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Sarah M Dickerson et al.
Toxicology and applied pharmacology, 252(1), 36-46 (2011-02-01)
Neonatal exposure to endocrine disrupting chemicals (EDCs) such as polychlorinated biphenyls (PCBs) can interfere with hormone-sensitive developmental processes, including brain sexual differentiation. We hypothesized that disruption of these processes by gestational PCB exposure would be detectable as early as the...
María-Esther Cruz et al.
Alcoholism, clinical and experimental research, 38(6), 1611-1621 (2014-05-14)
Intragastric or intraperitoneal ethanol (EtOH) treatment inhibits reproductive functions in females and male rats. The area of the hypothalamus where these effects take place is unknown. As the participations of the preoptic-anterior hypothalamic area (POA-AHA) in regulating ovulation is asymmetric...
T Kawarasaki et al.
Journal of animal science, 90(13), 4781-4787 (2012-07-26)
In the present study, we investigated the influence of exogenous estrogen on embryo survival after transfer into prepubertal gilts in which estrus had been induced. In the first experiment, estrus was induced in prepubertal gilts by the administration of 1,000...
Marcos Henrique Barreta et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 16(2), 275-283 (2013-06-15)
This study was based on the hypothesis that some components of the angiotensin-(1-7) (Ang-(1-7)) system are differentially expressed during follicular development and can be involved in the follicular health/atresia transition in bovine. The largest (F1) and second largest follicles (F2)...
Badr Khbouz et al.
The European journal of neuroscience, 52(1), 2627-2645 (2019-12-14)
Estrogens exert pleiotropic effects on multiple physiological and behavioral responses. Male and female sexual behavior in rodents constitutes some of the best-characterized responses activated by estrogens in adulthood and largely depend on ERα. Evidence exists that nucleus- and membrane-initiated estrogen...
Viktoria Y Topper et al.
Molecular and cellular endocrinology, 414, 42-52 (2015-07-21)
This study examined developmental changes and sexual dimorphisms in hypothalamic microRNAs, and whether gestational exposures to environmental endocrine-disrupting chemicals (EDCs) altered their expression patterns. Pregnant rat dams were treated on gestational days 16 and 18 with vehicle, estradiol benzoate, or...
Damian G Zuloaga et al.
Endocrinology, 153(9), 4432-4443 (2012-07-11)
Although several studies have reported the localization of membrane progesterone (P(4)) receptors (mPR) in various tissues, few have attempted to describe the distribution and regulation of these receptors in the brain. In the present study, we investigated expression of two...
B C Roy et al.
Meat science, 110, 109-117 (2015-07-24)
Increased meat toughness with animal age has been attributed to mature trivalent collagen cross-link formation. Intramuscular trivalent collagen cross-link content may be decreased by reducing animal age at slaughter and/or inducing muscle re-modeling with growth promotants. This hypothesis was tested...
Noriko Nakamura et al.
The Journal of toxicological sciences, 45(8), 435-447 (2020-08-04)
The imbalance of testosterone to estradiol ratio has been related to the development of prostate diseases. Although rat models of prostate diseases induced by endocrine-disrupting chemicals (EDCs) and/or hormone exposure are commonly used to analyze gene expression profiles in the...
Yaping Ji et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 32(7), e13833-e13833 (2020-03-11)
Stress exacerbates many chronic pain syndromes including irritable bowel syndrome (IBS). Among these patient populations, many suffer from comorbid or chronic overlapping pain conditions and are predominantly female. Nevertheless, basic studies investigating chronic psychological stress-induced changes in pain sensitivity have...
C M Martins et al.
Theriogenology, 78(5), 974-980 (2012-07-24)
Two experiments evaluated the effects of timing of the induction of ovulation in superstimulated lactating Holstein donor cows that were fixed-time artificially inseminated. Secondary objectives were to evaluate the effects of the timing of progesterone (P4) device removal (Experiment 1)...
Jesús Olayo-Lortia et al.
The journal of sexual medicine, 11(10), 2428-2438 (2014-07-24)
The multiple partner choice arena (MPCA) is an experimental setup in which male rats display a significant shortening of ejaculation latency, which is the main characteristic of premature ejaculation (PE) in men. Thus, the MPCA is a potential animal model...
Jessica Santollo et al.
Behavioural brain research, 191(2), 173-177 (2008-05-03)
Available data suggest that estradiol exerts an inhibitory effect on food intake by modulating the actions of multiple gut- and brain-derived peptides implicated in the control of food intake. For example, recent studies have shown that estradiol decreases the orexigenic...
R M Cleale et al.
Journal of animal science, 91(2), 970-977 (2013-01-12)
Trials were conducted with beef heifers at 4 sites to evaluate feedlot performance and carcass characteristics in response to implants containing 14 mg estradiol benzoate and 100 mg trenbolone acetate (EB/TBA; Synovex Choice, Zoetis LLC, New York, NY), 14 mg...
Hanne M Hoffmann et al.
