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Timothy Tidwell et al.
Blood, 123(4), 562-569 (2013-11-05)
Hereditary neutropenia is usually caused by heterozygous germline mutations in the ELANE gene encoding neutrophil elastase (NE). How mutations cause disease remains uncertain, but two hypotheses have been proposed. In one, ELANE mutations lead to mislocalization of NE. In the...
C Wiegand et al.
Journal of wound care, 22(11), 592-592 (2013-11-15)
To test the binding capacity of a hydrokinetic fiber dressing for PMN elastase, MMP-2 and MMP-9 in vitro, and to determine whether testing of dressing material samples in vitro is sufficient to predict the performance of the whole dressing. In...
Niels Borregaard
Blood, 123(4), 462-463 (2014-01-25)
In this issue of Blood, Tidwell et al1 demonstrate that mutations in the start codon (protein synthesis is initiated at the codon ATG) of neutrophil elastase (ELANE) result in the production of N-terminally truncated elastase, which mislocates to the nucleus...
Qing He et al.
The Journal of steroid biochemistry and molecular biology, 135, 7-14 (2012-12-04)
Vitamin D hormone (1,25-dihydroxyvitamin D) is involved in innate immunity and induces host defense peptides in epithelial cells, suggesting its involvement in mucosal defense against infections. Chlamydia trachomatis is a major cause of bacterial sexually transmitted disease worldwide. We tested...
Michael J Ungurs et al.
American journal of physiology. Lung cellular and molecular physiology, 306(1), L80-L87 (2013-11-05)
Progranulin (PGRN) is an anti-inflammatory protein, yet its digestion by neutrophil-derived proteinases generates products that can stimulate epithelial cell lines to secrete the neutrophil chemoattractant interleukin (IL)-8. Because dysregulated neutrophilic inflammation is implicated in the pathophysiology of chronic obstructive pulmonary...
Alice V Dubois et al.
American journal of respiratory and critical care medicine, 188(6), 703-709 (2013-08-21)
Neutrophil serine proteases in cystic fibrosis (CF) lung secretions partially resist inhibition by natural and exogenous inhibitors, mostly because DNA impairs their control. Cationic polypeptides display the property of condensing DNA and retain antimicrobial properties. We hypothesized that DNA condensation...
Koshi Kumagai et al.
Anticancer research, 33(9), 3653-3659 (2013-09-12)
We examined whether tumor growth is enhanced by cecal ligation and puncture (CLP) and suppressed by a neutrophil elastase inhibitor, sivelestat. C57BL/6 mice were divided in CLP/sivelestat, CLP alone, and control (simple laparotomy) groups. Murine CT26 colon carcinoma cells were...
Julia Hentschel et al.
Journal of immunological methods, 404, 41-51 (2013-12-29)
Non-invasive sampling of airway epithelial-lining-fluid by nasal lavage (NL) is an emerging method to monitor allergy, infection and inflammation in patients with respiratory diseases. However, the influences of collection-, processing- and storage-methods have not been sufficiently evaluated and standardized. Influences...
Julia Skokowa et al.
Hematology/oncology clinics of North America, 27(1), 75-88 (2013-01-29)
Several signaling systems downstream of G-CSFR have been identified that are defective or hyperactivated in myeloid cells of patients with congenital neutropenia: severely reduced expression of myeloid-specific transcription factors LEF-1 and C/EBPα, severely reduced expression and functions of HCLS1 protein...
Proteolytic Processing of the Epithelial Adherens Junction Molecule E-Cadherin by Neutrophil Elastase Generates Short Peptides With Novel Wound-Healing Bioactivity
Gordon MH, et al.
Cellular and molecular gastroenterology and hepatology, 7(2), 483-483 (2019)
L V Androsova et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(2), 49-53 (2013-03-27)
The following markers of inflammation: enzymatic activity of leukocyte elastase (LE), functional activity of alpha-1-proteinase inhibitor (α1-PI), levels of C-reactive protein (CRP) and interleukin-6 (IL-6) were measured in the blood plasma of patients with Alzheimer's disease (AD) and vascular dementia...
Marshall S Horwitz et al.
Hematology/oncology clinics of North America, 27(1), 19-41 (2013-01-29)
The 2 main forms of hereditary neutropenia are cyclic (CN) and severe congenital (SCN) neutropenia. CN is an autosomal dominant disorder in which neutrophil counts fluctuate with 21-day periodicity. SCN consists of static neutropenia, with promyelocytic maturation arrest in the...
Carey A Hobbs et al.
American journal of physiology. Lung cellular and molecular physiology, 305(12), L990-L1001 (2013-10-15)
The epithelial sodium channel (ENaC) is responsible for Na(+) and fluid absorption across colon, kidney, and airway epithelia. Short palate lung and nasal epithelial clone 1 (SPLUNC1) is a secreted, innate defense protein and an autocrine inhibitor of ENaC that...
Koichiro Mihara et al.
The Journal of biological chemistry, 288(46), 32979-32990 (2013-09-21)
Neutrophil proteinases released at sites of inflammation can affect tissue function by either activating or disarming signal transduction mediated by proteinase-activated receptors (PARs). Because PAR1 is expressed at sites where abundant neutrophil infiltration occurs, we hypothesized that neutrophil-derived enzymes might...
