of complications. We present a case of a patient with a large abdominal wall defect who had reconstruction with MatriDerm® (an...
Federica Boraldi et al.
Biochimica et biophysica acta, 1832(12), 2077-2084 (2013-08-01)
A number of beta-thalassemia (β-thal) patients in the course of the disease exhibit ectopic calcification affecting skin, eyes and the cardiovascular system. Clinical and histopathological features have been described similar to those in pseudoxanthoma elasticum (PXE), although different genes are...
Ju-Yi Chen et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(4), 839-846 (2013-02-16)
One potential mechanism through which obesity exerts adverse effects on the vascular system is by increasing aortic stiffness, a change known to be predictive of increased cardiovascular mortality. The aim of this study was to investigate the pathophysiology that links...
Irene M J Eurlings et al.
American journal of physiology. Lung cellular and molecular physiology, 307(7), L557-L565 (2014-08-12)
Remodeling in chronic obstructive pulmonary disease (COPD) has at least two dimensions: small airway wall thickening and destruction of alveolar walls. Recently we showed comparable alterations of the extracellular matrix (ECM) compounds collagen, hyaluoran, and elastin in alveolar and small...
Akira Shinaoka et al.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 19(2), 406-414 (2013-03-05)
Most blood vessels contain elastin that provides the vessels with the resilience and flexibility necessary to control hemodynamics. Pathophysiological hemodynamic changes affect the remodeling of elastic components, but little is known about their structural properties. The present study was designed...
Bo He et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(9), 1345-1353 (2013-05-08)
Elastin fibers are major extracellular matrix macromolecules that are critical in maintaining the elasticity and resilience of tissues such as blood vessels, lungs and skins. However, the role of elastin in articular cartilage is poorly defined. The present study investigated...
Kelly E Beazley et al.
The Journal of biological chemistry, 288(43), 31400-31408 (2013-09-17)
Mutations in matrix Gla protein (MGP) have been correlated with vascular calcification. In the mouse model, MGP null vascular disease presents as calcifying cartilaginous lesions and mineral deposition along elastin lamellae (elastocalcinosis). Here we examined the mechanisms underlying both of...
Smail Hadj-Rabia et al.
Orphanet journal of rare diseases, 8, 36-36 (2013-02-28)
Elastin gene mutations have been associated with a variety of phenotypes. Autosomal dominant cutis laxa (ADCL) is a rare disorder that presents with lax skin, typical facial characteristics, inguinal hernias, aortic root dilatation and pulmonary emphysema. In most patients, frameshift...
Andrea Grin et al.
Human pathology, 44(12), 2696-2705 (2013-10-01)
Peritoneal involvement in colorectal cancer (CRC) is an adverse prognostic feature, which may prompt consideration of adjuvant chemotherapy in stage II disease. Controversies and challenges surrounding its assessment have led to consideration of peritoneal elastic lamina invasion (ELI) as an...
Wei Li et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(5), 1028-1035 (2013-03-16)
Patients with elastin deficiency attributable to gene mutation (supravalvular aortic stenosis) or chromosomal microdeletion (Williams syndrome) are characterized by obstructive arteriopathy resulting from excessive smooth muscle cell (SMC) proliferation, mural expansion, and inadequate vessel size. We investigated whether rapamycin, an...
Alkystis Phinikaridou et al.
Radiology, 271(2), 390-399 (2014-01-31)
To compare delayed-enhancement (DE) magnetic resonance (MR) imaging with an elastin-specific contrast agent and unenhanced black-blood (BB) MR imaging with regard to vessel wall delineation and assessment of vascular remodeling and to test the prospective value for predicting plaque disruption...
Alexander H Nave et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(7), 1446-1458 (2014-05-17)
Pulmonary vascular remodeling, the pathological hallmark of pulmonary arterial hypertension, is attributed to proliferation, apoptosis resistance, and migration of vascular cells. A role of dysregulated matrix cross-linking and stability as a pathogenic mechanism has received little attention. We aimed to...
Heath B Henninger et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(8), 1226-1233 (2013-04-05)
Elastin is a structural protein that provides resilience to biological tissues. We examined the contributions of elastin to the quasi-static tensile response of porcine medial collateral ligament through targeted disruption of the elastin network with pancreatic elastase. Elastase concentration and...
Fabian C Emrich et al.
Arteriosclerosis, thrombosis, and vascular biology, 35(1), 146-154 (2014-11-02)
Rupture and dissection of aortic root aneurysms remain the leading causes of death in patients with the Marfan syndrome, a hereditary connective tissue disorder that affects 1 in 5000 individuals worldwide. In the present study, we use a Marfan mouse...
Jessica F Almine et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(9), 3455-3465 (2013-05-15)
Following penetrating injury of the skin, a highly orchestrated and overlapping sequence of events helps to facilitate wound resolution. Inflammation is a hallmark that is initiated early, but the reciprocal relationship between cells and matrix molecules that triggers and maintains...
Maxwell A Fung et al.
Journal of the American Academy of Dermatology, 69(5), 776-782 (2013-09-17)
Most biopsy specimens of cicatricial (scarring) alopecia can be readily subclassified as lymphocytic versus neutrophilic, but specific diagnosis remains difficult, particularly when a late stage of the disease is sampled. We sought to document patterns of scarring highlighted by elastic...
Wolfgang G Mouton et al.
Swiss medical weekly, 143, w13755-w13755 (2013-02-28)
The ultrastructure of venous valves and walls in chronic venous disease was investigated. Consecutive patients were categorised into one of three groups (group A: patients with C1 venous disease in accordance with CEAP (Clinical severity, Etiology, Anatomy, Pathophysiology); group B:...
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