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Bożena Nejman-Faleńczyk et al.
Toxins, 7(11), 4745-4757 (2015-11-19)
A novel procedure for the detection of specific DNA sequences has been developed. This procedure is based on the already known method employing PCR with appropriate primers and a sequence-specific DNA probe labeled with the fluorescent agent 6-carboxylfluorescein (FAM) at
Hua Chen et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(1), 24-33 (2015-05-01)
Autophagic cell death has recently been implicated in the pathophysiology of tendinopathy. Prostaglandin E2 (PGE2), a known inflammatory mediator of tendinitis, inhibits tenofibroblast proliferation in vitro; however, the underlying mechanism is unclear. The present study investigated the relationship between PGE2
Avery Sonnenberg et al.
Electrophoresis, 35(12-13), 1828-1836 (2014-04-12)
Conventional methods for the isolation of cancer-related circulating cell-free (ccf) DNA from patient blood (plasma) are time consuming and laborious. A DEP approach utilizing a microarray device now allows rapid isolation of ccf-DNA directly from a small volume of unprocessed
Pinaki B Patel et al.
Indian journal of experimental biology, 53(3), 152-157 (2015-04-16)
In systemic therapy, chemotherapeutic drugs, often, cause considerable side effects; and combination of natural compounds lessen the extent of such effects. In the present study, combined effect of citral and 5-fluorouracil was studied in Schizosaccharomyces pombe cells. The antagonistic combination
S Gupta et al.
Journal of postgraduate medicine, 61(1), 21-26 (2014-12-17)
The renin-angiotensin system (RAS) is an important facet of blood pressure regulation physiology. Treatment of essential hypertension targets the RAS using Angiotensin Converting Enzyme Inhibitors (ACEIs). However, ACEIs are not uniformly effective and show inter-individual pharmacodynamic variations. To assess the
Anna Zaczek et al.
BMC veterinary research, 11, 137-137 (2015-06-24)
Salmonellosis is of great economic concern in all phases of the poultry industry, from production to marketing, leading to severe economic losses. Monitoring the source of the bacterial contamination has fundamental importance in the spreading of salmonellosis. We applied a
Petronella Johansson et al.
Developmental and comparative immunology, 54(1), 55-65 (2015-08-19)
The C-type lectin domain containing (CLEC) receptors including CD209 are expressed in vivo by monocytes, monocyte-derived macrophages and dendritic cells and by in vitro generated monocyte-derived cells. This paper reports the cloning and sequencing of a lectin molecule, CLEC4T1, in
Viriya Nitteranon et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 69, 237-243 (2014-04-23)
The use of anthocyanins in food products as colorants has been limited because of their instability toward alkaline pH and high temperature. This study aimed to determine color stability and mutagenicity of the anthocyanin-based pigment extract from bulb cultures of
Stine A Danielsen et al.
Neuro-oncology, 17(1), 63-69 (2014-07-20)
Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A
Chengnan Zhang et al.
Acta biomaterialia, 22, 120-130 (2015-04-29)
The purpose of this study is to develop biodegradable cationic polyamides for non-viral gene delivery and elucidate their structural effects on gene transfection activity. To this end, a group of novel cationic polyamides were synthesized by polycondensation reaction between different
Arnis Strods et al.
Scientific reports, 5, 11639-11639 (2015-06-27)
Hepatitis B virus (HBV) core (HBc) virus-like particles (VLPs) are one of the most powerful protein engineering tools utilised to expose immunological epitopes and/or cell-targeting signals and for the packaging of genetic material and immune stimulatory sequences. Although HBc VLPs
Jianan Shen et al.
Molecular pharmaceutics, 11(8), 2579-2591 (2013-11-19)
Multidrug resistance (MDR) is one of the major obstacles in tumor treatment. Herein, we reported an active targeting strategy with peptide-mediated nanoparticles deep into tumor parenchyma, which iRGD conjugated d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) mediated codelivery of paclitaxel (PTX)
Elaine Vermaak et al.
The Journal of general virology, 96(Pt 7), 1811-1820 (2015-03-19)
Infection of cultured mammalian cells with African horse sickness virus (AHSV) is known to induce cell death. To date, the trigger(s) of this response, the apoptotic pathways activated during AHSV infection and the functional consequences of apoptosis on the virus
Sin-Hye Park et al.
PloS one, 9(10), e110581-e110581 (2014-10-22)
There is a growing body of evidence that excess lipids, hypoxic stress and other inflammatory signals can stimulate endoplasmic reticulum (ER) stress in metabolic diseases. However, the pathophysiological importance and the underlying mechanisms of this phenomenon remain unknown. The current
Yu-Feng Yan et al.
Molecular medicine reports, 12(3), 4734-4742 (2015-06-18)
DJ-1 protein, as a multifunctional intracellular protein, has an important role in transcriptional regulation and anti-oxidant stress. A recent study by our group showed that DJ-1 can regulate the expression of certain anti‑oxidant enzymes and attenuate hypoxia/re‑oxygenation (H/R)‑induced oxidative stress
Agnieszka Konopacka et al.
eLife, 4 (2015-11-13)
In response to an osmotic challenge, the synthesis of the antidiuretic hormone arginine vasopressin (AVP) increases in the hypothalamus, and this is accompanied by extension of the 3' poly(A) tail of the AVP mRNA, and the up-regulation of the expression
Joseph M McCoy et al.