Takafumi Hiramoto et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(8), 3023-3028 (2013-02-06)
The derivation of induced pluripotent stem (iPS) cells from individuals of genetic disorders offers new opportunities for basic research into these diseases and the development of therapeutic compounds. Severe congenital neutropenia (SCN) is a serious disorder characterized by severe neutropenia...
Alanine p-nitrophenyl esterase activity of human leucocyte granules.
A Janoff
The Biochemical journal, 114(1), 157-159 (1969-08-01)
Oriol Sibila et al.
Thorax, 74(9), 835-842 (2019-07-07)
Recently a frequent exacerbator phenotype has been described in bronchiectasis, but the underlying biological mechanisms are unknown. Antimicrobial peptides (AMPs) are important in host defence against microbes but can be proinflammatory in chronic lung disease. To determine pulmonary and systemic...
Bernard M Fischer et al.
American journal of physiology. Lung cellular and molecular physiology, 304(6), L394-L400 (2013-01-15)
Cystic Fibrosis (CF) is a chronic lung disease characterized by chronic neutrophilic airway inflammation and increased levels of neutrophil elastase (NE) in the airways. We have previously reported that NE treatment triggers cell cycle arrest. Cell cycle arrest can lead...
J W Harper et al.
Biochemistry, 23(13), 2995-3002 (1984-06-19)
The primary subsite specificities of human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin A alpha, and the protease from strain V-8 of Staphylococcus aureus have been mapped with a series of...
New insight into dry eye inflammation.
Alison M McDermott
Investigative ophthalmology & visual science, 53(13), 8264-8264 (2012-12-19)
Elastase: General Information1,2
Methods of Enzymatic Analysis, 2, 1041-1045 (1974)
Megan Meyer et al.
American journal of physiology. Lung cellular and molecular physiology, 306(3), L269-L276 (2013-11-29)
A hallmark of cigarette smoking is a shift in the protease/antiprotease balance, in favor of protease activity. However, it has recently been shown that smokers have increased expression of a key antiprotease, secretory leukoprotease inhibitor (SLPI), yet the mechanisms involved...
Susana D Lucas et al.
Journal of medicinal chemistry, 56(23), 9802-9806 (2013-11-15)
Human neutrophil elastase (HNE) is an attractive target for treating chronic and acute inflammatory lung diseases. An optimization campaign of the kojic acid scaffold to develop new potent HNE inhibitors is reported. O3-Pivaloyl derivatives were shown to be the most...
Carmen W van den Berg et al.
Journal of immunology (Baltimore, Md. : 1950), 192(4), 1787-1795 (2014-01-22)
Neutrophil dysfunction, resulting in inefficient bacterial clearance, is a feature of several serious medical conditions, including cystic fibrosis (CF) and sepsis. Poorly controlled neutrophil serine protease (NSP) activity and complement activation have been implicated in this phenomenon. The capacity for...
Shelby Landreth et al.
Vaccines, 8(2) (2020-05-07)
Avian influenza H7N9 viruses continue to pose a great threat to public health, which is evident by their high case-fatality rates. Although H7N9 was first isolated in humans in China in 2013, to date, there is no commercial vaccine available...
Robert Hanczko et al.
The Journal of clinical investigation, 119(6), 1546-1557 (2009-05-14)
Although oxidative stress has been implicated in acute acetaminophen-induced liver failure and in chronic liver cirrhosis and hepatocellular carcinoma (HCC), no common underlying metabolic pathway has been identified. Recent case reports suggest a link between the pentose phosphate pathway (PPP)...
Kun Shang et al.
PloS one, 7(12), e51848-e51848 (2012-12-29)
Ulcerative colitis (UC) is a major form of chronic inflammation that can frequently progress to colon cancer. Several studies have demonstrated massive infiltration of neutrophils and macrophages into the lamina propria and submucosa in the progression of UC-associated colon carcinogenesis....
Olga Klimenkova et al.
Blood, 123(8), 1239-1249 (2013-12-20)
We identified diminished levels of the natural inhibitor of neutrophil elastase (NE), secretory leukocyte protease inhibitor (SLPI), in myeloid cells and plasma of patients with severe congenital neutropenia (CN). We further found that downregulation of SLPI in CD34(+) bone marrow...
C Carollo et al.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 65(1), 69-76 (2013-03-30)
In chronic kidney disease (CKD) cardiovascular risk is increased. Oxidative stress is strictly involved in the pathophysiology of this enhanced risk as well as leukocytes' activation. To better elucidate these phaenomena we evaluated some parameters of leukocyte activation and oxidative...
Luis Donis-Maturano et al.
SpringerPlus, 4, 161-161 (2015-04-18)
Neutrophils are one the earliest, crucial innate defenses against innumerable pathogens. Their main microbicidal activities include phagocytosis and degranulation, with many pharmacologically active molecules contributing to inflammation. Recently, a novel antimicrobial mechanism was discovered; the Neutrophil Extracelullar Traps (NETs) formed...
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