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Reply to Elastin-based molecular MRI of liver fibrosis.
Antonella Pellicoro et al.
Hepatology (Baltimore, Md.), 58(4), 1518-1519 (2013-02-21)
Naoko Morisaki et al.
PloS one, 8(2), e55947-e55947 (2013-02-19)
In most mammals, each hair follicle undergoes a cyclic process of growing, regressing and resting phases (anagen, catagen, telogen, respectively) called the hair cycle. Various biological factors have been reported to regulate or to synchronize with the hair cycle. Some...
Miriam Votteler et al.
Development (Cambridge, England), 140(11), 2345-2353 (2013-05-03)
Semilunar valve leaflets have a well-described trilaminar histoarchitecture, with a sophisticated elastic fiber network. It was previously proposed that elastin-containing fibers play a subordinate role in early human cardiac valve development; however, this assumption was based on data obtained from...
Valérie Deckert et al.
The American journal of pathology, 183(3), 975-986 (2013-07-09)
Plasma phospholipid transfer protein (PLTP) increases the circulating levels of proatherogenic lipoproteins, accelerates blood coagulation, and modulates inflammation. The role of PLTP in the development of abdominal aortic aneurysm (AAA) was investigated by using either a combination of mechanical and...
Chris A Bashur et al.
Stem cells translational medicine, 2(6), 401-408 (2013-05-17)
Abdominal aortic aneurysms (AAAs) are potentially fatal conditions that are characterized by decreased flexibility of the aortic wall due to proteolytic loss of the structural matrix. This leads to their gradual weakening and ultimate rupture. Drug-based inhibition of proteolytic enzymes...
Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN)
Zhang MC, et al.
The Journal of biological chemistry, 274(2), 981-986 (1999)
Vincent Lemieux et al.
Methods in molecular biology (Clifton, N.J.), 991, 353-362 (2013-04-03)
Stimuli-responsive materials are playing an increasingly important role in a wide range of applications such as drug delivery, diagnostics, sensors, and tissue engineering. Among them, gold nanoparticles responding to changes in their surrounding environment are of particular interest due to...
Yuanming Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(27), E2780-E2786 (2014-06-25)
Ferroelectricity has long been speculated to have important biological functions, although its very existence in biology has never been firmly established. Here, we present compelling evidence that elastin, the key ECM protein found in connective tissues, is ferroelectric, and we...
Sébastien Blaise et al.
Diabetes, 62(11), 3807-3816 (2013-08-08)
Although it has long been established that the extracellular matrix acts as a mechanical support, its degradation products, which mainly accumulate during aging, have also been demonstrated to play an important role in cell physiology and the development of cardiovascular...
Nancy L Sehgel et al.
Hypertension (Dallas, Tex. : 1979), 65(2), 370-377 (2014-12-03)
Hypertension and aging are both recognized to increase aortic stiffness, but their interactions are not completely understood. Most previous studies have attributed increased aortic stiffness to changes in extracellular matrix proteins that alter the mechanical properties of the vascular wall....
Stefanie Michael et al.
PloS one, 8(3), e57741-e57741 (2013-03-08)
Tissue engineering plays an important role in the production of skin equivalents for the therapy of chronic and especially burn wounds. Actually, there exists no (cellularized) skin equivalent which might be able to satisfactorily mimic native skin. Here, we utilized...
Venugopal Gunda et al.
Investigative ophthalmology & visual science, 54(13), 7828-7835 (2013-11-07)
The inhibitory effects and mechanism(s) of type IV collagen α-6 chain-derived noncollagenous domain (α6[IV]NC1 or hexastatin) on elastin-derived peptide (EDP)-activated choroidal endothelial cell migration, kinase signaling, and membrane type 1 metalloproteinase (MT1-MMP) activation are explored. Mouse choroidal endothelial cells (MCECs)...
Maria Delio et al.
American journal of medical genetics. Part A, 161A(3), 527-533 (2013-02-13)
Haploinsufficiency of the elastin gene (ELN) on 7q11.23 is responsible for supravalvular aortic stenosis (SVAS) and other arteriopathies in patients with Williams-Beuren syndrome (WBS). These defects occur with variable penetrance and expressivity, but the basis of this is unknown. To...
A Panagopoulou et al.
Biochimica et biophysica acta, 1834(6), 977-988 (2013-03-27)
Dynamics of uncrystallized water and protein was studied in hydrated pellets of the fibrous protein elastin in a wide hydration range (0 to 23wt.%), by differential scanning calorimetry (DSC), thermally stimulated depolarization current technique (TSDC) and dielectric relaxation spectroscopy (DRS)....
Ursula Mirastschijski et al.
Plastic and reconstructive surgery, 132(4), 861-869 (2013-10-01)
Xenogenous dermal matrices are used for hernia repair and breast reconstruction. Full-thickness skin replacement is needed after burn or degloving injuries with exposure of tendons or bones. The authors used a human skin organ culture model to study whether porcine...
Branka Dabovic et al.