Journal of inflammation (London, England), 12, 13-13 (2015-02-27)
Nuclear receptor 4A2 (NR4A2) is an orphan nuclear receptor and constitutively active transcription factor expressed at elevated levels in inflamed joint tissues from patients with arthritis. Inflammatory mediators rapidly and potently induce NR4A2 expression in resident joint cells and infiltrating
Rita Trumpaite-Vanagiene et al.
Dental materials journal, 34(3), 294-301 (2015-04-24)
The study aimed to 1) evaluate the cytotoxicity of luting cements: Hoffmann's Zinc Phosphate (Hoffmann's ZP), GC Fuji Plus Resin Modified Glass Ionomer (Fuji Plus RMGI) and 3M ESPE RelyX Unicem Resin Cement (RelyX Unicem RC) and 2) test if
Alessio Perotti et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 20(1), 64-70 (2014-12-19)
Epigenotoxicology needs simple and fast tools to assess xenobiotic epigenetic load. This work proposes a comet assay modification designed to detect global methylation changes (Methy-sens Comet) through enzymatic digestion with two restriction enzymes (HpaII, MspI). In the methylation-sensitive protocol tested
Marloes L de Vries-van Melle et al.
Tissue engineering. Part A, 20(1-2), 23-33 (2013-08-29)
In articular cartilage repair, cells that will be responsible for the formation of repair tissue are often exposed to an osteochondral environment. To study cartilage repair mechanisms in vitro, we have recently developed a bovine osteochondral biopsy culture model in
E H Tan et al.
Oncogene, 33(25), 3325-3333 (2013-07-23)
Many tumours harbour mutations in the p53 tumour-suppressor gene that result in the expression of a mutant p53 protein. This mutant p53 protein has, in most cases, lost wild-type transcriptional activity and can also acquire novel functions in promoting invasion
Artak Tovmasyan et al.
Journal of inorganic biochemistry, 140, 94-103 (2014-08-03)
In the present study we have synthesized a novel amphiphilic porphyrin and its Ag(II) complex through modification of water-soluble porphyrinic structure in order to increase its lipophilicity and in turn pharmacological potency. New cationic non-symmetrical meso-substituted porphyrins were characterized by
Kristoffer Krogerus et al.
Journal of industrial microbiology & biotechnology, 42(5), 769-778 (2015-02-16)
The interspecific hybrid Saccharomyces pastorianus is the most commonly used yeast in brewery fermentations worldwide. Here, we generated de novo lager yeast hybrids by mating a domesticated and strongly flocculent Saccharomyces cerevisiae ale strain with the Saccharomyces eubayanus type strain.
Wei-Nan Zhu et al.
PLoS neglected tropical diseases, 8(8), e3103-e3103 (2014-08-22)
Previous genomic analysis of pathogenic Leptospira has identified two circular chromosomes but no plasmid. This study aims to investigate potential extrachromosomal elements of L.interrogans serovar Canicola strain Gui44. Two novel plasmids, pGui1 and pGui2, were isolated from the pathogenic strain
Yoshihiro Joshua Ono et al.
The Journal of endocrinology, 223(2), 203-216 (2014-09-24)
Dienogest, a synthetic progestin, has been shown to be effective against endometriosis, although it is still unclear as to how it affects the ectopic endometrial cells. Decorin has been shown to be a powerful endogenous tumor repressor acting in a
Linjie Huang et al.
International journal of molecular sciences, 15(7), 11817-11831 (2014-07-06)
mast cells play an important role in airway inflammation in asthma. The transient receptor potential melastatin-like 7 (TRPM7) channel is expressed in primary human lung mast cells and plays a critical role for cell survival. This study aimed to investigate
Guobing Lin et al.
Experimental and therapeutic medicine, 20(2), 1237-1244 (2020-08-04)
The present study aimed to investigate the clinical characteristics of von Hippel-Lindau (VHL) disease and the clinical significance of VHL gene detection. The clinical materials of patients with VHL disease were collected from 3 different families between May 1985 and
Wareed Ahmed et al.
Microbiology (Reading, England), 161(Pt 2), 341-353 (2014-12-18)
The steady-state negative supercoiling of eubacterial genomes is maintained by the action of DNA topoisomerases. Topoisomerase distribution varies in different species of mycobacteria. While Mycobacterium tuberculosis (Mtb) contains a single type I (TopoI) and a single type II (Gyrase) enzyme
Luiz de Pádua Queiroz Júnior et al.
Mycoses, 57(8), 466-472 (2014-03-19)
Clinical Paracoccidioides spp. isolates from patients with paracoccidioidomycosis (PCM) in Mato Grosso, Brazil exhibit different patterns of serologic reactivity. The results observed for reactions of radial immunodiffusion against the commonly used exoantigens containing a 43-kDa glycoprotein (gp43) suggest that this
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