etoposide induced 2.4 pseudogene 1

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Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis.

Kyoko Tsujimoto et al.

The Journal of biological chemistry, 280(30), 27638-27644 (2005-06-10)

Caspase-9 (Casp-9) induces death signals by triggering other types of caspase activation, and its expression greatly influences the onset of apoptosis. During the isolation of apoptosis-related genes involved in glucocorticoid (GC)-induced cell death in murine thymic lymphomas, we found that

EI24 tethers endoplasmic reticulum and mitochondria to regulate autophagy flux.

Lin Yuan et al.

Cellular and molecular life sciences : CMLS, 77(8), 1591-1606 (2019-07-25)

Etoposide-induced protein 2.4 (EI24), located on the endoplasmic reticulum (ER) membrane, has been proposed to be an essential autophagy protein. Specific ablation of EI24 in neuronal and liver tissues causes deficiency of autophagy flux. However, the molecular mechanism of the

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