Endocrinology, 155(10), 4043-4053 (2014-07-26)
The known genetic causes of idiopathic hypogonadotropic hypogonadism (IHH) are often associated with the loss of GnRH neurons, leading to the disruption of the hypothalamic pituitary gonadal axis and subfertility. The majority of IHH cases have unknown origins and likely...
Narjes Taherian et al.
Iranian journal of basic medical sciences, 24(2), 256-263 (2021-05-07)
Multiple sclerosis (MS) causes extensive damage in the hippocampus. Vitamin B12 (vit B12) and estradiol benzoate (EB) have anti-inflammatory and re-myelination properties that make them proper in improvement of cognitive impairment. This study aimed to evaluate the effects of these...
Enhancing Effects of beta-Estradiol 3-Benzoate but Not Methoxychlor on the Promotion/Progression Stage of Chemically-induced Mammary Carcinogenesis in Ovariectomized Rats
Ueda M, et al.
Japanese Journal of Cancer Research, 93(7), 752-759 (2002)
Shuhei Ito et al.
Biochemical and biophysical research communications, 462(4), 332-338 (2015-05-12)
In mammalian livers, sexual dimorphisms are observed in tissue-specific functions and diseases such as hepatocellular carcinoma. We identified sex-dependent differentially methylated regions (S-DMRs) which had been previously been characterized as growth hormone- STAT5 dependent. In this study, we performed genome-wide...
Chandra Suma J Miryala et al.
The journal of sexual medicine, 10(2), 350-361 (2012-11-01)
The selective serotonin reuptake inhibitor (SSRI), fluoxetine, leads to sexual dysfunction in a substantial proportion of women. In studies with the Fischer inbred rat, the 5-HT(1A) receptor has been implicated in this sexual dysfunction. Whether this association with 5-HT(1A) receptors...
Ravindranath Reddy Gilibili et al.
Toxicological sciences : an official journal of the Society of Toxicology, 140(1), 26-39 (2014-04-23)
There is a growing body of evidence that exposure to endocrine disrupting chemicals and to estrogenic compounds in particular can affect the testis and male fertility. In the present study, the constitutive expression of steroidogenic and non-steroidogenic cytochrome P450 (CYP)...
R M Cleale et al.
Journal of animal science, 90(13), 5056-5066 (2012-10-27)
Synovex Plus (SP) is a product that delivers 28 mg of estradiol benzoate (EB) and 200 mg of trenbolone acetate (TBA). We studied the impact of a polymeric, porous coating on SP implants (CSP) to prolong release of EB and...
Tatsuyuki Yoshida et al.
Animal science journal = Nihon chikusan Gakkaiho, 83(7), 529-534 (2012-07-11)
This study was designed to evaluate the effect of estrus synchronization treatments on recipient heifers for embryo transfer (ET). Holstein heifers were separated into the following three groups: (i) an administration of 50 µg GnRH (gonadotropin-releasing hormone) analog was given...
Tzu-Yun Chen et al.
Scientific reports, 9(1), 6661-6661 (2019-05-02)
The functional outcome of intracerebral hemorrhage (ICH) in young male patients are poor than in premenopausal women. After ICH, ferrous iron accumulation causes a higher level of oxidative injury associated with autophagic cell death in striatum of male mice than...
Kazunaga Oshima et al.
The Journal of veterinary medical science, 74(11), 1469-1475 (2012-07-13)
The reproductive performance of postpartum cows is affected by factors such as suckling and nutrition. We investigated the effect of a restricted suckling period on the superovulatory response and the fertility after flushing in postpartum Japanese Black cows. Forty-seven postpartum...
Vinícius G Pinheiro et al.
Theriogenology, 79(5), 797-802 (2013-01-17)
The objective was to evaluate when the LH reserve was re-established in postpartum Nellore (Bos indicus) cows by evaluating the response of the hypothalamic-pituitary axis responsiveness to exogenous GnRH or estradiol benzoate (EB). Additionally, we tested the influence of dietary...
Xi-Nan Shi et al.
Molecular medicine reports, 12(5), 6501-6508 (2015-09-24)
Cyclin-dependent kinase 2 (CDK2) has been reported to be overexpressed in human colorectal cancer; it is responsible for the G1‑to‑S‑phase transition in the cell cycle and its deregulation is a hallmark of cancer. The present study was the first to...
Scott M Belcher et al.
Endocrinology, 150(3), 1112-1121 (2008-11-15)
Medulloblastoma (MD) is the most common malignant brain tumor in children. These invasive neuroectodermal tumors arise from cerebellar granule cell-like precursors. In the developing cerebellum, estrogen influences growth and viability of granule cell precursors that transiently express elevated levels estrogen...
Brian P Kenealy et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(49), 19051-19059 (2013-12-07)
Release of gonadotropin releasing hormone (GnRH) from the medial basal hypothalamus (MBH)/median eminence region (S-ME) is essential for normal reproductive function. GnRH release is profoundly regulated by the negative and positive feedback effects of ovarian estradiol (E2). Here we report...
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