Showing 1-30 of 16462 results for "epigenetics"
Scott Berry et al.
Genes & development, 31(21), 2115-2120 (2017-12-08)
Epigenetic maintenance of gene repression is essential for development. Polycomb complexes are central to this memory, but many aspects of the underlying mechanism remain unclear. LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) binds Polycomb-deposited H3K27me3 and is required for repression of many...
Ricardo Malvicini et al.
International journal of molecular sciences, 20(13) (2019-07-07)
Mechanisms mediating mesenchymal stromal/stem cells' (MSCs) multipotency are unclear. Although the expression of the pluripotency factor OCT4 has been detected in MSCs, whether it has a functional role in adult stem cells is still controversial. We hypothesized that a physiological...
Flávia Caló Aquino Xavier et al.
Archives of oral biology, 59(8), 783-789 (2014-05-27)
Aberrant DNA methylation is a fundamental transcriptional control mechanism in carcinogenesis. The expression of homeobox genes is usually controlled by an epigenetic mechanism, such as the methylation of CpG islands in the promoter region. The aim of this study was...
Shotaro Tatekawa et al.
British journal of haematology, 178(4), 534-546 (2017-04-26)
Cytogenetic/molecular heterogeneity is the hallmark of multiple myeloma (MM). However, we recently showed that the serine/threonine kinase PDPK1 and its substrate RPS6KA3 (also termed RSK2) are universally active in MM, and play pivotal roles in myeloma pathophysiology. In this study...
Nagif Alata Jimenez et al.
Developmental biology, 444 Suppl 1, S193-S201 (2018-08-14)
Folate deficiency has been known to contribute to neural tube and neural crest defects, but why these tissues are particularly affected, and which are the molecular mechanisms involved in those abnormalities are important human health questions that remain unanswered. Here...
Alma Rodenas-Ruano et al.
Nature neuroscience, 15(10), 1382-1390 (2012-09-11)
NMDA receptors (NMDARs) are critical to synaptogenesis, neural circuitry and higher cognitive functions. A hallmark feature of NMDARs is an early postnatal developmental switch from those containing primarily GluN2B to primarily GluN2A subunits. Although the switch in phenotype has been...
Yadong Wang et al.
The Journal of biological chemistry, 292(12), 4811-4817 (2017-02-06)
Production of hemoglobin during development is tightly regulated. For example, expression from the human β-globin gene locus, comprising β-, δ-, ϵ-, and γ-globin genes, switches from ϵ-globin to γ-globin during embryonic development and then from γ-globin to β-globin after birth....
Natalia Shalginskikh et al.
Journal of virology, 87(4), 2137-2150 (2012-12-12)
Integrated retroviral DNA is subject to epigenetic transcriptional silencing at different frequencies. This process is mediated by repressive DNA methylation and histone modifications on viral chromatin. However, the detailed mechanisms by which retroviral silencing is initiated and maintained are not...
Vincent T Bicocca et al.
eLife, 7 (2018-11-24)
Methylation of histone H3 at lysine 36 (H3K36me), a widely-distributed chromatin mark, largely results from association of the lysine methyltransferase (KMT) SET-2 with RNA polymerase II (RNAPII), but most eukaryotes also have additional H3K36me KMTs that act independently of RNAPII....
James V Falvo et al.
Advances in immunology, 118, 37-128 (2013-05-21)
Epigenetics encompasses transient and heritable modifications to DNA and nucleosomes in the native chromatin context. For example, enzymatic addition of chemical moieties to the N-terminal "tails" of histones, particularly acetylation and methylation of lysine residues in the histone tails of...
Jesse H Arbuckle et al.
mBio, 5(1), e01027-e01013 (2014-01-16)
Upon infection, the genome of herpes simplex virus is rapidly incorporated into nucleosomes displaying histone modifications characteristic of heterochromatic structures. The initiation of infection requires complex viral-cellular interactions that ultimately circumvent this repression by utilizing host cell enzymes to remove...
Carson C Chow et al.
PLoS computational biology, 11(3), e1004122-e1004122 (2015-03-31)
Gene repression by transcription factors, and glucocorticoid receptors (GR) in particular, is a critical, but poorly understood, physiological response. Among the many unresolved questions is the difference between GR regulated induction and repression, and whether transcription cofactor action is the...
Chia-Ming Yeh et al.
International journal of oncology, 45(5), 2101-2107 (2014-09-02)
Ovarian cancer is the fifth leading cause of cancer death and the most deadly gynecological malignancy in women. Epigenetic modifications play an important role in regulating gene transcription. Specifically, aberrant promoter hypermethylation has been implicated as a hallmark of cancer....
Sangwon Byun et al.
The EMBO journal, 36(12), 1755-1769 (2017-04-28)
Lysosome-mediated autophagy is essential for cellular survival and homeostasis upon nutrient deprivation, but is repressed after feeding. Despite the emerging importance of transcriptional regulation of autophagy by nutrient-sensing factors, the role for epigenetic control is largely unexplored. Here, we show...
Katerina I Leonova et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(1), E89-E98 (2012-12-14)
Large parts of mammalian genomes are transcriptionally inactive and enriched with various classes of interspersed and tandem repeats. Here we show that the tumor suppressor protein p53 cooperates with DNA methylation to maintain silencing of a large portion of the...
Emeli M Nilsson et al.
