Maria J Gomez-Lamarca et al.
The Journal of cell biology, 210(2), 303-318 (2015-07-15)
Notch signaling is a major regulator of cell fate, proliferation, and differentiation. Like other signaling pathways, its activity is strongly influenced by intracellular trafficking. Besides contributing to signal activation and down-regulation, differential fluxes between trafficking routes can cause aberrant Notch