Journal of cellular physiology, 230(1), 226-236 (2014-06-26)
Mice deficient in Latent TGFβ Binding Protein 4 (Ltbp4) display a defect in lung septation and elastogenesis. The lung septation defect is normalized by genetically decreasing TGFβ2 levels. However, the elastic fiber assembly is not improved in Tgfb2(-/-) ;Ltbp4S(-/-) compared...
Tony Collins et al.
Microbial cell factories, 12, 21-21 (2013-03-01)
Silk-elastin-like proteins (SELPs) combining the physicochemical and biological properties of silk and elastin have a high potential for use in the pharmaceutical, regenerative medicine and materials fields. Their development for use is however restrained by their production levels. Here we...
Kumiko Takemori et al.
Life sciences, 120, 48-53 (2014-12-03)
To determine the prophylactic effects of an elastin peptide derived from the bulbus arteriosus of bonitos and prolylglycine (PG), a degradation product of elastin peptide, on vascular dysfunction in spontaneously hypertensive rats (SHRs). Male 15-week-old SHR/Izm rats were fed without...
Gianni Ciofani et al.
Expert opinion on drug delivery, 11(10), 1507-1512 (2014-06-10)
Mimicking the structure of natural proteins by recombinant biopolymers is a useful approach for the development of novel bioactive biomaterials with desired properties, that help elucidate molecular interactions in biological systems and elaborate strategies for tissue engineering and drug delivery...
Elastin: relation of protein and gene structure to disease.
Rosenbloom J
Laboratory Investigation; a Journal of Technical Methods and Pathology, 51(6), 605-623 (1984)
Samiya Al-Robaiy et al.
American journal of physiology. Lung cellular and molecular physiology, 305(7), L491-L500 (2013-09-03)
The receptor for advanced glycation end-products (RAGE) and its soluble forms are predominantly expressed in lung but its physiological importance in this organ is not yet fully understood. Since RAGE acts as a cell adhesion molecule, we postulated its physiological...
Shu Liu et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(7), 1568-1579 (2013-05-11)
Elevated plasma aldosterone concentrations in patients have been linked to a spectrum of cardiovascular diseases. Mineralocorticoid receptor antagonists provide additional benefits in patients with heart failure. However, whether aldosterone and the mineralocorticoid receptor are involved in aortic aneurysm is unknown....
Ryotaro Hashizume et al.
Biomaterials, 34(30), 7353-7363 (2013-07-06)
Biodegradable polyurethane patches have been applied as temporary mechanical supports to positively alter the remodeling and functional loss following myocardial infarction. How long such materials need to remain in place is unclear. Our objective was to compare the efficacy of...
[The role of electrothermoadhesion in creation of artificial vocal cord, and the voice quality improvement following chordectomy for laryngeal cancer].
R A Abyzov et al.
Klinichna khirurhiia, (2)(2), 77-77 (2013-05-28)
Frank M Davis et al.
Arteriosclerosis, thrombosis, and vascular biology, 35(1), 155-162 (2014-11-15)
Low-density lipoprotein receptor-related protein 1 (LRP1), a multifunctional protein involved in endocytosis and cell signaling pathways, leads to several vascular pathologies when deleted in vascular smooth muscle cells (SMCs). The purpose of this study was to determine whether LRP1 deletion...
O V Matseliukh et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 84(6), 25-36 (2013-02-08)
The scheme of isolation and purification of Bacillus thuringiensis IMV B-7324 peptidase has been developed. This scheme includes ammonium sulfate precipitation and chromatography on neutral and charged TSK-gels. It was found that the enzyme hydrolyzes elastin and fibrin. The molecular...
Xin Du et al.
The Journal of biological chemistry, 288(48), 34871-34881 (2013-10-15)
Cathepsin V is a highly effective elastase and has been implicated in physiological and pathological extracellular matrix degradation. However, its mechanism of action remains elusive. Whereas human cathepsin V exhibits a potent elastolytic activity, the structurally homologous cathepsin L, which...
Alex S Huang et al.
Investigative ophthalmology & visual science, 54(7), 4813-4820 (2013-06-08)
In situ 2-photon excitation fluorescence (TPEF) of the human trabecular meshwork (TM) reveals beams of heterogeneous autofluorescence (AF) comprising high intensity fluorescent fibers (AF-high) on a background of lower intensity fluorescence (AF-low). To determine the sources of this AF heterogeneity...
S Michael Sinclair et al.
Journal of controlled release : official journal of the Controlled Release Society, 171(1), 38-47 (2013-07-09)
Radiculopathy, a painful neuroinflammation that can accompany intervertebral disc herniation, is associated with locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα). Systemic administration of TNF antagonists for radiculopathy in the clinic has shown mixed results, and...
Cassandra A Latimer et al.
The Journal of surgical research, 186(1), 73-80 (2013-09-17)
Bipolar devices are routinely used to seal blood vessels instead of sutures and clips. Recent work examining the impact of vascular proteins on bipolar seal performance found that collagen and elastin (CE) content within porcine arteries was a significant predictor...
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