Oncotarget, 6(34), 35710-35725 (2015-10-16)
Androgens and the androgen receptor (AR) play crucial roles in male development and the pathogenesis and progression of prostate cancer (PCa). The AR functions as a ligand dependent transcription factor which recruits multiple enzymatically distinct epigenetic coregulators to facilitate transcriptional...
Robin L Adrianse et al.
Epigenetics & chromatin, 11(1), 50-50 (2018-09-02)
The long noncoding RNA Xist is critical for initiation and establishment of X-chromosome inactivation during embryogenesis in mammals, but it is unclear whether its continued expression is required for maintaining X-inactivation in vivo. By using an inactive X-chromosome-linked MeCP2-GFP reporter...
Michał Stefan Lach et al.
Stem cell research, 20, 34-37 (2017-04-12)
The primary human dermal fibroblasts (PHDFs) from breast cancer patient were obtained to generate the human induced pluripotent stem cell line GPCCi001-A via lentiviral transfection. Thus, a modified EF1a-hSTEMCCA-loxP with tetO operator which regulates transgene expression was used. This method...
Xian Zhong et al.
Journal of cancer research and clinical oncology, 139(3), 485-490 (2012-11-28)
Aberrant DNA methylation is common in cancer cells. Epigenetic alterations resulting in the loss of tumor suppression gene functions are frequently involved in tumor development and progression. Recently, methylation of PCDH10 was reported to be associated with multiple hematologic malignancies...
Liguo Zhang et al.
The Plant cell, 24(11), 4407-4421 (2012-11-15)
DNA methylation and histone H3 Lys 9 dimethylation (H3K9me2) are important epigenetic repression marks for silencing transposons in heterochromatin and for regulating gene expression. However, the mechanistic relationship to other repressive marks, such as histone H3 Lys 27 trimethylation (H3K27me3)...
Priyalakshmi Panikker et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(19), 4569-4583 (2018-04-15)
Cognitive decline is a debilitating hallmark during preclinical stages of Alzheimer's disease (AD), yet the causes remain unclear. Because histone acetylation homeostasis is critical for mediating epigenetic gene control throughout neuronal development, we postulated that its misregulation contributes to cognitive...
Yanxin Luo et al.
PLoS genetics, 9(7), e1003552-e1003552 (2013-07-23)
NTRK3 is a member of the neurotrophin receptor family and regulates cell survival. It appears to be a dependence receptor, and thus has the potential to act as an oncogene or as a tumor suppressor gene. NTRK3 is a receptor...
Yat-Yuen Lim et al.
Journal of cell science, 126(Pt 10), 2256-2266 (2013-03-26)
The miR-200 family is a key regulator of the epithelial-mesenchymal transition, however, its role in controlling the transition between cancer stem-cell-like and non-stem-cell-like phenotypes is not well understood. We utilized immortalized human mammary epithelial (HMLE) cells to investigate the regulation...
Kaori Nakayama-Hosoya et al.
The Journal of infectious diseases, 211(1), 28-39 (2014-07-09)
The molecular mechanisms for IL2 gene-specific dysregulation during chronic human immunodeficiency virus type 1 (HIV-1) infection are unknown. Here, we investigated the role of DNA methylation in suppressing interleukin 2 (IL-2) expression in memory CD4(+) T cells during chronic HIV-1...
Céline Vallot et al.
Cell stem cell, 16(5), 533-546 (2015-04-30)
Human pluripotent stem cells (hPSCs) display extensive epigenetic instability, particularly on the X chromosome. In this study, we show that, in hPSCs, the inactive X chromosome has a specific heterochromatin landscape that predisposes it to erosion of X chromosome inactivation...
Wenzheng Zhang et al.
American journal of physiology. Renal physiology, 304(4), F367-F375 (2012-11-16)
The epithelial Na(+) channel subunit-α (αENaC) of the distal nephron is essential for salt balance. We previously demonstrated that the histone methyltransferase Dot1a and its protein partner Af9 basally repress αENaC transcription in mouse inner medullary collecting duct type 3...
Jennifer Hernández-Juárez et al.
International journal of oncology, 54(5), 1613-1624 (2019-03-22)
The SLC5A8 gene encodes Na monocarboxylate transporter 1, which is epigenetically inactivated in various tumour types. This has been attributed to the fact that it prevents the entry of histone deacetylase (HDAC) inhibitors and favours the metabolic reprogramming of neoplastic cells....
Licong Shen et al.
The Journal of clinical endocrinology and metabolism, 98(4), 1575-1582 (2013-03-02)
Steroidogenic factor (SF)-1 and its downstream target genes involved in estrogen signaling are aberrantly expressed in ovarian endometriosis. Our objective was to explore the microRNA-mediated mechanism controlling aberrant SF-1 expression in ovarian endometriosis. Bioinformatics analysis predicted that microRNA23a and microRNA23b...
Masaki Yagi et al.
Nature communications, 11(1), 3199-3199 (2020-06-26)
De novo establishment of DNA methylation is accomplished by DNMT3A and DNMT3B. Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) derived from DNA-hypomethylated 2i/L ES cells with genetic ablation of Dnmt3a or Dnmt3b. We identify 355...
Shanshan Li et al.
Life sciences, 231, 116576-116576 (2019-06-19)
Studies suggest that cardiovascular function in offspring can be epigenetically programmed by environmental changes during pregnancy. CaV1.2 channel plays a major role in the regulation of the vascular tone. This study investigated the effects and underlying mechanisms of exercise during...

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