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Showing 1-30 of 320 results for "ecm gel" within Papers
Kelsey F Ruud et al.
Breast cancer research : BCR, 22(1), 82-82 (2020-08-02)
Breast cancer cells invading the connective tissues outside the mammary lobule or duct immerse in a reservoir of extracellular matrix (ECM) that is structurally and biochemically distinct from that of their site of origin. The ECM is a spatial network
Chiara E Ghezzi et al.
Journal of tissue engineering and regenerative medicine, 11(7), 2046-2059 (2015-11-10)
Type I collagen is a major structural and functional protein in connective tissues. However, collagen gels exhibit unstable geometrical properties, arising from extensive cell-mediated contraction. In an effort to stabilize collagen-based hydrogels, plastic compression was used to hybridize dense collagen
José A Jiménez-Torres et al.
Advanced healthcare materials, 5(2), 198-204 (2015-11-27)
In vitro biomimetic modeling of physio-logical structures bridges the gap between 2D in vitro culture and animal models. Lumens (tubular structures) are ubiquitous in vivo, being present in blood vessels, mammary ducts, and the lymphatic system. A method 'LumeNEXT' is
Sabrina Gioria et al.
Toxicology letters, 228(2), 111-126 (2014-05-02)
Although gold nanoparticles (AuNPs) are currently used in several industrial products and biomedical applications, information about their biological effects is very limited. Thus, it is becoming crucial to assess their safety and adequately investigate the complexity of cell-nanoparticles interactions. In
A Pinsino et al.
Marine environmental research, 93, 64-69 (2013-09-04)
In the marine environment, manganese represents a potential emerging contaminant, resulting from an increased production of manganese-containing compounds. In earlier reports we found that the exposure of Paracentrotus lividus sea urchin embryos to manganese produced phenotypes with no skeleton. In
Manman Feng et al.
Journal of biomedical materials research. Part A, 108(9), 1881-1889 (2020-04-22)
Restoring blood supply is an effective way for the therapy of myocardial infarction (MI). It was reported a specific angiogenic peptide (VMP) derived from vascular endothelial growth factor (VEGF) could activate its receptor to mimic the biological activity of VEGF.
H Capella-Monsonís et al.
Materials today. Bio, 7, 100057-100057 (2020-06-25)
The increasing economic burden of wound healing in healthcare systems requires the development of functional therapies. Xenografts with preserved extracellular matrix (ECM) structure and biofunctional components overcome major limitations of autografts and allografts (e.g. availability) and artificial biomaterials (e.g. foreign
Zun-Hong Liang et al.
Regenerative therapy, 15, 202-209 (2021-01-12)
The process of wound healing is complex. Increasing evidences have shown that lncRNA MALAT1 is abundant in fibroblasts and may be engaged in wound healing process. Therefore, we explored the mechanism of MALAT1 affecting wound healing. The expression levels of
Ho-Shin Gwak et al.
Journal of neurosurgery, 121(6), 1483-1491 (2014-10-11)
Local invasiveness of malignant glioma is a major reason for the failure of current treatments including surgery and radiation therapy. Tetraarsenic oxide (As4O6 [TAO]) is a trivalent arsenic compound that has potential anticancer and antiangiogenic effects in selected cancer cell
Artin Soroosh et al.
Cellular and molecular gastroenterology and hepatology, 2(3), 358-368 (2016-12-17)
Crohn's Disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Fibrosis, a serious complication of CD, occurs when activated intestinal fibroblasts deposit excessive amounts of extracellular matrix (ECM) in affected areas. A major component of the ECM is
Ali S Alqahtani et al.
Saudi journal of biological sciences, 28(1), 813-824 (2021-01-12)
Current pre-clinical evidences of Centella focus on its pharmacological effects on normal wound healing but there are limited studies on the bioactivity of Centella in cellular dysfunction associated with diabetic wounds. Hence we planned to examine the potential of Centella
Hongjun Lv et al.
Cell cycle (Georgetown, Tex.), 13(18), 2962-2974 (2014-12-09)
Periostin is usually considered as an oncogene in diverse human cancers, including breast, prostate, colon, esophagus, and pancreas cancers, whereas it acts as a tumor suppressor in bladder cancer. In gastric cancer, it has been demonstrated that periglandular periostin expression
Yilan Shen et al.
Acta pharmaceutica Sinica. B, 11(1), 127-142 (2021-02-04)
Diabetic nephropathy (DN) is considered the primary causes of end-stage renal disease (ESRD) and is related to abnormal glycolipid metabolism, hemodynamic abnormalities, oxidative stress and chronic inflammation. Antagonism of vascular endothelial growth factor B (VEGF-B) could efficiently ameliorate DN by
Batzaya Nyambat et al.
International journal of molecular sciences, 21(14) (2020-07-15)
The cell-derived extracellular matrix (ECM) is associated with a lower risk of pathogen transfer, and it possesses an ideal niche with growth factors and complex fibrillar proteins for cell attachment and growth. However, the cell-derived ECM is found to have
Hiroyuki Ijima et al.
Journal of bioscience and bioengineering, 128(3), 365-372 (2019-04-03)
A solubilized liver-specific extracellular matrix (L-ECM) substratum was obtained by decellularization of porcine liver using Triton X-100 and pepsin treatments. The L-ECM was able to immobilize hepatocyte growth factor at a high efficiency of 87%. L-ECM gelled spontaneously in a
Qi Li et al.
