Related Product Categories
Organism
Showing 1-25 of 25 results for "epigenetics"
KDM1B
lysine (K)-specific demethylase 1B
Synonyms:
AOF1, C6orf193, LSD2, bA204B7.3, dJ298J15.2
Species:
Human KDM1B (221656), Mouse Kdm1b (218214), Rat Kdm1b (306819), chicken KDM1B (420829), cow KDM1B (513667), Horse KDM1B (100066240), domestic cat KDM1B (101099460), dog KDM1B (478733), domestic guinea pig Kdm1b (100722433), naked mole-rat Kdm1b (101711296), sheep KDM1B (101122986)
Summary:
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342
Products:
CDK2AP1
cyclin-dependent kinase 2 associated protein 1
Synonyms:
DOC1, DORC1, ST19, doc-1, p12DOC-1
Species:
Human CDK2AP1 (8099), Mouse Cdk2ap1 (13445), Rat Cdk2ap1 (360804), chicken CDK2AP1 (416826), domestic cat CDK2AP1 (101089721), cow CDK2AP1 (615387), dog CDK2AP1 (477452), domestic guinea pig Cdk2ap1 (100734683), naked mole-rat Cdk2ap1 (101723683), sheep CDK2AP1 (101122554)
Summary:
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012
Products:
RHOXF1
Rhox homeobox family, member 1
Synonyms:
OTEX, PEPP1
Species:
Human RHOXF1 (158800), sheep RHOXF1 (101104563), chicken RHOXF1 (772262), dog RHOXF1 (481034), domestic cat RHOXF1 (101093839)
Summary:
This gene is a member of the PEPP subfamily of paired-like homoebox genes. The gene may be regulated by androgens and epigenetic mechanisms. The encoded nuclear protein is likely a transcription factor that may play a role in human reproduction. [provided by RefSeq, Dec 2012
Products:
CHD4
chromodomain helicase DNA binding protein 4
Synonyms:
Mi-2b, Mi2-BETA
Species:
Human CHD4 (1108), Mouse Chd4 (107932), Rat Chd4 (117535), chicken CHD4 (418278), cow CHD4 (506402), Horse CHD4 (100059817), domestic cat CHD4 (101081904), dog CHD4 (477714), sheep CHD4 (101109874), Domestic Rabbit CHD4 (100337729), naked mole-rat Chd4 (101707353), domestic guinea pig Chd4 (100735611)
Summary:
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. [provided by RefSeq, Jul 2008
Products:
POU3F4
POU class 3 homeobox 4
Synonyms:
BRAIN-4, BRN-4, BRN4, DFN3, DFNX2, OCT-9, OTF-9, OTF9
Species:
Human POU3F4 (5456), Mouse Pou3f4 (18994), Rat Pou3f4 (29589), chicken POU3F4 (100857422), Horse POU3F4 (100071720), dog POU3F4 (491988), domestic guinea pig Pou3f4 (100721430), naked mole-rat Pou3f4 (101704095), cow POU3F4 (539732)
Summary:
This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012
Products:
SETDB2
SET domain, bifurcated 2
Synonyms:
C13orf4, CLLD8, CLLL8, KMT1F
Species:
Human SETDB2 (83852), Mouse Setdb2 (239122), Rat Setdb2 (100361710), Zebrafish setdb2 (335153), chicken SETDB2 (418866), domestic cat SETDB2 (101100356), dog SETDB2 (485441), domestic guinea pig Setdb2 (100717131), naked mole-rat Setdb2 (101696702), Domestic Rabbit SETDB2 (100358988), cow SETDB2 (509382), sheep SETDB2 (101116064)
Summary:
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510
Products:
SFRP1
secreted frizzled-related protein 1
Synonyms:
FRP, FRP-1, FRP1, FrzA, SARP2
Species:
Human SFRP1 (6422), Mouse Sfrp1 (20377), Rat Sfrp1 (84402), chicken SFRP1 (395237), dog SFRP1 (482844), domestic cat SFRP1 (101083585), domestic guinea pig Sfrp1 (100727192), naked mole-rat Sfrp1 (101716300), cow SFRP1 (282068), sheep SFRP1 (101121066)
Summary:
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009
Products:
WIF1
WNT inhibitory factor 1
Synonyms:
WIF-1
Species:
Human WIF1 (11197), Mouse Wif1 (24117), Rat Wif1 (114557), naked mole-rat Wif1 (101708267), domestic guinea pig Wif1 (100736242), cow WIF1 (533672), sheep WIF1 (101109259), Zebrafish wif1 (30476), chicken WIF1 (417831), dog WIF1 (481148), domestic cat WIF1 (101088855)
Summary:
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010
Products:
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Synonyms:
ADERM, ETL1, HEL1