Frontiers in cell and developmental biology, 8, 694-694 (2020-09-10)
Articular cartilage damage remains a tough challenge for clinicians. Stem cells have emerged promising biologics in regenerative medicine. Previous research has widely demonstrated that adipose-derived mesenchymal stem cells (ADSCs) can promote cartilage repair due to their multipotency. However, enzymatic isolation
Sungmin Nam et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(20), 5492-5497 (2016-05-04)
The extracellular matrix (ECM) is a complex assembly of structural proteins that provides physical support and biochemical signaling to cells in tissues. The mechanical properties of the ECM have been found to play a key role in regulating cell behaviors
Robert S Fischer et al.
Nature protocols, 7(11), 2056-2066 (2012-10-27)
Regulation of cell functions by the physical properties of the extracellular matrix (ECM) has emerged as a crucial contributor to development and disease. Two specific physical properties of the ECM, stiffness and dimensionality, each influence cell signaling and function. As
Shiri Uriel et al.
Tissue engineering. Part C, Methods, 15(3), 309-321 (2009-01-01)
Interactions with the extracellular matrix (ECM) play an important role in regulating cell function. Cells cultured in, or on, three-dimensional ECM recapitulate similar features to those found in vivo that are not present in traditional two-dimensional culture. In addition, both
George S Hussey et al.
Acta biomaterialia, 108, 77-86 (2020-04-09)
Hydrogels composed of extracellular matrix (ECM) have been used as a substrate for 3D organoid culture, and in numerous preclinical and clinical applications to facilitate repair and reconstruction of a variety of tissues. However, these ECM hydrogel materials are fabricated
Corin Williams et al.
Acta biomaterialia, 14, 84-95 (2014-12-03)
Solubilized cardiac extracellular matrix (ECM) is being developed as an injectable therapeutic that offers promise for promoting cardiac repair. However, the ECM alone forms a hydrogel that is very soft compared to the native myocardium. As both the stiffness and
Y A Miroshnikova et al.
Physical biology, 8(2), 026013-026013 (2011-03-29)
The mechanical properties (e.g. stiffness) of the extracellular matrix (ECM) influence cell fate and tissue morphogenesis and contribute to disease progression. Nevertheless, our understanding of the mechanisms by which ECM rigidity modulates cell behavior and fate remains rudimentary. To address
Daniyil A Svystonyuk et al.
Journal of translational medicine, 13, 147-147 (2015-05-08)
Tissue fibrosis and chamber remodeling is a hallmark of the failing heart and the final common pathway for heart failure of diverse etiologies. Sustained elevation of pro-fibrotic cytokine transforming growth factor-beta1 (TGFβ1) induces cardiac myofibroblast-mediated fibrosis and progressive structural tissue
Fabienna Arends et al.
PloS one, 10(2), e0118090-e0118090 (2015-02-18)
The migration of cells within a three-dimensional extracellular matrix (ECM) depends sensitively on the biochemical and biophysical properties of the matrix. An example for a biological ECM is given by reconstituted basal lamina gels purified from the Engelbreth-Holm-Swarm sarcoma of
E A Davenport et al.
Experimental cell research, 223(1), 155-162 (1996-02-25)
Extracellular matrix (ECM) molecules, including those present in basement membranes, are known to play an important role in morphogenesis and differentiation. Primary rat tracheal epithelial (RTE) cells grown on permeable membranes in air-liquid interface (ALI) cultures differentiate into mucous and
Shune Xiao et al.
Stem cells international, 2020, 9054514-9054514 (2020-07-03)
Adipose-derived stem cell- (ADSC-) based regenerative medicine has expanded to include the treatment of hair loss. However, stem cell therapy remains a relatively recent technique, and reports of its use for treating alopecia are rare. ADSCs exert biological functions via
Yansong Ren et al.
Stem cell research & therapy, 13(1), 389-389 (2022-07-31)
Induced pluripotent stem cells (iPSCs) have the potential to promote wound healing; however, their adhesion to the extracellular matrix (ECM) might decrease iPSC migration, thereby limiting their therapeutic potential. Integrin β1 (Itgb1) is the major integrin subunit that mediates iPSC-ECM
Sophia P Pilipchuk et al.
Journal of biomedical materials research. Part A, 101(10), 2883-2895 (2013-03-19)
Natural hydrogels have been investigated for three-dimensional tissue reconstruction and regeneration given their ability to emulate the structural complexity of multi-component extracellular matrices (ECM). Hydrogels rich in ECM can be extracted and assembled from soft tissues, retain a composition specific
Hannu Järveläinen et al.
Arteriosclerosis, thrombosis, and vascular biology, 24(1), 67-72 (2003-11-15)
Overexpression of decorin reduces neointimal thickening in balloon-injured carotid arteries of rats by decreasing the volume of neointimal extracellular matrix (ECM). We examined the hypothesis that decorin regulates ECM volume by stimulating cell-mediated contraction of collagen-rich ECMs. Rat arterial smooth
Vasudha Shukla et al.
Annals of biomedical engineering, 46(1), 197-207 (2017-09-25)
The leading cause of neonatal mortality, pre-term birth, is often caused by pre-mature ripening/opening of the uterine cervix. Although cervical fibroblasts play an important role in modulating the cervix's extracellular matrix (ECM) and mechanical properties, it is not known how
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