Species:
Human SMARCAD1 (56916), Mouse Smarcad1 (13990), Rat Smarcad1 (312398), cow SMARCAD1 (530506), sheep SMARCAD1 (101116398), Domestic Rabbit SMARCAD1 (100354709), naked mole-rat Smarcad1 (101705896), domestic guinea pig Smarcad1 (100734914), Zebrafish smarcad1 (557875), chicken SMARCAD1 (422522), Horse SMARCAD1 (100053412), domestic cat SMARCAD1 (101083588), dog SMARCAD1 (478480)
Summary:
This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011
Products:
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
Synonyms:
DNMT3A2, M.HsaIIIA
Species:
Human DNMT3A (1788), Mouse Dnmt3a (13435), Rat Dnmt3a (444984), chicken DNMT3A (421991), dog DNMT3A (482996), domestic cat DNMT3A (100510798), cow DNMT3A (359716), Horse DNMT3A (100055881), sheep DNMT3A (100500776), Domestic Rabbit DNMT3A (100344715), domestic guinea pig Dnmt3a (100721625), naked mole-rat Dnmt3a (101718745)
Summary:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008
Products:
SIRT7
sirtuin 7
Synonyms:
SIR2L7
Species:
Human SIRT7 (51547), Mouse Sirt7 (209011), Rat Sirt7 (303745), domestic guinea pig Sirt7 (100714091), naked mole-rat Sirt7 (101716210), cow SIRT7 (505662), sheep SIRT7 (101108066), fruit fly Sirt7 (43433), Zebrafish sirt7 (654702), dog SIRT7 (483371), domestic cat SIRT7 (101100681)
Summary:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008
Products:
SIRT6
sirtuin 6
Synonyms:
SIR2L6
Species:
Human SIRT6 (51548), Mouse Sirt6 (50721), Rat Sirt6 (299638), fruit fly Sirt6 (41254), Zebrafish sirt6 (415161), chicken SIRT6 (428332), domestic cat SIRT6 (101100540), dog SIRT6 (485045), cow SIRT6 (535416), sheep SIRT6 (101113327), naked mole-rat Sirt6 (101706114), domestic guinea pig Sirt6 (100734667)
Summary:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010
Products:
SIRT1
sirtuin 1
Synonyms:
SIR2L1
Species:
Human SIRT1 (23411), Mouse Sirt1 (93759), Rat Sirt1 (309757), domestic guinea pig Sirt1 (100717014), naked mole-rat Sirt1 (101720282), Domestic Rabbit SIRT1 (100349271), cow SIRT1 (613629), sheep SIRT1 (101102956), Zebrafish sirt1 (797132), chicken SIRT1 (423646), dog SIRT1 (489012), domestic cat SIRT1 (101087610), Horse SIRT1 (100072571)
Summary:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008
Products:
IGF2
insulin-like growth factor 2 (somatomedin A)
Synonyms:
C11orf43, IGF-II, PP9974
Species:
Human IGF2 (3481), Mouse Igf2 (16002), Rat Igf2 (24483), Goat IGF2 (100861277), sheep IGF2 (443325), Domestic Rabbit IGF2 (100328792), domestic guinea pig Igf2 (100135552), naked mole-rat Igf2 (101720309), chicken IGF2 (395097), dog IGF2 (483664), Horse IGF2 (100034182), cow IGF2 (281240), domestic cat IGF2 (101093644)
Summary:
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010
Products:
SIRT4
sirtuin 4
Synonyms:
SIR2L4
Species:
Human SIRT4 (23409), Mouse Sirt4 (75387), Rat Sirt4 (304539), fruit fly Sirt4 (31480), domestic cat SIRT4 (101095286), dog SIRT4 (477507), chicken SIRT4 (416981), cow SIRT4 (519328), sheep SIRT4 (100217404), naked mole-rat Sirt4 (101700255), domestic guinea pig Sirt4 (100734585)
Summary:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008
Products:
SIRT5
sirtuin 5
Synonyms:
SIR2L5
Species:
Human SIRT5 (23408), Mouse Sirt5 (68346), Rat Sirt5 (306840), domestic guinea pig Sirt5 (100718110), naked mole-rat Sirt5 (101718891), cow SIRT5 (507347), Goat SIRT5 (100860989), sheep SIRT5 (101104099), Zebrafish sirt5 (436878), chicken SIRT5 (420834), domestic cat SIRT5 (101089862), dog SIRT5 (478726)
Summary:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010
Products:
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
Synonyms:
ICF, ICF1, M.HsaIIIB
Species:
Human DNMT3B (1789), Mouse Dnmt3b (13436), Rat Dnmt3b (444985), Zebrafish dnmt3b (321084), cow DNMT3B (353354), Horse DNMT3B (100053900), chicken DNMT3B (419287), dog DNMT3B (100685634), domestic cat DNMT3B (101092926), sheep DNMT3B (100500777), Domestic Rabbit DNMT3B (100349823), naked mole-rat Dnmt3b (101725788), domestic guinea pig Dnmt3b (100731772)
Summary:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011
Products:
SIRT2
sirtuin 2
Synonyms:
SIR2, SIR2L, SIR2L2
Species:
Human SIRT2 (22933), Mouse Sirt2 (64383), Rat Sirt2 (361532), fruit fly Sirt2 (42414), chicken SIRT2 (548628), domestic cat SIRT2 (101099513), dog SIRT2 (612558), Zebrafish sirt2 (322309), cow SIRT2 (504463), sheep SIRT2 (101113169), naked mole-rat Sirt2 (101715152), domestic guinea pig Sirt2 (100734519)
Summary:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010
Products:
PRMT6
protein arginine methyltransferase 6
Synonyms:
HRMT1L6
Species:
Human PRMT6 (55170), Mouse Prmt6 (99890), Rat Prmt6 (295384), Thale Cress PRMT6 (821541), domestic cat PRMT6 (101093626), dog PRMT6 (490133), Zebrafish prmt6 (448867), naked mole-rat Prmt6 (101715374), domestic guinea pig Prmt6 (100725259), cow PRMT6 (540228), sheep PRMT6 (101119859)
Summary:
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011
Products:
SIRT3
sirtuin 3
Synonyms:
SIR2L3
Species:
Human SIRT3 (23410), Mouse Sirt3 (64384), Rat Sirt3 (293615), domestic guinea pig Sirt3 (100714713), naked mole-rat Sirt3 (101697494), Domestic Rabbit SIRT3 (100354500), cow SIRT3 (614027), sheep SIRT3 (101105454), Zebrafish sirt3 (558775), domestic cat SIRT3 (101087609), dog SIRT3 (475933), chicken SIRT3 (422988)
Summary:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008
Products:
KMT2A
lysine (K)-specific methyltransferase 2A
Synonyms:
ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS
Species:
Human KMT2A (4297), Mouse Kmt2a (214162), Rat Kmt2a (315606), domestic guinea pig Kmt2a (100727230), naked mole-rat Kmt2a (101716671), Zebrafish kmt2a (557048), cow KMT2A (508330)
Summary:
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010
Products:
CBX1
chromobox homolog 1
Synonyms:
CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta
Species:
Human CBX1 (10951), Mouse Cbx1 (12412), Rat Cbx1 (360609), naked mole-rat Cbx1 (101706928), domestic guinea pig Cbx1 (100716439), sheep CBX1 (101116158), chicken CBX1 (374237), domestic cat CBX1 (101084070), cow CBX1 (616506), dog CBX1 (491051)
Summary:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008
Products:
DNMT3L
DNA (cytosine-5-)-methyltransferase 3-like
Species:
Human DNMT3L (29947), Mouse Dnmt3l (54427), Rat Dnmt3l (309680), domestic guinea pig Dnmt3l (100729608), naked mole-rat Dnmt3l (101719207), sheep DNMT3L (101102451), dog DNMT3L (608536), domestic cat DNMT3L (101091300), cow DNMT3L (613785), Horse DNMT3L (100050680)
Summary:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012
Products:
RASD1
RAS, dexamethasone-induced 1
Synonyms:
AGS1, DEXRAS1, MGC:26290
Species:
Human RASD1 (51655), Mouse Rasd1 (19416), Rat Rasd1 (64455), domestic guinea pig Rasd1 (100730809), naked mole-rat Rasd1 (101707211), cow RASD1 (507449), sheep RASD1 (100302075), Zebrafish rasd1 (393504), domestic cat RASD1 (101080588), dog RASD1 (489542), chicken RASD1 (416507)
Summary:
This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011
Products:
KDM2A
lysine (K)-specific demethylase 2A
Synonyms:
CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA
Species:
Human KDM2A (22992), Mouse Kdm2a (225876), Rat Kdm2a (361700), Zebrafish kdm2a (799441), cow KDM2A (540141), Horse KDM2A (100052955), domestic cat KDM2A (101090549), dog KDM2A (483702), chicken KDM2A (425999), sheep KDM2A (101108003), domestic guinea pig Kdm2a (100732285), naked mole-rat Kdm2a (101713712)
Summary:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012
Products:

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.